Debt Disclosure [Abstract] Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Lender Name [Axis] Lender Name [Axis] Line of Credit Facility, Lender [Domain] Line of Credit Facility, Lender [Domain] SVB and MidCap Silicon Valley Bank And MidCap Financial Services [Member] Silicon Valley Bank And MidCap Financial Services [Member] Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Term loan Term Loan [Member] Term Loan [Member] Debt Instrument [Line Items] Debt Instrument [Line Items] Repayments of debt Repayments of Debt Pre-payment premium (as a percent) Debt Instrument, Prepayment Premium Percentage Debt Instrument, Prepayment Premium Percentage Payment for debt extinguishment or debt prepayment cost Payment for Debt Extinguishment or Debt Prepayment Cost Stated percentage for final payment (as a percent) Debt Instrument, Interest Rate, Stated Percentage, Final Payment Due Upon Maturity Debt Instrument, Interest Rate, Stated Percentage, Final Payment Due Upon Maturity Debt instrument final payment Repayments of Debt, Final Payment Repayments of Debt, Final Payment Loss on extinguishment of debt Gain (Loss) on Extinguishment of Debt Cover page. 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Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Stock option exercises Stock Issued During Period, Value, Stock Options Exercised Shares issued under the Employee Stock Purchase Plan (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Shares issued under the Employee Stock Purchase Plan Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of warrants Adjustments to Additional Paid in Capital, Warrant Issued Exercise of warrants resulting in issuance of common stock (Note 11) (in shares) Exercise of warrants resulting in issuance of common stock Stock Issued During Period, Value, Exercise Of Warrants Stock Issued During Period, Value, Exercise Of Warrants Net change in unrealized (gain) loss on investments Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Ending balance (in shares) Ending balance Risks and Uncertainties 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Leasehold improvements Leasehold Improvements [Member] Construction in process Construction in Progress [Member] Property and equipment, net: Property, Plant and Equipment [Line Items] Total property and equipment, gross Property, Plant and Equipment, Gross Financing right-of-use lease Finance Lease, Right-of-Use Asset, before Accumulated Amortization Finance Lease, Right-of-Use Asset, before Accumulated Amortization Total property and equipment, gross Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, before Accumulated Depreciation and Amortization Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, before Accumulated Depreciation and Amortization Less accumulated depreciation Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, Accumulated Depreciation and Amortization Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, Accumulated Depreciation and Amortization Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, after Accumulated Depreciation and Amortization Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, after Accumulated Depreciation and Amortization Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, after Accumulated Depreciation and Amortization Less accumulated depreciation Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Property and Equipment Property, Plant and Equipment, Net Depreciation expense Depreciation Operating lease term (in years) Operating Lease, Weighted Average Remaining Lease Term Finance lease term (in years) Finance Lease, Weighted Average Remaining Lease Term Operating lease discount rate ( as a percent ) Operating Lease, Weighted Average Discount Rate, Percent Finance lease discount rate ( as a percent ) Finance Lease, Weighted Average Discount Rate, Percent Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Statistical Measurement [Axis] Statistical Measurement [Axis] Statistical Measurement [Domain] Statistical Measurement [Domain] Minimum Minimum [Member] Maximum Maximum [Member] Stock-Based Compensation Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Expected dividend rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Expected stock price volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Risk-free interest rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Expected life (years) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Inventory: Inventory, Net [Abstract] Raw materials Inventory, Raw Materials, Gross Work-in-process Inventory, Work in Process, Gross Finished goods Inventory, Finished Goods, Gross Inventory Inventory, Net Options Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Outstanding at the beginning of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Exercised (in shares) Expired (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Outstanding at the end of the period (in shares) Exercisable at the end of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Outstanding at the beginning of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Exercised (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Expired (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price Forfeited (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price Outstanding at the end of the period (in dollars per share) Exercisable at the end of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price Weighted Average Remaining Contractual Term Share Based Compensation Arrangement by Share Based Payment Award Options, Weighted Average Remaining Contractual Term [Abstract] Outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Exercisable at end of period Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Aggregate Intrinsic Value Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract] Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract] Outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Exercised Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value Exercisable at end of period Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Short-term lease costs (less than) Short-term Lease, Cost Net lease assets Lease liability Lease Liability Lease Liability Operating lease expense Operating Lease, Expense Finance lease expense Finance Lease, Interest Expense Operating lease expense Operating Leases, Rent Expense Finance lease expense Capital Leases, Income Statement, Interest Expense Measurement of lease liability Measurement Of Lease Liability Measurement Of Lease Liability Lease not yet commenced, liability Lessee, Lease Not yet Commenced, Liability Lessee, Lease Not yet Commenced, Liability Term of contract Lessee, Lease Not yet Commenced, Term of Contract Lessee, Lease Not yet Commenced, Term of Contract Rent expense Operating Leases, Rent Expense, Net Summary of valuation of the Company's investments and financial instruments that are measured at fair value on a recurring basis Fair Value, Liabilities Measured on Recurring Basis [Table Text Block] Number of Restricted Stock Awards Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Outstanding at December 31, 2018 (shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Granted (shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Vested (shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Forfeited (shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Unvested at December 31, 2019 (shares) Weighted Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Unvested at December 31, 2018 (in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Granted (in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Forfeited (in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Unvested at December 31, 2019 (in usd per share) Unvested at December 31, 2019, Weighted Average Term Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms Aggregate Intrinsic Value (Thousands) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value [Abstract] Granted, Aggregate Intrinsic Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Aggregate Intrinsic Value, Nonvested Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Aggregate Intrinsic Value, Nonvested Unvested at December 31, 2019, Aggregate Intrinsic Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Nonvested Schedule of future minimum payments related to operating and capital leases Net Loss Per Common Share Earnings Per Share [Text Block] Operating Leases 2020 Lessee, Operating Lease, Liability, Payments, Remainder of Fiscal Year 2021 Lessee, Operating Lease, Liability, Payments, Due Year Two 2022 Lessee, Operating Lease, Liability, Payments, Due Year Three 2023 Lessee, Operating Lease, Liability, Payments, Due Year Four 2024 Lessee, Operating Lease, Liability, Payments, Due Year Five more than 5 years Lessee, Operating Lease, Liability, Payments, Due after Year Six Lessee, Operating Lease, Liability, Payments, Due after Year Six Total Lessee, Operating Lease, Liability, Payments, Due Less: Interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Present value of lease liabilities Operating Lease, Liability Finance Leases 2020 Finance Lease, Liability, Payments, Remainder of Fiscal Year 2021 Finance Lease, Liability, Payments, Due Year Two 2022 Finance Lease, Liability, Payments, Due Year Three 2023 Finance Lease, Liability, Payments, Due Year Four 2024 Finance Lease, Liability, Payments, Due Year Five more than 5 years Finance Lease, Liability, Payments, Due after Year Six Finance Lease, Liability, Payments, Due after Year Six Total Finance Lease, Liability, Payment, Due Less: Interest Finance Lease, Liability, Undiscounted Excess Amount Present value of lease liabilities Finance Lease, Liability 2020 Lease Liability Payments Due, Next Twelve Months Lease Liability Payments Due, Next Twelve Months 2021 Lease Liability Payments Due Year Two Lease Liability Payments Due Year Two 2022 Lease Liability Payments Due Year Three Lease Liability Payments Due Year Three 2023 Lease Liability Payments Due Year Four Lease Liability Payments Due Year Four 2024 Lease Liability Payments Due Year Five Lease Liability Payments Due Year Five more than 5 years Lease Liability Payments Due After Year Six Lease Liability Payments Due After Year Six Total Lease Liability Payments Due Lease Liability Payments Due Less: Interest Lease, Liability, Undiscounted Excess Amount Lease, Liability, Undiscounted Excess Amount Present value of lease liabilities Nexobrid License and Supply Agreements License Agreement [Text Block] License Agreement [Text Block] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Gross profit Gross Profit Income (loss) from operations Net (loss) income Net (loss) income per share (Basic) (in USD per share) Earnings Per Share, Basic Net (loss) income per share (Diluted) (in USD per share) Earnings Per Share, Diluted Grantee Status [Axis] Grantee Status [Axis] Grantee Status [Domain] Grantee Status [Domain] Nonemployee directors Share-based Payment Arrangement, Nonemployee [Member] Plan Name [Axis] Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] Prior Plans Prior Plans [Member] Represents the information pertaining to the Prior Plans consisting of 1992 Stock Option Plan, the 2001 Stock Option Plan and the Amended and Restated 2004 Equity Incentive Plan. Omnibus Incentive Plan 2019 Omnibus Incentive Plan 2019 [Member] Omnibus Incentive Plan 2019 [Member] Employee stock Employee Stock [Member] Expiration period Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period Vesting period Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Awards available for future grant under the Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Common stock available for issuance (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Common stock granted since inception (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Granted Shares purchased during period (in shares) Shares issued under the Employee Stock Purchase Plan (in shares) Stock-based compensation expense Weighted average grant-date fair value (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Expected to vest (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Total unrecognized compensation cost Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Unrecognized compensation cost Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount Weighted average period over which unrecognized compensation is expected to be recognized Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Intrinsic value of stock options exercised Grant-date fair value of restricted stock units granted Restricted stock units granted (shares) Employee Savings Plan Pension and Other Postretirement Benefits Disclosure [Text Block] Income Statement [Abstract] Other revenue Other Revenue Other Revenue Total revenue Cost of product sales Cost of Goods and Services Sold Gross profit Research and development Research and Development Expense Selling, general and administrative Selling, General and Administrative Expense Total operating expenses Operating Expenses Loss from operations Other income (expense): Other Nonoperating Income (Expense) [Abstract] Increase in fair value of warrants Loss on extinguishment of debt Interest income Investment Income, Interest Interest expense Other Nonoperating Income (Expense) Other expense Interest Expense Total other income (expense) Nonoperating Income (Expense) Net loss Weighted average number of common shares outstanding (Basic and Diluted) (in shares) New Accounting Pronouncements and Changes in Accounting Principles [Abstract] Recent Accounting Pronouncements New Accounting Pronouncements and Changes in Accounting Principles [Text Block] ASSETS Current assets: Assets, Current [Abstract] Short term investments Short-term Investments Accounts receivable (net of allowance for doubtful accounts of $306 and $514, respectively) Accounts Receivable, after Allowance for Credit Loss, Current Inventory Other current assets Other Assets, Current Total current assets Assets, Current Property and equipment, net Property and equipment, net Right-of-use assets Long term investments Debt Securities, Available-for-sale, Noncurrent Total assets Assets LIABILITIES AND SHAREHOLDERS’ EQUITY Liabilities and Equity [Abstract] Current liabilities: Accounts payable Accounts Payable, Current Accrued expenses Current portion of operating lease liabilities Other liabilities Other Liabilities, Current Total current liabilities Liabilities, Current Operating lease liabilities Other long-term liabilities Other Liabilities, Noncurrent Total liabilities Liabilities COMMITMENTS AND CONTINGENCIES Commitments and Contingencies Shareholders’ equity: Stockholders' Equity Attributable to Parent [Abstract] Common stock, no par value; shares authorized — 75,000; shares issued and outstanding — 44,864 and 43,578, respectively Common Stock, Value, Issued Other comprehensive gain (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax Warrants Warrants and Rights Outstanding Accumulated deficit Total shareholders’ equity Total liabilities and shareholders’ equity Liabilities and Equity Equipment and computers Equipment And Computers [Member] Represents information pertaining to equipment and computers. Furniture and fixtures Building improvements and leasehold improvements Building Improvements And Leasehold Improvements [Member] Represents information pertaining to building improvements and leasehold improvements. Property, Plant and Equipment Right Of Use Asset Lease Liability Useful lives (in years) Property, Plant and Equipment, Useful Life Duration of lease renewal terms Lessee, Lease, Renewal Term Lessee, Lease, Renewal Term Statement of Comprehensive Income [Abstract] Other comprehensive income (loss): Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Unrealized gain (loss) on investments Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent