Statement of Financial Position [Abstract]
Statement [Table]
Statement [Table]
Class of Stock [Axis]
Class of Stock [Axis]
Class of Stock [Domain]
Class of Stock [Domain]
Series A
Series A Preferred Stock [Member]
Series B-2
Series B Preferred Stock [Member]
Statement
Statement [Line Items]
ASSETS
Assets [Abstract]
Current assets:
Assets, Current [Abstract]
Cash
Cash
Accounts receivable (net of allowance for doubtful accounts of $68 and $40, respectively)
Accounts Receivable, Net, Current
Inventory
Inventory, Net
Other current assets
Other Assets, Current
Total current assets
Assets, Current
Property and equipment, net
Property, Plant and Equipment, Net
Intangible assets
Intangible Assets, Net (Excluding Goodwill)
Total assets
Assets
LIABILITIES AND SHAREHOLDERS’ EQUITY
Liabilities and Equity [Abstract]
Current liabilities:
Liabilities, Current [Abstract]
Accounts payable
Accounts Payable, Current
Accrued expenses
Accrued Liabilities, Current
Warrant liabilities
Warrants and Rights Outstanding
Other
Other Liabilities, Current
Total current liabilities
Liabilities, Current
Long term debt
Liabilities, Noncurrent
Total liabilities
Liabilities
COMMITMENTS AND CONTINGENCIES
Commitments and Contingencies
Shareholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Series B-2 voting convertible preferred stock, no par value: shares authorized and reserved — 39, shares issued and outstanding — 12
Preferred Stock, Value, Outstanding
Common stock, no par value; shares authorized — 75,000; shares issued and outstanding — 23,789 and 23,786, respectively
Common Stock, Value, Issued
Treasury stock — 1,250 shares
Treasury Stock, Value
Other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated deficit
Development Stage Enterprise, Deficit Accumulated During Development Stage
Total shareholders’ equity
Stockholders' Equity Attributable to Parent
Total liabilities and shareholders’ equity
Liabilities and Equity
Risks and Uncertainties [Abstract]
Concentration Risk [Table]
Concentration Risk [Table]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark [Domain]
Concentration Risk Benchmark [Domain]
Revenue
Sales Revenue, Net [Member]
Accounts receivable
Accounts Receivable [Member]
Concentration Risk Type [Axis]
Concentration Risk Type [Axis]
Concentration Risk Type [Domain]
Concentration Risk Type [Domain]
Customer concentration
Customer Concentration Risk [Member]
Customer [Axis]
Customer [Axis]
Customer [Domain]
Customer [Domain]
One distributor in the U.S
One Third Party Customer In U S [Member]
Represents information pertaining to the one third party customer in the U.S.
One customer
One Other Third Party Customer In Us [Member]
Represents information pertaining to one other third party customer in the U.S.
CONCENTRATION
Concentration Risk [Line Items]
Concentration risk, Number of customers
Number of Customers
Represents number of customers.
Concentration risk
Concentration Risk, Percentage
Balance Sheet Related Disclosures [Abstract]
Accrued expenses
Accrued Liabilities, Current [Abstract]
Bonus
Accrued Bonuses, Current
Employee related accruals
Employee-related Liabilities, Current
Accrued expenses
Accrued Expenses, Current
Represents accrued expenses, current.
Asset retirement obligation
Asset Retirement Obligation, Current
Other
Accrued Expenses, Other, Current
Represents other accrued expenses, current.
Total
Statement of Comprehensive Income [Abstract]
Net loss
Net Income (Loss) Attributable to Parent
Other comprehensive loss
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Foreign currency translation
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Document and Entity Information
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Document Type
Document Type
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Amendment Flag
Amendment Flag
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
Entity Voluntary Filers
Entity Current Reporting Status
Entity Current Reporting Status
Entity Public Float
Entity Public Float
Statement of Stockholders' Equity [Abstract]
Issuance of stock, issuance cost
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Accounting Policies [Abstract]
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Inventory
Inventory, Policy [Policy Text Block]
Accounts Receivable
Receivables, Policy [Policy Text Block]
Property, Plant and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Intangible Assets and Other Long Lived Assets
Intangible Assets, Finite-Lived, Policy [Policy Text Block]
Revenue Recognition
Revenue Recognition, Policy [Policy Text Block]
Research and Development Expense
Research and Development Expense, Policy [Policy Text Block]
Diversity of Credit Risk
Investment, Policy [Policy Text Block]
Stock-Based Compensation
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Income Taxes
Income Tax, Policy [Policy Text Block]
Net Loss Per Share Attributable to Common Shareholders
Earnings Per Share, Policy [Policy Text Block]
Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Warrants
Warrants [Policy Text Block]
Disclosure of accounting policy for warrants.
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Fair Value Disclosures [Abstract]
Summary of valuation of the Company's investments and financial instruments that are measured at fair value on a recurring basis
Fair Value, Liabilities Measured on Recurring Basis [Table Text Block]
Summary of change in estimated fair values of warrant liabilities
Schedule of Change in Estimated Fair Value of Warrant Liabilities [Table Text Block]
Tabular disclosure of change in the estimated fair value of the warrant liabilities.
Schedule of reconciliation of beginning and ending balances for the Company's fair value measurements using Level 3 inputs
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Schedule of Indefinite-Lived Intangible Assets [Table]
Schedule of Indefinite-Lived Intangible Assets [Table]
Indefinite-lived Intangible Assets [Axis]
Indefinite-lived Intangible Assets [Axis]
Indefinite-lived Intangible Assets, Major Class Name [Domain]
Indefinite-lived Intangible Assets, Major Class Name [Domain]
Commercial rights
Contractual Rights [Member]
Intangible assets, net
Indefinite-lived Intangible Assets [Line Items]
Gross amount
Finite-Lived Intangible Assets, Gross
Accumulated amortization
Finite-Lived Intangible Assets, Accumulated Amortization
Intangible assets
Finite-Lived Intangible Assets, Net
Amortization expense
Amortization of Intangible Assets
Estimated future amortization expense
Finite-Lived Intangible Assets, Net, Amortization Expense, Rolling Maturity [Abstract]
2016
Finite-Lived Intangible Assets, Amortization Expense, Remainder of Fiscal Year
2017
Finite-Lived Intangible Assets, Amortization Expense, Year Two
2018
Finite-Lived Intangible Assets, Amortization Expense, Year Three
2019
Finite-Lived Intangible Assets, Amortization Expense, Year Four
2020
Finite-Lived Intangible Assets, Amortization Expense, Year Five
Thereafter
Finite-Lived Intangible Assets, Amortization Expense, after Year Five
Subsequent Events [Abstract]
Subsequent Events
Subsequent Events [Text Block]
Warrants and Rights Note Disclosure [Abstract]
Stock Purchase Warrants
Warrants and Rights Note Disclosure [Text Block]
The entire disclosure for warrants including description, amounts outstanding, fair value calculation and estimates.
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Fair Value, Measurement Frequency [Domain]
Fair Value, Measurement Frequency [Domain]
Recurring
Fair Value, Measurements, Recurring [Member]
Fair Value, Hierarchy [Axis]
Fair Value, Hierarchy [Axis]
Fair Value Hierarchy [Domain]
Fair Value Hierarchy [Domain]
Level 3
Fair Value, Inputs, Level 3 [Member]
Liability Class [Axis]
Liability Class [Axis]
Fair Value by Liability Class [Domain]
Fair Value by Liability Class [Domain]
Warrants
Warrant [Member]
Reconciliation of beginning and ending balances for the company's fair value measurements using Level 3 inputs
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Reconciliation of beginning and ending balances for the company's fair value measurements using Level 3 inputs
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning balance
Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value
Decrease in fair value
Fair Value, Liabilities Measured on Recurring Basis, Change in Unrealized Gain (Loss)
Ending balance
Schedule of warrants outstanding
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Schedule of assumptions used in calculating estimated fair value of warrants
Schedule of Class of Warrant or Right Valuation Assumptions [Table Text Block]
Tabular disclosure of the significant assumptions used during the period to estimate the fair value of warrant liabilities, including, but not limited to: (a) expected term of instruments, (b) expected volatility of the entity's shares, (c) closing stock price, (d) risk-free rate, and (e) dividend rate.
Allowance for doubtful accounts
Allowance for Doubtful Accounts Receivable, Current
Par value of convertible preferred stock (in dollars per share)
Preferred Stock, No Par Value
Convertible preferred stock, shares authorized
Preferred Stock, Shares Authorized
Convertible preferred stock, shares reserved
Convertible Preferred Stock, Shares Reserved for Future Issuance
Convertible preferred stock, shares issued
Preferred Stock, Shares Issued
Convertible preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Par value of common stock (in dollars per share)
Common Stock, No Par Value
Common stock, shares authorized
Common Stock, Shares Authorized
Common stock, shares issued
Common Stock, Shares, Issued
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Treasury stock, shares reserved
Treasury Stock, Shares
Fair Value Measurements
Fair Value Disclosures [Text Block]
Restructuring and Related Activities [Abstract]
Restructuring
Restructuring and Related Activities Disclosure [Text Block]
Schedule of future minimum payments related to leases
Schedule Of Future Minimum Rental Payments For Operating And Capital Leases Table Text Block
Tabular disclosure of operating and capital leases.
New Accounting Pronouncements and Changes in Accounting Principles [Abstract]
Recent Accounting Pronouncements
New Accounting Pronouncements and Changes in Accounting Principles [Text Block]
Income Tax Disclosure [Abstract]
Net unrealized built in gain
Net unrealized built in Gain
Net unrealized built-in gain
Compensation and Retirement Disclosure [Abstract]
Employee Savings Plan
Pension and Other Postretirement Benefits Disclosure [Text Block]
Schedule of Earnings Per Share, Basic, by Common Class, Including Two Class Method [Table]
Schedule of Earnings Per Share, Basic, by Common Class, Including Two Class Method [Table]
Series B voting convertible preferred stock
Net Loss Per Share Attributable to Common Shareholders
Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items]
Accumulated undeclared dividends
Accumulated Undeclared Dividends
Represents the undistributed shares to be used for payment of undeclared dividends of convertible preferred stock.
Subsequent Event [Table]
Subsequent Event [Table]
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
Subsequent event
Subsequent Event [Member]
Lender Name [Axis]
Lender Name [Axis]
Line of Credit Facility, Lender [Domain]
Line of Credit Facility, Lender [Domain]
SVB
Silicon Valley Bank [Member]
Silicon Valley Bank [Member]
Debt Instrument [Axis]
Debt Instrument [Axis]
Debt Instrument, Name [Domain]
Debt Instrument, Name [Domain]
Debt financing agreement
Debt Financing Agreement [Member]
Debt Financing Agreement [Member]
Term loan
Term Loan [Member]
Term Loan [Member]
Debt Instrument, Redemption, Period [Axis]
Debt Instrument, Redemption, Period [Axis]
Debt Instrument, Redemption, Period [Domain]
Debt Instrument, Redemption, Period [Domain]
Available immediately upon closing
Debt Instrument, Redemption, Period One [Member]
Available upon FDA approval of MACI BLA
Debt Instrument, Redemption, Period Two [Member]
Credit Facility [Axis]
Credit Facility [Axis]
Credit Facility [Domain]
Credit Facility [Domain]
Revolving credit facility
Revolving Credit Facility [Member]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Domain]
Long-term Debt, Type [Domain]
Line of credit
Line of Credit [Member]
Variable Rate [Axis]
Variable Rate [Axis]
Variable Rate [Domain]
Variable Rate [Domain]
Prime Rate
Prime Rate [Member]
Range [Axis]
Range [Axis]
Range [Domain]
Range [Domain]
Minimum
Minimum [Member]
Maximum
Maximum [Member]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Debt instrument, face amount
Debt Instrument, Face Amount
Revolving line of credit, borrowing capacity (up to)
Line of Credit Facility, Maximum Borrowing Capacity
Basis spread on variable rate
Debt Instrument, Basis Spread on Variable Rate
Debt instrument, number of payments
Debt Instrument, Number of Payments
Debt Instrument, Number of Payments
Adjusted quick ratio (greater than or equal to)
Adjusted Quick Ratio
Adjusted Quick Ratio
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Income Tax Authority [Axis]
Income Tax Authority [Axis]
Income Tax Authority [Domain]
Income Tax Authority [Domain]
U.S.
Domestic Tax Authority [Member]
Non U.S.
Foreign Tax Authority [Member]
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Loss before income taxes
Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest
Earnings Per Share [Abstract]
Numerator:
Net Income (Loss) Attributable to Parent [Abstract]
Less: dividends accumulated on convertible preferred stock
Preferred Stock Dividends, Income Statement Impact
Numerator of basic and diluted EPS
Net Income (Loss) Available to Common Stockholders, Basic
Denominator for basic and diluted EPS:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Weighted-average common shares outstanding
Weighted Average Number of Shares Outstanding, Basic and Diluted
Net loss per share attributable to common shareholders (basic and diluted) (in dollars per share)
Earnings Per Share, Basic and Diluted
Aggregate number of common equivalent shares (related to options, warrants and preferred stock) that have been excluded from computations of diluted net loss per common share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Business Combinations [Abstract]
Schedule of total purchase price consideration
Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block]
Schedule of final purchase price allocation
Schedule of Business Combination Consideration Transferred [Table Text Block]
Tabular disclosure of the consideration transferred, consisting of acquisition-date fair value of assets transferred by the acquirer, liabilities incurred by the acquirer, and equity interest issued by the acquirer.
Schedule of unaudited pro forma condensed combined statements
Business Acquisition, Pro Forma Information [Table Text Block]
Schedule of inventory
Schedule of Inventory, Current [Table Text Block]
Schedule of property and equipment, net
Property, Plant and Equipment [Table Text Block]
Schedule of intangible assets, net
Schedule of Finite-Lived Intangible Assets [Table Text Block]
Schedule of estimated future amortization expense
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]
Schedule of accrued expenses
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Schedule of Restructuring and Related Costs [Table]
Schedule of Restructuring and Related Costs [Table]
Business Acquisition [Axis]
Business Acquisition [Axis]
Business Acquisition, Acquiree [Domain]
Business Acquisition, Acquiree [Domain]
CTRM Business
Cell Therapy And Regenerative Medicine Business [Member]
Represents information pertaining to cell therapy and regenerative medicine business.
Income Statement Location [Axis]
Income Statement Location [Axis]
Income Statement Location [Domain]
Income Statement Location [Domain]
Cost of product sales
Cost of Sales [Member]
Selling, general and administrative expenses
Selling, General and Administrative Expenses [Member]
Restructuring
Restructuring Cost and Reserve [Line Items]
Number of full time employee positions eliminated
Restructuring and Related Cost, Number of Positions Eliminated, Inception to Date
Percentage of full time employee positions eliminated
Restructuring and Related Cost, Number of Positions Eliminated, Inception to Date Percent
Restructuring charge
Restructuring Charges
Restructuring reserve related to severance payments
Restructuring Reserve
Stockholders' Equity Note [Abstract]
Shareholders' Equity
Stockholders' Equity Note Disclosure [Text Block]
Reconciliation of income taxes computed using the federal statutory rate to the taxes reported in consolidated statements of operations
Effective Income Tax Rate Reconciliation, Amount [Abstract]
Loss before income taxes
Federal statutory rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Taxes computed at federal statutory rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
State taxes (net of federal benefit)
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Warrants
Income Tax Reconciliation Warrants
The portion of the difference between total income tax expense or benefit as reported in the Income Statement for the period and the expected income tax expense or benefit computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations attributable to warrant expenses under enacted tax laws.
Nondeductible stock compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Compensation Cost, Amount
Michigan NOL benefit
Income Tax Reconciliation Net Operating Loss (Benefit)
The sum of the differences between total income tax expense (benefit) as reported in the income statement for the period and the expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations attributable to net operating loss benefit.
Net operating loss expirations
Income Tax Reconciliation Net Operating Loss Expirations
The sum of the differences between total income tax expense (benefit) as reported in the income statement for the period and the expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations attributable to net operating loss expirations.
Write-off of Section 382 limited NOL’s
Income Tax Reconciliation Limitations On Net Operating Loss
Represents the change in income tax amount due to limitations on net operating loss.
Write-off of Section 383 limited R&D credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Other
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Tax Adjustments, Settlements, and Unusual Provisions
Tax Adjustments, Settlements, and Unusual Provisions
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Reported income taxes
Income Tax Expense (Benefit)
Deferred tax assets
Deferred Tax Assets, Net [Abstract]
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Employee benefits and stock compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits
Research and development costs
Deferred Tax Assets, Research and Development Costs
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from research and development costs.
Fixed assets
Deferred Tax Assets, Property, Plant and Equipment
Intangible assets
Deferred Tax Assets, Goodwill and Intangible Assets
Asset retirement obligation
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Asset Retirement Obligations
Inventory reserve
Deferred Tax Assets, Inventory
Other, net
Deferred Tax Assets, Other
Total deferred tax assets
Deferred Tax Assets, Gross
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Net deferred tax assets
Deferred Tax Assets, Net
Class of Warrant or Right [Table]
Class of Warrant or Right [Table]
Class of Warrant or Right [Axis]
Class of Warrant or Right [Axis]
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
December 2010 Warrants
Warrants Issued In December2010 [Member]
Represents the warrants issued by the entity in December 2010.
August 2013 warrants
Warrants Issued In August2013 [Member]
Represents the warrants issued by the entity in August 2013.
Stock Purchase Warrants
Class of Warrant or Right [Line Items]
Exercise price per share (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Total shares issuable on exercise
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Assumptions used in calculating the estimated fair value of the warrants
Fair Value Assumptions and Methodology for Assets and Liabilities [Abstract]
Closing stock price (in dollars per share)
Share Price
Expected dividend rate
Fair Value Assumptions, Expected Dividend Rate
Expected stock price volatility
Fair Value Assumptions, Expected Volatility Rate
Risk-free interest rate
Fair Value Assumptions, Risk Free Interest Rate
Expected life
Fair Value Assumptions, Expected Term
Schedule of Stock by Class [Table]
Schedule of Stock by Class [Table]
Equity Components [Axis]
Equity Components [Axis]
Equity Component [Domain]
Equity Component [Domain]
Common Stock
Common Stock [Member]
Counterparty Name [Axis]
Counterparty Name [Axis]
Counterparty Name [Domain]
Counterparty Name [Domain]
Lincoln Park
Lincoln Park Capital Fund L L C [Member]
Represents information pertaining to Lincoln Park Capital Fund, LLC.
Legal Entity [Axis]
Legal Entity [Axis]
Entity [Domain]
Entity [Domain]
MLV
Mc Nicoll Lewis And Vlak L L C [Member]
Represents details pertaining to McNicoll, Lewis & Vlak LLC with whom the entity entered into an At the Market Sales Agreement.
Series A Convertible Preferred Stock
Shareholders' Equity
Class of Stock [Line Items]
Number of common shares sold
Stock Issued During Period, Shares, New Issues
Number of shares purchased on exercise of warrants
Stock issued to underwriter for exercise of over allotment option (in shares)
Stock Issued to Underwriter for Exercise of Over Allotment Option
Represents the shares issued to the underwriter pursuant to the exercise of its over-allotment option.
Offering price (in dollars per share)
Proceeds from issuance of common stock
Proceeds from Issuance of Common Stock
Fair market value of the warrants
Class of Warrant or Right Warrants Issued Value
Represents the value of warrants issued during the period.
Number of warrant holders
Number of Warrant Holders
Represents the number of warrant holders.
Exercise price of warrants (in dollars per share)
Net proceeds from exercise of warrants
Proceeds from Warrant Exercises
Value of shares of common stock to be sold
Value of Shares of Common Stock to be Sold
Represents the value of shares of common stock to be sold as per the purchase agreement entered into by the entity.
Period over which shares of common stock to be purchased
Period over which Shares of Common Stock to be Purchased
Represents the period over which shares of common stock to be purchased as per the purchase agreement entered into by the entity.
Number of shares of common stock to be purchased in regular purchases
Number of Shares of Common Stock to be Purchased in Regular Purchases
Represents the number of shares of common stock to be purchased in regular purchases, if directed by the entity as per the purchase agreement.
Number of shares of common stock to be purchased depending upon the closing sale price of the common stock
Number of Shares of Common Stock to be Purchased Based on Closing Sale Price of Common Stock
Represents the number of shares of common stock to be purchased depending upon the closing sale price of the common stock, if directed by the entity as per the purchase agreement.
Threshold closing sale price of the common stock on the date of a regular purchase to trigger purchase of additional amounts as accelerated purchases (in dollars per share) (equals or exceeds)
Threshold Closing Sale Price of Common Stock on Date of Regular Purchase to Trigger Accelerated Purchases of Additional Common Stock
Represents the threshold closing sale price of the common stock on the date of a regular purchase to trigger accelerated purchases of additional shares of common stock, if directed by the entity as per the purchase agreement.
Period of business days over which purchase price of shares of common stock will be determined
Period of Business Days over which Purchase Price of Shares of Common Stock will be Determined
Represents the period of business days over which purchase price of shares of common stock will be determined as per the purchase agreement entered into by the entity.
Floor price for sale of shares of common stock (in dollars per share) (less than)
Floor Price for Sale of Shares of Common Stock
Represents the floor price for the sale of shares of common stock as per the purchase agreement entered into by the entity.
Threshold on percentage of outstanding shares of the common stock that can be beneficially owned by counterparty (more than)
Threshold on Percentage of Outstanding Shares of Common Stock that can be Beneficially Owned by Counterparty
Represents the threshold on percentage of outstanding shares of the common stock that can be beneficially owned by counterparty to the agreement.
Number of shares of common stock sold
Value of remaining shares of common stock to be sold
Value of Remaining Shares of Common Stock to be Sold
Represents the value of remaining shares of common stock to be sold as per the purchase agreement entered into by the entity.
Expected proceeds from sale of common stock
Expected Proceeds from Issuance or Sale of Equity
The expected cash inflow from the issuance of common stock under at the Market Sales Agreement.
Percentage of gross proceeds payable as commission
Percentage of Gross Proceeds Payable as Commission
Represents the percentage of gross proceeds payable as commission.
Amount of net capacity remaining on the ATM
Common Stock Remaining Capacity
Represents the amount of remaining capacity of common stock.
Underwriter's discount
Underwriters Discount
Represents the information about underwriters' discount on common stock.
Issuance cost
Payments of Stock Issuance Costs
Shares converted
Conversion of Stock, Shares Converted
Shares issued upon conversion
Conversion of Stock, Shares Issued
Conversion of stock, amount converted
Conversion of Stock, Amount Converted
Equity [Abstract]
Convertible preferred stock, shares issued upon conversion
Convertible Preferred Stock, Shares Issued upon Conversion
Maximum beneficial ownership percentage
Convertible Preferred Stock, Maximum Beneficial Ownership Percentage
Convertible Preferred Stock, Maximum Beneficial Ownership Percentage
Maximum beneficial ownership percentage upon holder's election
Convertible Preferred Stock, Maximum Beneficial Ownership Percentage Upon Holder's Election
Convertible Preferred Stock, Maximum Beneficial Ownership Percentage Upon Holder's Election
Schedule of Business Acquisitions, by Acquisition [Table]
Schedule of Business Acquisitions, by Acquisition [Table]
Sanofi
Sanofi [Member]
Represents information pertaining to Sanofi.
Geographical [Axis]
Geographical [Axis]
Geographical [Domain]
Geographical [Domain]
Denmark
DENMARK
Finite-Lived Intangible Assets by Major Class [Axis]
Finite-Lived Intangible Assets by Major Class [Axis]
Finite-Lived Intangible Assets, Major Class Name [Domain]
Finite-Lived Intangible Assets, Major Class Name [Domain]
Business Acquisition [Line Items]
Business Acquisition [Line Items]
Number of patents and patents applications acquired (over)
Number of Patents and Patent Applications Acquired
Represents the number of patents and patent applications acquired by the entity.
Total purchase price consideration
Business Combination, Consideration Transferred [Abstract]
Cash payment
Payments to Acquire Businesses, Gross
Promissory note
Business Combination, Consideration Transferred, Liabilities Incurred
Total acquisition consideration
Business Combination, Consideration Transferred
Total purchase price allocation
Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net [Abstract]
Cash
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents
Accounts receivable
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Receivables
Inventory
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Inventory
Other current assets
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Other
Accounts payable and accrued expenses
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable
Asset retirement obligation
Property and equipment
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment
Intangible assets
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles
Bargain purchase gain
Business Combination, Bargain Purchase, Gain Recognized, Amount
Total consideration
Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net
Cash received in order to fund the restructuring of the Denmark operations and close the facility
Cash Acquired from Acquisition
Identifiable intangible assets acquired and their estimated useful lives
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Intangible Assets, Other than Goodwill [Abstract]
Useful Life
Finite-Lived Intangible Asset, Useful Life
Unaudited pro forma condensed combined statements
Business Acquisition, Pro Forma Information [Abstract]
Pro forma revenue
Business Acquisition, Pro Forma Revenue
Pro forma net loss
Business Acquisition, Pro Forma Net Income (Loss)
Preferred Stock
Preferred Stock [Member]
Treasury Stock
Treasury Stock [Member]
Accumulated Other Comprehensive Loss
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Deficit
Retained Earnings [Member]
Increase (Decrease) in Shareholders' Equity
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Beginning balance, Shares
Shares, Outstanding
Beginning balance
Common stock exchanged for preferred stock and held in treasury shares, Shares
Stock Repurchased During Period, Shares
Common stock exchanged for preferred stock and held in treasury shares
Stock Repurchased During Period, Value
Compensation expense related to stock options granted
Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition
Exercise of stock purchase warrants (in shares)
Exercise of stock purchase warrants
Conversion of Stock, Amount Issued
Issuance of common stock, net of issuance costs of [ ] and $3,167 for 2015 and 2014, respectively (in shares)
Issuance of common stock, net of issuance costs of [ ] and $3,167 for 2015 and 2014, respectively
Stock Issued During Period, Value, New Issues
Shares issued under the Employee Stock Purchase Plan
Ending balance, Shares
Ending balance
Supplementary Quarterly Financial Information (unaudited) [Abstract]
Supplementary Quarterly Financial Information (unaudited) [Abstract]
Schedule of quarterly financial information
Schedule of Quarterly Financial Information [Table Text Block]
Contributions made under 401(k) savings plan
Defined Contribution Plan, Cost Recognized
Inventory:
Inventory, Net [Abstract]
Raw materials
Inventory, Raw Materials, Gross
Work-in-process
Inventory, Work in Process, Gross
Finished goods
Inventory, Finished Goods, Gross
Inventory
Schedule of net loss attributable to common shareholders and share data used in the basic and diluted earnings per share computations using the two class method
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Income Taxes
Income Tax Disclosure [Text Block]
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Award Type [Axis]
Award Type [Axis]
Equity Award [Domain]
Equity Award [Domain]
Service-based stock options
Employee Stock Option [Member]
Employee stock
Employee Stock [Member]
Plan Name [Axis]
Plan Name [Axis]
Plan Name [Domain]
Plan Name [Domain]
2004, 2001 and 1992 PLANS
Prior Plans [Member]
Represents the information pertaining to the Prior Plans consisting of 1992 Stock Option Plan, the 2001 Stock Option Plan and the Amended and Restated 2004 Equity Incentive Plan.
2009 Plan
Omnibus Incentive Plan2009 [Member]
Represents the information pertaining to 2009 Omnibus Incentive Plan.
Title of Individual [Axis]
Title of Individual [Axis]
Relationship to Entity [Domain]
Relationship to Entity [Domain]
Non-employee
Non Employee [Member]
Represents the non-employee director of the entity.
Stock-Based Compensation
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expiration period
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period
Vesting period
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Awards available for future grant under the Plan (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Common stock available for issuance
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Shares purchased during period
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Value of shares purchased during period
Stock Issued During Period, Value, Employee Stock Purchase Plan
Weighted average grant-date fair value (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Stock-based compensation expense (less than $0.1 million - 2015 ESPP)
Allocated Share-based Compensation Expense
Weighted average assumptions used to estimate fair value of each service-based stock option grant
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Expected dividend rate (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected stock price volatility (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Risk-free interest rate (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Expected life
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Outstanding at the beginning of the period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Expired (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Outstanding at the end of the period (in shares)
Exercisable at the end of the period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Outstanding at the beginning of the period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Granted (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Exercised (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Expired (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Cancelled (in dollars per share)
Share Based Compensation Arrangements by Share Based Payment Award Options Cancelled in Period Weighted Average Exercise Price
Represents the weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were cancelled.
Forfeited or expired (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Outstanding at the end of the period (in dollars per share)
Exercisable at the end of the period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted Average Remaining Contractual Term
Share Based Compensation Arrangement by Share Based Payment Award Options, Weighted Average Remaining Contractual Term [Abstract]
Outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Exercisable at the end of the period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract]
Outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Exercisable at end of period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Additional disclosures
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Total unrecognized compensation cost
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options
Weighted average period over which unrecognized compensation is expected to be recognized
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Total fair value of options vested
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table]
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table]
Type of Arrangement and Non-arrangement Transactions [Axis]
Type of Arrangement and Non-arrangement Transactions [Axis]
Arrangements and Non-arrangement Transactions [Domain]
Arrangements and Non-arrangement Transactions [Domain]
Corning
Sublicense Agreement [Member]
Represents the details pertaining to sublicense agreement relating to the entity's cell transfection technology.
Licenses, Royalties and Collaborative Agreements and Commitments
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty revenue as a percentage of net sales of products
Collaborative Arrangement Royalty Revenue as Percentage of Net Sales of Products
Represents the amount of royalty revenue as a percentage of net sales of products under the collaborative arrangement.
Future royalty revenue
Royalty Revenue
Purchase obligation, due in next twelve months
Purchase Obligation, Due in Next Twelve Months
Purchase obligation, due in second year
Purchase Obligation, Due in Second Year
Purchase obligation, renewal option, term
Purchase Obligation, Renewal Option, Term
Purchase Obligation, Renewal Option, Term
Purchase obligation, automatic renewal, term
Purchase Obligation, Automatic Renewal, Term
Purchase Obligation, Automatic Renewal, Term
Operating leases
Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract]
Total
Operating Leases, Future Minimum Payments Due
2016
Operating Leases, Future Minimum Payments Due, Next Twelve Months
2017
Operating Leases, Future Minimum Payments, Due in Two Years
2018
Operating Leases, Future Minimum Payments, Due in Three Years
2019
Operating Leases, Future Minimum Payments, Due in Four Years
2020
Operating Leases, Future Minimum Payments, Due in Five Years
More than 5 years
Operating Leases, Future Minimum Payments, Due Thereafter
Purchase commitments
Purchase Obligation, Fiscal Year Maturity [Abstract]
Total
Purchase Obligation
2016
2017
2018
Purchase Obligation, Due in Third Year
2019
Purchase Obligation, Due in Fourth Year
2020
Purchase Obligation, Due in Fifth Year
More than 5 years
Purchase Obligation, Due after Fifth Year
Capital leases
Capital Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract]
Total
Capital Leases, Future Minimum Payments Due
2016
Capital Leases, Future Minimum Payments Due, Next Twelve Months
2017
Capital Leases, Future Minimum Payments Due in Two Years
2018
Capital Leases, Future Minimum Payments Due in Three Years
2019
Capital Leases, Future Minimum Payments Due in Four Years
2020
Capital Leases, Future Minimum Payments Due in Five Years
More than 5 years
Capital Leases, Future Minimum Payments Due Thereafter
Operating and capital leases and purchase commitments
Operating And Capital Leases Future Minimum Payments Due Abstract
Represents the information pertaining to future payments of operating and capital leases.
Total operating and capital leases and purchase commitments
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due
2016
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due, Current
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due, Current
2017
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Two Years
Operating and Capital Leases and Purchase Commitments, Due In Two Years
2018
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Three Years
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Three Years
2019
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Four Years
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Four Years
2020
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due in Five Years
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due in Five Years
More than 5 years
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due Thereafter
Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due Thereafter
Rent expense
Operating Leases, Rent Expense, Net
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Domain]
Property, Plant and Equipment, Type [Domain]
Machinery and equipment
Machinery and Equipment [Member]
Furniture, fixtures and office equipment
Furniture and Fixtures [Member]
Computer equipment and software
Computer Equipment And Computer Software Intangible Asset [Member]
Long lived, depreciable assets that are used in the creation, maintenance and utilization of information systems and the collection of computer programs and related data that provide instructions to a computer, for example, but not limited to, application program, control module or operating system, that perform one or more particular functions or tasks.
Leasehold improvements
Leasehold Improvements [Member]
Construction in progress
Construction in Progress [Member]
Property and equipment, net:
Property, Plant and Equipment [Line Items]
Depreciation
Depreciation
Total property and equipment, gross
Property, Plant and Equipment, Gross
Less: Accumulated amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Property and Equipment
Depreciation expense
Depreciation, Depletion and Amortization
Stock-Based Compensation
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
Adjustments for Error Corrections [Axis]
Adjustments for Error Corrections [Axis]
Adjustments for Error Correction [Domain]
Adjustments for Error Correction [Domain]
Prior Period Adjustment, Immaterial
Prior Period Adjustment, Immaterial [Member]
Prior Period Adjustment, Immaterial [Member]
Pro forma net loss per share - basic and diluted (in dollars per share)
Business Acquisition Pro Forma Earnings Per Share Basic and Diluted
The pro forma basic and diluted net income per share for a period as if the business combination or combinations had been completed at the beginning of a period.
Fair Value Measurements, Recurring and Nonrecurring [Table]
Fair Value Measurements, Recurring and Nonrecurring [Table]
Level 2
Fair Value, Inputs, Level 2 [Member]
Liabilities that are measured at fair value on a recurring basis
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Change in the estimated fair value of warrant liabilities
Warrants and Rights [Roll Forward]
A roll forward is a reconciliation of a concept from the beginning of a period to the end of the period.
Balance at the beginning of the period
Warrant exercise
Class of Warrant or Right Warrants Exercised Value
Represents the value of warrants exercised during the period.
Increase (decrease) in fair value
Fair Value Adjustment of Warrants
Balance at the end of the period
Rolling period over which cumulative change of ownership is required for change in control
Period over which Cumulative Change of Ownership Required for Change in Control
The rolling period over which cumulative percentage change of ownership positions is required for change in control.
Federal
State
State and Local Jurisdiction [Member]
Income Tax Authority, Name [Axis]
Income Tax Authority, Name [Axis]
Income Tax Authority, Name [Domain]
Income Tax Authority, Name [Domain]
Internal Revenue Service
Internal Revenue Service (IRS) [Member]
Projected annual limitation on the use of the net operating losses that existed prior to September 17, 2014
Operating Loss Carryforwards Limitations On Use Projected Annual Limitation On Use Of Net Operating Losses
The limitation on the use of operating loss carryforwards available to reduce future taxable income.
Net operating loss carryforwards
Operating Loss Carryforwards
Increase (decrease) in net operating loss
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Balance at the beginning of the period
Unrecognized Tax Benefits
Decrease in prior year tax positions
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Balance at the end of the period
Summary of income (loss) before income taxes for U.S. and non-U.S. operations
Schedule of Income (Loss) before Income Taxes [Table Text Block]
Tabular disclosure of income (loss) before income taxes for U.S. and non-U.S. operations.
Schedule of reconciliation of income taxes computed using the federal statutory rate to the taxes reported in consolidated statements of operations
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of deferred tax assets
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of reconciliation of uncertain tax provision
Schedule of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns Roll Forward [Table Text Block]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of reportable segments
Number of Reportable Segments
Statement of Cash Flows [Abstract]
Operating activities:
Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract]
Adjustments to reconcile net loss to net cash used for operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Depreciation and amortization
Stock compensation expense
Share-based Compensation
Inventory provision
Inventory Write-down
Change in fair value of warrants
Foreign currency translation loss (gain)
Foreign Currency Transaction Gain (Loss), Realized
(Gain) loss on sale of fixed assets
Gain (Loss) on Disposition of Assets
Write down of asset retirement obligation
Asset Retirement Obligation, Liabilities Settled
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Inventory
Increase (Decrease) in Inventories
Accounts receivable
Increase (Decrease) in Receivables
Other current assets
Increase (Decrease) in Other Current Assets
Accounts payable
Increase (Decrease) in Accounts Payable
Accrued expenses
Increase (Decrease) in Accrued Liabilities
Asset retirement obligation
Increase (Decrease) in Asset Retirement Obligations
Other non-current assets and liabilities, net
Increase (Decrease) in Other Operating Liabilities
Net cash used for operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations
Investing activities:
Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract]
Acquisition of CTRM business, net of cash acquired
Payments to Acquire Businesses, Net of Cash Acquired
Expenditures for property, plant and equipment
Payments to Acquire Property, Plant, and Equipment
Other
Payments for (Proceeds from) Other Investing Activities
Net cash used for investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations
Financing activities:
Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract]
Net proceeds from issuance of common stock and warrants
Proceeds from Issuance or Sale of Equity
Payments on long-term debt
Repayments of Debt
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash and Cash Equivalents
Net increase (decrease) in cash
Net Cash Provided by (Used in) Continuing Operations
Cash at beginning of period
Cash at end of period
Supplemental cash flow information (non-cash):
Supplemental Cash Flow Information [Abstract]
Acquisition of business through promissory note
Repayments of Notes Payable
Accretion of convertible preferred stock
Preferred Stock, Accretion of Redemption Discount
Common shares exchanged for preferred stock
Stock Issued
Warrants exchanged for common stock
Stock and Warrants Issued During Period, Value, Preferred Stock and Warrants
Additions to equipment in process included in accounts payable
Capital Expenditures Incurred but Not yet Paid
Equipment acquired under capital lease
Capital Lease Obligations Incurred
Selected Balance Sheet Components
Supplemental Balance Sheet Disclosures [Text Block]
Organization
Nature of Operations [Text Block]
Net Loss Per Common Share
Earnings Per Share [Text Block]
Schedule of weighted average assumptions used to estimate fair value of each service-based stock option grant
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of activity for service-based stock options
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
Income Statement [Abstract]
Revenues:
Revenues [Abstract]
Product sales
Sales Revenue, Goods, Net
Total revenues
Revenue, Net
Costs and expenses:
Costs and Expenses [Abstract]
Cost of product sales
Cost of Goods Sold
Gross profit
Gross Profit
Research and development
Research and Development Expense
Selling, general and administrative
Selling, General and Administrative Expense
Total operating expenses
Operating Expenses
Loss from operations
Operating Income (Loss)
Other income (expense):
Other Nonoperating Income (Expense) [Abstract]
(Increase) decrease in fair value of warrants
Bargain purchase gain
Foreign currency translation gain (loss)
Interest income
Investment Income, Interest
Other income (expense)
Other Nonoperating Income (Expense)
Interest expense
Interest Expense
Total other income (expense)
Nonoperating Income (Expense)
Net loss
Weighted average number of common shares outstanding (Basic and Diluted)
Acquisitions
Business Combination Disclosure [Text Block]
Preferred Stock
Preferred Stock [Text Block]
Series B-1 non-voting convertible preferred stock
Series B1 Preferred Stock [Member]
Convertible preferred shares with no voting rights, reported as temporary equity not forming the part of equity.
Series B Convertible Preferred Stock
Offering price per share (in dollars per share)
Stock Issued During Period Offering Price Per Share
Represents the offering price per share of preferred stock issued during the period.
Period of closing of offering after which shares are convertible
Preferred Stock, Period of Closing of Offering after which Shares are Convertible
Represents the period of closing of offering after which shares are convertible.
Conversion price per share (in dollars per share)
Preferred Stock Conversion Price Per Share
Represents the conversion price per share of convertible preferred stock.
Conversion ratio, the number of shares of common stock received per share of convertible preferred stock
Convertible Preferred Stock Conversion Ratio
Represents, in the form of a ratio, the number of shares of common stock received in conversion per share of convertible preferred stock.
Percentage of cumulative dividend rate
Preferred Stock, Cumulative Dividend Rate, Percentage
Represents the cumulative percentage rate used to calculate dividend payments on preferred stock.
Accumulated shares but undeclared dividends
Accumulated Undeclared Dividends Shares
Represents the accumulated shares but undeclared dividends related to convertible preferred stock.
Redemption price (in dollars per share)
Preferred Stock, Redemption Price Per Share
Reclassification of Series B preferred stock into shareholders' equity
Temporary Equity, Carrying Amount, Period Increase (Decrease)
Concentration of Credit
Concentration Risk Disclosure [Text Block]
Equipment and computers
Equipment And Computers [Member]
Represents information pertaining to equipment and computers.
Furniture and fixtures
Building improvements and leasehold improvements
Building Improvements And Leasehold Improvements [Member]
Represents information pertaining to building improvements and leasehold improvements.
Property, Plant and Equipment
Useful lives
Property, Plant and Equipment, Useful Life
Eastern Capital Limited and its affiliates
Eastern Capital Limited And Affiliates [Member]
Represents information pertaining to Eastern Capital Limited and its affiliates.
Series A Junior Participating Cumulative Preferred Stock
Rights [Member]
Shareholder Rights Plan
Percentage of common stock approved to be purchased
Class of Warrant or Right Percentage of Common Stock Approved to be Purchased
Represents the percentage of common stock approved to be purchased.
Number of rights for each outstanding share of common stock
Class of Warrant or Right Number of Rights Per Common Stock Share
Represents the number of rights for each outstanding share of common stock.
Additional number of rights per common share
Class of Warrant or Right, Additional Number of Rights Distributed Per Common Share
The additional number of rights distributed to shareholders per share of common stock issued between close of business date and distribution date.
Number of rights deemed to be delivered for each share of common stock issued or transferred
Class of Warrant or Right Number of Rights Deemed to be Delivered Per Common Stock Share Issued or Transferred
Represents the number of rights deemed to be delivered for each share of common stock issued or transferred by the entity.
Preferred stock, shares authorized
Preferred stock, shares issued
Preferred stock, shares outstanding
Percentage of common stock to be acquired for rights to be exercisable by an individual or group
Class of Warrant or Right, Condition on Exercise of Rights Percentage of Common Stock Acquired
Represents the percentage of the entity's outstanding common stock that must be acquired for rights to become exercisable by an individual or group.
Percentage of common stock to be owned for rights to be exercisable by an individual or group commencing a tender offer
Class of Warrant or Right, Condition on Exercise of Rights, Percentage of Common Stock Owned by Person or Group Commencing Tender Offer
Represents the percentage of the entity's outstanding common stock that must be owned for rights to become exercisable by an individual or group commencing a tender offer.
Multiple of the value of common stock acquired (after conversion from preferred) to the exercise price of stock purchase right in the event of an acquiring person event
Class of Right Condition on Exercise of Rights Number of Multiples of Exercise Price Holder Can Receive in Common Stock Value
Represents the number of multiples of the exercise price of the right that the right holder will receive in value of the entity's common stock when an acquiring person event occurs.
Multiple of the value of common stock acquired to the exercise price of stock purchase right in the event of a merger of the entity
Class of Right Condition on Exercise of Rights Number of Multiples of Exercise Price Holder Can Receive in Common Stock Value in Event of Merger
Represents the number of multiples of the exercise price of the right that the right holder will receive in value of the entity's common stock when a merger of the entity occurs.
Redemption price per right (in dollars per right)
Class of Warrant or Rights Redemption Price Per Right
Represents the redemption price per right, which will expire unless earlier redeemed.
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Revenues
Gross profit (loss)
Loss from operations
Net loss per share (basic and diluted) (in dollars per share)
Supplementary Quarterly Financial Information (unaudited)
Quarterly Financial Information [Text Block]