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  <xs:element id="vcel_AssetsAndLiabilitiesLeasesTableTextBlock" abstract="false" name="AssetsAndLiabilitiesLeasesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="vcel_NumberOfProducts" abstract="false" name="NumberOfProducts" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="vcel_NumberOfContractedSpecialtyPharmacies" abstract="false" name="NumberOfContractedSpecialtyPharmacies" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="vcel_RevenueRevenueRecognizedChangeinUncollectibleAnalysisPercentage" abstract="false" name="RevenueRevenueRecognizedChangeinUncollectibleAnalysisPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="vcel_RevenueRevenueRecognizedEffectOf0.5ChangeInTheEstimatedUncollectiblePercentageAmount" abstract="false" name="RevenueRevenueRecognizedEffectOf0.5ChangeInTheEstimatedUncollectiblePercentageAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_ProviderorFacilityMember" abstract="true" name="ProviderorFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_ImplantsMember" abstract="true" name="ImplantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_BiopsyKitsMember" abstract="true" name="BiopsyKitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_MACIImplantsAndKitsMember" abstract="true" name="MACIImplantsAndKitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_EpicelMember" abstract="true" name="EpicelMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_NexoBridMember" abstract="true" name="NexoBridMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_ComputerEquipmentAndComputerSoftwareIntangibleAssetMember" abstract="false" name="ComputerEquipmentAndComputerSoftwareIntangibleAssetMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" abstract="false" name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_AccruedExpensesOtherCurrent" abstract="false" name="AccruedExpensesOtherCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_A25NetworkDriveBurlingtonMassachusettsMember" abstract="true" name="A25NetworkDriveBurlingtonMassachusettsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_RightOfUseAsset" abstract="false" name="RightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LeaseLiabilityNoncurrent" abstract="false" name="LeaseLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LongtermInvestmentsMember" abstract="true" name="LongtermInvestmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_DebtSecuritiesAvailableForSaleContractualMaturityPeriod" abstract="false" name="DebtSecuritiesAvailableForSaleContractualMaturityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcel_DebtInstrumentCovenantLeverageRatioMaximum" abstract="false" name="DebtInstrumentCovenantLeverageRatioMaximum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="vcel_DebtInstrumentCovenantIncreaseOptionLeverageRatioMaximum" abstract="false" name="DebtInstrumentCovenantIncreaseOptionLeverageRatioMaximum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="vcel_EmployeeStockAndEmployeeStockOptionMember" abstract="true" name="EmployeeStockAndEmployeeStockOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_MediWoundLtdMember" abstract="true" name="MediWoundLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_LicenseAgreementConsideration" abstract="false" name="LicenseAgreementConsideration" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LicenseAgreementContingentConsideration" abstract="false" name="LicenseAgreementContingentConsideration" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LicenseAgreementsMilestonePaymentsAssumedIntangibleAssets" abstract="false" name="LicenseAgreementsMilestonePaymentsAssumedIntangibleAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LicenseAgreementContingentConsiderationMaximum" abstract="false" name="LicenseAgreementContingentConsiderationMaximum" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LicenseAgreementInitialMilestoneSales" abstract="false" name="LicenseAgreementInitialMilestoneSales" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LicenseAgreementSupplyAgreementTerm" abstract="false" name="LicenseAgreementSupplyAgreementTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcel_LicenseAgreementSupplyAgreementRenewalTerm" abstract="false" name="LicenseAgreementSupplyAgreementRenewalTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcel_LicenseAgreementSupplyAgreementOptionalAdditionalTerm" abstract="false" name="LicenseAgreementSupplyAgreementOptionalAdditionalTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcel_U.S.BiomedicalAdvancedResearchAndDevelopmentAuthorityBARDAMember" abstract="true" name="U.S.BiomedicalAdvancedResearchAndDevelopmentAuthorityBARDAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_CollaborativeArrangementContractTerm" abstract="false" name="CollaborativeArrangementContractTerm" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcel_CollaborativeArrangementContractValue" abstract="false" name="CollaborativeArrangementContractValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_CollaborativeArrangementBasePeriodMaximumFunding" abstract="false" name="CollaborativeArrangementBasePeriodMaximumFunding" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_CollaborativeArrangementInitialProcurementFunds" abstract="false" name="CollaborativeArrangementInitialProcurementFunds" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
