

<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://vcel.com/role/CashEquivalentsAndInvestments" xlink:href="astm-20181231.xsd#CashEquivalentsAndInvestments" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/CashEquivalentsAndInvestmentsDetails" xlink:href="astm-20181231.xsd#CashEquivalentsAndInvestmentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/CashEquivalentsAndInvestmentsTables" xlink:href="astm-20181231.xsd#CashEquivalentsAndInvestmentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/CommitmentsAndContingencies" xlink:href="astm-20181231.xsd#CommitmentsAndContingencies" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/CommitmentsAndContingenciesFutureMinimumPaymentsDetails" xlink:href="astm-20181231.xsd#CommitmentsAndContingenciesFutureMinimumPaymentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/CommitmentsAndContingenciesNarrativeDetails" xlink:href="astm-20181231.xsd#CommitmentsAndContingenciesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/CommitmentsAndContingenciesTables" xlink:href="astm-20181231.xsd#CommitmentsAndContingenciesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/ConsolidatedBalanceSheets" xlink:href="astm-20181231.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="astm-20181231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="astm-20181231.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/ConsolidatedStatementsOfComprehensiveLoss" xlink:href="astm-20181231.xsd#ConsolidatedStatementsOfComprehensiveLoss" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/ConsolidatedStatementsOfOperations" xlink:href="astm-20181231.xsd#ConsolidatedStatementsOfOperations" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/ConsolidatedStatementsOfShareholdersEquity" xlink:href="astm-20181231.xsd#ConsolidatedStatementsOfShareholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/ConsolidatedStatementsOfShareholdersEquityParenthetical" xlink:href="astm-20181231.xsd#ConsolidatedStatementsOfShareholdersEquityParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/Debt" xlink:href="astm-20181231.xsd#Debt" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/DebtDetails" xlink:href="astm-20181231.xsd#DebtDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/DocumentAndEntityInformation" xlink:href="astm-20181231.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/EmployeeSavingsPlan" xlink:href="astm-20181231.xsd#EmployeeSavingsPlan" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/EmployeeSavingsPlanDetails" xlink:href="astm-20181231.xsd#EmployeeSavingsPlanDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/FairValueMeasurements" xlink:href="astm-20181231.xsd#FairValueMeasurements" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/FairValueMeasurementsDetails" xlink:href="astm-20181231.xsd#FairValueMeasurementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/FairValueMeasurementsTables" xlink:href="astm-20181231.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/IncomeTaxes" xlink:href="astm-20181231.xsd#IncomeTaxes" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/IncomeTaxesComponentsOfIncomeLossBeforeTaxesDetails" xlink:href="astm-20181231.xsd#IncomeTaxesComponentsOfIncomeLossBeforeTaxesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/IncomeTaxesDeferredTaxAssetsDetails" xlink:href="astm-20181231.xsd#IncomeTaxesDeferredTaxAssetsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/IncomeTaxesNarrativeDetails" xlink:href="astm-20181231.xsd#IncomeTaxesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/IncomeTaxesTables" xlink:href="astm-20181231.xsd#IncomeTaxesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/NetLossPerCommonShare" xlink:href="astm-20181231.xsd#NetLossPerCommonShare" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/NetLossPerCommonShareDetails" xlink:href="astm-20181231.xsd#NetLossPerCommonShareDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/NetLossPerCommonShareTables" xlink:href="astm-20181231.xsd#NetLossPerCommonShareTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/Organization" xlink:href="astm-20181231.xsd#Organization" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/OrganizationDetails" xlink:href="astm-20181231.xsd#OrganizationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/PreferredStock" xlink:href="astm-20181231.xsd#PreferredStock" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/PreferredStockSeriesBConvertiblePreferredStockDetails" xlink:href="astm-20181231.xsd#PreferredStockSeriesBConvertiblePreferredStockDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/RecentAccountingPronouncements" xlink:href="astm-20181231.xsd#RecentAccountingPronouncements" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/RecentAccountingPronouncementsDetails" xlink:href="astm-20181231.xsd#RecentAccountingPronouncementsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/Revenue" xlink:href="astm-20181231.xsd#Revenue" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/RevenueDetails" xlink:href="astm-20181231.xsd#RevenueDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/RevenueDisaggregationOfRevenueDetails" xlink:href="astm-20181231.xsd#RevenueDisaggregationOfRevenueDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/RevenueReservesRollForwardDetails" xlink:href="astm-20181231.xsd#RevenueReservesRollForwardDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/RevenueTables" xlink:href="astm-20181231.xsd#RevenueTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponents" xlink:href="astm-20181231.xsd#SelectedBalanceSheetComponents" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsAccruedExpensesDetails" xlink:href="astm-20181231.xsd#SelectedBalanceSheetComponentsAccruedExpensesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsDetails" xlink:href="astm-20181231.xsd#SelectedBalanceSheetComponentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsPropertyAndEquipmentDetails" xlink:href="astm-20181231.xsd#SelectedBalanceSheetComponentsPropertyAndEquipmentDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsTables" xlink:href="astm-20181231.xsd#SelectedBalanceSheetComponentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/ShareholdersEquity" xlink:href="astm-20181231.xsd#ShareholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/ShareholdersEquityDetails" xlink:href="astm-20181231.xsd#ShareholdersEquityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensation" xlink:href="astm-20181231.xsd#StockBasedCompensation" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensationDetails" xlink:href="astm-20181231.xsd#StockBasedCompensationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensationNonCashStockCompensationExpenseDetails" xlink:href="astm-20181231.xsd#StockBasedCompensationNonCashStockCompensationExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensationTables" xlink:href="astm-20181231.xsd#StockBasedCompensationTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/StockPurchaseWarrants" xlink:href="astm-20181231.xsd#StockPurchaseWarrants" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/StockPurchaseWarrantsDetails" xlink:href="astm-20181231.xsd#StockPurchaseWarrantsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/StockPurchaseWarrantsTables" xlink:href="astm-20181231.xsd#StockPurchaseWarrantsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="astm-20181231.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesConsolidatedStatementOfCashFlowsDetails" xlink:href="astm-20181231.xsd#SummaryOfSignificantAccountingPoliciesConsolidatedStatementOfCashFlowsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="astm-20181231.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:href="astm-20181231.xsd#SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:href="astm-20181231.xsd#SummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesUndeclaredDividendsDetails" xlink:href="astm-20181231.xsd#SummaryOfSignificantAccountingPoliciesUndeclaredDividendsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SupplementaryQuarterlyFinancialInformationUnaudited" xlink:href="astm-20181231.xsd#SupplementaryQuarterlyFinancialInformationUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SupplementaryQuarterlyFinancialInformationUnauditedDetails" xlink:href="astm-20181231.xsd#SupplementaryQuarterlyFinancialInformationUnauditedDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://vcel.com/role/SupplementaryQuarterlyFinancialInformationUnauditedTables" xlink:href="astm-20181231.xsd#SupplementaryQuarterlyFinancialInformationUnauditedTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <link:presentationLink xlink:role="http://vcel.com/role/CashEquivalentsAndInvestments" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAbstract" xlink:label="loc_us-gaap_CashAndCashEquivalentsAbstract_65FCF1245910D260DF42EDA9B75C58A3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock" xlink:label="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_B7F686DB00D6462C4AE0EDA9B75D411E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_65FCF1245910D260DF42EDA9B75C58A3" xlink:to="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_B7F686DB00D6462C4AE0EDA9B75D411E" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/CashEquivalentsAndInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAbstract" xlink:label="loc_us-gaap_CashAndCashEquivalentsAbstract_4EC44F01FC7812A0192C25648A3FB2EE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecuritiesTable" xlink:label="loc_us-gaap_MarketableSecuritiesTable_375D6A4C17A9900E36D725648A3F2F17" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_4EC44F01FC7812A0192C25648A3FB2EE" xlink:to="loc_us-gaap_MarketableSecuritiesTable_375D6A4C17A9900E36D725648A3F2F17" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_0C8DFE103D2CDBFB415E25648A3F7AEC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesTable_375D6A4C17A9900E36D725648A3F2F17" xlink:to="loc_us-gaap_FinancialInstrumentAxis_0C8DFE103D2CDBFB415E25648A3F7AEC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_46C857A5036C7EA53E2925648A3FEA95" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0C8DFE103D2CDBFB415E25648A3F7AEC" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_46C857A5036C7EA53E2925648A3FEA95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MoneyMarketFundsMember" xlink:label="loc_us-gaap_MoneyMarketFundsMember_1F6E38F41C4401D467B225648A40FB15" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_46C857A5036C7EA53E2925648A3FEA95" xlink:to="loc_us-gaap_MoneyMarketFundsMember_1F6E38F41C4401D467B225648A40FB15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_7F616903DC1FE007454325648A406F74" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_46C857A5036C7EA53E2925648A3FEA95" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_7F616903DC1FE007454325648A406F74" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommercialPaperMember" xlink:label="loc_us-gaap_CommercialPaperMember_4BF0C216E86A2A21B1EE25648A408A43" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_46C857A5036C7EA53E2925648A3FEA95" xlink:to="loc_us-gaap_CommercialPaperMember_4BF0C216E86A2A21B1EE25648A408A43" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_1565EA6017F3B70BA34625648A40BAEE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_46C857A5036C7EA53E2925648A3FEA95" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_1565EA6017F3B70BA34625648A40BAEE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_F0BA912CE53D0AC9444525648A40916F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_46C857A5036C7EA53E2925648A3FEA95" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_F0BA912CE53D0AC9444525648A40916F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_DFD0D342E09C4CD09BC925648A412154" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_46C857A5036C7EA53E2925648A3FEA95" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_DFD0D342E09C4CD09BC925648A412154" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_53B29BF7EC712075C87A25648A41D14C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesTable_375D6A4C17A9900E36D725648A3F2F17" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_53B29BF7EC712075C87A25648A41D14C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_E8210E0A242F6FA0B60525648A41F74F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_53B29BF7EC712075C87A25648A41D14C" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_E8210E0A242F6FA0B60525648A41F74F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashEquivalentsMember" xlink:label="loc_us-gaap_CashEquivalentsMember_B4EBD1F965BCECEB543625648A417F72" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_E8210E0A242F6FA0B60525648A41F74F" xlink:to="loc_us-gaap_CashEquivalentsMember_B4EBD1F965BCECEB543625648A417F72" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestmentsMember" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_F0F9BF696B80B3794AD025648A4188D5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_E8210E0A242F6FA0B60525648A41F74F" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_F0F9BF696B80B3794AD025648A4188D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecuritiesLineItems" xlink:label="loc_us-gaap_MarketableSecuritiesLineItems_322E6F1FA6C3A6B2C64025648A4200A3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesTable_375D6A4C17A9900E36D725648A3F2F17" xlink:to="loc_us-gaap_MarketableSecuritiesLineItems_322E6F1FA6C3A6B2C64025648A4200A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_73996DFFD94F8D5863A0257D16ADBC73" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_322E6F1FA6C3A6B2C64025648A4200A3" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_73996DFFD94F8D5863A0257D16ADBC73" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_863CDB31CA967E75418325648A428F5C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_322E6F1FA6C3A6B2C64025648A4200A3" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_863CDB31CA967E75418325648A428F5C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_F3EE4C496831E5210D7B25648A42F5AB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_322E6F1FA6C3A6B2C64025648A4200A3" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_F3EE4C496831E5210D7B25648A42F5AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_9FF2FD3EC21DF82EBA7225648A423165" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_322E6F1FA6C3A6B2C64025648A4200A3" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_9FF2FD3EC21DF82EBA7225648A423165" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_E16BFC5112759C221F1625648A422798" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_322E6F1FA6C3A6B2C64025648A4200A3" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_E16BFC5112759C221F1625648A422798" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/CashEquivalentsAndInvestmentsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAbstract" xlink:label="loc_us-gaap_CashAndCashEquivalentsAbstract_582F8FCAA0872704476FEDA9B75A5AA2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_A50C3EE5FEC09A693B24EDA9B75BB848" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_582F8FCAA0872704476FEDA9B75A5AA2" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_A50C3EE5FEC09A693B24EDA9B75BB848" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/CommitmentsAndContingencies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_2DBD91E5C14FBBA845F358BDB969B551" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_DB1F5281DCEF58BD6D4A58BDB96A4C83" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_2DBD91E5C14FBBA845F358BDB969B551" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_DB1F5281DCEF58BD6D4A58BDB96A4C83" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/CommitmentsAndContingenciesFutureMinimumPaymentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_4607EE1691499818019D58BDB9865759" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_33BCAD873AFAE3A35EDD58BDB9862A03" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_4607EE1691499818019D58BDB9865759" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_33BCAD873AFAE3A35EDD58BDB9862A03" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_DBD63052B85A2BA9AB8258BDB986D18B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_33BCAD873AFAE3A35EDD58BDB9862A03" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_DBD63052B85A2BA9AB8258BDB986D18B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_BE088EB8F6A7260A9AF358BDB987EE55" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_33BCAD873AFAE3A35EDD58BDB9862A03" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_BE088EB8F6A7260A9AF358BDB987EE55" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_5152232B70414D54684158BDB9873761" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_33BCAD873AFAE3A35EDD58BDB9862A03" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_5152232B70414D54684158BDB9873761" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_724BD85B8EC12DF6AB2158BDB98760B6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_33BCAD873AFAE3A35EDD58BDB9862A03" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_724BD85B8EC12DF6AB2158BDB98760B6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_97F048FE33153C27148058BDB987BD2C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_33BCAD873AFAE3A35EDD58BDB9862A03" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_97F048FE33153C27148058BDB987BD2C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_6E351A629218F02C0ABD58BDB987D967" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_33BCAD873AFAE3A35EDD58BDB9862A03" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_6E351A629218F02C0ABD58BDB987D967" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_70C742EA10AF3BEEAEE058BDB98851F0" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_33BCAD873AFAE3A35EDD58BDB9862A03" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_70C742EA10AF3BEEAEE058BDB98851F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PurchaseObligationFiscalYearMaturityAbstract" xlink:label="loc_us-gaap_PurchaseObligationFiscalYearMaturityAbstract_696B79D232365B2DFEA158BDB9884B47" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_4607EE1691499818019D58BDB9865759" xlink:to="loc_us-gaap_PurchaseObligationFiscalYearMaturityAbstract_696B79D232365B2DFEA158BDB9884B47" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PurchaseObligation" xlink:label="loc_us-gaap_PurchaseObligation_836328EA67D065D93A4758BDB98864BE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PurchaseObligationFiscalYearMaturityAbstract_696B79D232365B2DFEA158BDB9884B47" xlink:to="loc_us-gaap_PurchaseObligation_836328EA67D065D93A4758BDB98864BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PurchaseObligationDueInNextTwelveMonths" xlink:label="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_A7A3EBC10CA0F51312D258BDB9887890" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PurchaseObligationFiscalYearMaturityAbstract_696B79D232365B2DFEA158BDB9884B47" xlink:to="loc_us-gaap_PurchaseObligationDueInNextTwelveMonths_A7A3EBC10CA0F51312D258BDB9887890" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PurchaseObligationDueInSecondYear" xlink:label="loc_us-gaap_PurchaseObligationDueInSecondYear_55EFC1181489EABA00DF58BDB98807CE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PurchaseObligationFiscalYearMaturityAbstract_696B79D232365B2DFEA158BDB9884B47" xlink:to="loc_us-gaap_PurchaseObligationDueInSecondYear_55EFC1181489EABA00DF58BDB98807CE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PurchaseObligationDueInThirdYear" xlink:label="loc_us-gaap_PurchaseObligationDueInThirdYear_402AB1C91342444E9E9A58BDB9892408" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PurchaseObligationFiscalYearMaturityAbstract_696B79D232365B2DFEA158BDB9884B47" xlink:to="loc_us-gaap_PurchaseObligationDueInThirdYear_402AB1C91342444E9E9A58BDB9892408" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PurchaseObligationDueInFourthYear" xlink:label="loc_us-gaap_PurchaseObligationDueInFourthYear_1FD15BBF6C23CC1EEB6E58BDB989DA2A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PurchaseObligationFiscalYearMaturityAbstract_696B79D232365B2DFEA158BDB9884B47" xlink:to="loc_us-gaap_PurchaseObligationDueInFourthYear_1FD15BBF6C23CC1EEB6E58BDB989DA2A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PurchaseObligationDueInFifthYear" xlink:label="loc_us-gaap_PurchaseObligationDueInFifthYear_DCEF8516ED81AF613C6758BDB9894DB5" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PurchaseObligationFiscalYearMaturityAbstract_696B79D232365B2DFEA158BDB9884B47" xlink:to="loc_us-gaap_PurchaseObligationDueInFifthYear_DCEF8516ED81AF613C6758BDB9894DB5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PurchaseObligationDueAfterFifthYear" xlink:label="loc_us-gaap_PurchaseObligationDueAfterFifthYear_1EFF3E1A83568FFC33F158BDB9898834" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PurchaseObligationFiscalYearMaturityAbstract_696B79D232365B2DFEA158BDB9884B47" xlink:to="loc_us-gaap_PurchaseObligationDueAfterFifthYear_1EFF3E1A83568FFC33F158BDB9898834" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract_359BBFC7AB6881DFD7F458BDB989129E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_4607EE1691499818019D58BDB9865759" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract_359BBFC7AB6881DFD7F458BDB989129E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDue_DBC4F2B45AC2A7BBA79A58BDB9898CAC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract_359BBFC7AB6881DFD7F458BDB989129E" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDue_DBC4F2B45AC2A7BBA79A58BDB9898CAC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent_4C66EFB095D278E7926558BDB98A78FF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract_359BBFC7AB6881DFD7F458BDB989129E" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent_4C66EFB095D278E7926558BDB98A78FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears_7E00EC945211424B200258BDB98A8D85" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract_359BBFC7AB6881DFD7F458BDB989129E" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears_7E00EC945211424B200258BDB98A8D85" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears_6F88E46B17CFA73AED9358BDB98A5D4C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract_359BBFC7AB6881DFD7F458BDB989129E" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears_6F88E46B17CFA73AED9358BDB98A5D4C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears_C545A8AE77F8ECF2D89558BDB98AA039" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract_359BBFC7AB6881DFD7F458BDB989129E" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears_C545A8AE77F8ECF2D89558BDB98AA039" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears_29E14169B9E144C04A1558BDB98A7903" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract_359BBFC7AB6881DFD7F458BDB989129E" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears_29E14169B9E144C04A1558BDB98A7903" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter_A64A36E051E5ECAE2E8258BDB98A56EB" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueAbstract_359BBFC7AB6881DFD7F458BDB989129E" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter_A64A36E051E5ECAE2E8258BDB98A56EB" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract" xlink:label="loc_astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract_036868DD6522A9E0A2F958BDB98BB722" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_4607EE1691499818019D58BDB9865759" xlink:to="loc_astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract_036868DD6522A9E0A2F958BDB98BB722" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDue" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDue_E1CD5839431460CF9EA258BDB98B7239" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract_036868DD6522A9E0A2F958BDB98BB722" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDue_E1CD5839431460CF9EA258BDB98B7239" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueCurrent" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueCurrent_55108D9C081C64A0F39B58BDB98BDEDE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract_036868DD6522A9E0A2F958BDB98BB722" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueCurrent_55108D9C081C64A0F39B58BDB98BDEDE" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInTwoYears_C0559D195C01BD35DC9F58BDB98B4AE8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract_036868DD6522A9E0A2F958BDB98BB722" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInTwoYears_C0559D195C01BD35DC9F58BDB98B4AE8" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInThreeYears_855478C3449F9B62535A58BDB98BAB49" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract_036868DD6522A9E0A2F958BDB98BB722" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInThreeYears_855478C3449F9B62535A58BDB98BAB49" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInFourYears" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInFourYears_12688EEDCE5CA424E38158BDB98B03D2" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract_036868DD6522A9E0A2F958BDB98BB722" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInFourYears_12688EEDCE5CA424E38158BDB98B03D2" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueinFiveYears" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueinFiveYears_26EE1AE3C175D25AC36F58BDB98CF2DE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract_036868DD6522A9E0A2F958BDB98BB722" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueinFiveYears_26EE1AE3C175D25AC36F58BDB98CF2DE" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueThereafter" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueThereafter_8361B3A67BE071121D9E58BDB98C45DB" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesFutureMinimumPaymentsDueAbstract_036868DD6522A9E0A2F958BDB98BB722" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueThereafter_8361B3A67BE071121D9E58BDB98C45DB" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/CommitmentsAndContingenciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_EB614FA1DCF4862FE2FE25950F3B71B5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_B7AB6B0646DF502ED27225950F3CD2C7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_EB614FA1DCF4862FE2FE25950F3B71B5" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_B7AB6B0646DF502ED27225950F3CD2C7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_A03E6A629115D7BB757425950F3CC4F5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_B7AB6B0646DF502ED27225950F3CD2C7" xlink:to="loc_srt_CounterpartyNameAxis_A03E6A629115D7BB757425950F3CC4F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_E28E96BFBFC1E5C86F6A25950F3CA845" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_A03E6A629115D7BB757425950F3CC4F5" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_E28E96BFBFC1E5C86F6A25950F3CA845" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_InnovativeCellularTherapeuticsMember" xlink:label="loc_astm_InnovativeCellularTherapeuticsMember_2711D9B71E955915119A25950F3CF715" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_E28E96BFBFC1E5C86F6A25950F3CA845" xlink:to="loc_astm_InnovativeCellularTherapeuticsMember_2711D9B71E955915119A25950F3CF715" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_B7AB6B0646DF502ED27225950F3CD2C7" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PurchaseObligationDueInSecondYear" xlink:label="loc_us-gaap_PurchaseObligationDueInSecondYear_1457DE54C5E7F16D1C8825950F3DE938" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:to="loc_us-gaap_PurchaseObligationDueInSecondYear_1457DE54C5E7F16D1C8825950F3DE938" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_PurchaseObligationRenewalOptionTerm" xlink:label="loc_astm_PurchaseObligationRenewalOptionTerm_3A7F6CEB09AAAB63140325950F3D5405" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:to="loc_astm_PurchaseObligationRenewalOptionTerm_3A7F6CEB09AAAB63140325950F3D5405" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_PurchaseObligationAutomaticRenewalTerm" xlink:label="loc_astm_PurchaseObligationAutomaticRenewalTerm_82E839EA10162FC519E625950F3DF7F8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:to="loc_astm_PurchaseObligationAutomaticRenewalTerm_82E839EA10162FC519E625950F3DF7F8" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ProceedsFromLicenseFeesReceivedAndIssuanceOfWarrants" xlink:label="loc_astm_ProceedsFromLicenseFeesReceivedAndIssuanceOfWarrants_74652FEDD4A941DEEEA725950F3D73E4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:to="loc_astm_ProceedsFromLicenseFeesReceivedAndIssuanceOfWarrants_74652FEDD4A941DEEEA725950F3D73E4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_3043647F6D71B7D8050125950F3D2980" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_3043647F6D71B7D8050125950F3D2980" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncentiveFromLessor" xlink:label="loc_us-gaap_IncentiveFromLessor_E779E6DB1F1715D3C15925950F3E5E66" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:to="loc_us-gaap_IncentiveFromLessor_E779E6DB1F1715D3C15925950F3E5E66" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredRentCredit" xlink:label="loc_us-gaap_DeferredRentCredit_3361728A72A5E96A857A25950F3E282F" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:to="loc_us-gaap_DeferredRentCredit_3361728A72A5E96A857A25950F3E282F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesRentExpenseNet" xlink:label="loc_us-gaap_OperatingLeasesRentExpenseNet_E458C4A255EB7DBA796525950F3E7A8A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_1B4B72EF33BE4FC2E93E25950F3DD2B7" xlink:to="loc_us-gaap_OperatingLeasesRentExpenseNet_E458C4A255EB7DBA796525950F3E7A8A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/CommitmentsAndContingenciesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_87F55AD038AD4768124158BDBA05BEE6" xlink:type="locator" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ScheduleOfFutureMinimumRentalPaymentsForOperatingAndCapitalLeasesTableTextBlock" xlink:label="loc_astm_ScheduleOfFutureMinimumRentalPaymentsForOperatingAndCapitalLeasesTableTextBlock_E25B761741F16C7B5A9358BDBA05BE37" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_87F55AD038AD4768124158BDBA05BEE6" xlink:to="loc_astm_ScheduleOfFutureMinimumRentalPaymentsForOperatingAndCapitalLeasesTableTextBlock_E25B761741F16C7B5A9358BDBA05BE37" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_65FBE7DDC84C38AFAE80ED5493A53471" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_096D4FF63D13104EC2A8ED5493A5904E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_65FBE7DDC84C38AFAE80ED5493A53471" xlink:to="loc_us-gaap_StatementTable_096D4FF63D13104EC2A8ED5493A5904E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_664EB471C0FE5B676168ED5493A527AC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_096D4FF63D13104EC2A8ED5493A5904E" xlink:to="loc_us-gaap_StatementClassOfStockAxis_664EB471C0FE5B676168ED5493A527AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_EC52418241A010898766ED5493A6852D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_664EB471C0FE5B676168ED5493A527AC" xlink:to="loc_us-gaap_ClassOfStockDomain_EC52418241A010898766ED5493A6852D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_15B893FDC3BCA3D7A6C0ED5493A7B49B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_EC52418241A010898766ED5493A6852D" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_15B893FDC3BCA3D7A6C0ED5493A7B49B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_C54DF039B7B2CED36AD2ED5493A71251" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_096D4FF63D13104EC2A8ED5493A5904E" xlink:to="loc_us-gaap_StatementLineItems_C54DF039B7B2CED36AD2ED5493A71251" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_D3CC5AE22271AF8A8D16ED5493A70031" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C54DF039B7B2CED36AD2ED5493A71251" xlink:to="loc_us-gaap_AssetsAbstract_D3CC5AE22271AF8A8D16ED5493A70031" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_D6557AA7BF887892B2ADED5493A78BC5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_D3CC5AE22271AF8A8D16ED5493A70031" xlink:to="loc_us-gaap_AssetsCurrentAbstract_D6557AA7BF887892B2ADED5493A78BC5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Cash" xlink:label="loc_us-gaap_Cash_8B6DE5485B23047043F9ED5493A77E68" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_D6557AA7BF887892B2ADED5493A78BC5" xlink:to="loc_us-gaap_Cash_8B6DE5485B23047043F9ED5493A77E68" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_3E6D09E19E47A685E001ED57E9AB35DE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_D6557AA7BF887892B2ADED5493A78BC5" xlink:to="loc_us-gaap_ShortTermInvestments_3E6D09E19E47A685E001ED57E9AB35DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_AB51D07B995938DBE73FED5493A8D94E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_D6557AA7BF887892B2ADED5493A78BC5" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_AB51D07B995938DBE73FED5493A8D94E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_8C1C636C5E107683E2BBED5493A8EC4D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_D6557AA7BF887892B2ADED5493A78BC5" xlink:to="loc_us-gaap_InventoryNet_8C1C636C5E107683E2BBED5493A8EC4D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaap_OtherAssetsCurrent_194FF300E8CEB653BF0AED5493A8D6BB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_D6557AA7BF887892B2ADED5493A78BC5" xlink:to="loc_us-gaap_OtherAssetsCurrent_194FF300E8CEB653BF0AED5493A8D6BB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_461F9B5473FE207BDC4FED5493A811C2" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_D6557AA7BF887892B2ADED5493A78BC5" xlink:to="loc_us-gaap_AssetsCurrent_461F9B5473FE207BDC4FED5493A811C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_78EC1004AAAA11B424EDED5493A9DAFE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_D3CC5AE22271AF8A8D16ED5493A70031" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_78EC1004AAAA11B424EDED5493A9DAFE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_10691DE32CAE87AC38DDED5493A918AA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_D3CC5AE22271AF8A8D16ED5493A70031" xlink:to="loc_us-gaap_Assets_10691DE32CAE87AC38DDED5493A918AA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_C54DF039B7B2CED36AD2ED5493A71251" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_0F6A4D125EC0ACB6F055ED5493A94CCE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_0F6A4D125EC0ACB6F055ED5493A94CCE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_560FDA519DBD2F40437EED5493AA0723" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0F6A4D125EC0ACB6F055ED5493A94CCE" xlink:to="loc_us-gaap_AccountsPayableCurrent_560FDA519DBD2F40437EED5493AA0723" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_59D964C3FBD909023D07ED5493AABD9A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0F6A4D125EC0ACB6F055ED5493A94CCE" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_59D964C3FBD909023D07ED5493AABD9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredRentCreditCurrent" xlink:label="loc_us-gaap_DeferredRentCreditCurrent_98BA61AA87D9839EC630ED5493AAC326" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0F6A4D125EC0ACB6F055ED5493A94CCE" xlink:to="loc_us-gaap_DeferredRentCreditCurrent_98BA61AA87D9839EC630ED5493AAC326" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_C6B61D80A2F1C4DF582FED66BEC3F34B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0F6A4D125EC0ACB6F055ED5493A94CCE" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_C6B61D80A2F1C4DF582FED66BEC3F34B" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_LineofCreditandTermLoanCreditAgreementCurrentNetofDeferredCosts" xlink:label="loc_astm_LineofCreditandTermLoanCreditAgreementCurrentNetofDeferredCosts_0426501D2A1ABDD0FA17ED5493AB6C95" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0F6A4D125EC0ACB6F055ED5493A94CCE" xlink:to="loc_astm_LineofCreditandTermLoanCreditAgreementCurrentNetofDeferredCosts_0426501D2A1ABDD0FA17ED5493AB6C95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_457ACE733C4674C5F6FFED5493AB8E36" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0F6A4D125EC0ACB6F055ED5493A94CCE" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_457ACE733C4674C5F6FFED5493AB8E36" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_28CA3D31F0BB18E2EA13ED5493ABB2FC" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_0F6A4D125EC0ACB6F055ED5493A94CCE" xlink:to="loc_us-gaap_LiabilitiesCurrent_28CA3D31F0BB18E2EA13ED5493ABB2FC" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_LineofCreditandTermLoanCreditAgreementNoncurrentNetofDeferredCosts" xlink:label="loc_astm_LineofCreditandTermLoanCreditAgreementNoncurrentNetofDeferredCosts_1E11C650E13D83FB0D02ED5493AB1F5C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:to="loc_astm_LineofCreditandTermLoanCreditAgreementNoncurrentNetofDeferredCosts_1E11C650E13D83FB0D02ED5493AB1F5C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_1982D4D3199807D458E1ED5493ACCF41" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_1982D4D3199807D458E1ED5493ACCF41" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_87591C6E5D886FDFE4EBED5493ACCA73" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:to="loc_us-gaap_Liabilities_87591C6E5D886FDFE4EBED5493ACCA73" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaap_CommitmentsAndContingencies_1E2323BA2BEC0F2DE83BED5493ACB4B1" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:to="loc_us-gaap_CommitmentsAndContingencies_1E2323BA2BEC0F2DE83BED5493ACB4B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_A0C9A460E691424EC20AED5493AC9F70" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:to="loc_us-gaap_StockholdersEquityAbstract_A0C9A460E691424EC20AED5493AC9F70" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_CFEAEF5493AE3494DED8ED5493AD280D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_A0C9A460E691424EC20AED5493AC9F70" xlink:to="loc_us-gaap_CommonStockValue_CFEAEF5493AE3494DED8ED5493AD280D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_9611045F5BD666B85B47ED5493AD33FD" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_9611045F5BD666B85B47ED5493AD33FD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_EA18E3ED36884563AD04ED5493AEE935" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_9611045F5BD666B85B47ED5493AD33FD" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_EA18E3ED36884563AD04ED5493AEE935" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_41F470ACFD1685ADEB62ED5493AAFF70" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_9611045F5BD666B85B47ED5493AD33FD" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_41F470ACFD1685ADEB62ED5493AAFF70" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_DF797F3D96BA22710BF6ED5493AEDE38" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_9611045F5BD666B85B47ED5493AD33FD" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_DF797F3D96BA22710BF6ED5493AEDE38" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_CB2A8F7646FF56E191E8ED5493AEAA50" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:to="loc_us-gaap_StockholdersEquity_CB2A8F7646FF56E191E8ED5493AEAA50" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_70ABB3A2C5D33C5D657EED5493AED08B" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_B3CF83BDDFC06FBA369CED5493A98DDF" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_70ABB3A2C5D33C5D657EED5493AED08B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_5CF55F3C6ACA4D7D3A145C79FE62F1EA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_4E44A280CE992085EF7A5C79FE62E27F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5CF55F3C6ACA4D7D3A145C79FE62F1EA" xlink:to="loc_us-gaap_StatementTable_4E44A280CE992085EF7A5C79FE62E27F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_D1020777714402A439DD5C79FE63B651" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_4E44A280CE992085EF7A5C79FE62E27F" xlink:to="loc_us-gaap_StatementClassOfStockAxis_D1020777714402A439DD5C79FE63B651" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_7F94AE491E8CA9B182045C79FE632AC5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_D1020777714402A439DD5C79FE63B651" xlink:to="loc_us-gaap_ClassOfStockDomain_7F94AE491E8CA9B182045C79FE632AC5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_AF06D7A2633D6A2A65DF5C79FE639B05" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_7F94AE491E8CA9B182045C79FE632AC5" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_AF06D7A2633D6A2A65DF5C79FE639B05" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_4E44A280CE992085EF7A5C79FE62E27F" xlink:to="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_17202F14D320FF5852425C79FE64F0F1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_17202F14D320FF5852425C79FE64F0F1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredFinanceCostsCurrentNet" xlink:label="loc_us-gaap_DeferredFinanceCostsCurrentNet_734D5599481BFC28FA515C79FE64C56B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_DeferredFinanceCostsCurrentNet_734D5599481BFC28FA515C79FE64C56B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredFinanceCostsNoncurrentNet" xlink:label="loc_us-gaap_DeferredFinanceCostsNoncurrentNet_FAD047399E9E58472CFA5C79FE648A74" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_DeferredFinanceCostsNoncurrentNet_FAD047399E9E58472CFA5C79FE648A74" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_9BFE2CC42A4AC5C558FA5C79FE658122" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_9BFE2CC42A4AC5C558FA5C79FE658122" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_3690C7DA581FD71C31235C79FE65CBF0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_CommonStockSharesIssued_3690C7DA581FD71C31235C79FE65CBF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_3B121E5CF7E82089C0475C79FE652CD8" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_3B121E5CF7E82089C0475C79FE652CD8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_994C6E7DAF8064E760D05C79FE64B898" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_994C6E7DAF8064E760D05C79FE64B898" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertiblePreferredStockSharesReservedForFutureIssuance" xlink:label="loc_us-gaap_ConvertiblePreferredStockSharesReservedForFutureIssuance_115129D19C4228585F015C79FE64B31E" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_ConvertiblePreferredStockSharesReservedForFutureIssuance_115129D19C4228585F015C79FE64B31E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_5DAC0925DE2BFD7F2E605C79FE650833" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_PreferredStockSharesIssued_5DAC0925DE2BFD7F2E605C79FE650833" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_042ECDD7896D1ABDBB555C79FE657587" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_74A58C7921DA6CF2905D5C79FE6499D8" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_042ECDD7896D1ABDBB555C79FE657587" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_AD2B871F1725B413E2702595104ECD9E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_4E9A7798A96175FB96532595104EB76A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_AD2B871F1725B413E2702595104ECD9E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_4E9A7798A96175FB96532595104EB76A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_75D2394F2B77D5B4C0D42595104E68FE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_4E9A7798A96175FB96532595104EB76A" xlink:to="loc_us-gaap_NetIncomeLoss_75D2394F2B77D5B4C0D42595104E68FE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_4E9A7798A96175FB96532595104EB76A" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_E3F46C74B4DD6F162E822595104F5242" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_E3F46C74B4DD6F162E822595104F5242" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_169D53DF738498928BD12595104FCA04" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_169D53DF738498928BD12595104FCA04" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_4CF1D7171250EED3DD622595104FB977" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:to="loc_us-gaap_ShareBasedCompensation_4CF1D7171250EED3DD622595104FB977" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_7B1981E25671BEF928BE25951050119A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_7B1981E25671BEF928BE25951050119A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_64A46FD4933EBEC634DD25951050937E" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_64A46FD4933EBEC634DD25951050937E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossRealized" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_8B6B95189B46528AF9482595105061B6" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_8B6B95189B46528AF9482595105061B6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnDispositionOfAssets1" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_741D572ED3948F6B4969259510502915" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_741D572ED3948F6B4969259510502915" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_5C2F2BD627C6308F311E25951050CAAE" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_5C2F2BD627C6308F311E25951050CAAE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_F4CDA5780E7F03A42823259510503156" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_97A6BF8E575B7B2C64322595104FB25C" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_F4CDA5780E7F03A42823259510503156" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_4B8F7BA6BB27A4E8F45525951051980E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_F4CDA5780E7F03A42823259510503156" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_4B8F7BA6BB27A4E8F45525951051980E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidRent" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidRent_C6740F10068D2D7B6FFD259510516D3E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_F4CDA5780E7F03A42823259510503156" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidRent_C6740F10068D2D7B6FFD259510516D3E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInReceivables" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_E6D01F0B5DDAEC53306025951051F0D4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_F4CDA5780E7F03A42823259510503156" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_E6D01F0B5DDAEC53306025951051F0D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherCurrentAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_F30CC06A12226F24B8E1259510518947" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_F4CDA5780E7F03A42823259510503156" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_F30CC06A12226F24B8E1259510518947" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_AA5EF070BA11211AC9A12595105174C2" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_F4CDA5780E7F03A42823259510503156" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_AA5EF070BA11211AC9A12595105174C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_F2D4E7555CE8AB1E1D2A259510519ED6" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_F4CDA5780E7F03A42823259510503156" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_F2D4E7555CE8AB1E1D2A259510519ED6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_CD96E4D9010350855FC525951052D6B9" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_F4CDA5780E7F03A42823259510503156" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_CD96E4D9010350855FC525951052D6B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_AF9966CBFC3A842561B025951052C475" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_4E9A7798A96175FB96532595104EB76A" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_AF9966CBFC3A842561B025951052C475" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_EED053EB01CCDDEA3F6E25951052BA38" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_AD2B871F1725B413E2702595104ECD9E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_EED053EB01CCDDEA3F6E25951052BA38" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_97AA10CF887F3D95A665259510523ED5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_EED053EB01CCDDEA3F6E25951052BA38" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_97AA10CF887F3D95A665259510523ED5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_E32EE03D5EF2919B161225951052FA84" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_EED053EB01CCDDEA3F6E25951052BA38" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_E32EE03D5EF2919B161225951052FA84" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_73B188E9E619CA36AF292595105233E7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_EED053EB01CCDDEA3F6E25951052BA38" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_73B188E9E619CA36AF292595105233E7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_02B9EB6FEB8AC6118D00259510533349" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_EED053EB01CCDDEA3F6E25951052BA38" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_02B9EB6FEB8AC6118D00259510533349" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_AD2B871F1725B413E2702595104ECD9E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_091408748BB404C14528259510536CC3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_091408748BB404C14528259510536CC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOrSaleOfEquity" xlink:label="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_CDCA2DC00401003A2D4B259510538B43" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_CDCA2DC00401003A2D4B259510538B43" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfFinancingCosts" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_483D725718270020D483259510530C0C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_483D725718270020D483259510530C0C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromWarrantExercises" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_A43B22DC6A6748860E7B259510540699" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_A43B22DC6A6748860E7B259510540699" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSecuredLinesOfCredit" xlink:label="loc_us-gaap_ProceedsFromSecuredLinesOfCredit_A8C9825917BCAE78533E259510545304" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_ProceedsFromSecuredLinesOfCredit_A8C9825917BCAE78533E259510545304" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_387CBEA38420B6DAD4FA25951054FF48" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_387CBEA38420B6DAD4FA25951054FF48" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfLinesOfCredit" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_DD5F08E5F8BB1FB80A6B2595105439C1" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_RepaymentsOfLinesOfCredit_DD5F08E5F8BB1FB80A6B2595105439C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfDebt" xlink:label="loc_us-gaap_RepaymentsOfDebt_6123BA24178FFCF6B4CD259510548AEB" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" priority="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_RepaymentsOfDebt_6123BA24178FFCF6B4CD259510548AEB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_BA559157C8AB270CE1E02595105477BD" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_BA559157C8AB270CE1E02595105477BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_BB3932B8516A2CA1AD9B25951054E3D9" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_C18E7D6C63C7476BAC2D25951053A28F" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_BB3932B8516A2CA1AD9B25951054E3D9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInContinuingOperations" xlink:label="loc_us-gaap_NetCashProvidedByUsedInContinuingOperations_53B288840EA34B0C783A25951055BAF9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_AD2B871F1725B413E2702595104ECD9E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInContinuingOperations_53B288840EA34B0C783A25951055BAF9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Cash" xlink:label="loc_us-gaap_Cash_CC04CAF6AA376306BD4825951055AD45" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_AD2B871F1725B413E2702595104ECD9E" xlink:to="loc_us-gaap_Cash_CC04CAF6AA376306BD4825951055AD45" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Cash" xlink:label="loc_us-gaap_Cash_E50FC2AE84B51FCD123625951055C761" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_AD2B871F1725B413E2702595104ECD9E" xlink:to="loc_us-gaap_Cash_E50FC2AE84B51FCD123625951055C761" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_82CE8FF62531BC65298A259510558D16" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_AD2B871F1725B413E2702595104ECD9E" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_82CE8FF62531BC65298A259510558D16" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssued1" xlink:label="loc_us-gaap_StockIssued1_5D5677EBA279B9CD8C29259510555BF1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_82CE8FF62531BC65298A259510558D16" xlink:to="loc_us-gaap_StockIssued1_5D5677EBA279B9CD8C29259510555BF1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalExpendituresIncurredButNotYetPaid" xlink:label="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_1C829CEEABC50FD29E032595105570BA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_82CE8FF62531BC65298A259510558D16" xlink:to="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_1C829CEEABC50FD29E032595105570BA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/ConsolidatedStatementsOfComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_09D39D14B963F1A0E92458BDB899A4C1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_950AFA4E5A01DFBA893F58BDB89970BF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_09D39D14B963F1A0E92458BDB899A4C1" xlink:to="loc_us-gaap_NetIncomeLoss_950AFA4E5A01DFBA893F58BDB89970BF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_FD3AB1CCD365D216E15B58BDB899AAFB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_09D39D14B963F1A0E92458BDB899A4C1" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_FD3AB1CCD365D216E15B58BDB899AAFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_8DEA2BFE2214B5132AF258BDB899DDAF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_09D39D14B963F1A0E92458BDB899A4C1" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_8DEA2BFE2214B5132AF258BDB899DDAF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/ConsolidatedStatementsOfOperations" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3E1A85C5E73846C4502426045059A0A7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3E1A85C5E73846C4502426045059A0A7" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OtherRevenue" xlink:label="loc_astm_OtherRevenue_9A647D9FB7687E3F0E3A260450596A68" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_astm_OtherRevenue_9A647D9FB7687E3F0E3A260450596A68" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_A599B06BB6B1F220E4BC26045059EEAC" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_Revenues_A599B06BB6B1F220E4BC26045059EEAC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_C3E3F6A62F8DEEFBC97B2604505996ED" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_C3E3F6A62F8DEEFBC97B2604505996ED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GrossProfit" xlink:label="loc_us-gaap_GrossProfit_B114637EA05A124154602604505A0B02" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_GrossProfit_B114637EA05A124154602604505A0B02" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_9916FB83ABD43D1105682604505AB7C7" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_9916FB83ABD43D1105682604505AB7C7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_5951BEF332619813865D2604505ABB36" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_5951BEF332619813865D2604505ABB36" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_6A8A9763C1AC6FBC74572604505A236C" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_6A8A9763C1AC6FBC74572604505A236C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_144B10663EBC5753DA072604505B4FC8" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_OperatingExpenses_144B10663EBC5753DA072604505B4FC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_0B989F9C0A19AD688CAE2604505BA308" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_OperatingIncomeLoss_0B989F9C0A19AD688CAE2604505BA308" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_FFC4690AD0757C257F8C2604505B55D9" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_FFC4690AD0757C257F8C2604505B55D9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_398464A44E5972A852712604505BCB60" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_FFC4690AD0757C257F8C2604505B55D9" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_398464A44E5972A852712604505BCB60" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_F73B05DFC7BA6D8DB1FB2604505C4E93" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_FFC4690AD0757C257F8C2604505B55D9" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_F73B05DFC7BA6D8DB1FB2604505C4E93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaap_InvestmentIncomeInterest_334AA91DBC8F49D4A22D2604505C9E51" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_FFC4690AD0757C257F8C2604505B55D9" xlink:to="loc_us-gaap_InvestmentIncomeInterest_334AA91DBC8F49D4A22D2604505C9E51" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_3195E8E87FA6C6F36E5A2604505C7B0B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_FFC4690AD0757C257F8C2604505B55D9" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_3195E8E87FA6C6F36E5A2604505C7B0B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_3EB621146EF80F2906662604505D7FAA" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_FFC4690AD0757C257F8C2604505B55D9" xlink:to="loc_us-gaap_InterestExpense_3EB621146EF80F2906662604505D7FAA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_2E0203F4BAD7209F3C992604505D0DC5" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_FFC4690AD0757C257F8C2604505B55D9" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_2E0203F4BAD7209F3C992604505D0DC5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_F34C16D339FC437EF3D72604505DD9BC" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_NetIncomeLoss_F34C16D339FC437EF3D72604505DD9BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_3EDC5EB3AF2F101AD9682604505D1571" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_3EDC5EB3AF2F101AD9682604505D1571" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xlink:label="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_0ABAB2B6F16C9CD72C0F2604505D4091" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_59E20A741619DD5D600B260450586B94" xlink:to="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_0ABAB2B6F16C9CD72C0F2604505D4091" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/ConsolidatedStatementsOfShareholdersEquity" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_B57E5C85D51F13F646162595106020AB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_EF348E7A2CE770A2414A259510607586" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_B57E5C85D51F13F646162595106020AB" xlink:to="loc_us-gaap_StatementTable_EF348E7A2CE770A2414A259510607586" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_331925AE245123BDBEE5259510611A96" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_EF348E7A2CE770A2414A259510607586" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_331925AE245123BDBEE5259510611A96" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_BC2505AC86ECD266D64525951061D5FC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_331925AE245123BDBEE5259510611A96" xlink:to="loc_us-gaap_EquityComponentDomain_BC2505AC86ECD266D64525951061D5FC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_us-gaap_PreferredStockMember_9ECB0B6BA500174F64A525951061DCB6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_BC2505AC86ECD266D64525951061D5FC" xlink:to="loc_us-gaap_PreferredStockMember_9ECB0B6BA500174F64A525951061DCB6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_478BD6623B80868DF00925951061DF5D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_BC2505AC86ECD266D64525951061D5FC" xlink:to="loc_us-gaap_CommonStockMember_478BD6623B80868DF00925951061DF5D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_2BC734DCD5436001EF3625951062D9CC" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_BC2505AC86ECD266D64525951061D5FC" xlink:to="loc_us-gaap_TreasuryStockMember_2BC734DCD5436001EF3625951062D9CC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_D67F0AC98A51A89F7C43259510627631" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_BC2505AC86ECD266D64525951061D5FC" xlink:to="loc_us-gaap_WarrantMember_D67F0AC98A51A89F7C43259510627631" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_48C937AD815CDC3A8FAF25951062923B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_BC2505AC86ECD266D64525951061D5FC" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_48C937AD815CDC3A8FAF25951062923B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_98DAE59AD9CA1B13FC99259510621F37" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_BC2505AC86ECD266D64525951061D5FC" xlink:to="loc_us-gaap_RetainedEarningsMember_98DAE59AD9CA1B13FC99259510621F37" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_F421D6094B8D13B8DCB425951062D158" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_EF348E7A2CE770A2414A259510607586" xlink:to="loc_us-gaap_StatementLineItems_F421D6094B8D13B8DCB425951062D158" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F421D6094B8D13B8DCB425951062D158" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_7DE844A41F123E46FF1B259510631A56" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_SharesOutstanding_7DE844A41F123E46FF1B259510631A56" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_478F04586CB4270E32D125951063AC30" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockholdersEquity_478F04586CB4270E32D125951063AC30" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_0B770CF0540137F39F57259510632E56" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_NetIncomeLoss_0B770CF0540137F39F57259510632E56" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_F1C7DDA54D799999A82F259510630510" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_F1C7DDA54D799999A82F259510630510" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_93EB9A02346DBBE30F7A25951063BAFB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_93EB9A02346DBBE30F7A25951063BAFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_BCC2D0F62F8E32E3DEEB25951064339D" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_BCC2D0F62F8E32E3DEEB25951064339D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_51C1B4E0079CA1B973A925951064D4E5" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" priority="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_51C1B4E0079CA1B973A925951064D4E5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_8DE1A86D2BF74FC6C4DD259510644CE7" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_8DE1A86D2BF74FC6C4DD259510644CE7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_987AA0593A06B8673298259510643FEE" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_987AA0593A06B8673298259510643FEE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_5095C0E35DF828FBF69E25951064A36A" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_5095C0E35DF828FBF69E25951064A36A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_5E735D6C19FAB49AD2B325951064A5F2" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_5E735D6C19FAB49AD2B325951064A5F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_7B5B0655D67241442CBB259510655B15" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_7B5B0655D67241442CBB259510655B15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_FDED18BD98C08D7A7E3B25951065B76E" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_FDED18BD98C08D7A7E3B25951065B76E" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_StockIssuedDuringPeriodSharesExerciseOfWarrants" xlink:label="loc_astm_StockIssuedDuringPeriodSharesExerciseOfWarrants_E9EB4963A0C5C72ACB0B259510651AF2" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_astm_StockIssuedDuringPeriodSharesExerciseOfWarrants_E9EB4963A0C5C72ACB0B259510651AF2" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_StockIssuedDuringPeriodValueExerciseOfWarrants" xlink:label="loc_astm_StockIssuedDuringPeriodValueExerciseOfWarrants_D5A851A9CA9D4113BED6259510653189" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_astm_StockIssuedDuringPeriodValueExerciseOfWarrants_D5A851A9CA9D4113BED6259510653189" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrealizedLossOnSecurities" xlink:label="loc_us-gaap_UnrealizedLossOnSecurities_8B50A81682E0E6AA7B93259510653CBB" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_UnrealizedLossOnSecurities_8B50A81682E0E6AA7B93259510653CBB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_B33E303D11C58CD7EDBD2595106573B4" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_SharesOutstanding_B33E303D11C58CD7EDBD2595106573B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_5E8CEFF636DC1CECC416259510667F71" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_3CD0482741BA7559FF3025951063C130" xlink:to="loc_us-gaap_StockholdersEquity_5E8CEFF636DC1CECC416259510667F71" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/ConsolidatedStatementsOfShareholdersEquityParenthetical" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_ECBBEE290E597174146AED87E37E38D5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_6B11FA18F2544A2CA539ED87E37E7B52" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_ECBBEE290E597174146AED87E37E38D5" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_6B11FA18F2544A2CA539ED87E37E7B52" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/Debt" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_47548DC839517B9676CE58BDB9D68F1F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureTextBlock" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_EA1FBC111827BD665E6C58BDB9D61B5A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_47548DC839517B9676CE58BDB9D68F1F" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_EA1FBC111827BD665E6C58BDB9D61B5A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/DebtDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_28513578982500A458F1274C9480B7B1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_1B9B589A8E32B035D4DC274C94807F7E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_28513578982500A458F1274C9480B7B1" xlink:to="loc_us-gaap_DebtInstrumentTable_1B9B589A8E32B035D4DC274C94807F7E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_6FA80255932984A7AB04274C94819F99" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_1B9B589A8E32B035D4DC274C94807F7E" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_6FA80255932984A7AB04274C94819F99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_025B72B46FAD00F59348274C94811E0E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_6FA80255932984A7AB04274C94819F99" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_025B72B46FAD00F59348274C94811E0E" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_SiliconValleyBankAndMidCapFinancialServicesMember" xlink:label="loc_astm_SiliconValleyBankAndMidCapFinancialServicesMember_53B3A0ABBF4A0EB8B626274C9481D1CF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_025B72B46FAD00F59348274C94811E0E" xlink:to="loc_astm_SiliconValleyBankAndMidCapFinancialServicesMember_53B3A0ABBF4A0EB8B626274C9481D1CF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_91D13640D45DF06F7A9A274C948114C1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_1B9B589A8E32B035D4DC274C94807F7E" xlink:to="loc_us-gaap_DebtInstrumentAxis_91D13640D45DF06F7A9A274C948114C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1DFF929021E37CB16094274C94817413" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_91D13640D45DF06F7A9A274C948114C1" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_1DFF929021E37CB16094274C94817413" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_DebtFinancingAgreementMember" xlink:label="loc_astm_DebtFinancingAgreementMember_7AADD4879896D9F80093274C94825592" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1DFF929021E37CB16094274C94817413" xlink:to="loc_astm_DebtFinancingAgreementMember_7AADD4879896D9F80093274C94825592" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_TermLoanMember" xlink:label="loc_astm_TermLoanMember_7A48648E54F71439063D274C9482884D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1DFF929021E37CB16094274C94817413" xlink:to="loc_astm_TermLoanMember_7A48648E54F71439063D274C9482884D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_870162DCA161FE246533274C9482354A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_1B9B589A8E32B035D4DC274C94807F7E" xlink:to="loc_us-gaap_CreditFacilityAxis_870162DCA161FE246533274C9482354A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_76E205AB0F15CBE64C53274C94823B7F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityAxis_870162DCA161FE246533274C9482354A" xlink:to="loc_us-gaap_CreditFacilityDomain_76E205AB0F15CBE64C53274C94823B7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_90D0192161C7B1873F3B274C94883FA5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_76E205AB0F15CBE64C53274C94823B7F" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_90D0192161C7B1873F3B274C94883FA5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_3DF07C533111D2C74F92274C9488E9F2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_1B9B589A8E32B035D4DC274C94807F7E" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_3DF07C533111D2C74F92274C9488E9F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_BF755C475C003BFA400D274C9488C99F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_3DF07C533111D2C74F92274C9488E9F2" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_BF755C475C003BFA400D274C9488C99F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="loc_us-gaap_LineOfCreditMember_9B95DDF2D0A88238BD37274C94897048" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_BF755C475C003BFA400D274C9488C99F" xlink:to="loc_us-gaap_LineOfCreditMember_9B95DDF2D0A88238BD37274C94897048" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_9F3F278B2287591A3B56274C9489CE26" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_1B9B589A8E32B035D4DC274C94807F7E" xlink:to="loc_us-gaap_VariableRateAxis_9F3F278B2287591A3B56274C9489CE26" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_29F976177AF3459A5610274C94898F8C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_9F3F278B2287591A3B56274C9489CE26" xlink:to="loc_us-gaap_VariableRateDomain_29F976177AF3459A5610274C94898F8C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PrimeRateMember" xlink:label="loc_us-gaap_PrimeRateMember_6169FF0C3A86735A1001274C94898AE9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_29F976177AF3459A5610274C94898F8C" xlink:to="loc_us-gaap_PrimeRateMember_6169FF0C3A86735A1001274C94898AE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_47510A61485121C7B573274C9489E529" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_1B9B589A8E32B035D4DC274C94807F7E" xlink:to="loc_srt_RangeAxis_47510A61485121C7B573274C9489E529" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_3E15B61485C67B853218274C948AC29F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_47510A61485121C7B573274C9489E529" xlink:to="loc_srt_RangeMember_3E15B61485C67B853218274C948AC29F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_DD10D10DF4B3FB08D508274C948ACE75" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_3E15B61485C67B853218274C948AC29F" xlink:to="loc_srt_MinimumMember_DD10D10DF4B3FB08D508274C948ACE75" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_1B9B589A8E32B035D4DC274C94807F7E" xlink:to="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_73E666622150E2175DB8274C948A803D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_73E666622150E2175DB8274C948A803D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_4BAF37DFFA048FC8F4A2274C948B8A9A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_4BAF37DFFA048FC8F4A2274C948B8A9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_88E76D6583914EA87715274C948BED8B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_88E76D6583914EA87715274C948BED8B" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_DebtInstrumentNumberofInstallments" xlink:label="loc_astm_DebtInstrumentNumberofInstallments_25BDD73E3794D48AE8B6274C948B52EE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_astm_DebtInstrumentNumberofInstallments_25BDD73E3794D48AE8B6274C948B52EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfDebt" xlink:label="loc_us-gaap_RepaymentsOfDebt_E03DAE339E9895409F51274C948B43B2" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_us-gaap_RepaymentsOfDebt_E03DAE339E9895409F51274C948B43B2" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_DebtInstrumentPrepaymentPremiumPercentage" xlink:label="loc_astm_DebtInstrumentPrepaymentPremiumPercentage_24BE49AD136A2F3FC383274C948B82C2" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_astm_DebtInstrumentPrepaymentPremiumPercentage_24BE49AD136A2F3FC383274C948B82C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfDebtExtinguishmentCosts" xlink:label="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_75B590331DF98CCEBA63274C948B0CE2" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_75B590331DF98CCEBA63274C948B0CE2" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_DebtInstrumentInterestRateStatedPercentageFinalPaymentDueUponMaturity" xlink:label="loc_astm_DebtInstrumentInterestRateStatedPercentageFinalPaymentDueUponMaturity_967578CEB4C70C4F892B274C948CA678" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_astm_DebtInstrumentInterestRateStatedPercentageFinalPaymentDueUponMaturity_967578CEB4C70C4F892B274C948CA678" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_RepaymentsofDebtFinalPayment" xlink:label="loc_astm_RepaymentsofDebtFinalPayment_8644A09EDCF49D7F999C274C948C3D4B" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_astm_RepaymentsofDebtFinalPayment_8644A09EDCF49D7F999C274C948C3D4B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_11DD3483394D33ACE75B274C948C2DDE" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_1CD4E2F08C4EDD04C349274C948A70E8" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_11DD3483394D33ACE75B274C948C2DDE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/DocumentAndEntityInformation" xlink:type="extended">
    <link:loc xlink:href="astm-20181231.xsd#astm_DocumentAndEntityInformationAbstract" xlink:label="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_E0E0080EE2D6A538DA7DEE6F28D91A42" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityRegistrantName_E0E0080EE2D6A538DA7DEE6F28D91A42" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_8B4C01F2B8CB1C02C00BEE6F28D9890A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityCentralIndexKey_8B4C01F2B8CB1C02C00BEE6F28D9890A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_78D5284AC56400E4BA49EE6F28D9CF0F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_CurrentFiscalYearEndDate_78D5284AC56400E4BA49EE6F28D9CF0F" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_9F05885311F987FDF528EE6F28D91434" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityFilerCategory_9F05885311F987FDF528EE6F28D91434" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_16FDC44001E05821C223EE6F28D9D7E6" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_DocumentType_16FDC44001E05821C223EE6F28D9D7E6" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_C1043B9DE7A26A5F0C24EE6F28DAFF48" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_DocumentPeriodEndDate_C1043B9DE7A26A5F0C24EE6F28DAFF48" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_12562C9E331C81FC5FD8EE6F28DA0425" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_DocumentFiscalYearFocus_12562C9E331C81FC5FD8EE6F28DA0425" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_50D228345B349AC7E3E5EE6F28DAE6DB" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_DocumentFiscalPeriodFocus_50D228345B349AC7E3E5EE6F28DAE6DB" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_D176CC73C0B7D29F7B52EE6F28DAB034" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_AmendmentFlag_D176CC73C0B7D29F7B52EE6F28DAB034" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntitySmallBusiness" xlink:label="loc_dei_EntitySmallBusiness_772F2829AD26DC5D1D64EE6F28DA3741" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntitySmallBusiness_772F2829AD26DC5D1D64EE6F28DA3741" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_dei_EntityEmergingGrowthCompany_8C2723E5B4EF11AAD5A4EE6F28DA3670" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityEmergingGrowthCompany_8C2723E5B4EF11AAD5A4EE6F28DA3670" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityShellCompany" xlink:label="loc_dei_EntityShellCompany_6FD78696F955B73ACB2DEE6F28DBB0BD" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityShellCompany_6FD78696F955B73ACB2DEE6F28DBB0BD" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_00C7AC4FA1F209B41C7AEE6F28DB43CF" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_00C7AC4FA1F209B41C7AEE6F28DB43CF" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_268365EB8283EEA6186AEE6F28DB5E58" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_268365EB8283EEA6186AEE6F28DB5E58" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_5445FF2D7AFDC07DE5C6EE6F28DB52E6" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityVoluntaryFilers_5445FF2D7AFDC07DE5C6EE6F28DB52E6" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_3A6C5E94DB716381D728EE6F28DBE238" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityCurrentReportingStatus_3A6C5E94DB716381D728EE6F28DBE238" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityPublicFloat" xlink:label="loc_dei_EntityPublicFloat_6889AF113074BA47333FEE6F28DB347F" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_5E8D96651F3C742F9DE4EE6F28D892D7" xlink:to="loc_dei_EntityPublicFloat_6889AF113074BA47333FEE6F28DB347F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/EmployeeSavingsPlan" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_7DC657E2B5E5945BD6F758BDB994E9A0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock" xlink:label="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_E46C8CC67F2DBC0480B558BDB9948F63" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_7DC657E2B5E5945BD6F758BDB994E9A0" xlink:to="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_E46C8CC67F2DBC0480B558BDB9948F63" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/EmployeeSavingsPlanDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_8F460C8B795A9093612758BDB90EE2E7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DefinedContributionPlanCostRecognized" xlink:label="loc_us-gaap_DefinedContributionPlanCostRecognized_F6B90F4F8F62A4755BEC58BDB90EA824" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_8F460C8B795A9093612758BDB90EE2E7" xlink:to="loc_us-gaap_DefinedContributionPlanCostRecognized_F6B90F4F8F62A4755BEC58BDB90EA824" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_71C3CE0EEE85A49DAB5B58BDBA4F3515" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_F8B3CCCF03EED917348158BDBA4FD879" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_71C3CE0EEE85A49DAB5B58BDBA4F3515" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_F8B3CCCF03EED917348158BDBA4FD879" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_B818FFE4769D2F8B278A274C93892567" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3BC50ADA239A16D95C86274C938A72F2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_B818FFE4769D2F8B278A274C93892567" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3BC50ADA239A16D95C86274C938A72F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_D50A1C68AEA0CCCD5B34274C938A2704" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3BC50ADA239A16D95C86274C938A72F2" xlink:to="loc_us-gaap_FinancialInstrumentAxis_D50A1C68AEA0CCCD5B34274C938A2704" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_98A98F0F5D521D9AE51E274C938AC800" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_D50A1C68AEA0CCCD5B34274C938A2704" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_98A98F0F5D521D9AE51E274C938AC800" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember" xlink:label="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_DCC4CAA8D390FE0CC201274C938A34B4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_98A98F0F5D521D9AE51E274C938AC800" xlink:to="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_DCC4CAA8D390FE0CC201274C938A34B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USGovernmentDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_E04A0FA0F5598F15A756274C938BECAE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_98A98F0F5D521D9AE51E274C938AC800" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_E04A0FA0F5598F15A756274C938BECAE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_2CAB2E9ED21F5CFCA084274C938B3C00" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_98A98F0F5D521D9AE51E274C938AC800" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_2CAB2E9ED21F5CFCA084274C938B3C00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateNoteSecuritiesMember" xlink:label="loc_us-gaap_CorporateNoteSecuritiesMember_E56A1148A53CC3130BFF274C938B0984" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_98A98F0F5D521D9AE51E274C938AC800" xlink:to="loc_us-gaap_CorporateNoteSecuritiesMember_E56A1148A53CC3130BFF274C938B0984" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAxis" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_F115DDAEAE90B5D06CB8274C938B0D63" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3BC50ADA239A16D95C86274C938A72F2" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_F115DDAEAE90B5D06CB8274C938B0D63" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_4117165C8FD25DBE0482274C938BE047" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_F115DDAEAE90B5D06CB8274C938B0D63" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_4117165C8FD25DBE0482274C938BE047" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MoneyMarketFundsMember" xlink:label="loc_us-gaap_MoneyMarketFundsMember_8102E433B016A67D491F274C938C65EE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_4117165C8FD25DBE0482274C938BE047" xlink:to="loc_us-gaap_MoneyMarketFundsMember_8102E433B016A67D491F274C938C65EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_C01B0926D92E6A6EE106274C938C7298" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3BC50ADA239A16D95C86274C938A72F2" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_C01B0926D92E6A6EE106274C938C7298" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_FD56C134DEC6A0EA8169274C938C1D5C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_C01B0926D92E6A6EE106274C938C7298" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_FD56C134DEC6A0EA8169274C938C1D5C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_AC50D4B104BFF0522BAF274C938CBDC9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_FD56C134DEC6A0EA8169274C938C1D5C" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_AC50D4B104BFF0522BAF274C938CBDC9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2462C3DF8775E6ED572B274C938DF5E7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3BC50ADA239A16D95C86274C938A72F2" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2462C3DF8775E6ED572B274C938DF5E7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DEC5483B5E6F5F61F788274C938D8790" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_2462C3DF8775E6ED572B274C938DF5E7" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DEC5483B5E6F5F61F788274C938D8790" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_AA7B7D53222CA4DCFE26274C938D38C5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DEC5483B5E6F5F61F788274C938D8790" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_AA7B7D53222CA4DCFE26274C938D38C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_835F22A9ACF635DC673F274C938D6D7F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DEC5483B5E6F5F61F788274C938D8790" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_835F22A9ACF635DC673F274C938D6D7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_E6D224DE3A57E6B1027B274C938DE5A1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_DEC5483B5E6F5F61F788274C938D8790" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_E6D224DE3A57E6B1027B274C938DE5A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_DECADE346022C22D948E274C938EA72F" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3BC50ADA239A16D95C86274C938A72F2" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_DECADE346022C22D948E274C938EA72F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_1445D91316E15937A581274C938EBC46" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_DECADE346022C22D948E274C938EA72F" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_1445D91316E15937A581274C938EBC46" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsMember" xlink:label="loc_us-gaap_OtherAssetsMember_E4E0C4BB20BDF64E1EF1274C938E1C71" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_1445D91316E15937A581274C938EBC46" xlink:to="loc_us-gaap_OtherAssetsMember_E4E0C4BB20BDF64E1EF1274C938E1C71" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F3620EDB04FFD55506FC274C938EB041" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3BC50ADA239A16D95C86274C938A72F2" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F3620EDB04FFD55506FC274C938EB041" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestReceivable" xlink:label="loc_us-gaap_InterestReceivable_6B6AEE175847D346E0B8274ECCF0680E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F3620EDB04FFD55506FC274C938EB041" xlink:to="loc_us-gaap_InterestReceivable_6B6AEE175847D346E0B8274ECCF0680E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_AABC0CACF1E1EAA09035274C938FDA5F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F3620EDB04FFD55506FC274C938EB041" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_AABC0CACF1E1EAA09035274C938FDA5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAsset" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAsset_BDA7FE7DBFBA170BEAC0274C938FCCFB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F3620EDB04FFD55506FC274C938EB041" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAsset_BDA7FE7DBFBA170BEAC0274C938FCCFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_87060256C1FB7FE58475274C938F7900" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F3620EDB04FFD55506FC274C938EB041" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_87060256C1FB7FE58475274C938F7900" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_07102EEE1F4DFCBF694F274C938FD263" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F3620EDB04FFD55506FC274C938EB041" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_07102EEE1F4DFCBF694F274C938FD263" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_4F4D4847457804B9BCD3274C938F4936" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F3620EDB04FFD55506FC274C938EB041" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_4F4D4847457804B9BCD3274C938F4936" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsAndRightsRollForward" xlink:label="loc_astm_WarrantsAndRightsRollForward_36605FC3B00B3052A5CE274C938F4FE3" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F3620EDB04FFD55506FC274C938EB041" xlink:to="loc_astm_WarrantsAndRightsRollForward_36605FC3B00B3052A5CE274C938F4FE3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_689660FB4ADA6C6658CF274C9390E290" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_WarrantsAndRightsRollForward_36605FC3B00B3052A5CE274C938F4FE3" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_689660FB4ADA6C6658CF274C9390E290" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_BC56A1833E34B06DE645274C939014C1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_WarrantsAndRightsRollForward_36605FC3B00B3052A5CE274C938F4FE3" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_BC56A1833E34B06DE645274C939014C1" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsExercisedForCommonStock" xlink:label="loc_astm_WarrantsExercisedForCommonStock_F19E00D617496085D65D274C9390C5CF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_WarrantsAndRightsRollForward_36605FC3B00B3052A5CE274C938F4FE3" xlink:to="loc_astm_WarrantsExercisedForCommonStock_F19E00D617496085D65D274C9390C5CF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_E90EEF0FDDE633D8D12D274C93902FC1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_WarrantsAndRightsRollForward_36605FC3B00B3052A5CE274C938F4FE3" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_E90EEF0FDDE633D8D12D274C93902FC1" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_90345E47EE0E656C569D58BDB88D877F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_83262A1FBD64F4520E1558BDB88D820A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_90345E47EE0E656C569D58BDB88D877F" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_83262A1FBD64F4520E1558BDB88D820A" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ScheduleOfChangeInEstimatedFairValueOfWarrantLiabilitiesTableTextBlock" xlink:label="loc_astm_ScheduleOfChangeInEstimatedFairValueOfWarrantLiabilitiesTableTextBlock_0F9BF8634C27A547666658BDB88DE059" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_90345E47EE0E656C569D58BDB88D877F" xlink:to="loc_astm_ScheduleOfChangeInEstimatedFairValueOfWarrantLiabilitiesTableTextBlock_0F9BF8634C27A547666658BDB88DE059" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/IncomeTaxes" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_8480312CA94991664AFD58BDB923A6BD" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_538059733BEFD2355C8C58BDB923D1DC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_8480312CA94991664AFD58BDB923A6BD" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_538059733BEFD2355C8C58BDB923D1DC" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/IncomeTaxesComponentsOfIncomeLossBeforeTaxesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_ECBD9617FDD3CAE6892C5DD25FDDABCA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_09FA1F997CB7D18190E55DD25FDD3D9E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_ECBD9617FDD3CAE6892C5DD25FDDABCA" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_09FA1F997CB7D18190E55DD25FDD3D9E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_BE717B12C44DCEF797445DD25FDD4073" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_09FA1F997CB7D18190E55DD25FDD3D9E" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_BE717B12C44DCEF797445DD25FDD4073" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_0DA59AB182D46F59270B5DD25FDE04A8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_BE717B12C44DCEF797445DD25FDD4073" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_0DA59AB182D46F59270B5DD25FDE04A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DomesticCountryMember" xlink:label="loc_us-gaap_DomesticCountryMember_6DB10ACB65A327EAA7B05DD25FDE9492" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_0DA59AB182D46F59270B5DD25FDE04A8" xlink:to="loc_us-gaap_DomesticCountryMember_6DB10ACB65A327EAA7B05DD25FDE9492" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ForeignCountryMember" xlink:label="loc_us-gaap_ForeignCountryMember_CADE30F40977DCE05D3D5DD25FDE3B7A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_0DA59AB182D46F59270B5DD25FDE04A8" xlink:to="loc_us-gaap_ForeignCountryMember_CADE30F40977DCE05D3D5DD25FDE3B7A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_7356C06051BD1BD1C24D5DD25FDEEFB2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_09FA1F997CB7D18190E55DD25FDD3D9E" xlink:to="loc_us-gaap_OperatingLossCarryforwardsLineItems_7356C06051BD1BD1C24D5DD25FDEEFB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5653E425817906C1C4065DD25FDE5F63" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_7356C06051BD1BD1C24D5DD25FDEEFB2" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5653E425817906C1C4065DD25FDE5F63" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/IncomeTaxesDeferredTaxAssetsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_CEB77CAB3C9F942DAEF925950F5683EF" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_CEB77CAB3C9F942DAEF925950F5683EF" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_7C49CB05286C7381581C25950F57D695" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_7C49CB05286C7381581C25950F57D695" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_A7F9D46524A2F2740FF925950F57B574" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_A7F9D46524A2F2740FF925950F57B574" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_EB906327E061D01F5E2925950F571EC3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_EB906327E061D01F5E2925950F571EC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_72B36A217AC6E80C6D3125950F57BDF2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_72B36A217AC6E80C6D3125950F57BDF2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_9C069AD7B1715C094E1425950F58DF51" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_9C069AD7B1715C094E1425950F58DF51" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_2A9A2BB5D8CCCD7219B825950F58290E" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_2A9A2BB5D8CCCD7219B825950F58290E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_2799D823FFE86AD587A425950F587227" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_2799D823FFE86AD587A425950F587227" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_A76E97D8E49E5875B10925950F58263F" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_A76E97D8E49E5875B10925950F58263F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_824405334221C0118BD025950F59D382" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_7A6C1C22B734B672067625950F560663" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_824405334221C0118BD025950F59D382" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsNetAbstract" xlink:label="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_CEB77CAB3C9F942DAEF925950F5683EF" xlink:to="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_4087CE4047FC32DF116C25950F59D138" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_4087CE4047FC32DF116C25950F59D138" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_5A6DA9B3825AB10BBFD025950F59775C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_5A6DA9B3825AB10BBFD025950F59775C" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_DeferredTaxAssetsResearchAndDevelopmentCosts" xlink:label="loc_astm_DeferredTaxAssetsResearchAndDevelopmentCosts_A7B38F44CD9AE12DDA0D25950F59F4F1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:to="loc_astm_DeferredTaxAssetsResearchAndDevelopmentCosts_A7B38F44CD9AE12DDA0D25950F59F4F1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment" xlink:label="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_C1FDF45CCFBF59011E5A25950F59C640" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:to="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_C1FDF45CCFBF59011E5A25950F59C640" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsInventory" xlink:label="loc_us-gaap_DeferredTaxAssetsInventory_E0C228ECF84AC0E9A45F25950F5A11BA" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:to="loc_us-gaap_DeferredTaxAssetsInventory_E0C228ECF84AC0E9A45F25950F5A11BA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsOther" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_F8A1E4A5D16ABB0532B125950F5A1ABC" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_F8A1E4A5D16ABB0532B125950F5A1ABC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsGross" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_090CDBCAEBAB28886A6E25950F5A2E18" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_090CDBCAEBAB28886A6E25950F5A2E18" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_44C1C38001EE6C58944025950F5ADA62" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_44C1C38001EE6C58944025950F5ADA62" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_DB6E87083D040A11A69825950F5A09E9" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsNetAbstract_87E61004E164A105D3EF25950F597723" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_DB6E87083D040A11A69825950F5A09E9" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_BF998D7A70E6644A2EF725950F4BB6B8" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_8B93A127DF50C36DAECE25950F4BECE0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_BF998D7A70E6644A2EF725950F4BB6B8" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_8B93A127DF50C36DAECE25950F4BECE0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_78D8A1727FE8324E0DFA25950F4B5573" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_8B93A127DF50C36DAECE25950F4BECE0" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_78D8A1727FE8324E0DFA25950F4B5573" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_C9D5E5FF82EF37140E6225950F4B48C5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_78D8A1727FE8324E0DFA25950F4B5573" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_C9D5E5FF82EF37140E6225950F4B48C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DomesticCountryMember" xlink:label="loc_us-gaap_DomesticCountryMember_9FAEDF8242A2ADF6D1DE25950F4C240E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_C9D5E5FF82EF37140E6225950F4B48C5" xlink:to="loc_us-gaap_DomesticCountryMember_9FAEDF8242A2ADF6D1DE25950F4C240E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_6DE36DA66F602261E41B25950F4C5F0C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_C9D5E5FF82EF37140E6225950F4B48C5" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_6DE36DA66F602261E41B25950F4C5F0C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityNameAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameAxis_39FE3C028EA1ADDEDF4825950F4CDAB9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_8B93A127DF50C36DAECE25950F4BECE0" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameAxis_39FE3C028EA1ADDEDF4825950F4CDAB9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityNameDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameDomain_7A81174F666F3563633625950F4C31F0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_39FE3C028EA1ADDEDF4825950F4CDAB9" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameDomain_7A81174F666F3563633625950F4C31F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InternalRevenueServiceIRSMember" xlink:label="loc_us-gaap_InternalRevenueServiceIRSMember_EEBCFDC150C7DAC76CB225950F4D28D1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameDomain_7A81174F666F3563633625950F4C31F0" xlink:to="loc_us-gaap_InternalRevenueServiceIRSMember_EEBCFDC150C7DAC76CB225950F4D28D1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_5124D616001DC7F36F6E25950F4D0D6B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_8B93A127DF50C36DAECE25950F4BECE0" xlink:to="loc_us-gaap_OperatingLossCarryforwardsLineItems_5124D616001DC7F36F6E25950F4D0D6B" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OperatingLossCarryforwardsLimitationsOnUseProjectedAnnualLimitationOnUseOfNetOperatingLosses" xlink:label="loc_astm_OperatingLossCarryforwardsLimitationsOnUseProjectedAnnualLimitationOnUseOfNetOperatingLosses_408B88AA7A97B84C88A625950F4DC6A4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_5124D616001DC7F36F6E25950F4D0D6B" xlink:to="loc_astm_OperatingLossCarryforwardsLimitationsOnUseProjectedAnnualLimitationOnUseOfNetOperatingLosses_408B88AA7A97B84C88A625950F4DC6A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_us-gaap_OperatingLossCarryforwards_D49EDCADE8D7ED782C3825950F4D0897" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_5124D616001DC7F36F6E25950F4D0D6B" xlink:to="loc_us-gaap_OperatingLossCarryforwards_D49EDCADE8D7ED782C3825950F4D0897" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_2D3570E0AA8FFEBB4FED25950F4E5022" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_5124D616001DC7F36F6E25950F4D0D6B" xlink:to="loc_us-gaap_OperatingIncomeLoss_2D3570E0AA8FFEBB4FED25950F4E5022" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_A52F4824F3BF2098832E25950F4EA376" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_5124D616001DC7F36F6E25950F4D0D6B" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_A52F4824F3BF2098832E25950F4EA376" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_50BECB2B27E980828C1E25950F4ECC46" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_5124D616001DC7F36F6E25950F4D0D6B" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_50BECB2B27E980828C1E25950F4ECC46" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxAssetProvisionalIncomeTaxExpense" xlink:label="loc_astm_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxAssetProvisionalIncomeTaxExpense_468B2A57E94CFE028EEF25950F4E79B4" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_5124D616001DC7F36F6E25950F4D0D6B" xlink:to="loc_astm_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxAssetProvisionalIncomeTaxExpense_468B2A57E94CFE028EEF25950F4E79B4" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/IncomeTaxesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_867CBCB07BBD5D4AC21958BDBA1C9E2A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_B25D88910B4A12DF4D9258BDBA1CAC6B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_867CBCB07BBD5D4AC21958BDBA1C9E2A" xlink:to="loc_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_B25D88910B4A12DF4D9258BDBA1CAC6B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_5DDBC48DB81DB32DB52658BDBA1CB896" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_867CBCB07BBD5D4AC21958BDBA1C9E2A" xlink:to="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_5DDBC48DB81DB32DB52658BDBA1CB896" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_CBB16221E05F454A02CB58BDBA1DC033" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_867CBCB07BBD5D4AC21958BDBA1C9E2A" xlink:to="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_CBB16221E05F454A02CB58BDBA1DC033" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/NetLossPerCommonShare" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_B137EB7435354A33371958BDB9C03E87" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_F76C2DFA35EF7DF49B8558BDB9C00352" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_B137EB7435354A33371958BDB9C03E87" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_F76C2DFA35EF7DF49B8558BDB9C00352" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/NetLossPerCommonShareDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_112B44CA7C5C23CBA6755DD261380DFE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLossAbstract" xlink:label="loc_us-gaap_NetIncomeLossAbstract_36B50335E28E57984D8E5DD261399B0F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_112B44CA7C5C23CBA6755DD261380DFE" xlink:to="loc_us-gaap_NetIncomeLossAbstract_36B50335E28E57984D8E5DD261399B0F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_ACFAE6A06D9D2172951A5DD2613981EF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_36B50335E28E57984D8E5DD261399B0F" xlink:to="loc_us-gaap_NetIncomeLoss_ACFAE6A06D9D2172951A5DD2613981EF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_CABCF9883BD8097814AA5DD26139F8F5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_36B50335E28E57984D8E5DD261399B0F" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_CABCF9883BD8097814AA5DD26139F8F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_0D45DFA34977B6CE200A5DD26139BDA1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_36B50335E28E57984D8E5DD261399B0F" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_0D45DFA34977B6CE200A5DD26139BDA1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_8DCD27B0910CF9EF7FCF5DD26139ECC9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_112B44CA7C5C23CBA6755DD261380DFE" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_8DCD27B0910CF9EF7FCF5DD26139ECC9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xlink:label="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_76E06365A2EE103161FF5DD2613A7B85" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_8DCD27B0910CF9EF7FCF5DD26139ECC9" xlink:to="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_76E06365A2EE103161FF5DD2613A7B85" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_97FD76642CE9B18BB40B5DD2613A348C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_8DCD27B0910CF9EF7FCF5DD26139ECC9" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_97FD76642CE9B18BB40B5DD2613A348C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_7CD99EC277452D1830565DD2613AA9BC" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_112B44CA7C5C23CBA6755DD261380DFE" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_7CD99EC277452D1830565DD2613AA9BC" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/NetLossPerCommonShareTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_DD70BFF037780B51982F58BDB9327EAA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_96B094B08E8FC7C9CA5658BDB93316BE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_DD70BFF037780B51982F58BDB9327EAA" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_96B094B08E8FC7C9CA5658BDB93316BE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/Organization" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4A87CFF4C4705492539458BDB8912FBC" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NatureOfOperations" xlink:label="loc_us-gaap_NatureOfOperations_CDCFF2DC884C182960AA58BDB8914D17" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4A87CFF4C4705492539458BDB8912FBC" xlink:to="loc_us-gaap_NatureOfOperations_CDCFF2DC884C182960AA58BDB8914D17" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/OrganizationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_225AAA98EE55714076C6EE6F287C4B9C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_A690A563869816AE9136EE6F287C6CCC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_225AAA98EE55714076C6EE6F287C4B9C" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_A690A563869816AE9136EE6F287C6CCC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_20DFB7D3D66F09E0652DEE6F287C5714" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_A690A563869816AE9136EE6F287C6CCC" xlink:to="loc_us-gaap_StatementScenarioAxis_20DFB7D3D66F09E0652DEE6F287C5714" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_D3CAD04925E9189DAB32EE6F287C2B16" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_20DFB7D3D66F09E0652DEE6F287C5714" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_D3CAD04925E9189DAB32EE6F287C2B16" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_496298B635471EBD9253EE6F287DEEEA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_A690A563869816AE9136EE6F287C6CCC" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_496298B635471EBD9253EE6F287DEEEA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_FF247C3DFE614EDDBCC6EE6F287D8390" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_496298B635471EBD9253EE6F287DEEEA" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_FF247C3DFE614EDDBCC6EE6F287D8390" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_SiliconValleyBankAndMidCapFinancialServicesMember" xlink:label="loc_astm_SiliconValleyBankAndMidCapFinancialServicesMember_26985A9095F6384968C8EE6F287D3DC3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_FF247C3DFE614EDDBCC6EE6F287D8390" xlink:to="loc_astm_SiliconValleyBankAndMidCapFinancialServicesMember_26985A9095F6384968C8EE6F287D3DC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_5A0A5A78B48D7B2FE540EE6F287E6BD4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_A690A563869816AE9136EE6F287C6CCC" xlink:to="loc_us-gaap_DebtInstrumentAxis_5A0A5A78B48D7B2FE540EE6F287E6BD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7D7DCD4E47F8A74AC646EE6F287E3650" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_5A0A5A78B48D7B2FE540EE6F287E6BD4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7D7DCD4E47F8A74AC646EE6F287E3650" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_DebtFinancingAgreementMember" xlink:label="loc_astm_DebtFinancingAgreementMember_C27FC698DB91C3F448F9EE6F287E1CB8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7D7DCD4E47F8A74AC646EE6F287E3650" xlink:to="loc_astm_DebtFinancingAgreementMember_C27FC698DB91C3F448F9EE6F287E1CB8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_3E2A19403E0D5802A9EBEE6F287F6F19" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_A690A563869816AE9136EE6F287C6CCC" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_3E2A19403E0D5802A9EBEE6F287F6F19" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_CFDE5FE7CC3F9EC5D37CEE6F287F6FA9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3E2A19403E0D5802A9EBEE6F287F6F19" xlink:to="loc_us-gaap_NumberOfReportableSegments_CFDE5FE7CC3F9EC5D37CEE6F287F6FA9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_695F05265DD47126621BEE6F287F1DBC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3E2A19403E0D5802A9EBEE6F287F6F19" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_695F05265DD47126621BEE6F287F1DBC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_5F5C915C082E68998D8FEE6F287FF7BA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3E2A19403E0D5802A9EBEE6F287F6F19" xlink:to="loc_us-gaap_NetIncomeLoss_5F5C915C082E68998D8FEE6F287FF7BA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Cash" xlink:label="loc_us-gaap_Cash_7153AE729AC8F71910A9EE6F287FEF4D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3E2A19403E0D5802A9EBEE6F287F6F19" xlink:to="loc_us-gaap_Cash_7153AE729AC8F71910A9EE6F287FEF4D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_E5C622803D12335EF6B2EE6F2880891D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3E2A19403E0D5802A9EBEE6F287F6F19" xlink:to="loc_us-gaap_ShortTermInvestments_E5C622803D12335EF6B2EE6F2880891D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/PreferredStock" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_EE17B7DA9024C6A8F7ADEDA9B7225414" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockTextBlock" xlink:label="loc_us-gaap_PreferredStockTextBlock_1CAA0E2E9A0145803820EDA9B7227AC3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_EE17B7DA9024C6A8F7ADEDA9B7225414" xlink:to="loc_us-gaap_PreferredStockTextBlock_1CAA0E2E9A0145803820EDA9B7227AC3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/PreferredStockSeriesBConvertiblePreferredStockDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_8AE5FAD5290173785EA1EDA9B71122C6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_D611D8DE53C136908027EDA9B711B66E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_8AE5FAD5290173785EA1EDA9B71122C6" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_D611D8DE53C136908027EDA9B711B66E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_CC94F14AA3A515A17DAFEDA9B711DD02" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D611D8DE53C136908027EDA9B711B66E" xlink:to="loc_us-gaap_StatementClassOfStockAxis_CC94F14AA3A515A17DAFEDA9B711DD02" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_7FB406F80CAF2495D565EDA9B7126031" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_CC94F14AA3A515A17DAFEDA9B711DD02" xlink:to="loc_us-gaap_ClassOfStockDomain_7FB406F80CAF2495D565EDA9B7126031" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_A490F86037FB38504EE3EDA9B7125DCB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_7FB406F80CAF2495D565EDA9B7126031" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_A490F86037FB38504EE3EDA9B7125DCB" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_SeriesB1PreferredStockMember" xlink:label="loc_astm_SeriesB1PreferredStockMember_9E9447627987D839F502EDA9B712C165" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SeriesBPreferredStockMember_A490F86037FB38504EE3EDA9B7125DCB" xlink:to="loc_astm_SeriesB1PreferredStockMember_9E9447627987D839F502EDA9B712C165" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_PreferredClassAAndClassBMember" xlink:label="loc_astm_PreferredClassAAndClassBMember_68FC789DB4420ADE7DEFEDA9B712079C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SeriesBPreferredStockMember_A490F86037FB38504EE3EDA9B7125DCB" xlink:to="loc_astm_PreferredClassAAndClassBMember_68FC789DB4420ADE7DEFEDA9B712079C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_E80831E664674F575BBFEDA9B71251F7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SeriesBPreferredStockMember_A490F86037FB38504EE3EDA9B7125DCB" xlink:to="loc_us-gaap_CommonClassAMember_E80831E664674F575BBFEDA9B71251F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_D611D8DE53C136908027EDA9B711B66E" xlink:to="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_BB59FD334BD32A3FCA78EDA9B71350A4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_BB59FD334BD32A3FCA78EDA9B71350A4" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_StockIssuedDuringPeriodOfferingPricePerShare" xlink:label="loc_astm_StockIssuedDuringPeriodOfferingPricePerShare_1EB48F9CABB6C05DC6B0EDA9B71379AF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:to="loc_astm_StockIssuedDuringPeriodOfferingPricePerShare_1EB48F9CABB6C05DC6B0EDA9B71379AF" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_PreferredStockPeriodOfClosingOfOfferingAfterWhichSharesAreConvertible" xlink:label="loc_astm_PreferredStockPeriodOfClosingOfOfferingAfterWhichSharesAreConvertible_1FACFE731440B20CDDECEDA9B7133230" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:to="loc_astm_PreferredStockPeriodOfClosingOfOfferingAfterWhichSharesAreConvertible_1FACFE731440B20CDDECEDA9B7133230" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_PreferredStockConversionPricePerShare" xlink:label="loc_astm_PreferredStockConversionPricePerShare_1382AAEC9D30FD8A1C57EDA9B71363D0" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:to="loc_astm_PreferredStockConversionPricePerShare_1382AAEC9D30FD8A1C57EDA9B71363D0" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ConvertiblePreferredStockConversionRatioShares" xlink:label="loc_astm_ConvertiblePreferredStockConversionRatioShares_D50C4542DE9AFB88C292EDA9B71412F5" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:to="loc_astm_ConvertiblePreferredStockConversionRatioShares_D50C4542DE9AFB88C292EDA9B71412F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConversionOfStockSharesConverted1" xlink:label="loc_us-gaap_ConversionOfStockSharesConverted1_56F7DEAE1E1D6F1F2718EDA9B714F251" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:to="loc_us-gaap_ConversionOfStockSharesConverted1_56F7DEAE1E1D6F1F2718EDA9B714F251" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_AccumulatedUndeclaredDividendsShares" xlink:label="loc_astm_AccumulatedUndeclaredDividendsShares_49296FBCA41727F5423FEDA9B7143C00" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:to="loc_astm_AccumulatedUndeclaredDividendsShares_49296FBCA41727F5423FEDA9B7143C00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConversionOfStockSharesIssued1" xlink:label="loc_us-gaap_ConversionOfStockSharesIssued1_B3AFE8E82BE08E2A4584EDA9B71401F2" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_0B4CB96B4B90BB78FEB5EDA9B71373A7" xlink:to="loc_us-gaap_ConversionOfStockSharesIssued1_B3AFE8E82BE08E2A4584EDA9B71401F2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/RecentAccountingPronouncements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_CEEC3B737DCD20CD5F0D58BDBA056DCE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_E75CCB92D94A292060DB58BDBA059C62" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_CEEC3B737DCD20CD5F0D58BDBA056DCE" xlink:to="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_E75CCB92D94A292060DB58BDBA059C62" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/RecentAccountingPronouncementsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract" xlink:label="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_40E273B36EAAAA15B0C958BDBA40F87E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_F54801D971B1EC1687E258BDBA407284" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesAbstract_40E273B36EAAAA15B0C958BDBA40F87E" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_F54801D971B1EC1687E258BDBA407284" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/Revenue" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RisksAndUncertaintiesAbstract" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_ECE4F56920A312C32B17EE2A08567128" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskDisclosureTextBlock" xlink:label="loc_us-gaap_ConcentrationRiskDisclosureTextBlock_171243F6C57691832351EE2A0856D365" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_ECE4F56920A312C32B17EE2A08567128" xlink:to="loc_us-gaap_ConcentrationRiskDisclosureTextBlock_171243F6C57691832351EE2A0856D365" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/RevenueDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RisksAndUncertaintiesAbstract" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_378BFF32655A70C8C15810CBE1CE056C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTable" xlink:label="loc_us-gaap_ConcentrationRiskTable_1845F81F59EAB822523B10CBE1CFDB28" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_378BFF32655A70C8C15810CBE1CE056C" xlink:to="loc_us-gaap_ConcentrationRiskTable_1845F81F59EAB822523B10CBE1CFDB28" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_B323F15A5065D1564C8210EC2F84018F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_1845F81F59EAB822523B10CBE1CFDB28" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_B323F15A5065D1564C8210EC2F84018F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_9144EA35C531AE659C5810EC2F85AF24" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_B323F15A5065D1564C8210EC2F84018F" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_9144EA35C531AE659C5810EC2F85AF24" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsIssuedDecember212017Member" xlink:label="loc_astm_WarrantsIssuedDecember212017Member_C96BE377EE104DB1D31A10EC2F9A9ACC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_9144EA35C531AE659C5810EC2F85AF24" xlink:to="loc_astm_WarrantsIssuedDecember212017Member_C96BE377EE104DB1D31A10EC2F9A9ACC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_5340A8B5A131AB98C59710EBA2D3ACB8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_1845F81F59EAB822523B10CBE1CFDB28" xlink:to="loc_srt_CounterpartyNameAxis_5340A8B5A131AB98C59710EBA2D3ACB8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4C6E994ABCA5191EF8D210EBA2D6DDB9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_5340A8B5A131AB98C59710EBA2D3ACB8" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4C6E994ABCA5191EF8D210EBA2D6DDB9" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_InnovativeCellularTherapeuticsMember" xlink:label="loc_astm_InnovativeCellularTherapeuticsMember_2AEB39802D66D21DAF2510EBA373B066" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_4C6E994ABCA5191EF8D210EBA2D6DDB9" xlink:to="loc_astm_InnovativeCellularTherapeuticsMember_2AEB39802D66D21DAF2510EBA373B066" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3C861611BA2A7EFAB36F10E7BD0FDD92" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_1845F81F59EAB822523B10CBE1CFDB28" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3C861611BA2A7EFAB36F10E7BD0FDD92" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingencyNatureDomain" xlink:label="loc_us-gaap_LossContingencyNatureDomain_A2084A25A73AF58E6CC5110C0D921D36" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3C861611BA2A7EFAB36F10E7BD0FDD92" xlink:to="loc_us-gaap_LossContingencyNatureDomain_A2084A25A73AF58E6CC5110C0D921D36" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_AgreementWithOrsiniPotentialPaymentIfMinimumPaymentObligationsNotAchievedMember" xlink:label="loc_astm_AgreementWithOrsiniPotentialPaymentIfMinimumPaymentObligationsNotAchievedMember_D3EACF11D5BB60F921CD10E7BD38E274" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyNatureDomain_A2084A25A73AF58E6CC5110C0D921D36" xlink:to="loc_astm_AgreementWithOrsiniPotentialPaymentIfMinimumPaymentObligationsNotAchievedMember_D3EACF11D5BB60F921CD10E7BD38E274" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis" xlink:label="loc_srt_MajorCustomersAxis_6C47A884691A2A0F1E8E10CBE1CF008E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_1845F81F59EAB822523B10CBE1CFDB28" xlink:to="loc_srt_MajorCustomersAxis_6C47A884691A2A0F1E8E10CBE1CF008E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_D26028A69083D238583110CBE1CF5B32" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_MajorCustomersAxis_6C47A884691A2A0F1E8E10CBE1CF008E" xlink:to="loc_srt_NameOfMajorCustomerDomain_D26028A69083D238583110CBE1CF5B32" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_CarticelAndMACIDistributorMember" xlink:label="loc_astm_CarticelAndMACIDistributorMember_3F43DE37799567B696F110CBE1D0F55D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_D26028A69083D238583110CBE1CF5B32" xlink:to="loc_astm_CarticelAndMACIDistributorMember_3F43DE37799567B696F110CBE1D0F55D" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_EpicelMember" xlink:label="loc_astm_EpicelMember_5F180A78700AE488BFAF10CBE1D07EB7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_D26028A69083D238583110CBE1CF5B32" xlink:to="loc_astm_EpicelMember_5F180A78700AE488BFAF10CBE1D07EB7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_105BC9F933737E093BD110CBE1D04FAA" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_1845F81F59EAB822523B10CBE1CFDB28" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_105BC9F933737E093BD110CBE1D04FAA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_C2B6C89C8CA591B6C4C410CBE1D08B19" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_105BC9F933737E093BD110CBE1D04FAA" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_C2B6C89C8CA591B6C4C410CBE1D08B19" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_E8E8CA89EDD68F0CB8CA10CBE1D18E31" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_C2B6C89C8CA591B6C4C410CBE1D08B19" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_E8E8CA89EDD68F0CB8CA10CBE1D18E31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_E7C6FA7A03D89277983A10CBE1D129B1" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_1845F81F59EAB822523B10CBE1CFDB28" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_E7C6FA7A03D89277983A10CBE1D129B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_A7A77E11B419444A77E810CBE1D1A1B5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_E7C6FA7A03D89277983A10CBE1D129B1" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_A7A77E11B419444A77E810CBE1D1A1B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesRevenueNetMember" xlink:label="loc_us-gaap_SalesRevenueNetMember_E3F1CEDABE3B957E8FCF10CBE1D2A97C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_A7A77E11B419444A77E810CBE1D1A1B5" xlink:to="loc_us-gaap_SalesRevenueNetMember_E3F1CEDABE3B957E8FCF10CBE1D2A97C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_8D4E0CF3ED44E751FED510CBE1D29CDE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_A7A77E11B419444A77E810CBE1D1A1B5" xlink:to="loc_us-gaap_AccountsReceivableMember_8D4E0CF3ED44E751FED510CBE1D29CDE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskLineItems" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_F429282CBB16F77794D510CBE1D2FA19" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_1845F81F59EAB822523B10CBE1CFDB28" xlink:to="loc_us-gaap_ConcentrationRiskLineItems_F429282CBB16F77794D510CBE1D2FA19" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ProceedsFromLicenseFeesReceivedAndIssuanceOfWarrants" xlink:label="loc_astm_ProceedsFromLicenseFeesReceivedAndIssuanceOfWarrants_5D3CAAD4843707D642A910EBA1FDB94E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_F429282CBB16F77794D510CBE1D2FA19" xlink:to="loc_astm_ProceedsFromLicenseFeesReceivedAndIssuanceOfWarrants_5D3CAAD4843707D642A910EBA1FDB94E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_94AB2BA9FAB5858BE60C10EC2F6FF226" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_F429282CBB16F77794D510CBE1D2FA19" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_94AB2BA9FAB5858BE60C10EC2F6FF226" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherCommitment" xlink:label="loc_us-gaap_OtherCommitment_CA0D9B2203EBEC45BB7C10E7BCA5A2F0" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_F429282CBB16F77794D510CBE1D2FA19" xlink:to="loc_us-gaap_OtherCommitment_CA0D9B2203EBEC45BB7C10E7BCA5A2F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_DDC84B144CA1FD4DE88A10CBE1D2270B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_F429282CBB16F77794D510CBE1D2FA19" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_DDC84B144CA1FD4DE88A10CBE1D2270B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/RevenueDisaggregationOfRevenueDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RisksAndUncertaintiesAbstract" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_0A8CB28A5B83ABDD0F2316A7E24C60BC" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_32F2DF410761FC26C1EA16A7E24D93F5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_0A8CB28A5B83ABDD0F2316A7E24C60BC" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_32F2DF410761FC26C1EA16A7E24D93F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_7D4F9DCE74953F0DC36916A7E24D4C20" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_32F2DF410761FC26C1EA16A7E24D93F5" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_7D4F9DCE74953F0DC36916A7E24D4C20" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_00494BAC27B7FBB4D36616A7E24D352D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_7D4F9DCE74953F0DC36916A7E24D4C20" xlink:to="loc_us-gaap_TypeOfAdoptionMember_00494BAC27B7FBB4D36616A7E24D352D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_91D45717209151AB2BF616A7E24D0AB0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_00494BAC27B7FBB4D36616A7E24D352D" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_91D45717209151AB2BF616A7E24D0AB0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_B53AD80052A1B6C5080216A7E24EA675" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_32F2DF410761FC26C1EA16A7E24D93F5" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_B53AD80052A1B6C5080216A7E24EA675" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_4568DEFF1336656873CF16A7E24E1E45" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_B53AD80052A1B6C5080216A7E24EA675" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_4568DEFF1336656873CF16A7E24E1E45" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:label="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_F4B016B162738A91158C16A7E24E7934" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_4568DEFF1336656873CF16A7E24E1E45" xlink:to="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_F4B016B162738A91158C16A7E24E7934" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerBasisOfPricingAxis" xlink:label="loc_us-gaap_ContractWithCustomerBasisOfPricingAxis_923710D6B27D3752083916A7E24E1170" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_32F2DF410761FC26C1EA16A7E24D93F5" xlink:to="loc_us-gaap_ContractWithCustomerBasisOfPricingAxis_923710D6B27D3752083916A7E24E1170" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerBasisOfPricingDomain" xlink:label="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_3C020EDA9F02F377198516A7E24F6225" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerBasisOfPricingAxis_923710D6B27D3752083916A7E24E1170" xlink:to="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_3C020EDA9F02F377198516A7E24F6225" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FixedPriceContractMember" xlink:label="loc_us-gaap_FixedPriceContractMember_0F37C287CDBB0286CF1E16A7E24F4591" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_3C020EDA9F02F377198516A7E24F6225" xlink:to="loc_us-gaap_FixedPriceContractMember_0F37C287CDBB0286CF1E16A7E24F4591" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TimeAndMaterialsContractMember" xlink:label="loc_us-gaap_TimeAndMaterialsContractMember_C8AB3026BF35E08DA90C16A7E24F2787" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_3C020EDA9F02F377198516A7E24F6225" xlink:to="loc_us-gaap_TimeAndMaterialsContractMember_C8AB3026BF35E08DA90C16A7E24F2787" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerSalesChannelAxis" xlink:label="loc_us-gaap_ContractWithCustomerSalesChannelAxis_981B96CB9C023DC96A4D16A7E24FEC1E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_32F2DF410761FC26C1EA16A7E24D93F5" xlink:to="loc_us-gaap_ContractWithCustomerSalesChannelAxis_981B96CB9C023DC96A4D16A7E24FEC1E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerSalesChannelDomain" xlink:label="loc_us-gaap_ContractWithCustomerSalesChannelDomain_F878CBD50E15458A3E7516A7E24F2068" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelAxis_981B96CB9C023DC96A4D16A7E24FEC1E" xlink:to="loc_us-gaap_ContractWithCustomerSalesChannelDomain_F878CBD50E15458A3E7516A7E24F2068" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesChannelThroughIntermediaryMember" xlink:label="loc_us-gaap_SalesChannelThroughIntermediaryMember_50A2F4E069020B21D15516A7E25055F1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_F878CBD50E15458A3E7516A7E24F2068" xlink:to="loc_us-gaap_SalesChannelThroughIntermediaryMember_50A2F4E069020B21D15516A7E25055F1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesChannelDirectlyToConsumerMember" xlink:label="loc_us-gaap_SalesChannelDirectlyToConsumerMember_CEC0560359CD5F14848016A7E250A2F5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_F878CBD50E15458A3E7516A7E24F2068" xlink:to="loc_us-gaap_SalesChannelDirectlyToConsumerMember_CEC0560359CD5F14848016A7E250A2F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueRightsGrantedMember" xlink:label="loc_us-gaap_RevenueRightsGrantedMember_6598A31C3C9098E5E3D216A7E2507884" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_F878CBD50E15458A3E7516A7E24F2068" xlink:to="loc_us-gaap_RevenueRightsGrantedMember_6598A31C3C9098E5E3D216A7E2507884" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_E385D409E108B739450116A7E2508F78" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_32F2DF410761FC26C1EA16A7E24D93F5" xlink:to="loc_srt_ProductOrServiceAxis_E385D409E108B739450116A7E2508F78" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_928F5790AC9509F0928616A7E2503D99" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_E385D409E108B739450116A7E2508F78" xlink:to="loc_srt_ProductsAndServicesDomain_928F5790AC9509F0928616A7E2503D99" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ImplantsMember" xlink:label="loc_astm_ImplantsMember_155B44D00FEBA1A1DB4E16A7E251FA53" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_928F5790AC9509F0928616A7E2503D99" xlink:to="loc_astm_ImplantsMember_155B44D00FEBA1A1DB4E16A7E251FA53" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_BiopsyKitsMember" xlink:label="loc_astm_BiopsyKitsMember_44782B239D19AFA6116016A7E2517471" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_928F5790AC9509F0928616A7E2503D99" xlink:to="loc_astm_BiopsyKitsMember_44782B239D19AFA6116016A7E2517471" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_EpicelMember" xlink:label="loc_astm_EpicelMember_E848F0248F3A00EA875A16A7E251BD51" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_928F5790AC9509F0928616A7E2503D99" xlink:to="loc_astm_EpicelMember_E848F0248F3A00EA875A16A7E251BD51" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_843C27DF76C09DA764D216A7E25133EE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_32F2DF410761FC26C1EA16A7E24D93F5" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_843C27DF76C09DA764D216A7E25133EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_40CD7095AFDE2DEE714C16A7E2529F4A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_843C27DF76C09DA764D216A7E25133EE" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_40CD7095AFDE2DEE714C16A7E2529F4A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_732BA6D0DA97D458A83B16B07043F632" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_843C27DF76C09DA764D216A7E25133EE" xlink:to="loc_us-gaap_Revenues_732BA6D0DA97D458A83B16B07043F632" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/RevenueReservesRollForwardDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RisksAndUncertaintiesAbstract" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_078439F54A3826E5DB1725FA73F657EB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AirlineProductsAndServicesTable" xlink:label="loc_us-gaap_AirlineProductsAndServicesTable_7A3A33AACBD6CE6B1E7A25FA73F6E7DA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_078439F54A3826E5DB1725FA73F657EB" xlink:to="loc_us-gaap_AirlineProductsAndServicesTable_7A3A33AACBD6CE6B1E7A25FA73F6E7DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_B3325C0ABE336C5FCC6825FA73F69C8F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AirlineProductsAndServicesTable_7A3A33AACBD6CE6B1E7A25FA73F6E7DA" xlink:to="loc_srt_ProductOrServiceAxis_B3325C0ABE336C5FCC6825FA73F69C8F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_243CE6B9DD3C7592052A25FA73F63001" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_B3325C0ABE336C5FCC6825FA73F69C8F" xlink:to="loc_srt_ProductsAndServicesDomain_243CE6B9DD3C7592052A25FA73F63001" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_CarticelAndMACIDistributorMember" xlink:label="loc_astm_CarticelAndMACIDistributorMember_1E58362320B48692214225FA73F78080" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_243CE6B9DD3C7592052A25FA73F63001" xlink:to="loc_astm_CarticelAndMACIDistributorMember_1E58362320B48692214225FA73F78080" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProductInformationLineItems" xlink:label="loc_us-gaap_ProductInformationLineItems_30362234AA79B167AE2E25FA73F750EE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AirlineProductsAndServicesTable_7A3A33AACBD6CE6B1E7A25FA73F6E7DA" xlink:to="loc_us-gaap_ProductInformationLineItems_30362234AA79B167AE2E25FA73F750EE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/RevenueTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RisksAndUncertaintiesAbstract" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_0B0F58440622A586082326044F826CA1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_0598D9EC62AA5B44BD8D26044F82208F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_0B0F58440622A586082326044F826CA1" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_0598D9EC62AA5B44BD8D26044F82208F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" xlink:label="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_81AA45B35036D5E24B4626044F8372D1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_0B0F58440622A586082326044F826CA1" xlink:to="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_81AA45B35036D5E24B4626044F8372D1" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponents" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_682A9550863685999C0258BDB88FFC28" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_A43B92EECC5D1DBB79C858BDB88F2259" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_682A9550863685999C0258BDB88FFC28" xlink:to="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_A43B92EECC5D1DBB79C858BDB88F2259" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_2ACB7BDA50F6A7BC1DDC58BDB92073B7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_AAEF043D261BD75F17D258BDB920B14F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_2ACB7BDA50F6A7BC1DDC58BDB92073B7" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_AAEF043D261BD75F17D258BDB920B14F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedBonusesCurrent" xlink:label="loc_us-gaap_AccruedBonusesCurrent_D83BFBE581AF850FD98D58BDB920843A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_AAEF043D261BD75F17D258BDB920B14F" xlink:to="loc_us-gaap_AccruedBonusesCurrent_D83BFBE581AF850FD98D58BDB920843A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_DF33B51CCEF856DB4A2A58BDB9215CA1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_AAEF043D261BD75F17D258BDB920B14F" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_DF33B51CCEF856DB4A2A58BDB9215CA1" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_AccruedExpensesOtherCurrent" xlink:label="loc_astm_AccruedExpensesOtherCurrent_862690FF871E6DEB78AA58BDB921031E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_AAEF043D261BD75F17D258BDB920B14F" xlink:to="loc_astm_AccruedExpensesOtherCurrent_862690FF871E6DEB78AA58BDB921031E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_485A69CFB98EAEF5406A58BDB921C749" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" priority="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_AAEF043D261BD75F17D258BDB920B14F" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_485A69CFB98EAEF5406A58BDB921C749" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_A80F8CFF25AEFC4F70E958BDB9B699B3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNetAbstract" xlink:label="loc_us-gaap_InventoryNetAbstract_79883A07E0B69E537C0A58BDB9B6217D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_A80F8CFF25AEFC4F70E958BDB9B699B3" xlink:to="loc_us-gaap_InventoryNetAbstract_79883A07E0B69E537C0A58BDB9B6217D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryRawMaterials" xlink:label="loc_us-gaap_InventoryRawMaterials_D3DA3B8A064F4316698158BDB9B745C6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_79883A07E0B69E537C0A58BDB9B6217D" xlink:to="loc_us-gaap_InventoryRawMaterials_D3DA3B8A064F4316698158BDB9B745C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryWorkInProcess" xlink:label="loc_us-gaap_InventoryWorkInProcess_37707E139080DC31870258BDB9B72E83" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_79883A07E0B69E537C0A58BDB9B6217D" xlink:to="loc_us-gaap_InventoryWorkInProcess_37707E139080DC31870258BDB9B72E83" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryFinishedGoods" xlink:label="loc_us-gaap_InventoryFinishedGoods_74FDC5D390F72BF6A17958BDB9B7B540" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_79883A07E0B69E537C0A58BDB9B6217D" xlink:to="loc_us-gaap_InventoryFinishedGoods_74FDC5D390F72BF6A17958BDB9B7B540" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_A284E1309D689F5B109058BDB9B7C8FD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_79883A07E0B69E537C0A58BDB9B6217D" xlink:to="loc_us-gaap_InventoryNet_A284E1309D689F5B109058BDB9B7C8FD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsPropertyAndEquipmentDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_888E30B34461EFCCD0CF58BDBA205C8F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_BE834C954C70748FD65558BDBA20E0AC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_888E30B34461EFCCD0CF58BDBA205C8F" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_BE834C954C70748FD65558BDBA20E0AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2613D9905C643706788958BDBA2031CE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_BE834C954C70748FD65558BDBA20E0AC" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2613D9905C643706788958BDBA2031CE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_998CDB7583A8A147E68F58BDBA216CB6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2613D9905C643706788958BDBA2031CE" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_998CDB7583A8A147E68F58BDBA216CB6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MachineryAndEquipmentMember" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_85F6966D724663FD3E8858BDBA21933B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_998CDB7583A8A147E68F58BDBA216CB6" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_85F6966D724663FD3E8858BDBA21933B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_EEB8DA9135FE38835D5D58BDBA215779" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_998CDB7583A8A147E68F58BDBA216CB6" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_EEB8DA9135FE38835D5D58BDBA215779" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ComputerEquipmentAndComputerSoftwareIntangibleAssetMember" xlink:label="loc_astm_ComputerEquipmentAndComputerSoftwareIntangibleAssetMember_96A6605A1F3D56919F2258BDBA210818" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_998CDB7583A8A147E68F58BDBA216CB6" xlink:to="loc_astm_ComputerEquipmentAndComputerSoftwareIntangibleAssetMember_96A6605A1F3D56919F2258BDBA210818" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_4FDE103464FF78DBD4E558BDBA22934D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_998CDB7583A8A147E68F58BDBA216CB6" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_4FDE103464FF78DBD4E558BDBA22934D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConstructionInProgressMember" xlink:label="loc_us-gaap_ConstructionInProgressMember_C9A180C84346E3453B8D58BDBA2279B1" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_998CDB7583A8A147E68F58BDBA216CB6" xlink:to="loc_us-gaap_ConstructionInProgressMember_C9A180C84346E3453B8D58BDBA2279B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_B036350F677C5BD6999558BDBA22DBDB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_BE834C954C70748FD65558BDBA20E0AC" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_B036350F677C5BD6999558BDBA22DBDB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_94390F1E4EB0677A91F758BDBA222A6F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_B036350F677C5BD6999558BDBA22DBDB" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_94390F1E4EB0677A91F758BDBA222A6F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_A295AB22473A1BD1B66658BDBA2257B7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_B036350F677C5BD6999558BDBA22DBDB" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_A295AB22473A1BD1B66658BDBA2257B7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_9660516CDDDE002CFE4458BDBA239041" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_B036350F677C5BD6999558BDBA22DBDB" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_9660516CDDDE002CFE4458BDBA239041" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaap_Depreciation_39ED1ABD62DBBD388E5B58BDBA237939" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_B036350F677C5BD6999558BDBA22DBDB" xlink:to="loc_us-gaap_Depreciation_39ED1ABD62DBBD388E5B58BDBA237939" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_05802D545BEFBA822E7358BDB93E199C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_CA23961B0BD25E69C98158BDB93FA7CA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_05802D545BEFBA822E7358BDB93E199C" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_CA23961B0BD25E69C98158BDB93FA7CA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_2648345351AFB4A90A8958BDB93FDB88" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_05802D545BEFBA822E7358BDB93E199C" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_2648345351AFB4A90A8958BDB93FDB88" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_BA38E3CC3E0B8323886958BDB93F4275" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_05802D545BEFBA822E7358BDB93E199C" xlink:to="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_BA38E3CC3E0B8323886958BDB93F4275" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/ShareholdersEquity" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityNoteAbstract" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_9C20DD119A0E048975ED58BDB96FE26A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_20501F4440632CC969D858BDB96FEDCD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_9C20DD119A0E048975ED58BDB96FE26A" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_20501F4440632CC969D858BDB96FEDCD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/ShareholdersEquityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityNoteAbstract" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_21C498F3052DCD13F884EE6F27EFAA6E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_4C7F54FF28AAC0D5CDA2EE6F27EF1E63" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_21C498F3052DCD13F884EE6F27EFAA6E" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_4C7F54FF28AAC0D5CDA2EE6F27EF1E63" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_E428953D9E36D368F22BEE6F27EF80C9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_4C7F54FF28AAC0D5CDA2EE6F27EF1E63" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_E428953D9E36D368F22BEE6F27EF80C9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_1C60DC45EB579B9123F7EE6F27F0BAEC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_E428953D9E36D368F22BEE6F27EF80C9" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_1C60DC45EB579B9123F7EE6F27F0BAEC" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_PublicStockOfferingMember" xlink:label="loc_astm_PublicStockOfferingMember_4800F26D7632874989CFEE6F27F03371" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_1C60DC45EB579B9123F7EE6F27F0BAEC" xlink:to="loc_astm_PublicStockOfferingMember_4800F26D7632874989CFEE6F27F03371" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_704EC2BAA4AA6A286C92EE6F27F03008" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_4C7F54FF28AAC0D5CDA2EE6F27EF1E63" xlink:to="loc_srt_CounterpartyNameAxis_704EC2BAA4AA6A286C92EE6F27F03008" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7A7C210C9F3D34D0825FEE6F27F0F572" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_704EC2BAA4AA6A286C92EE6F27F03008" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7A7C210C9F3D34D0825FEE6F27F0F572" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_CowenandCompanyLLCMember" xlink:label="loc_astm_CowenandCompanyLLCMember_47EDC0CF530E03C75396EE6F27F16B41" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7A7C210C9F3D34D0825FEE6F27F0F572" xlink:to="loc_astm_CowenandCompanyLLCMember_47EDC0CF530E03C75396EE6F27F16B41" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_CC8FA53BEC281B947EE1EE6F27F1BF9D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_4C7F54FF28AAC0D5CDA2EE6F27EF1E63" xlink:to="loc_srt_RangeAxis_CC8FA53BEC281B947EE1EE6F27F1BF9D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_04AE6EADD80DAD4B1C37EE6F27F149B7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_CC8FA53BEC281B947EE1EE6F27F1BF9D" xlink:to="loc_srt_RangeMember_04AE6EADD80DAD4B1C37EE6F27F149B7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_E7DA71A0C1F152E6DE19EE6F27F1F3FA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_04AE6EADD80DAD4B1C37EE6F27F149B7" xlink:to="loc_srt_MaximumMember_E7DA71A0C1F152E6DE19EE6F27F1F3FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_2794C91B7FC963A5ABCFEE6F27F2145F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_4C7F54FF28AAC0D5CDA2EE6F27EF1E63" xlink:to="loc_us-gaap_StatementClassOfStockAxis_2794C91B7FC963A5ABCFEE6F27F2145F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_E98333238C0F8524CDBDEE6F27F2123E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_2794C91B7FC963A5ABCFEE6F27F2145F" xlink:to="loc_us-gaap_ClassOfStockDomain_E98333238C0F8524CDBDEE6F27F2123E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_CD6B876304A9CDF3A852EE6F27F25ADA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_E98333238C0F8524CDBDEE6F27F2123E" xlink:to="loc_us-gaap_CommonClassAMember_CD6B876304A9CDF3A852EE6F27F25ADA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_348248861AF791AC00EEEE6F27F2D141" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_4C7F54FF28AAC0D5CDA2EE6F27EF1E63" xlink:to="loc_us-gaap_ClassOfStockLineItems_348248861AF791AC00EEEE6F27F2D141" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_PercentageOfGrossProceedsPayableAsCommission" xlink:label="loc_astm_PercentageOfGrossProceedsPayableAsCommission_D311EAFB458014083264EE6F27F25D9D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_348248861AF791AC00EEEE6F27F2D141" xlink:to="loc_astm_PercentageOfGrossProceedsPayableAsCommission_D311EAFB458014083264EE6F27F25D9D" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_AttheMarketSalesAgreementSharesIssued" xlink:label="loc_astm_AttheMarketSalesAgreementSharesIssued_129AB894368053F4437EEE6F27F3FD95" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_348248861AF791AC00EEEE6F27F2D141" xlink:to="loc_astm_AttheMarketSalesAgreementSharesIssued_129AB894368053F4437EEE6F27F3FD95" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_AtTheMarketSalesAgreementProceedsFromIssuanceOfCommonStock" xlink:label="loc_astm_AtTheMarketSalesAgreementProceedsFromIssuanceOfCommonStock_3F9F38310936E53529F5EE6F27F38BE0" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_348248861AF791AC00EEEE6F27F2D141" xlink:to="loc_astm_AtTheMarketSalesAgreementProceedsFromIssuanceOfCommonStock_3F9F38310936E53529F5EE6F27F38BE0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_67775024441BE1353583EE6F27F3F591" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_348248861AF791AC00EEEE6F27F2D141" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_67775024441BE1353583EE6F27F3F591" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_4DC9ABB7BDBDD4C30FD9EE6F27F3C292" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_348248861AF791AC00EEEE6F27F2D141" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_4DC9ABB7BDBDD4C30FD9EE6F27F3C292" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_E2E98A2A99A57E3435F5EE6F27F4EAAE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_348248861AF791AC00EEEE6F27F2D141" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_E2E98A2A99A57E3435F5EE6F27F4EAAE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_1D616657067F56AB5761EE6F27F47519" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_348248861AF791AC00EEEE6F27F2D141" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_1D616657067F56AB5761EE6F27F47519" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/StockBasedCompensation" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_B33AE0CA36E8491D7F7658BDB94126D4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_F6D573BB76437D3A82F458BDB94102F1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_B33AE0CA36E8491D7F7658BDB94126D4" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_F6D573BB76437D3A82F458BDB94102F1" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/StockBasedCompensationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_F75B23110B90C88083F5EDA9B73A1175" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_DC3DD6FBF15C322C95A1EDA9B73B1A94" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_F75B23110B90C88083F5EDA9B73A1175" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_DC3DD6FBF15C322C95A1EDA9B73B1A94" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_DAF127D8A016C95E59AAEDA9B73B65E9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_DC3DD6FBF15C322C95A1EDA9B73B1A94" xlink:to="loc_us-gaap_PlanNameAxis_DAF127D8A016C95E59AAEDA9B73B65E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_F06D5E2F2FC781561485EDA9B73B2A32" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_DAF127D8A016C95E59AAEDA9B73B65E9" xlink:to="loc_us-gaap_PlanNameDomain_F06D5E2F2FC781561485EDA9B73B2A32" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_PriorPlansMember" xlink:label="loc_astm_PriorPlansMember_616B94D2DB31ADFEEDF3EDA9B73B9448" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_F06D5E2F2FC781561485EDA9B73B2A32" xlink:to="loc_astm_PriorPlansMember_616B94D2DB31ADFEEDF3EDA9B73B9448" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_OmnibusIncentivePlan2017Member" xlink:label="loc_astm_OmnibusIncentivePlan2017Member_0FCE04CD029BA41D720EEDA9B73CCFD5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_F06D5E2F2FC781561485EDA9B73B2A32" xlink:to="loc_astm_OmnibusIncentivePlan2017Member_0FCE04CD029BA41D720EEDA9B73CCFD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_408B10C8BCA876EE5D25EDA9B73CF4EC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_DC3DD6FBF15C322C95A1EDA9B73B1A94" xlink:to="loc_us-gaap_AwardTypeAxis_408B10C8BCA876EE5D25EDA9B73CF4EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2D0CCF48BF3646DC2BAEDA9B73C8A05" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_408B10C8BCA876EE5D25EDA9B73CF4EC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2D0CCF48BF3646DC2BAEDA9B73C8A05" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_7BBF149D184132B370D6EDA9B73C9366" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2D0CCF48BF3646DC2BAEDA9B73C8A05" xlink:to="loc_us-gaap_EmployeeStockOptionMember_7BBF149D184132B370D6EDA9B73C9366" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockMember" xlink:label="loc_us-gaap_EmployeeStockMember_834F170F1AF2082862F3EDA9B73DBE39" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_F2D0CCF48BF3646DC2BAEDA9B73C8A05" xlink:to="loc_us-gaap_EmployeeStockMember_834F170F1AF2082862F3EDA9B73DBE39" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualAxis" xlink:label="loc_us-gaap_TitleOfIndividualAxis_4F891025544594B0850EEDA9B73DB99F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_DC3DD6FBF15C322C95A1EDA9B73B1A94" xlink:to="loc_us-gaap_TitleOfIndividualAxis_4F891025544594B0850EEDA9B73DB99F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_9DA958A516880D5B10E3EDA9B73DE73B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TitleOfIndividualAxis_4F891025544594B0850EEDA9B73DB99F" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_9DA958A516880D5B10E3EDA9B73DE73B" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_NonEmployeeMember" xlink:label="loc_astm_NonEmployeeMember_13A25B8903311AC972D9EDA9B73D21D4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_9DA958A516880D5B10E3EDA9B73DE73B" xlink:to="loc_astm_NonEmployeeMember_13A25B8903311AC972D9EDA9B73D21D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_177B1D73A09DE8BD111AEDA9B73E3FD1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_DC3DD6FBF15C322C95A1EDA9B73B1A94" xlink:to="loc_srt_RangeAxis_177B1D73A09DE8BD111AEDA9B73E3FD1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_27F9CDB9DEE531D8C045EDA9B73E40B0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_177B1D73A09DE8BD111AEDA9B73E3FD1" xlink:to="loc_srt_RangeMember_27F9CDB9DEE531D8C045EDA9B73E40B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_A64F0BD1070BD7958B39EDA9B73E87C0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_27F9CDB9DEE531D8C045EDA9B73E40B0" xlink:to="loc_srt_MinimumMember_A64F0BD1070BD7958B39EDA9B73E87C0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_FF73BE846FDE7616BED9EDA9B73E5FC9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_27F9CDB9DEE531D8C045EDA9B73E40B0" xlink:to="loc_srt_MaximumMember_FF73BE846FDE7616BED9EDA9B73E5FC9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_DC3DD6FBF15C322C95A1EDA9B73B1A94" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_7FAECD6D281708893BD3EDA9B73E5D99" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_7FAECD6D281708893BD3EDA9B73E5D99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_D4A6A9BA054117F5A6CBEDA9B73EA338" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_D4A6A9BA054117F5A6CBEDA9B73EA338" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_C559B06DA827A603F9E1EDA9B73F38DD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_C559B06DA827A603F9E1EDA9B73F38DD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_E3871B8EA23C54B27D87EDA9B73F50C1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_E3871B8EA23C54B27D87EDA9B73F50C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_DE9BFA8D192F0D4F21FAEDA9B73F5E8B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_DE9BFA8D192F0D4F21FAEDA9B73F5E8B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_F48EC8071522494A3758EDA9B73F2012" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_F48EC8071522494A3758EDA9B73F2012" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_6FD3F71B94EE5DAF18BAEDA9B73FF2C7" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_6FD3F71B94EE5DAF18BAEDA9B73FF2C7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_B406583F3157551AED0FEDA9B73FD3C0" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_B406583F3157551AED0FEDA9B73FD3C0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_F54D3E9193D76ED4180BEDA9B73FA83D" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_F54D3E9193D76ED4180BEDA9B73FA83D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_D5E431AD92F245ED6CF8EDA9B740EC1F" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_D5E431AD92F245ED6CF8EDA9B740EC1F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_7D42F75540D05D4E448DEDA9B7400A9B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_D5E431AD92F245ED6CF8EDA9B740EC1F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_7D42F75540D05D4E448DEDA9B7400A9B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_9AA37831FD8585B1CFBEEDA9B74020DC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_D5E431AD92F245ED6CF8EDA9B740EC1F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_9AA37831FD8585B1CFBEEDA9B74020DC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_4E6D8BF12EA1D63883B8EDA9B74050A1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_D5E431AD92F245ED6CF8EDA9B740EC1F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_4E6D8BF12EA1D63883B8EDA9B74050A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_C7084A5FF901BE1B5C42EDA9B74062B5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_D5E431AD92F245ED6CF8EDA9B740EC1F" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_C7084A5FF901BE1B5C42EDA9B74062B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_447CB1008CB230A5E45BEDA9B7416AEB" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_447CB1008CB230A5E45BEDA9B7416AEB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_B70451A6A8F5E6BB46C8EDA9B7412AF1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_447CB1008CB230A5E45BEDA9B7416AEB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_B70451A6A8F5E6BB46C8EDA9B7412AF1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_089241ACCEE53C140BE6EDA9B741A6C2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_447CB1008CB230A5E45BEDA9B7416AEB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_089241ACCEE53C140BE6EDA9B741A6C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_BBDDBE33E55378E8011EEDA9B74174D7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_447CB1008CB230A5E45BEDA9B7416AEB" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_BBDDBE33E55378E8011EEDA9B74174D7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_8F4654901C0BEF2815F2EDA9B7417373" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_447CB1008CB230A5E45BEDA9B7416AEB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_8F4654901C0BEF2815F2EDA9B7417373" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_DF91DC869FC2E8DE9470EDA9B7415638" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_447CB1008CB230A5E45BEDA9B7416AEB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_DF91DC869FC2E8DE9470EDA9B7415638" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_0783B745242D87B59CC4EDA9B742C684" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_447CB1008CB230A5E45BEDA9B7416AEB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_0783B745242D87B59CC4EDA9B742C684" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_75712D32029C03E03506EDA9B74215B9" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_447CB1008CB230A5E45BEDA9B7416AEB" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_75712D32029C03E03506EDA9B74215B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_266024A67F79A63A5B58EDA9B74279A1" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_266024A67F79A63A5B58EDA9B74279A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_A272E6DA0B5931F6AA6FEDA9B742A432" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_266024A67F79A63A5B58EDA9B74279A1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_A272E6DA0B5931F6AA6FEDA9B742A432" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_3F2C2C730F565DB80941EDA9B7424723" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_266024A67F79A63A5B58EDA9B74279A1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_3F2C2C730F565DB80941EDA9B7424723" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_396F7D53924784052484EDA9B7431F4D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_266024A67F79A63A5B58EDA9B74279A1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_396F7D53924784052484EDA9B7431F4D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_EA736AAA4FDE62459994EDA9B7438DF9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_266024A67F79A63A5B58EDA9B74279A1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_EA736AAA4FDE62459994EDA9B7438DF9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_305BB4E73079A0F1AB67EDA9B743CCDB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_266024A67F79A63A5B58EDA9B74279A1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_305BB4E73079A0F1AB67EDA9B743CCDB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_B6F01A1297CB10E5BB94EDA9B7438045" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_266024A67F79A63A5B58EDA9B74279A1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_B6F01A1297CB10E5BB94EDA9B7438045" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_7BB77DCFF24994F58B1BEDA9B743B644" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_266024A67F79A63A5B58EDA9B74279A1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_7BB77DCFF24994F58B1BEDA9B743B644" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" xlink:label="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_044CE95BB90A23311EF4EDA9B743AE09" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_044CE95BB90A23311EF4EDA9B743AE09" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_2DCD433A6A9E7CAD692AEDA9B7447266" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract_044CE95BB90A23311EF4EDA9B743AE09" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_2DCD433A6A9E7CAD692AEDA9B7447266" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" xlink:label="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_BAFED7B5B3A3758FC7BCEDA9B74497F5" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_BAFED7B5B3A3758FC7BCEDA9B74497F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_6C9FF29E9BEF6A1C241DEDA9B744BE28" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_BAFED7B5B3A3758FC7BCEDA9B74497F5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_6C9FF29E9BEF6A1C241DEDA9B744BE28" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_BC3943BDB86026D5974DEDA9B744E0F5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_BAFED7B5B3A3758FC7BCEDA9B74497F5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_BC3943BDB86026D5974DEDA9B744E0F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_F35C57141EDC82F4ABD7EDA9B74425D7" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract_BAFED7B5B3A3758FC7BCEDA9B74497F5" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_F35C57141EDC82F4ABD7EDA9B74425D7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_B565731EC2332053672FEDA9B7446266" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4F078BC8B3FC5A544CD5EDA9B73E45AA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_B565731EC2332053672FEDA9B7446266" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_2A3B3B1E675CC7F314F3EDA9B745D3B0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_B565731EC2332053672FEDA9B7446266" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_2A3B3B1E675CC7F314F3EDA9B745D3B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_2B5A53F4A44E41B229F2EDA9B7459ED7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_B565731EC2332053672FEDA9B7446266" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_2B5A53F4A44E41B229F2EDA9B7459ED7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_18C8F99C5E16EA8BA44EEDA9B745134F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_B565731EC2332053672FEDA9B7446266" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_18C8F99C5E16EA8BA44EEDA9B745134F" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedInPeriodIntrinsicValue" xlink:label="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedInPeriodIntrinsicValue_567F6CDEBF8E5BA09B6CEDA9B7451D4C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_B565731EC2332053672FEDA9B7446266" xlink:to="loc_astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedInPeriodIntrinsicValue_567F6CDEBF8E5BA09B6CEDA9B7451D4C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/StockBasedCompensationNonCashStockCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_4FCAC3E072188324EC1958BDB94BA396" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_447ABEA11596CA579EC758BDB94BF5C6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_4FCAC3E072188324EC1958BDB94BA396" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_447ABEA11596CA579EC758BDB94BF5C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_852DD63FAF053294814258BDB94BD7F0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_447ABEA11596CA579EC758BDB94BF5C6" xlink:to="loc_us-gaap_AwardTypeAxis_852DD63FAF053294814258BDB94BD7F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_71CCC33502F4B39127E058BDB94BC701" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_852DD63FAF053294814258BDB94BD7F0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_71CCC33502F4B39127E058BDB94BC701" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_EmployeeStockAndEmployeeStockOptionMember" xlink:label="loc_astm_EmployeeStockAndEmployeeStockOptionMember_850F3E4C90D23B62DB6F58BDB94CD563" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_71CCC33502F4B39127E058BDB94BC701" xlink:to="loc_astm_EmployeeStockAndEmployeeStockOptionMember_850F3E4C90D23B62DB6F58BDB94CD563" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_505C8FECFF14BFC0D9E558BDB94C4AC5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_447ABEA11596CA579EC758BDB94BF5C6" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_505C8FECFF14BFC0D9E558BDB94C4AC5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_57261658F115662FD2AB58BDB94CDBFB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_505C8FECFF14BFC0D9E558BDB94C4AC5" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_57261658F115662FD2AB58BDB94CDBFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfSalesMember" xlink:label="loc_us-gaap_CostOfSalesMember_009D572CC60462B1F16258BDB94DAB18" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_57261658F115662FD2AB58BDB94CDBFB" xlink:to="loc_us-gaap_CostOfSalesMember_009D572CC60462B1F16258BDB94DAB18" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_47357BCA832E880AA06B58BDB94D4223" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_57261658F115662FD2AB58BDB94CDBFB" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_47357BCA832E880AA06B58BDB94D4223" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_A4191620E3C639C0750658BDB94D7CC4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_57261658F115662FD2AB58BDB94CDBFB" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_A4191620E3C639C0750658BDB94D7CC4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_B2E9C0837BB6FB7725F658BDB94DDB1E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_447ABEA11596CA579EC758BDB94BF5C6" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_B2E9C0837BB6FB7725F658BDB94DDB1E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_268AA474A92205633B5058BDB94DF836" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_B2E9C0837BB6FB7725F658BDB94DDB1E" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_268AA474A92205633B5058BDB94DF836" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/StockBasedCompensationTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_C2D1C35F4F15BDE434E758BDB9438570" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_A4AEC268463B2352E93058BDB943678C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_C2D1C35F4F15BDE434E758BDB9438570" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_A4AEC268463B2352E93058BDB943678C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_C4BD629A613F4034E59758BDB9438828" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_C2D1C35F4F15BDE434E758BDB9438570" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_C4BD629A613F4034E59758BDB9438828" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_2E5FB242371E17D8DC2F58BDB944B051" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_C2D1C35F4F15BDE434E758BDB9438570" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_2E5FB242371E17D8DC2F58BDB944B051" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/StockPurchaseWarrants" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsNoteDisclosureAbstract" xlink:label="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_819EEC9DA0995744EE4558BDB9657901" xlink:type="locator" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsAndRightsNoteDisclosureTextBlock" xlink:label="loc_astm_WarrantsAndRightsNoteDisclosureTextBlock_B96B4AACCEBD52D0465358BDB966051C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_819EEC9DA0995744EE4558BDB9657901" xlink:to="loc_astm_WarrantsAndRightsNoteDisclosureTextBlock_B96B4AACCEBD52D0465358BDB966051C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/StockPurchaseWarrantsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsNoteDisclosureAbstract" xlink:label="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_96FC81F85AD982205E2725D9F587451B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightTable" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_99B7B5F631E8745D765325D9F5871CCF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_96FC81F85AD982205E2725D9F587451B" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_99B7B5F631E8745D765325D9F5871CCF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3CA378EF35E2FA62778F25D9F5886AF7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_99B7B5F631E8745D765325D9F5871CCF" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3CA378EF35E2FA62778F25D9F5886AF7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingencyNatureDomain" xlink:label="loc_us-gaap_LossContingencyNatureDomain_65A8B8FC0887B084AE9925D9F588C706" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_3CA378EF35E2FA62778F25D9F5886AF7" xlink:to="loc_us-gaap_LossContingencyNatureDomain_65A8B8FC0887B084AE9925D9F588C706" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_AgreementWithOrsiniPotentialPaymentIfMinimumPaymentObligationsNotAchievedMember" xlink:label="loc_astm_AgreementWithOrsiniPotentialPaymentIfMinimumPaymentObligationsNotAchievedMember_FE229CC02B1BF8C8689125D9F5880DCF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingencyNatureDomain_65A8B8FC0887B084AE9925D9F588C706" xlink:to="loc_astm_AgreementWithOrsiniPotentialPaymentIfMinimumPaymentObligationsNotAchievedMember_FE229CC02B1BF8C8689125D9F5880DCF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_DC5EF101D2FF8953C80425D9F58973DC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_99B7B5F631E8745D765325D9F5871CCF" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_DC5EF101D2FF8953C80425D9F58973DC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_CD088851B02826BF0E0C25D9F5898DB1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_DC5EF101D2FF8953C80425D9F58973DC" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_CD088851B02826BF0E0C25D9F5898DB1" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsIssuedinDecember2017Member" xlink:label="loc_astm_WarrantsIssuedinDecember2017Member_57028661527379B23FC725D9F589DAC7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_CD088851B02826BF0E0C25D9F5898DB1" xlink:to="loc_astm_WarrantsIssuedinDecember2017Member_57028661527379B23FC725D9F589DAC7" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsIssuedInAugust2013Member" xlink:label="loc_astm_WarrantsIssuedInAugust2013Member_28793C6AEB24C231D2A025D9F5891E87" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_CD088851B02826BF0E0C25D9F5898DB1" xlink:to="loc_astm_WarrantsIssuedInAugust2013Member_28793C6AEB24C231D2A025D9F5891E87" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsIssuedInSeptember2016Member" xlink:label="loc_astm_WarrantsIssuedInSeptember2016Member_59F7E6D8AE638D7FE58C25D9F589170B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_CD088851B02826BF0E0C25D9F5898DB1" xlink:to="loc_astm_WarrantsIssuedInSeptember2016Member_59F7E6D8AE638D7FE58C25D9F589170B" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsIssuedDecember212017Member" xlink:label="loc_astm_WarrantsIssuedDecember212017Member_7B496FBE7440680A42D225D9F58A5AA6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_CD088851B02826BF0E0C25D9F5898DB1" xlink:to="loc_astm_WarrantsIssuedDecember212017Member_7B496FBE7440680A42D225D9F58A5AA6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_6FC090F145670A6BC36225D9F58AB022" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_99B7B5F631E8745D765325D9F5871CCF" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_6FC090F145670A6BC36225D9F58AB022" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_B19877B746AE8DCFC33525D9F58A1595" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_6FC090F145670A6BC36225D9F58AB022" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_B19877B746AE8DCFC33525D9F58A1595" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputSharePriceMember" xlink:label="loc_us-gaap_MeasurementInputSharePriceMember_CE86275FC0EBFF34E9CF25D9F58A357E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_B19877B746AE8DCFC33525D9F58A1595" xlink:to="loc_us-gaap_MeasurementInputSharePriceMember_CE86275FC0EBFF34E9CF25D9F58A357E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputExpectedDividendRateMember" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_BC230483B136B895BC2625D9F58AC7F9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_B19877B746AE8DCFC33525D9F58A1595" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_BC230483B136B895BC2625D9F58AC7F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputPriceVolatilityMember" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_95D4C330F358BF15E6C125D9F58B1D0B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_B19877B746AE8DCFC33525D9F58A1595" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_95D4C330F358BF15E6C125D9F58B1D0B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_3505F9C1F954CED17FDF25D9F58BE9CF" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_B19877B746AE8DCFC33525D9F58A1595" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_3505F9C1F954CED17FDF25D9F58BE9CF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_69D0252B707497AFA3F425D9F58B5D0B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_99B7B5F631E8745D765325D9F5871CCF" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_69D0252B707497AFA3F425D9F58B5D0B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_86CD890B88E5CF11E0C325D9F58B1C5A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_69D0252B707497AFA3F425D9F58B5D0B" xlink:to="loc_us-gaap_EquityComponentDomain_86CD890B88E5CF11E0C325D9F58B1C5A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_A755CC7C1CDDAEF354E525D9F58BB935" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_86CD890B88E5CF11E0C325D9F58B1C5A" xlink:to="loc_us-gaap_CommonStockMember_A755CC7C1CDDAEF354E525D9F58BB935" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_B83A063285C10DD7317D25D9F58C6376" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_99B7B5F631E8745D765325D9F5871CCF" xlink:to="loc_srt_CounterpartyNameAxis_B83A063285C10DD7317D25D9F58C6376" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_8C1AD062757595D4A42025D9F58CFDD9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_B83A063285C10DD7317D25D9F58C6376" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_8C1AD062757595D4A42025D9F58CFDD9" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_InnovativeCellularTherapeuticsMember" xlink:label="loc_astm_InnovativeCellularTherapeuticsMember_48D36517431B7411D83925D9F58C0F6C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_8C1AD062757595D4A42025D9F58CFDD9" xlink:to="loc_astm_InnovativeCellularTherapeuticsMember_48D36517431B7411D83925D9F58C0F6C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightLineItems" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_99B7B5F631E8745D765325D9F5871CCF" xlink:to="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_BE1BF719DBA1FA11B88F25D9F58DBAAD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_BE1BF719DBA1FA11B88F25D9F58DBAAD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_E580F51E7F271D68149925D9F58DEA5D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_E580F51E7F271D68149925D9F58DEA5D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherCommitment" xlink:label="loc_us-gaap_OtherCommitment_FAF79E61EBB32AB9D9A625D9F58D63B0" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_us-gaap_OtherCommitment_FAF79E61EBB32AB9D9A625D9F58D63B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_5ABF4F28019359A9798E25D9F58D54FD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_5ABF4F28019359A9798E25D9F58D54FD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstandingMeasurementInput" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_C7B13EF7EE01AB3F690C25D9F58D4F92" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_C7B13EF7EE01AB3F690C25D9F58D4F92" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ProceedsFromLicenseFeesReceivedAndIssuanceOfWarrants" xlink:label="loc_astm_ProceedsFromLicenseFeesReceivedAndIssuanceOfWarrants_AFBAC94E4D5F392E482C25D9F58DAC08" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_astm_ProceedsFromLicenseFeesReceivedAndIssuanceOfWarrants_AFBAC94E4D5F392E482C25D9F58DAC08" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_us-gaap_SharePrice_78250E31EA2A5D3FEB3925D9F58EF7C6" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_us-gaap_SharePrice_78250E31EA2A5D3FEB3925D9F58EF7C6" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_StockIssuedDuringPeriodSharesExerciseOfWarrants" xlink:label="loc_astm_StockIssuedDuringPeriodSharesExerciseOfWarrants_B0556A68761BE82F48EC25D9F58E149B" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_astm_StockIssuedDuringPeriodSharesExerciseOfWarrants_B0556A68761BE82F48EC25D9F58E149B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_07BD12AA6C0DB3D6762625D9F58E57EC" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_07BD12AA6C0DB3D6762625D9F58E57EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstandingTerm" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingTerm_F234B33F329209756CC425D9F58E5D0F" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingTerm_F234B33F329209756CC425D9F58E5D0F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_AAAFB1B77B23684157A925DC2D531F08" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1EF775654A08825D52D725D9F58C929D" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_AAAFB1B77B23684157A925DC2D531F08" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/StockPurchaseWarrantsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsNoteDisclosureAbstract" xlink:label="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_C86ECDF7197B247BBD3858BDB9E6A48D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock" xlink:label="loc_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_4AF52296E4DD77BC100758BDB9E6E691" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_C86ECDF7197B247BBD3858BDB9E6A48D" xlink:to="loc_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_4AF52296E4DD77BC100758BDB9E6E691" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ScheduleOfClassOfWarrantOrRightValuationAssumptionsTableTextBlock" xlink:label="loc_astm_ScheduleOfClassOfWarrantOrRightValuationAssumptionsTableTextBlock_9B109D9A49018CA2BCB458BDB9E68264" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_C86ECDF7197B247BBD3858BDB9E6A48D" xlink:to="loc_astm_ScheduleOfClassOfWarrantOrRightValuationAssumptionsTableTextBlock_9B109D9A49018CA2BCB458BDB9E68264" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_DE61593DFE29F5CEB55358BDB9B4A486" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_4DA0DBA63807AF77F5E458BDB9B4F0A2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_DE61593DFE29F5CEB55358BDB9B4A486" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_4DA0DBA63807AF77F5E458BDB9B4F0A2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesConsolidatedStatementOfCashFlowsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_553BF356991D88FD6558F2BCAF3CD855" xlink:type="locator" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsExercisedForCommonStock" xlink:label="loc_astm_WarrantsExercisedForCommonStock_2CA3ADBEE7EAECFA2C8AF2BCAF3CAEBA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_553BF356991D88FD6558F2BCAF3CD855" xlink:to="loc_astm_WarrantsExercisedForCommonStock_2CA3ADBEE7EAECFA2C8AF2BCAF3CAEBA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestPaidNet" xlink:label="loc_us-gaap_InterestPaidNet_58D014651F3CC644ACC0F2BCAF3DCE56" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_553BF356991D88FD6558F2BCAF3CD855" xlink:to="loc_us-gaap_InterestPaidNet_58D014651F3CC644ACC0F2BCAF3DCE56" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssued1" xlink:label="loc_us-gaap_StockIssued1_CF3EA2ECC383D2E6199DF2BCAF3D6E7A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_553BF356991D88FD6558F2BCAF3CD855" xlink:to="loc_us-gaap_StockIssued1_CF3EA2ECC383D2E6199DF2BCAF3D6E7A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxesPaid" xlink:label="loc_us-gaap_IncomeTaxesPaid_B1D908C972D303D78E1DF2BCAF3D9D1E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_553BF356991D88FD6558F2BCAF3CD855" xlink:to="loc_us-gaap_IncomeTaxesPaid_B1D908C972D303D78E1DF2BCAF3D9D1E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalExpendituresIncurredButNotYetPaid" xlink:label="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_94999ADD81785855A1C6F2BCAF3E90C6" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_553BF356991D88FD6558F2BCAF3CD855" xlink:to="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_94999ADD81785855A1C6F2BCAF3E90C6" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_B25423DED4189EB6ECC325FA20A6F315" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_544E04DD786E2328CF8325FA20A6EAFB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_B25423DED4189EB6ECC325FA20A6F315" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_544E04DD786E2328CF8325FA20A6EAFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_09B899BD2AFB34FCDB2225FA20A79C21" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_544E04DD786E2328CF8325FA20A6EAFB" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_09B899BD2AFB34FCDB2225FA20A79C21" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_51A01643FFD8BAC8F57B25FA20A71131" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_09B899BD2AFB34FCDB2225FA20A79C21" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_51A01643FFD8BAC8F57B25FA20A71131" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_EquipmentAndComputersMember" xlink:label="loc_astm_EquipmentAndComputersMember_7BBA99F4DDF679BF713425FA20A7CA70" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_51A01643FFD8BAC8F57B25FA20A71131" xlink:to="loc_astm_EquipmentAndComputersMember_7BBA99F4DDF679BF713425FA20A7CA70" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_67E3061E9DEC02690B8325FA20A809A9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_51A01643FFD8BAC8F57B25FA20A71131" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_67E3061E9DEC02690B8325FA20A809A9" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_BuildingImprovementsAndLeaseholdImprovementsMember" xlink:label="loc_astm_BuildingImprovementsAndLeaseholdImprovementsMember_D91E0BD3E6B8C4F941B325FA20A8EA38" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_51A01643FFD8BAC8F57B25FA20A71131" xlink:to="loc_astm_BuildingImprovementsAndLeaseholdImprovementsMember_D91E0BD3E6B8C4F941B325FA20A8EA38" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_07169571D6A983CB09E225FA20A86E76" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_544E04DD786E2328CF8325FA20A6EAFB" xlink:to="loc_srt_RangeAxis_07169571D6A983CB09E225FA20A86E76" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_311290D7F14F8B272FD125FA20A83BD7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_07169571D6A983CB09E225FA20A86E76" xlink:to="loc_srt_RangeMember_311290D7F14F8B272FD125FA20A83BD7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_B8042B9F471157BDD0FC25FA20A85F8D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_311290D7F14F8B272FD125FA20A83BD7" xlink:to="loc_srt_MinimumMember_B8042B9F471157BDD0FC25FA20A85F8D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_B3077B7152685C2A5D2825FA20A9BF21" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_311290D7F14F8B272FD125FA20A83BD7" xlink:to="loc_srt_MaximumMember_B3077B7152685C2A5D2825FA20A9BF21" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ValuationAllowancesAndReservesPeriodAxis" xlink:label="loc_astm_ValuationAllowancesAndReservesPeriodAxis_ECE141CC36B35F1DD37825FA20A964D0" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_544E04DD786E2328CF8325FA20A6EAFB" xlink:to="loc_astm_ValuationAllowancesAndReservesPeriodAxis_ECE141CC36B35F1DD37825FA20A964D0" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_ValuationAllowancesAndReservesPeriodDomain" xlink:label="loc_astm_ValuationAllowancesAndReservesPeriodDomain_246127AD18CAEDCFC5D025FA20A95176" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_ValuationAllowancesAndReservesPeriodAxis_ECE141CC36B35F1DD37825FA20A964D0" xlink:to="loc_astm_ValuationAllowancesAndReservesPeriodDomain_246127AD18CAEDCFC5D025FA20A95176" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_CE0AF5C1A6385A3DBF3625FA20A9ECDD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_544E04DD786E2328CF8325FA20A6EAFB" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_CE0AF5C1A6385A3DBF3625FA20A9ECDD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesDomain" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_2383A580C979DA8AD5B025FA20A98D8E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_CE0AF5C1A6385A3DBF3625FA20A9ECDD" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_2383A580C979DA8AD5B025FA20A98D8E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ChangeInAccountingEstimateByTypeAxis" xlink:label="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_3B68FE6365783669B84C25FA20AA717C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_544E04DD786E2328CF8325FA20A6EAFB" xlink:to="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_3B68FE6365783669B84C25FA20AA717C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ChangeInAccountingEstimateTypeDomain" xlink:label="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_5590A58D5F946E7229E625FA20AA0C9A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_3B68FE6365783669B84C25FA20AA717C" xlink:to="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_5590A58D5F946E7229E625FA20AA0C9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_7300614FCA6B0FF3441825FA20AACA01" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_544E04DD786E2328CF8325FA20A6EAFB" xlink:to="loc_srt_CounterpartyNameAxis_7300614FCA6B0FF3441825FA20AACA01" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_E6CB881B341DBABCF7CA25FA20AA967B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_7300614FCA6B0FF3441825FA20AACA01" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_E6CB881B341DBABCF7CA25FA20AA967B" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_InnovativeCellularTherapeuticsMember" xlink:label="loc_astm_InnovativeCellularTherapeuticsMember_3CA806422285E0C10FE825FA20ABAF84" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_E6CB881B341DBABCF7CA25FA20AA967B" xlink:to="loc_astm_InnovativeCellularTherapeuticsMember_3CA806422285E0C10FE825FA20ABAF84" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A5DE43D3C15F5B9F5CFF25FA20AB5DF7" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_544E04DD786E2328CF8325FA20A6EAFB" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A5DE43D3C15F5B9F5CFF25FA20AB5DF7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_90CFBE9C4C52EF10C6A025FA20ABB9B4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A5DE43D3C15F5B9F5CFF25FA20AB5DF7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_90CFBE9C4C52EF10C6A025FA20ABB9B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_459B436CD166AD81E63B25FA20ABFD64" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_A5DE43D3C15F5B9F5CFF25FA20AB5DF7" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_459B436CD166AD81E63B25FA20ABFD64" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_8FD99735837C7C8113DEEE6F28729567" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_ConsolidationPolicyTextBlock_8FD99735837C7C8113DEEE6F28729567" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_9EC60779807F2CCA4F72EE6F28722649" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_UseOfEstimates_9EC60779807F2CCA4F72EE6F28722649" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_510FCE128FFEEE3FF981EE6F28725453" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_InventoryPolicyTextBlock_510FCE128FFEEE3FF981EE6F28725453" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReceivablesPolicyTextBlock" xlink:label="loc_us-gaap_ReceivablesPolicyTextBlock_2DD9879C0045625606D0EE6F2873792B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_ReceivablesPolicyTextBlock_2DD9879C0045625606D0EE6F2873792B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_2D58451440BD8194A584EE6F287305EE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_2D58451440BD8194A584EE6F287305EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsFiniteLivedPolicy" xlink:label="loc_us-gaap_IntangibleAssetsFiniteLivedPolicy_6223304EAE20CEDA23E3EE6F287389E9" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_IntangibleAssetsFiniteLivedPolicy_6223304EAE20CEDA23E3EE6F287389E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_98CE272DD085E8B6A6FCEE6F2873D8FF" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_98CE272DD085E8B6A6FCEE6F2873D8FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_B70ACE121BE9044588A7EE6F28744168" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_B70ACE121BE9044588A7EE6F28744168" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_1484B28C4AEF9AF92E69EE6F287496EF" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_1484B28C4AEF9AF92E69EE6F287496EF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_DBB5B69436A005E4FB66EE6F287403E2" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_DBB5B69436A005E4FB66EE6F287403E2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_A154662282E526578CF7EE6F28749B31" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_A154662282E526578CF7EE6F28749B31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueOfFinancialInstrumentsPolicy" xlink:label="loc_us-gaap_FairValueOfFinancialInstrumentsPolicy_809CCFF41E06981A6FA5EE6F287419C6" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_FairValueOfFinancialInstrumentsPolicy_809CCFF41E06981A6FA5EE6F287419C6" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_WarrantsPolicyTextBlock" xlink:label="loc_astm_WarrantsPolicyTextBlock_D1AD88404E6B58C369CAEE6F28745638" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_astm_WarrantsPolicyTextBlock_D1AD88404E6B58C369CAEE6F28745638" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_DD9451CA411CE95E4BD4EE6F28753A89" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_F7F721EDA5D2EA3398E8EE6F2872058A" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_DD9451CA411CE95E4BD4EE6F28753A89" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_8485CB8D2A05552FADF958BDB9756C8D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock_26F871AA74B4F34C11A358BDB97590A4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_8485CB8D2A05552FADF958BDB9756C8D" xlink:to="loc_us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock_26F871AA74B4F34C11A358BDB97590A4" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SummaryOfSignificantAccountingPoliciesUndeclaredDividendsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_FC99EB008970BFC674BF58BDB972FB68" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_765FDBF5B2F83C23218B58BDB97270F9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_FC99EB008970BFC674BF58BDB972FB68" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_765FDBF5B2F83C23218B58BDB97270F9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5BC1E57891F8815C027A58BDB9726A81" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_765FDBF5B2F83C23218B58BDB97270F9" xlink:to="loc_us-gaap_StatementClassOfStockAxis_5BC1E57891F8815C027A58BDB9726A81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_D806DC627A2847EB1E5058BDB972FE3C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5BC1E57891F8815C027A58BDB9726A81" xlink:to="loc_us-gaap_ClassOfStockDomain_D806DC627A2847EB1E5058BDB972FE3C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_8F729F4497BA0B439FE558BDB973057F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_D806DC627A2847EB1E5058BDB972FE3C" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_8F729F4497BA0B439FE558BDB973057F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicLineItems" xlink:label="loc_us-gaap_EarningsPerShareBasicLineItems_F28C6E39D0C37DA8575258BDB973CB17" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_765FDBF5B2F83C23218B58BDB97270F9" xlink:to="loc_us-gaap_EarningsPerShareBasicLineItems_F28C6E39D0C37DA8575258BDB973CB17" xlink:type="arc" />
    <link:loc xlink:href="astm-20181231.xsd#astm_AccumulatedUndeclaredDividends" xlink:label="loc_astm_AccumulatedUndeclaredDividends_5A24C4EFB6E05F3094BA58BDB9736AC7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_F28C6E39D0C37DA8575258BDB973CB17" xlink:to="loc_astm_AccumulatedUndeclaredDividends_5A24C4EFB6E05F3094BA58BDB9736AC7" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SupplementaryQuarterlyFinancialInformationUnaudited" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_3F9536B8071231265D1C58BDB9D6B5A0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_D2A614FB204C9A48A78658BDB9D6349F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_3F9536B8071231265D1C58BDB9D6B5A0" xlink:to="loc_us-gaap_QuarterlyFinancialInformationTextBlock_D2A614FB204C9A48A78658BDB9D6349F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SupplementaryQuarterlyFinancialInformationUnauditedDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_2CA6CB79F7B8B16766E3EE503AF2B044" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_244ED510BD22C427EC11EE5785BB534C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_2CA6CB79F7B8B16766E3EE503AF2B044" xlink:to="loc_us-gaap_Revenues_244ED510BD22C427EC11EE5785BB534C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GrossProfit" xlink:label="loc_us-gaap_GrossProfit_A35D9D5653461856229BEE503AF283AC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_2CA6CB79F7B8B16766E3EE503AF2B044" xlink:to="loc_us-gaap_GrossProfit_A35D9D5653461856229BEE503AF283AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_186E3B17DA490091F9E7EE503AF3FF29" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_2CA6CB79F7B8B16766E3EE503AF2B044" xlink:to="loc_us-gaap_OperatingIncomeLoss_186E3B17DA490091F9E7EE503AF3FF29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_3DA079C9A278E79AA5B7EE503AF3AFC1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_2CA6CB79F7B8B16766E3EE503AF2B044" xlink:to="loc_us-gaap_NetIncomeLoss_3DA079C9A278E79AA5B7EE503AF3AFC1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_43E589A622AB0D78E640EE503AF38F26" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_2CA6CB79F7B8B16766E3EE503AF2B044" xlink:to="loc_us-gaap_EarningsPerShareBasic_43E589A622AB0D78E640EE503AF38F26" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_E6925C7B93AA98AB30F7EE503AF3F99A" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_2CA6CB79F7B8B16766E3EE503AF2B044" xlink:to="loc_us-gaap_EarningsPerShareDiluted_E6925C7B93AA98AB30F7EE503AF3F99A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_A7E1042627C7A9A8241CEE503AF3AAC7" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_2CA6CB79F7B8B16766E3EE503AF2B044" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_A7E1042627C7A9A8241CEE503AF3AAC7" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://vcel.com/role/SupplementaryQuarterlyFinancialInformationUnauditedTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_5EB1C62EF834B8F9475258BDB945C136" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_750EDB049D1E671C252858BDB9457E3D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_5EB1C62EF834B8F9475258BDB945C136" xlink:to="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_750EDB049D1E671C252858BDB9457E3D" xlink:type="arc" />
  </link:presentationLink>
</link:linkbase>