<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:43d0ba38-e301-4b7a-9244-41b258dc4c4a,g:0a468787-69d8-4612-9c06-55490371bb31-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://vcel.com/role/CoverPage" xlink:type="simple" xlink:href="vcel-20200930.xsd#CoverPage"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CoverPage" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="vcel-20200930.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_4c5b8c0c-21e7-45df-a93d-3fe3106e2a9e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_531252a9-2e62-472d-bcf2-0e076d47429c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4c5b8c0c-21e7-45df-a93d-3fe3106e2a9e" xlink:to="loc_us-gaap_CommonStockValue_531252a9-2e62-472d-bcf2-0e076d47429c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_f3ac073e-6a8e-4fa4-8ec0-308333818d4f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4c5b8c0c-21e7-45df-a93d-3fe3106e2a9e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_f3ac073e-6a8e-4fa4-8ec0-308333818d4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_c4b0e94c-9c95-4628-98a2-871d1a88bd0b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4c5b8c0c-21e7-45df-a93d-3fe3106e2a9e" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_c4b0e94c-9c95-4628-98a2-871d1a88bd0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_703f7411-ad80-4417-ac4f-76d414e5a87b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_22ef63a7-c618-4cc9-8fe0-0597e63a0a53" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_703f7411-ad80-4417-ac4f-76d414e5a87b" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_22ef63a7-c618-4cc9-8fe0-0597e63a0a53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_aa4e81b1-5ecb-4ac9-abd5-4516e8cf4f40" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_703f7411-ad80-4417-ac4f-76d414e5a87b" xlink:to="loc_us-gaap_ShortTermInvestments_aa4e81b1-5ecb-4ac9-abd5-4516e8cf4f40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_a9c26023-264d-45a3-8e56-fa20af930d9e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_703f7411-ad80-4417-ac4f-76d414e5a87b" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_a9c26023-264d-45a3-8e56-fa20af930d9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_421396a5-dc01-42ed-8728-9c299ec8192c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_703f7411-ad80-4417-ac4f-76d414e5a87b" xlink:to="loc_us-gaap_InventoryNet_421396a5-dc01-42ed-8728-9c299ec8192c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_aa7f58a2-a5d8-4fec-8985-a407e244892c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_703f7411-ad80-4417-ac4f-76d414e5a87b" xlink:to="loc_us-gaap_OtherAssetsCurrent_aa7f58a2-a5d8-4fec-8985-a407e244892c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_f15323ef-2405-4b5a-a8d8-9ea5bf6dcc56" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_904cb20f-9927-4887-9eb3-974a04f46cb7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_f15323ef-2405-4b5a-a8d8-9ea5bf6dcc56" xlink:to="loc_us-gaap_LiabilitiesCurrent_904cb20f-9927-4887-9eb3-974a04f46cb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_cbee3fc6-8954-4190-9eb5-b74f9d1d3d69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_f15323ef-2405-4b5a-a8d8-9ea5bf6dcc56" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_cbee3fc6-8954-4190-9eb5-b74f9d1d3d69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_40a8b3b7-2359-4875-a2a5-519251636109" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_f15323ef-2405-4b5a-a8d8-9ea5bf6dcc56" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_40a8b3b7-2359-4875-a2a5-519251636109" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_ed85e3b6-1167-4fe9-a50a-fcff215ceac2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_f3618699-2312-4d00-adac-a569a5a0d22f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ed85e3b6-1167-4fe9-a50a-fcff215ceac2" xlink:to="loc_us-gaap_AssetsCurrent_f3618699-2312-4d00-adac-a569a5a0d22f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_7be6a97c-19c5-4804-84f2-5ec372c1d5c7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ed85e3b6-1167-4fe9-a50a-fcff215ceac2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_7be6a97c-19c5-4804-84f2-5ec372c1d5c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_b4b5936e-52b3-44d9-9642-2fd08c33e26b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ed85e3b6-1167-4fe9-a50a-fcff215ceac2" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_b4b5936e-52b3-44d9-9642-2fd08c33e26b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_56db6da9-ec25-4867-ade0-e6c5c340ae25" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ed85e3b6-1167-4fe9-a50a-fcff215ceac2" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_56db6da9-ec25-4867-ade0-e6c5c340ae25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_501beb09-6f1d-4d96-9511-fc5697727fda" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_ed85e3b6-1167-4fe9-a50a-fcff215ceac2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_501beb09-6f1d-4d96-9511-fc5697727fda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_d30d3dbf-d7c6-4aba-b86c-3ba19735bc69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_02804494-c391-4d56-b8ff-99d012cfe695" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_d30d3dbf-d7c6-4aba-b86c-3ba19735bc69" xlink:to="loc_us-gaap_AccountsPayableCurrent_02804494-c391-4d56-b8ff-99d012cfe695" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_a806afc1-db13-478d-bdef-2061f8bedaa6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_d30d3dbf-d7c6-4aba-b86c-3ba19735bc69" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_a806afc1-db13-478d-bdef-2061f8bedaa6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_bb42636c-95f7-44e1-909d-b81a9d41f063" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_d30d3dbf-d7c6-4aba-b86c-3ba19735bc69" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_bb42636c-95f7-44e1-909d-b81a9d41f063" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_51edbb1c-89d8-4ed1-a925-d77c82e5f846" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_d30d3dbf-d7c6-4aba-b86c-3ba19735bc69" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_51edbb1c-89d8-4ed1-a925-d77c82e5f846" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_f30f845c-165e-49ec-a9df-468b070ae846" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c121de66-8b71-402b-9d41-44fb6f9cfc87" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f30f845c-165e-49ec-a9df-468b070ae846" xlink:to="loc_us-gaap_StockholdersEquity_c121de66-8b71-402b-9d41-44fb6f9cfc87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_321acb8b-4739-495d-a853-75d781068d5e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f30f845c-165e-49ec-a9df-468b070ae846" xlink:to="loc_us-gaap_Liabilities_321acb8b-4739-495d-a853-75d781068d5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_f3adea36-51cc-4c28-aae4-5f0f5230de98" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_f30f845c-165e-49ec-a9df-468b070ae846" xlink:to="loc_us-gaap_CommitmentsAndContingencies_f3adea36-51cc-4c28-aae4-5f0f5230de98" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="vcel-20200930.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="vcel-20200930.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_184595a4-bbd7-4d1e-a99c-f721583d37d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_9f224757-8db7-4fed-b739-df13c166e8a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_184595a4-bbd7-4d1e-a99c-f721583d37d4" xlink:to="loc_us-gaap_Revenues_9f224757-8db7-4fed-b739-df13c166e8a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_ae1cb697-795e-4252-b9e7-4364252af41f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_184595a4-bbd7-4d1e-a99c-f721583d37d4" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_ae1cb697-795e-4252-b9e7-4364252af41f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_c94b2d86-21bb-4a07-9ff7-b66255203ed7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_5d46f3db-3e01-4ab6-aef7-bec2f62a67e2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_c94b2d86-21bb-4a07-9ff7-b66255203ed7" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_5d46f3db-3e01-4ab6-aef7-bec2f62a67e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_f641e962-638c-4086-82d6-deded55ec6a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_c94b2d86-21bb-4a07-9ff7-b66255203ed7" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_f641e962-638c-4086-82d6-deded55ec6a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c52cd032-cff3-44db-9768-8f41cce38587" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_1516f1d2-91b6-4488-9779-5dba2d7a9823" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_c52cd032-cff3-44db-9768-8f41cce38587" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_1516f1d2-91b6-4488-9779-5dba2d7a9823" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ebe27c79-9655-42e5-a181-a38e8a5dbd1e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_c52cd032-cff3-44db-9768-8f41cce38587" xlink:to="loc_us-gaap_OperatingIncomeLoss_ebe27c79-9655-42e5-a181-a38e8a5dbd1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_28b5c4c0-04cf-4b91-b851-3e6f6d3ddc58" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_73206b90-d1be-49bd-8000-c4061d79d9b8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_28b5c4c0-04cf-4b91-b851-3e6f6d3ddc58" xlink:to="loc_us-gaap_GrossProfit_73206b90-d1be-49bd-8000-c4061d79d9b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_6025a20c-1b9a-4334-86cf-51c29d4d8567" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_28b5c4c0-04cf-4b91-b851-3e6f6d3ddc58" xlink:to="loc_us-gaap_OperatingExpenses_6025a20c-1b9a-4334-86cf-51c29d4d8567" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_ab6659cd-1b87-42b7-8a3f-35696ea9e781" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_c98e3b22-78ab-43b8-a0b6-364657114ad7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_ab6659cd-1b87-42b7-8a3f-35696ea9e781" xlink:to="loc_us-gaap_InvestmentIncomeInterest_c98e3b22-78ab-43b8-a0b6-364657114ad7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_f394788c-2fd1-47c5-993e-80d5fd941b5e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_ab6659cd-1b87-42b7-8a3f-35696ea9e781" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_f394788c-2fd1-47c5-993e-80d5fd941b5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_c3ee0dd0-5020-4a62-a7a4-efd9aa78d3f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_ab6659cd-1b87-42b7-8a3f-35696ea9e781" xlink:to="loc_us-gaap_InterestExpense_c3ee0dd0-5020-4a62-a7a4-efd9aa78d3f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_a6ba7c1f-0580-4217-b8c5-d36b74925d8e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomerOther_16b18577-24bd-46bb-986e-85af01732341" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueNotFromContractWithCustomerOther"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_a6ba7c1f-0580-4217-b8c5-d36b74925d8e" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomerOther_16b18577-24bd-46bb-986e-85af01732341" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_addee181-1071-4637-ac96-77a2af1871d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_a6ba7c1f-0580-4217-b8c5-d36b74925d8e" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_addee181-1071-4637-ac96-77a2af1871d4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="vcel-20200930.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_3340de29-42e1-491e-b228-5c21742641bb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b41a7c17-5d8e-439d-b617-17ea6fbbe26d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_3340de29-42e1-491e-b228-5c21742641bb" xlink:to="loc_us-gaap_NetIncomeLoss_b41a7c17-5d8e-439d-b617-17ea6fbbe26d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_1d0c80a3-8bac-47be-a88a-6120a8689462" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_3340de29-42e1-491e-b228-5c21742641bb" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_1d0c80a3-8bac-47be-a88a-6120a8689462" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vcel.com/role/CONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="simple" xlink:href="vcel-20200930.xsd#CONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="vcel-20200930.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_a5ee0e69-9297-4960-bde9-893d46b3d752" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_NetIncomeLoss_a5ee0e69-9297-4960-bde9-893d46b3d752" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_2fa47ef9-772f-465a-8396-ffd430f2836c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_2fa47ef9-772f-465a-8396-ffd430f2836c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_b844a8e2-7e01-4c86-bb68-f4fb7f0699b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_ShareBasedCompensation_b844a8e2-7e01-4c86-bb68-f4fb7f0699b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_26b8f633-929a-4c0e-bb5e-58b02b3bdf93" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossRealized"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossRealized_26b8f633-929a-4c0e-bb5e-58b02b3bdf93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_184ef1be-a457-4320-a616-fd45f3c81853" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnDispositionOfAssets1"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_184ef1be-a457-4320-a616-fd45f3c81853" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_07634f42-f84b-442f-9bca-2a4b1fd74655" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_07634f42-f84b-442f-9bca-2a4b1fd74655" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_f9d1e006-d767-440b-a13e-c85227d1dd76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_f9d1e006-d767-440b-a13e-c85227d1dd76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_5823bb5b-7f9a-493b-9912-241233c18ee0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInReceivables"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_5823bb5b-7f9a-493b-9912-241233c18ee0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_7823b4ca-b887-48f5-83a7-ccb712622a21" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherCurrentAssets"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_7823b4ca-b887-48f5-83a7-ccb712622a21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_7efa9601-24ee-46f8-bf08-5dfc413fb2bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_7efa9601-24ee-46f8-bf08-5dfc413fb2bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_f879e9cc-63e2-4a42-a8c8-9b55ba3d198c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_f879e9cc-63e2-4a42-a8c8-9b55ba3d198c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_121405aa-9f31-4503-a8fc-c23d9706e159" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_121405aa-9f31-4503-a8fc-c23d9706e159" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_IncreaseDecreaseInLeaseLiabilities_af190b76-e566-4ce7-8ebd-a1622b699311" xlink:href="vcel-20200930.xsd#vcel_IncreaseDecreaseInLeaseLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_vcel_IncreaseDecreaseInLeaseLiabilities_af190b76-e566-4ce7-8ebd-a1622b699311" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_OperatingLeaseRightOfUseAssetAmortization_5055aa87-ee99-4fd4-a584-c44e62f6fca2" xlink:href="vcel-20200930.xsd#vcel_OperatingLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_27094351-c8ea-443f-b07a-e1a3fceb4271" xlink:to="loc_vcel_OperatingLeaseRightOfUseAssetAmortization_5055aa87-ee99-4fd4-a584-c44e62f6fca2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f61f6e7d-f980-4dee-9ec7-4aa6028feb0a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_72e4b062-936a-4dad-993a-66bd5179f7d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f61f6e7d-f980-4dee-9ec7-4aa6028feb0a" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_72e4b062-936a-4dad-993a-66bd5179f7d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_6bc387dc-6d89-4f85-873f-a6e3a5d07cb1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f61f6e7d-f980-4dee-9ec7-4aa6028feb0a" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_6bc387dc-6d89-4f85-873f-a6e3a5d07cb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_fee54c4c-58a5-4f10-be96-aff0aa592baa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f61f6e7d-f980-4dee-9ec7-4aa6028feb0a" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_fee54c4c-58a5-4f10-be96-aff0aa592baa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e9da82a6-3ee6-4400-8e99-154dbf1bd267" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7e489431-2a2c-4ceb-9ccc-3a4944d96119" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e9da82a6-3ee6-4400-8e99-154dbf1bd267" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7e489431-2a2c-4ceb-9ccc-3a4944d96119" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4d34d330-cd70-41ae-a65c-d6ecda74021c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e9da82a6-3ee6-4400-8e99-154dbf1bd267" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4d34d330-cd70-41ae-a65c-d6ecda74021c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a352781a-245e-4463-801c-217789d7487b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e9da82a6-3ee6-4400-8e99-154dbf1bd267" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a352781a-245e-4463-801c-217789d7487b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_193fc4ea-8481-4bb0-8ded-39d89ff28445" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_ae087f7b-d9aa-4465-9cdc-fa9fb6a7e5e4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_193fc4ea-8481-4bb0-8ded-39d89ff28445" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_ae087f7b-d9aa-4465-9cdc-fa9fb6a7e5e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_456a900c-3c04-422c-ae1c-dddb37a30d34" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_193fc4ea-8481-4bb0-8ded-39d89ff28445" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_456a900c-3c04-422c-ae1c-dddb37a30d34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_d3eac034-b151-4487-bb2a-6b5c56e06763" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_193fc4ea-8481-4bb0-8ded-39d89ff28445" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_d3eac034-b151-4487-bb2a-6b5c56e06763" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vcel.com/role/Organization" xlink:type="simple" xlink:href="vcel-20200930.xsd#Organization"/>
  <link:calculationLink xlink:role="http://vcel.com/role/Organization" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/OrganizationNarrativeDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#OrganizationNarrativeDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/OrganizationNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/BasisofPresentation" xlink:type="simple" xlink:href="vcel-20200930.xsd#BasisofPresentation"/>
  <link:calculationLink xlink:role="http://vcel.com/role/BasisofPresentation" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/BasisofPresentationPolicies" xlink:type="simple" xlink:href="vcel-20200930.xsd#BasisofPresentationPolicies"/>
  <link:calculationLink xlink:role="http://vcel.com/role/BasisofPresentationPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/BasisofPresentationTables" xlink:type="simple" xlink:href="vcel-20200930.xsd#BasisofPresentationTables"/>
  <link:calculationLink xlink:role="http://vcel.com/role/BasisofPresentationTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/BasisofPresentationSupplementarycashflowsinformationDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#BasisofPresentationSupplementarycashflowsinformationDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/BasisofPresentationSupplementarycashflowsinformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/BasisofPresentationNarrativeDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#BasisofPresentationNarrativeDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/BasisofPresentationNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/RecentAccountingPronouncements" xlink:type="simple" xlink:href="vcel-20200930.xsd#RecentAccountingPronouncements"/>
  <link:calculationLink xlink:role="http://vcel.com/role/RecentAccountingPronouncements" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/Revenue" xlink:type="simple" xlink:href="vcel-20200930.xsd#Revenue"/>
  <link:calculationLink xlink:role="http://vcel.com/role/Revenue" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/RevenueTables" xlink:type="simple" xlink:href="vcel-20200930.xsd#RevenueTables"/>
  <link:calculationLink xlink:role="http://vcel.com/role/RevenueTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/RevenueDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#RevenueDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/RevenueDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/RevenueDisaggregationofRevenueDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#RevenueDisaggregationofRevenueDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/RevenueDisaggregationofRevenueDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/RevenueSchedulesofconcentrationofriskDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#RevenueSchedulesofconcentrationofriskDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/RevenueSchedulesofconcentrationofriskDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponents" xlink:type="simple" xlink:href="vcel-20200930.xsd#SelectedBalanceSheetComponents"/>
  <link:calculationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponents" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsTables" xlink:type="simple" xlink:href="vcel-20200930.xsd#SelectedBalanceSheetComponentsTables"/>
  <link:calculationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofinventoryDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#SelectedBalanceSheetComponentsScheduleofinventoryDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofinventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_747b3cc4-6e25-4cdf-b871-22c41620551e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_d721593d-e206-45ff-b734-1d9b215d9610" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryRawMaterials"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_747b3cc4-6e25-4cdf-b871-22c41620551e" xlink:to="loc_us-gaap_InventoryRawMaterials_d721593d-e206-45ff-b734-1d9b215d9610" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_75b5996c-843d-4d68-94fe-4158cec70703" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_747b3cc4-6e25-4cdf-b871-22c41620551e" xlink:to="loc_us-gaap_InventoryWorkInProcess_75b5996c-843d-4d68-94fe-4158cec70703" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_e2a488fb-dcb2-44de-909c-6ed6dab3ef27" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_747b3cc4-6e25-4cdf-b871-22c41620551e" xlink:to="loc_us-gaap_InventoryFinishedGoods_e2a488fb-dcb2-44de-909c-6ed6dab3ef27" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofpropertyandequipmentnetDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#SelectedBalanceSheetComponentsScheduleofpropertyandequipmentnetDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofpropertyandequipmentnetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_7a35fdc1-3271-47ec-89b8-ac51487b55f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_4a312534-5426-4d3c-b483-9ac381163df1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_7a35fdc1-3271-47ec-89b8-ac51487b55f2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_4a312534-5426-4d3c-b483-9ac381163df1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_ab6d2e52-6626-4ea3-86a8-89805181c34c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_7a35fdc1-3271-47ec-89b8-ac51487b55f2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_ab6d2e52-6626-4ea3-86a8-89805181c34c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_a23a61ab-7092-44b9-9556-5c049fd18ba2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetBeforeAccumulatedAmortization_c4c91f52-f671-41b6-a021-0aea866ae290" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAssetBeforeAccumulatedAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_a23a61ab-7092-44b9-9556-5c049fd18ba2" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetBeforeAccumulatedAmortization_c4c91f52-f671-41b6-a021-0aea866ae290" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_f6b9690a-bf79-44a3-9ad7-ef6855c4fae0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_a23a61ab-7092-44b9-9556-5c049fd18ba2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_f6b9690a-bf79-44a3-9ad7-ef6855c4fae0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofaccruedexpensesDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#SelectedBalanceSheetComponentsScheduleofaccruedexpensesDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofaccruedexpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_60d45665-2c55-42b0-ad4c-cb48376a4bbb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedBonusesCurrent_fbbf6eb8-c4cf-431c-9833-c1f41586b3c0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedBonusesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_60d45665-2c55-42b0-ad4c-cb48376a4bbb" xlink:to="loc_us-gaap_AccruedBonusesCurrent_fbbf6eb8-c4cf-431c-9833-c1f41586b3c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_a18326cb-c811-4362-8ed9-bcd66e4bf7fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_60d45665-2c55-42b0-ad4c-cb48376a4bbb" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_a18326cb-c811-4362-8ed9-bcd66e4bf7fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_AccruedExpensesOtherCurrent_e4840202-4cf8-4b66-9643-47a297e48cc9" xlink:href="vcel-20200930.xsd#vcel_AccruedExpensesOtherCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_60d45665-2c55-42b0-ad4c-cb48376a4bbb" xlink:to="loc_vcel_AccruedExpensesOtherCurrent_e4840202-4cf8-4b66-9643-47a297e48cc9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vcel.com/role/Leases" xlink:type="simple" xlink:href="vcel-20200930.xsd#Leases"/>
  <link:calculationLink xlink:role="http://vcel.com/role/Leases" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/LeasesTables" xlink:type="simple" xlink:href="vcel-20200930.xsd#LeasesTables"/>
  <link:calculationLink xlink:role="http://vcel.com/role/LeasesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#LeasesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/LeasesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/LeasesAssetsAndLiabilitiesDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#LeasesAssetsAndLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/LeasesAssetsAndLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LeaseLiabilityNoncurrent_e0a115b8-1dae-43d4-bfd6-2f6c6b31ac92" xlink:href="vcel-20200930.xsd#vcel_LeaseLiabilityNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_65a6d5fc-46a4-44c2-b999-f5efd5fc3e64" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vcel_LeaseLiabilityNoncurrent_e0a115b8-1dae-43d4-bfd6-2f6c6b31ac92" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_65a6d5fc-46a4-44c2-b999-f5efd5fc3e64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_d31d10e1-2154-489f-8f07-c8003b4cab35" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vcel_LeaseLiabilityNoncurrent_e0a115b8-1dae-43d4-bfd6-2f6c6b31ac92" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_d31d10e1-2154-489f-8f07-c8003b4cab35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LeaseLiabilityCurrent_1021a769-16bd-4e62-8443-b39c1e3ea379" xlink:href="vcel-20200930.xsd#vcel_LeaseLiabilityCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_5b289bda-c198-4ef1-959a-250925d38243" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vcel_LeaseLiabilityCurrent_1021a769-16bd-4e62-8443-b39c1e3ea379" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_5b289bda-c198-4ef1-959a-250925d38243" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_da3b9b98-5cfd-49f8-8d3a-cc2f56cd0ddb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vcel_LeaseLiabilityCurrent_1021a769-16bd-4e62-8443-b39c1e3ea379" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_da3b9b98-5cfd-49f8-8d3a-cc2f56cd0ddb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_RightOfUseAsset_4c4b727d-605f-4500-8c94-b2681dff65db" xlink:href="vcel-20200930.xsd#vcel_RightOfUseAsset"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_78423f85-aa82-4f5a-9a81-385791420edd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vcel_RightOfUseAsset_4c4b727d-605f-4500-8c94-b2681dff65db" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_78423f85-aa82-4f5a-9a81-385791420edd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_9813f54d-630e-4218-b226-c0ab00ce2ff9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vcel_RightOfUseAsset_4c4b727d-605f-4500-8c94-b2681dff65db" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_9813f54d-630e-4218-b226-c0ab00ce2ff9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="vcel-20200930.xsd#StockBasedCompensation"/>
  <link:calculationLink xlink:role="http://vcel.com/role/StockBasedCompensation" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="vcel-20200930.xsd#StockBasedCompensationTables"/>
  <link:calculationLink xlink:role="http://vcel.com/role/StockBasedCompensationTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#StockBasedCompensationNarrativeDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/StockBasedCompensationNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensationScheduleofnoncashstockbasedcompensationexpenseDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#StockBasedCompensationScheduleofnoncashstockbasedcompensationexpenseDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/StockBasedCompensationScheduleofnoncashstockbasedcompensationexpenseDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/CashEquivalentsandInvestments" xlink:type="simple" xlink:href="vcel-20200930.xsd#CashEquivalentsandInvestments"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CashEquivalentsandInvestments" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/CashEquivalentsandInvestmentsTables" xlink:type="simple" xlink:href="vcel-20200930.xsd#CashEquivalentsandInvestmentsTables"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CashEquivalentsandInvestmentsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/CashEquivalentsandInvestmentsDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#CashEquivalentsandInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CashEquivalentsandInvestmentsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="vcel-20200930.xsd#FairValueMeasurements"/>
  <link:calculationLink xlink:role="http://vcel.com/role/FairValueMeasurements" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="vcel-20200930.xsd#FairValueMeasurementsTables"/>
  <link:calculationLink xlink:role="http://vcel.com/role/FairValueMeasurementsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#FairValueMeasurementsDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_3ecdfdaf-f5ac-404e-ba94-923ddd13e18c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_32e03e5d-523f-4916-990a-a1d0c0cd9da6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_3ecdfdaf-f5ac-404e-ba94-923ddd13e18c" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_32e03e5d-523f-4916-990a-a1d0c0cd9da6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_e47bad4a-ae56-4d46-80a3-29918cbed51b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_3ecdfdaf-f5ac-404e-ba94-923ddd13e18c" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_e47bad4a-ae56-4d46-80a3-29918cbed51b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vcel.com/role/NetIncomeLossPerCommonShare" xlink:type="simple" xlink:href="vcel-20200930.xsd#NetIncomeLossPerCommonShare"/>
  <link:calculationLink xlink:role="http://vcel.com/role/NetIncomeLossPerCommonShare" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/NetIncomeLossPerCommonShareTables" xlink:type="simple" xlink:href="vcel-20200930.xsd#NetIncomeLossPerCommonShareTables"/>
  <link:calculationLink xlink:role="http://vcel.com/role/NetIncomeLossPerCommonShareTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/NetIncomeLossPerCommonShareDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#NetIncomeLossPerCommonShareDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/NetIncomeLossPerCommonShareDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/NexobridLicenseandSupplyAgreements" xlink:type="simple" xlink:href="vcel-20200930.xsd#NexobridLicenseandSupplyAgreements"/>
  <link:calculationLink xlink:role="http://vcel.com/role/NexobridLicenseandSupplyAgreements" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/NexobridLicenseandSupplyAgreementsDetails" xlink:type="simple" xlink:href="vcel-20200930.xsd#NexobridLicenseandSupplyAgreementsDetails"/>
  <link:calculationLink xlink:role="http://vcel.com/role/NexobridLicenseandSupplyAgreementsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://vcel.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="vcel-20200930.xsd#CommitmentsandContingencies"/>
  <link:calculationLink xlink:role="http://vcel.com/role/CommitmentsandContingencies" xlink:type="extended"/>
</link:linkbase>
