<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:f17d4925-6c3d-498e-872b-22f514715be2,g:94af1f4d-ee97-4cd6-95a3-119d31831d52-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://vcel.com/role/Cover" xlink:type="simple" xlink:href="vcel-20230331.xsd#Cover"/>
  <link:presentationLink xlink:role="http://vcel.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_879f509f-b6e1-46df-84c8-5f5a02023502" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_DocumentType_879f509f-b6e1-46df-84c8-5f5a02023502" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_ba4dd019-97f8-4222-bdf6-d5555192caa0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_DocumentQuarterlyReport_ba4dd019-97f8-4222-bdf6-d5555192caa0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_11691d5c-60cd-40b0-a5e8-ccf61f4d0ef3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_DocumentPeriodEndDate_11691d5c-60cd-40b0-a5e8-ccf61f4d0ef3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_51cb0933-7857-4b22-8666-082c0bd952ec" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_DocumentTransitionReport_51cb0933-7857-4b22-8666-082c0bd952ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_f63702a1-e337-4dcd-959b-5f1c3483e710" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityFileNumber_f63702a1-e337-4dcd-959b-5f1c3483e710" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_c4134ba6-5ba8-4648-8cf2-e73538214e9e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityRegistrantName_c4134ba6-5ba8-4648-8cf2-e73538214e9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_aff69472-d216-4cd5-b9b1-faccca9be9b8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityIncorporationStateCountryCode_aff69472-d216-4cd5-b9b1-faccca9be9b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_fc7c1ef4-9254-4b14-bbc6-697bd24e0fde" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityTaxIdentificationNumber_fc7c1ef4-9254-4b14-bbc6-697bd24e0fde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_1cbd64da-9c22-4b62-9184-d73f916818ca" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityAddressAddressLine1_1cbd64da-9c22-4b62-9184-d73f916818ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_2ad7d759-d549-4387-a50a-173b45b2ca63" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityAddressCityOrTown_2ad7d759-d549-4387-a50a-173b45b2ca63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_7c103129-1e9b-4f67-a17e-4978b65161ce" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityAddressStateOrProvince_7c103129-1e9b-4f67-a17e-4978b65161ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_6d1e1ed1-e0c0-4cdc-adae-6f66086c47be" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityAddressPostalZipCode_6d1e1ed1-e0c0-4cdc-adae-6f66086c47be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_cafd8c8d-c1b4-4217-beb4-8341464fdf28" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_CityAreaCode_cafd8c8d-c1b4-4217-beb4-8341464fdf28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_d3cc8e0a-a7f2-4848-ba0c-f8041eb1994b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_LocalPhoneNumber_d3cc8e0a-a7f2-4848-ba0c-f8041eb1994b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_90677ac7-8098-4e75-a35a-7b90b779dea8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_Security12bTitle_90677ac7-8098-4e75-a35a-7b90b779dea8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_e1c5996b-1962-4320-b62d-03eb9cc5c3c2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_TradingSymbol_e1c5996b-1962-4320-b62d-03eb9cc5c3c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_1d40b524-3490-45f1-8b5a-90c902cb3235" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_SecurityExchangeName_1d40b524-3490-45f1-8b5a-90c902cb3235" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_dc867655-e454-4e14-aa87-46ec9ba3b2e3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityCurrentReportingStatus_dc867655-e454-4e14-aa87-46ec9ba3b2e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_f2c458d1-490f-41cb-b5cd-ed8ea4b530e5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityInteractiveDataCurrent_f2c458d1-490f-41cb-b5cd-ed8ea4b530e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_79bb8901-c474-4229-b60e-1b18f4b3ae9c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityFilerCategory_79bb8901-c474-4229-b60e-1b18f4b3ae9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_7007fa2b-702f-4afe-acb4-daf34ab8ec7c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntitySmallBusiness_7007fa2b-702f-4afe-acb4-daf34ab8ec7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_21394a20-0415-413c-85b3-464bb51c0322" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityEmergingGrowthCompany_21394a20-0415-413c-85b3-464bb51c0322" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_16ccfa4d-064d-46fb-b41d-36214f7a485e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityShellCompany_16ccfa4d-064d-46fb-b41d-36214f7a485e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_9285f9b5-8eba-4b9b-8786-a7e25bc4128e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_9285f9b5-8eba-4b9b-8786-a7e25bc4128e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_0f8a87e5-4e2a-4b28-85e1-566cb981da16" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_EntityCentralIndexKey_0f8a87e5-4e2a-4b28-85e1-566cb981da16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_a2cfd6ea-94d2-40b6-b0b7-77702f06d4ef" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_CurrentFiscalYearEndDate_a2cfd6ea-94d2-40b6-b0b7-77702f06d4ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_53812560-5f89-4fcd-9af9-883dab6a9302" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_DocumentFiscalYearFocus_53812560-5f89-4fcd-9af9-883dab6a9302" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_523369f3-5c2b-41d8-945c-4d50bdd5f875" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_DocumentFiscalPeriodFocus_523369f3-5c2b-41d8-945c-4d50bdd5f875" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_7950151e-5367-4fb2-8ea6-f4d1635d9a2b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_73a0023c-408a-4338-b3c3-3e02bdecacf6" xlink:to="loc_dei_AmendmentFlag_7950151e-5367-4fb2-8ea6-f4d1635d9a2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="vcel-20230331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:presentationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_63b5fee8-df7b-4ceb-9c37-87c9e8c59485" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_35252896-e0b6-4770-8ef1-a976cf221fda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_63b5fee8-df7b-4ceb-9c37-87c9e8c59485" xlink:to="loc_us-gaap_AssetsAbstract_35252896-e0b6-4770-8ef1-a976cf221fda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_68014dbe-4bd8-4779-9ac9-4c4c11edb43d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_35252896-e0b6-4770-8ef1-a976cf221fda" xlink:to="loc_us-gaap_AssetsCurrentAbstract_68014dbe-4bd8-4779-9ac9-4c4c11edb43d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3003283a-9b4f-4372-b4ff-82f383d16fca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_68014dbe-4bd8-4779-9ac9-4c4c11edb43d" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3003283a-9b4f-4372-b4ff-82f383d16fca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_0b66ca72-654d-4095-bacf-4333caeaad42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_68014dbe-4bd8-4779-9ac9-4c4c11edb43d" xlink:to="loc_us-gaap_ShortTermInvestments_0b66ca72-654d-4095-bacf-4333caeaad42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_8c5a8e67-34fa-4447-ae94-2a8b3ea1e5aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_68014dbe-4bd8-4779-9ac9-4c4c11edb43d" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_8c5a8e67-34fa-4447-ae94-2a8b3ea1e5aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_9dcb1958-6fab-4d3a-9fad-605cd9bd3da4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_68014dbe-4bd8-4779-9ac9-4c4c11edb43d" xlink:to="loc_us-gaap_InventoryNet_9dcb1958-6fab-4d3a-9fad-605cd9bd3da4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_b6f4f9fa-b5c9-4dbb-ac8a-afcaf54958aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_68014dbe-4bd8-4779-9ac9-4c4c11edb43d" xlink:to="loc_us-gaap_OtherAssetsCurrent_b6f4f9fa-b5c9-4dbb-ac8a-afcaf54958aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_32d42de3-9c9e-446d-8eb3-826adcb1e881" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_68014dbe-4bd8-4779-9ac9-4c4c11edb43d" xlink:to="loc_us-gaap_AssetsCurrent_32d42de3-9c9e-446d-8eb3-826adcb1e881" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_0269a4fe-b087-42df-acf4-52836a08668c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_35252896-e0b6-4770-8ef1-a976cf221fda" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_0269a4fe-b087-42df-acf4-52836a08668c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_8b019c52-d22c-4955-99aa-c598907f4b8e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_35252896-e0b6-4770-8ef1-a976cf221fda" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_8b019c52-d22c-4955-99aa-c598907f4b8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_8a1a3e41-2c5d-494b-930e-11a2e45ea747" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_35252896-e0b6-4770-8ef1-a976cf221fda" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_8a1a3e41-2c5d-494b-930e-11a2e45ea747" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_71d9c1ba-245d-4b64-8d3a-925b8177b2e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_35252896-e0b6-4770-8ef1-a976cf221fda" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_71d9c1ba-245d-4b64-8d3a-925b8177b2e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_a03e1e01-034d-40ae-a081-9f5fb8d6dc5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_35252896-e0b6-4770-8ef1-a976cf221fda" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_a03e1e01-034d-40ae-a081-9f5fb8d6dc5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_7b4a789b-15e5-4aa6-bdb1-718a62fca65d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_35252896-e0b6-4770-8ef1-a976cf221fda" xlink:to="loc_us-gaap_Assets_7b4a789b-15e5-4aa6-bdb1-718a62fca65d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_12d13492-9e00-4754-8a53-8e6462ba65e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_63b5fee8-df7b-4ceb-9c37-87c9e8c59485" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_12d13492-9e00-4754-8a53-8e6462ba65e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_a5a667df-0c7c-4c00-8693-794ca878cdf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_12d13492-9e00-4754-8a53-8e6462ba65e9" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_a5a667df-0c7c-4c00-8693-794ca878cdf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_8dbe6c2e-144a-4112-8f11-bd29dcb1b20a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_a5a667df-0c7c-4c00-8693-794ca878cdf4" xlink:to="loc_us-gaap_AccountsPayableCurrent_8dbe6c2e-144a-4112-8f11-bd29dcb1b20a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_f4f664ad-a4e1-42cb-8bab-244ac2c809d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_a5a667df-0c7c-4c00-8693-794ca878cdf4" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_f4f664ad-a4e1-42cb-8bab-244ac2c809d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_ed4afb9c-59e5-4769-b268-d288eaf8a33a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_a5a667df-0c7c-4c00-8693-794ca878cdf4" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_ed4afb9c-59e5-4769-b268-d288eaf8a33a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_8305da7d-13c3-4dee-a5d5-e873a8c63266" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_a5a667df-0c7c-4c00-8693-794ca878cdf4" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_8305da7d-13c3-4dee-a5d5-e873a8c63266" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_73fb554d-c093-4cfd-a464-b70eeecc9655" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_a5a667df-0c7c-4c00-8693-794ca878cdf4" xlink:to="loc_us-gaap_LiabilitiesCurrent_73fb554d-c093-4cfd-a464-b70eeecc9655" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_25e6af26-2f16-40d8-9d93-7539e6897714" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_12d13492-9e00-4754-8a53-8e6462ba65e9" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_25e6af26-2f16-40d8-9d93-7539e6897714" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_f9828b13-6dd5-4ee4-bd6a-f98efdaf223f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_12d13492-9e00-4754-8a53-8e6462ba65e9" xlink:to="loc_us-gaap_Liabilities_f9828b13-6dd5-4ee4-bd6a-f98efdaf223f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_6f643f3d-5007-4731-92f0-a03d0ac9ed5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_12d13492-9e00-4754-8a53-8e6462ba65e9" xlink:to="loc_us-gaap_CommitmentsAndContingencies_6f643f3d-5007-4731-92f0-a03d0ac9ed5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_556080e6-70b5-4bcc-bcc5-e3d968fde835" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_12d13492-9e00-4754-8a53-8e6462ba65e9" xlink:to="loc_us-gaap_StockholdersEquityAbstract_556080e6-70b5-4bcc-bcc5-e3d968fde835" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_e3e38f90-fdb5-4043-aeab-ecab6f41126e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_556080e6-70b5-4bcc-bcc5-e3d968fde835" xlink:to="loc_us-gaap_CommonStockValue_e3e38f90-fdb5-4043-aeab-ecab6f41126e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_7b5efb09-c087-4e75-824e-8428b417ec9d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_556080e6-70b5-4bcc-bcc5-e3d968fde835" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_7b5efb09-c087-4e75-824e-8428b417ec9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_efdd33f8-2708-41da-9bca-67a88430e4aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_556080e6-70b5-4bcc-bcc5-e3d968fde835" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_efdd33f8-2708-41da-9bca-67a88430e4aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_a3f8a4ab-0934-4b98-9bd3-e5e73de70d36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_556080e6-70b5-4bcc-bcc5-e3d968fde835" xlink:to="loc_us-gaap_StockholdersEquity_a3f8a4ab-0934-4b98-9bd3-e5e73de70d36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_681b402d-2d45-47c5-8650-6f117300eb5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_12d13492-9e00-4754-8a53-8e6462ba65e9" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_681b402d-2d45-47c5-8650-6f117300eb5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="vcel-20230331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:presentationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_a5a6ef81-e547-41b6-9408-a1aa1409a46e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_197911a5-b028-406d-8d08-a473240ca6c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_a5a6ef81-e547-41b6-9408-a1aa1409a46e" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_197911a5-b028-406d-8d08-a473240ca6c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_84cf012b-6c38-4226-a9d4-3d3d793fbb5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_a5a6ef81-e547-41b6-9408-a1aa1409a46e" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_84cf012b-6c38-4226-a9d4-3d3d793fbb5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_a92aa538-a8de-4e42-84b8-6a16ae02b665" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_a5a6ef81-e547-41b6-9408-a1aa1409a46e" xlink:to="loc_us-gaap_CommonStockSharesIssued_a92aa538-a8de-4e42-84b8-6a16ae02b665" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_5a918334-14a0-4efa-b348-34af3aa24ea7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_a5a6ef81-e547-41b6-9408-a1aa1409a46e" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_5a918334-14a0-4efa-b348-34af3aa24ea7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="vcel-20230331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:presentationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRevenueExtensibleList_0c42d10e-f55b-4a7e-9179-8c2534b837f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfRevenueExtensibleList"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_TypeOfRevenueExtensibleList_0c42d10e-f55b-4a7e-9179-8c2534b837f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4a4daebe-ae53-4203-94ea-97986ba749bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4a4daebe-ae53-4203-94ea-97986ba749bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomerOther_a9166be0-1544-49f7-b87d-fb3f04bce6e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueNotFromContractWithCustomerOther"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomerOther_a9166be0-1544-49f7-b87d-fb3f04bce6e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_7a01ed28-dff3-4bed-8332-a64d7bf849cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_Revenues_7a01ed28-dff3-4bed-8332-a64d7bf849cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfCostGoodOrServiceExtensibleList_ad15694a-4e68-433d-a36c-334fe526e8c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfCostGoodOrServiceExtensibleList"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_TypeOfCostGoodOrServiceExtensibleList_ad15694a-4e68-433d-a36c-334fe526e8c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_61bb8cd1-1056-473f-9d36-c4a580392e97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_61bb8cd1-1056-473f-9d36-c4a580392e97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_a9bfbeb5-508e-4ecf-b334-105d19eee776" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_GrossProfit_a9bfbeb5-508e-4ecf-b334-105d19eee776" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_16dd1b3c-74c0-4cf4-8bb0-6017d16d661c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_16dd1b3c-74c0-4cf4-8bb0-6017d16d661c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ba61635d-e74a-4f4e-9456-b5bde875e39f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ba61635d-e74a-4f4e-9456-b5bde875e39f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_6b6c7305-4779-4e73-bca4-e3e059f89f59" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_OperatingExpenses_6b6c7305-4779-4e73-bca4-e3e059f89f59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_639f4153-b12f-452e-960e-bd57c310589d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_OperatingIncomeLoss_639f4153-b12f-452e-960e-bd57c310589d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_93eee0b8-cd3e-46e5-878e-02accc212aaf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_93eee0b8-cd3e-46e5-878e-02accc212aaf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_74c9c8ab-d504-4147-995c-9632473224e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_93eee0b8-cd3e-46e5-878e-02accc212aaf" xlink:to="loc_us-gaap_InvestmentIncomeInterest_74c9c8ab-d504-4147-995c-9632473224e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_2d7ce4ad-1392-4909-a3f7-de2091afbd88" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_93eee0b8-cd3e-46e5-878e-02accc212aaf" xlink:to="loc_us-gaap_InterestExpense_2d7ce4ad-1392-4909-a3f7-de2091afbd88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_7fdb950f-8577-41b5-abc3-72212cf5b971" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_93eee0b8-cd3e-46e5-878e-02accc212aaf" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_7fdb950f-8577-41b5-abc3-72212cf5b971" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_53cd7987-2bf0-4841-bde1-577179f445ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_93eee0b8-cd3e-46e5-878e-02accc212aaf" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_53cd7987-2bf0-4841-bde1-577179f445ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_13dff020-04af-45c7-abc4-82afbd9a59be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_NetIncomeLoss_13dff020-04af-45c7-abc4-82afbd9a59be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_a56c56bc-d77f-4bdd-a5ea-468699a208df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_EarningsPerShareAbstract_a56c56bc-d77f-4bdd-a5ea-468699a208df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_6b5a92da-7d21-4e61-9b6d-6c2db09607cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_a56c56bc-d77f-4bdd-a5ea-468699a208df" xlink:to="loc_us-gaap_EarningsPerShareBasic_6b5a92da-7d21-4e61-9b6d-6c2db09607cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_bb4817db-f833-450e-b60d-0ebb2ccb42d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_a56c56bc-d77f-4bdd-a5ea-468699a208df" xlink:to="loc_us-gaap_EarningsPerShareDiluted_bb4817db-f833-450e-b60d-0ebb2ccb42d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_3da25f7a-95f4-4d50-b87e-a95b5d86e29b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_15153d53-46a0-45d4-89b2-9edad2820e8a" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_3da25f7a-95f4-4d50-b87e-a95b5d86e29b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_9c0fd1ef-366c-4b00-8286-851e567afd8b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_3da25f7a-95f4-4d50-b87e-a95b5d86e29b" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_9c0fd1ef-366c-4b00-8286-851e567afd8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ba953de0-3301-4e1d-ae2f-befcfd98028b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_3da25f7a-95f4-4d50-b87e-a95b5d86e29b" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ba953de0-3301-4e1d-ae2f-befcfd98028b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="vcel-20230331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS"/>
  <link:presentationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_778bc8e9-3552-4c31-bb25-676410d49ead" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_45472834-b9fe-48f3-9dd5-e1d6bc112733" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_778bc8e9-3552-4c31-bb25-676410d49ead" xlink:to="loc_us-gaap_NetIncomeLoss_45472834-b9fe-48f3-9dd5-e1d6bc112733" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_94b3cd36-5c94-4aa6-87d1-cba90612a48c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_778bc8e9-3552-4c31-bb25-676410d49ead" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_94b3cd36-5c94-4aa6-87d1-cba90612a48c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_9126c34f-846b-4e63-9674-d5bcdb095435" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_94b3cd36-5c94-4aa6-87d1-cba90612a48c" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_9126c34f-846b-4e63-9674-d5bcdb095435" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_ccdf9801-067c-4958-9c95-9ba60c46253f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_778bc8e9-3552-4c31-bb25-676410d49ead" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_ccdf9801-067c-4958-9c95-9ba60c46253f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="simple" xlink:href="vcel-20230331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY"/>
  <link:presentationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_8c235dd6-d60b-452d-91a2-dd9310a284e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_8d19e7e8-dc14-4cae-b1c0-6cee287e3d00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_8c235dd6-d60b-452d-91a2-dd9310a284e0" xlink:to="loc_us-gaap_StatementTable_8d19e7e8-dc14-4cae-b1c0-6cee287e3d00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_e554d28b-30a1-47f6-ab4b-9bcd3524e9c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_8d19e7e8-dc14-4cae-b1c0-6cee287e3d00" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_e554d28b-30a1-47f6-ab4b-9bcd3524e9c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_a724758a-1a7a-442a-b524-f7ffd10f417e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_e554d28b-30a1-47f6-ab4b-9bcd3524e9c7" xlink:to="loc_us-gaap_EquityComponentDomain_a724758a-1a7a-442a-b524-f7ffd10f417e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_ba934c23-57db-46f2-a497-4fcdb2d7e544" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_a724758a-1a7a-442a-b524-f7ffd10f417e" xlink:to="loc_us-gaap_CommonStockMember_ba934c23-57db-46f2-a497-4fcdb2d7e544" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_0db93503-05fa-4715-9b9a-116a19eb45d7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_a724758a-1a7a-442a-b524-f7ffd10f417e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_0db93503-05fa-4715-9b9a-116a19eb45d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_c6bc4ae3-556a-4f40-952f-409befbb531a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_a724758a-1a7a-442a-b524-f7ffd10f417e" xlink:to="loc_us-gaap_RetainedEarningsMember_c6bc4ae3-556a-4f40-952f-409befbb531a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_24700047-352d-4ece-9cd5-c71857c8387a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_8d19e7e8-dc14-4cae-b1c0-6cee287e3d00" xlink:to="loc_us-gaap_StatementLineItems_24700047-352d-4ece-9cd5-c71857c8387a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_24700047-352d-4ece-9cd5-c71857c8387a" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_b5a1c63e-21e6-40e6-b5d5-69e5040fa093" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_b5a1c63e-21e6-40e6-b5d5-69e5040fa093" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_009c4a62-6f93-4783-b601-8585411dab1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_StockholdersEquity_009c4a62-6f93-4783-b601-8585411dab1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_4f374994-4242-438d-88cb-9e2c0a3e4506" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_NetIncomeLoss_4f374994-4242-438d-88cb-9e2c0a3e4506" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_dd74cf26-54bd-48a7-9f02-842d584ca94f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_dd74cf26-54bd-48a7-9f02-842d584ca94f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_15478022-f8c8-45f7-9ee0-10dcc25c7359" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_15478022-f8c8-45f7-9ee0-10dcc25c7359" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_a2ed3592-91f4-46be-a757-9b7f1ac99af1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_a2ed3592-91f4-46be-a757-9b7f1ac99af1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_5b3f16cf-fe4b-4270-b267-96d7a8170777" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_5b3f16cf-fe4b-4270-b267-96d7a8170777" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_1d332a11-e519-40ac-b680-076ce6c81481" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_1d332a11-e519-40ac-b680-076ce6c81481" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_7b68b91f-969b-44f9-87cb-bfa31b106724" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_7b68b91f-969b-44f9-87cb-bfa31b106724" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_56065c97-9a8d-4d32-95d2-cb25b9281283" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_56065c97-9a8d-4d32-95d2-cb25b9281283" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_46591343-53a9-483b-a4ee-933249f68494" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_46591343-53a9-483b-a4ee-933249f68494" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_e77cb017-05b2-4f48-8c5e-72e5b5f5a26a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_e77cb017-05b2-4f48-8c5e-72e5b5f5a26a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_03a6b899-ddb9-4441-87ad-b46672e65b4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_03a6b899-ddb9-4441-87ad-b46672e65b4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_81247bb9-c651-4273-879f-76f73c695b6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6c9c7eb8-6227-4c57-be41-2c7288d01a8e" xlink:to="loc_us-gaap_StockholdersEquity_81247bb9-c651-4273-879f-76f73c695b6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="vcel-20230331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:presentationLink xlink:role="http://vcel.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_99610c53-aa01-45cb-9850-47571cc21a32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_b4fe7f82-651d-49bf-bc9b-4b2e28ce78e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_99610c53-aa01-45cb-9850-47571cc21a32" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_b4fe7f82-651d-49bf-bc9b-4b2e28ce78e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_f5354da7-ac8a-4d0f-b310-129f322b1ffd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_b4fe7f82-651d-49bf-bc9b-4b2e28ce78e1" xlink:to="loc_us-gaap_NetIncomeLoss_f5354da7-ac8a-4d0f-b310-129f322b1ffd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_c4e03102-6543-4201-9433-83f4879f62c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_b4fe7f82-651d-49bf-bc9b-4b2e28ce78e1" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_c4e03102-6543-4201-9433-83f4879f62c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_8ae0f87a-eff7-4eb7-9774-9664451e08ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_c4e03102-6543-4201-9433-83f4879f62c9" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_8ae0f87a-eff7-4eb7-9774-9664451e08ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_cd345a68-cde3-4285-a4f6-4e3f8e9ff5c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_c4e03102-6543-4201-9433-83f4879f62c9" xlink:to="loc_us-gaap_ShareBasedCompensation_cd345a68-cde3-4285-a4f6-4e3f8e9ff5c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_558293d3-5ae0-47c7-a3df-ff45d90821f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_c4e03102-6543-4201-9433-83f4879f62c9" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_558293d3-5ae0-47c7-a3df-ff45d90821f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_bf32ffa0-9366-4889-b2a5-19549da49bdf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_c4e03102-6543-4201-9433-83f4879f62c9" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_bf32ffa0-9366-4889-b2a5-19549da49bdf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_abc9c48f-b451-4aa5-8aaf-b75f8dc3b31e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_c4e03102-6543-4201-9433-83f4879f62c9" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_abc9c48f-b451-4aa5-8aaf-b75f8dc3b31e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_22bb186f-8d93-42d7-b602-4462059e8b3b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_c4e03102-6543-4201-9433-83f4879f62c9" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_22bb186f-8d93-42d7-b602-4462059e8b3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9af68cde-2920-4d5a-afed-aefef6bc77bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_c4e03102-6543-4201-9433-83f4879f62c9" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9af68cde-2920-4d5a-afed-aefef6bc77bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_acaf1c7b-abb4-4a99-b6b6-2752e8c20c4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9af68cde-2920-4d5a-afed-aefef6bc77bc" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_acaf1c7b-abb4-4a99-b6b6-2752e8c20c4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_5983d58d-7f56-4da9-b0b0-27c197bf3410" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInReceivables"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9af68cde-2920-4d5a-afed-aefef6bc77bc" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_5983d58d-7f56-4da9-b0b0-27c197bf3410" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_6f39f7ef-a3ac-4798-895e-d8ee05a30d0e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherCurrentAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9af68cde-2920-4d5a-afed-aefef6bc77bc" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_6f39f7ef-a3ac-4798-895e-d8ee05a30d0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_44ad1813-2501-41f6-b51a-f0d23184de59" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9af68cde-2920-4d5a-afed-aefef6bc77bc" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_44ad1813-2501-41f6-b51a-f0d23184de59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_b9b9a8f8-9ff4-49f2-8532-894e85ad4665" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9af68cde-2920-4d5a-afed-aefef6bc77bc" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_b9b9a8f8-9ff4-49f2-8532-894e85ad4665" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_IncreaseDecreaseInLeaseLiabilities_b7604b8e-7b27-4175-a5fb-d036efe35cf6" xlink:href="vcel-20230331.xsd#vcel_IncreaseDecreaseInLeaseLiabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9af68cde-2920-4d5a-afed-aefef6bc77bc" xlink:to="loc_vcel_IncreaseDecreaseInLeaseLiabilities_b7604b8e-7b27-4175-a5fb-d036efe35cf6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f15c6963-cdac-48bc-b642-aafe9049b843" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_b4fe7f82-651d-49bf-bc9b-4b2e28ce78e1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f15c6963-cdac-48bc-b642-aafe9049b843" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_5188fbc2-1d7d-48ef-b10d-a295bbd9eb02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_99610c53-aa01-45cb-9850-47571cc21a32" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_5188fbc2-1d7d-48ef-b10d-a295bbd9eb02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_c7a1b1e9-6cae-4984-9b23-745e04b747e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_5188fbc2-1d7d-48ef-b10d-a295bbd9eb02" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_c7a1b1e9-6cae-4984-9b23-745e04b747e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_c9e5dedc-deee-489c-99b9-9a9aab776dab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_5188fbc2-1d7d-48ef-b10d-a295bbd9eb02" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_c9e5dedc-deee-489c-99b9-9a9aab776dab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_06e2ca9b-4d20-45b8-a2f6-63520a9ce366" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_5188fbc2-1d7d-48ef-b10d-a295bbd9eb02" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_06e2ca9b-4d20-45b8-a2f6-63520a9ce366" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_b7fccb1f-b6af-42a5-9c90-3b05151653c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireIntangibleAssets"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_5188fbc2-1d7d-48ef-b10d-a295bbd9eb02" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_b7fccb1f-b6af-42a5-9c90-3b05151653c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b190be8f-4f94-402c-952e-c6ddeb3582bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_5188fbc2-1d7d-48ef-b10d-a295bbd9eb02" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b190be8f-4f94-402c-952e-c6ddeb3582bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_1e74c68f-96ce-4085-8fda-3c739c06c0fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_99610c53-aa01-45cb-9850-47571cc21a32" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_1e74c68f-96ce-4085-8fda-3c739c06c0fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_4c8d86e8-0f95-4005-b892-515fb3145cc1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_1e74c68f-96ce-4085-8fda-3c739c06c0fc" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_4c8d86e8-0f95-4005-b892-515fb3145cc1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_0aada281-f20a-4013-8e95-ecacb2bcaa5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_1e74c68f-96ce-4085-8fda-3c739c06c0fc" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_0aada281-f20a-4013-8e95-ecacb2bcaa5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_ae702f45-18fd-409f-9d1a-447963a1bc85" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_1e74c68f-96ce-4085-8fda-3c739c06c0fc" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_ae702f45-18fd-409f-9d1a-447963a1bc85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4fb9e99a-2673-4b21-b2c1-116946d89796" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_1e74c68f-96ce-4085-8fda-3c739c06c0fc" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4fb9e99a-2673-4b21-b2c1-116946d89796" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_259ed564-f84e-4b82-b5e3-4bf50f5acc47" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_99610c53-aa01-45cb-9850-47571cc21a32" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_259ed564-f84e-4b82-b5e3-4bf50f5acc47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_61a682bd-a211-4828-82f6-1198df00e840" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_99610c53-aa01-45cb-9850-47571cc21a32" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_61a682bd-a211-4828-82f6-1198df00e840" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_acf20dae-ce79-4cab-a686-d1b299dece9d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_99610c53-aa01-45cb-9850-47571cc21a32" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_acf20dae-ce79-4cab-a686-d1b299dece9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_143086c3-b1dc-4389-947c-35ec39fabb65" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_99610c53-aa01-45cb-9850-47571cc21a32" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_143086c3-b1dc-4389-947c-35ec39fabb65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_cdb1eeb9-2bcd-46c0-ad74-a2cbc93b1256" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_143086c3-b1dc-4389-947c-35ec39fabb65" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_cdb1eeb9-2bcd-46c0-ad74-a2cbc93b1256" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_493bf755-712a-4347-951b-62fde1173845" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalExpendituresIncurredButNotYetPaid"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_143086c3-b1dc-4389-947c-35ec39fabb65" xlink:to="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_493bf755-712a-4347-951b-62fde1173845" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_RestrictedStockHeldForEmployeeTaxRemittanceIncludedInAccountsPayable_d11f0757-e084-4c53-b6c0-e29776a22aa6" xlink:href="vcel-20230331.xsd#vcel_RestrictedStockHeldForEmployeeTaxRemittanceIncludedInAccountsPayable"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_143086c3-b1dc-4389-947c-35ec39fabb65" xlink:to="loc_vcel_RestrictedStockHeldForEmployeeTaxRemittanceIncludedInAccountsPayable_d11f0757-e084-4c53-b6c0-e29776a22aa6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAbstract_3ac8d77e-7616-45a6-a6b2-c3d14de77448" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_99610c53-aa01-45cb-9850-47571cc21a32" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAbstract_3ac8d77e-7616-45a6-a6b2-c3d14de77448" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6927aac2-5902-4d1e-8362-6cc336e8df58" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAbstract_3ac8d77e-7616-45a6-a6b2-c3d14de77448" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_6927aac2-5902-4d1e-8362-6cc336e8df58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_d242561e-280e-4726-b89b-63940374ddc7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAbstract_3ac8d77e-7616-45a6-a6b2-c3d14de77448" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_d242561e-280e-4726-b89b-63940374ddc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_edd02eb7-a64c-423e-95a0-31e0098e31d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsAbstract_3ac8d77e-7616-45a6-a6b2-c3d14de77448" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_edd02eb7-a64c-423e-95a0-31e0098e31d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/Organization" xlink:type="simple" xlink:href="vcel-20230331.xsd#Organization"/>
  <link:presentationLink xlink:role="http://vcel.com/role/Organization" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_20fd5bad-38d2-4dad-8519-5bc903aadf2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NatureOfOperations_0f991fd9-1c28-4162-bced-8fbbb45dc190" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NatureOfOperations"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_20fd5bad-38d2-4dad-8519-5bc903aadf2d" xlink:to="loc_us-gaap_NatureOfOperations_0f991fd9-1c28-4162-bced-8fbbb45dc190" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/BasisofPresentation" xlink:type="simple" xlink:href="vcel-20230331.xsd#BasisofPresentation"/>
  <link:presentationLink xlink:role="http://vcel.com/role/BasisofPresentation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_0458569d-a83f-4d18-b786-ed9a8968e7d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfAccounting_0bf45af7-b04b-4ad7-a280-9a6ba595a50a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BasisOfAccounting"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_0458569d-a83f-4d18-b786-ed9a8968e7d0" xlink:to="loc_us-gaap_BasisOfAccounting_0bf45af7-b04b-4ad7-a280-9a6ba595a50a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/Revenue" xlink:type="simple" xlink:href="vcel-20230331.xsd#Revenue"/>
  <link:presentationLink xlink:role="http://vcel.com/role/Revenue" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_620e8df2-a4dd-4542-b4f2-35f0af37e9c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RisksAndUncertaintiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_ee4e6299-c22a-4ef7-a4ee-3079b152741a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_620e8df2-a4dd-4542-b4f2-35f0af37e9c7" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_ee4e6299-c22a-4ef7-a4ee-3079b152741a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponents" xlink:type="simple" xlink:href="vcel-20230331.xsd#SelectedBalanceSheetComponents"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponents" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_ab607e61-0429-439f-a826-d72841418a9d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_2a1bd850-c98e-46bb-ac08-a57324d24066" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_ab607e61-0429-439f-a826-d72841418a9d" xlink:to="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_2a1bd850-c98e-46bb-ac08-a57324d24066" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/Leases" xlink:type="simple" xlink:href="vcel-20230331.xsd#Leases"/>
  <link:presentationLink xlink:role="http://vcel.com/role/Leases" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_ed5fb77f-601e-4004-865b-a8606169b32f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeasesTextBlock_58140259-caf9-45c2-8053-e358870e8c25" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeasesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_ed5fb77f-601e-4004-865b-a8606169b32f" xlink:to="loc_us-gaap_LesseeOperatingLeasesTextBlock_58140259-caf9-45c2-8053-e358870e8c25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeFinanceLeasesTextBlock_895d92d2-51db-49c8-9c30-0bbb64da57bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeFinanceLeasesTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_ed5fb77f-601e-4004-865b-a8606169b32f" xlink:to="loc_us-gaap_LesseeFinanceLeasesTextBlock_895d92d2-51db-49c8-9c30-0bbb64da57bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/RevolvingCreditAgreement" xlink:type="simple" xlink:href="vcel-20230331.xsd#RevolvingCreditAgreement"/>
  <link:presentationLink xlink:role="http://vcel.com/role/RevolvingCreditAgreement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_25768ec8-6f8a-4223-8bc1-347558ee43f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_87e0ff64-ae3e-4ae7-ad23-2f31cd99f042" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_25768ec8-6f8a-4223-8bc1-347558ee43f6" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_87e0ff64-ae3e-4ae7-ad23-2f31cd99f042" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="vcel-20230331.xsd#StockBasedCompensation"/>
  <link:presentationLink xlink:role="http://vcel.com/role/StockBasedCompensation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_dbaba514-6afc-49a2-ac61-47a8a31c7d9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_1d81b9da-1593-41df-9b0e-c723282f96fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_dbaba514-6afc-49a2-ac61-47a8a31c7d9f" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_1d81b9da-1593-41df-9b0e-c723282f96fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/Investments" xlink:type="simple" xlink:href="vcel-20230331.xsd#Investments"/>
  <link:presentationLink xlink:role="http://vcel.com/role/Investments" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_69469c9b-df01-4cd0-bd54-335ebae4fcb5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_aad8bcc8-f558-4f0f-bbb8-47a361e78d77" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_69469c9b-df01-4cd0-bd54-335ebae4fcb5" xlink:to="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_aad8bcc8-f558-4f0f-bbb8-47a361e78d77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="vcel-20230331.xsd#FairValueMeasurements"/>
  <link:presentationLink xlink:role="http://vcel.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_5485701b-8161-4bd6-99c4-c216a3775150" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_6ea51bbf-c845-4f59-b55b-ae5f505094c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_5485701b-8161-4bd6-99c4-c216a3775150" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_6ea51bbf-c845-4f59-b55b-ae5f505094c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/NetLossPerCommonShare" xlink:type="simple" xlink:href="vcel-20230331.xsd#NetLossPerCommonShare"/>
  <link:presentationLink xlink:role="http://vcel.com/role/NetLossPerCommonShare" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_b0125942-ea87-4e49-b49d-c4d583222f1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_30a9f089-c5d5-4de8-a255-a890d52270af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_b0125942-ea87-4e49-b49d-c4d583222f1b" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_30a9f089-c5d5-4de8-a255-a890d52270af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/NexoBridLicenseandSupplyAgreements" xlink:type="simple" xlink:href="vcel-20230331.xsd#NexoBridLicenseandSupplyAgreements"/>
  <link:presentationLink xlink:role="http://vcel.com/role/NexoBridLicenseandSupplyAgreements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_631b14bc-f5df-4640-89a4-a8d61efde176" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LicenseAgreementTextBlock_426633d5-6556-4e96-81eb-6111bf29cddf" xlink:href="vcel-20230331.xsd#vcel_LicenseAgreementTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_631b14bc-f5df-4640-89a4-a8d61efde176" xlink:to="loc_vcel_LicenseAgreementTextBlock_426633d5-6556-4e96-81eb-6111bf29cddf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="vcel-20230331.xsd#CommitmentsandContingencies"/>
  <link:presentationLink xlink:role="http://vcel.com/role/CommitmentsandContingencies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_5ee75d03-9497-468f-a1ab-58b57da156f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_6f121b63-5f78-4f3c-9402-02374b96be24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_5ee75d03-9497-468f-a1ab-58b57da156f0" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_6f121b63-5f78-4f3c-9402-02374b96be24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SubsequentEvents" xlink:type="simple" xlink:href="vcel-20230331.xsd#SubsequentEvents"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SubsequentEvents" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsAbstract_f96593f1-6ec5-4740-807e-7881ef798ddc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_85af0291-8d5c-4f14-bd36-8b3e5b6816f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_f96593f1-6ec5-4740-807e-7881ef798ddc" xlink:to="loc_us-gaap_SubsequentEventsTextBlock_85af0291-8d5c-4f14-bd36-8b3e5b6816f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/BasisofPresentationPolicies" xlink:type="simple" xlink:href="vcel-20230331.xsd#BasisofPresentationPolicies"/>
  <link:presentationLink xlink:role="http://vcel.com/role/BasisofPresentationPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_ff7ee414-21f4-40a1-82b1-9d0c4d7c5b19" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk_a313293e-d9ed-4ee8-b5d4-8d5a24ff303c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskCreditRisk"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_ff7ee414-21f4-40a1-82b1-9d0c4d7c5b19" xlink:to="loc_us-gaap_ConcentrationRiskCreditRisk_a313293e-d9ed-4ee8-b5d4-8d5a24ff303c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_00637e38-049d-4d53-ab73-e5628330ce67" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_ff7ee414-21f4-40a1-82b1-9d0c4d7c5b19" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_00637e38-049d-4d53-ab73-e5628330ce67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/RevenueTables" xlink:type="simple" xlink:href="vcel-20230331.xsd#RevenueTables"/>
  <link:presentationLink xlink:role="http://vcel.com/role/RevenueTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_7bacd00e-de9f-4fb9-9528-9cd07b245d7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RisksAndUncertaintiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_0729bab6-59f9-4426-8616-c4ac43d1d243" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_7bacd00e-de9f-4fb9-9528-9cd07b245d7e" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_0729bab6-59f9-4426-8616-c4ac43d1d243" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsTables" xlink:type="simple" xlink:href="vcel-20230331.xsd#SelectedBalanceSheetComponentsTables"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_d165bd8d-e3b2-4ef0-89d0-443e51310009" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_125b9cda-5881-49f7-89e4-a5279eff262c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_d165bd8d-e3b2-4ef0-89d0-443e51310009" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_125b9cda-5881-49f7-89e4-a5279eff262c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_bdf72a4f-ef3e-4b1b-9307-ec5cf491080b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_d165bd8d-e3b2-4ef0-89d0-443e51310009" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_bdf72a4f-ef3e-4b1b-9307-ec5cf491080b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock_d45949fd-c0f8-40ee-9e67-08d0dc7764bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_d165bd8d-e3b2-4ef0-89d0-443e51310009" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock_d45949fd-c0f8-40ee-9e67-08d0dc7764bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_28c82f29-18b2-4eab-8721-bf40bb2abe23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_d165bd8d-e3b2-4ef0-89d0-443e51310009" xlink:to="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_28c82f29-18b2-4eab-8721-bf40bb2abe23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_24d5cbfb-b1e1-4118-a521-44ecc0375668" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_d165bd8d-e3b2-4ef0-89d0-443e51310009" xlink:to="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_24d5cbfb-b1e1-4118-a521-44ecc0375668" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/LeasesTables" xlink:type="simple" xlink:href="vcel-20230331.xsd#LeasesTables"/>
  <link:presentationLink xlink:role="http://vcel.com/role/LeasesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_7b48d296-3556-4c0b-89b2-829144b9dae5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_AssetsAndLiabilitiesLeasesTableTextBlock_33b34999-f5cd-4f1d-83b7-34715dc0ceeb" xlink:href="vcel-20230331.xsd#vcel_AssetsAndLiabilitiesLeasesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_7b48d296-3556-4c0b-89b2-829144b9dae5" xlink:to="loc_vcel_AssetsAndLiabilitiesLeasesTableTextBlock_33b34999-f5cd-4f1d-83b7-34715dc0ceeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="vcel-20230331.xsd#StockBasedCompensationTables"/>
  <link:presentationLink xlink:role="http://vcel.com/role/StockBasedCompensationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_5d45899a-82fe-4624-939c-756931647561" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_2b1cbcda-9f75-4785-bff6-bc49ae76b6a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_5d45899a-82fe-4624-939c-756931647561" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_2b1cbcda-9f75-4785-bff6-bc49ae76b6a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/InvestmentsTables" xlink:type="simple" xlink:href="vcel-20230331.xsd#InvestmentsTables"/>
  <link:presentationLink xlink:role="http://vcel.com/role/InvestmentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_76e40852-8397-44a9-9b40-9ebd235fa7de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_95ecd92e-8bd9-4b4b-93e9-7708fd2c0939" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_76e40852-8397-44a9-9b40-9ebd235fa7de" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_95ecd92e-8bd9-4b4b-93e9-7708fd2c0939" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="vcel-20230331.xsd#FairValueMeasurementsTables"/>
  <link:presentationLink xlink:role="http://vcel.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_9c27f9ff-9c96-457b-9c1c-fc726b983789" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_73791528-6470-4dfa-8215-6ac9580b6267" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_9c27f9ff-9c96-457b-9c1c-fc726b983789" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_73791528-6470-4dfa-8215-6ac9580b6267" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/NetLossPerCommonShareTables" xlink:type="simple" xlink:href="vcel-20230331.xsd#NetLossPerCommonShareTables"/>
  <link:presentationLink xlink:role="http://vcel.com/role/NetLossPerCommonShareTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_7db6c419-5844-4f00-822a-e2e37f84d5d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_3a7dee90-6c46-4b43-8e94-ff5da9f7761b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_7db6c419-5844-4f00-822a-e2e37f84d5d2" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_3a7dee90-6c46-4b43-8e94-ff5da9f7761b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/OrganizationDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#OrganizationDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/OrganizationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_7f074e7b-8dec-4269-bda0-a6907c0f0c12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_NumberOfProducts_d21b6163-207e-45c8-a23b-ac654621d74c" xlink:href="vcel-20230331.xsd#vcel_NumberOfProducts"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_7f074e7b-8dec-4269-bda0-a6907c0f0c12" xlink:to="loc_vcel_NumberOfProducts_d21b6163-207e-45c8-a23b-ac654621d74c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_fa07a279-46de-4ca3-a599-94cd3fda95d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_7f074e7b-8dec-4269-bda0-a6907c0f0c12" xlink:to="loc_us-gaap_NumberOfReportableSegments_fa07a279-46de-4ca3-a599-94cd3fda95d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_cdab549d-c231-47af-a763-9da9df528ab5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_7f074e7b-8dec-4269-bda0-a6907c0f0c12" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_cdab549d-c231-47af-a763-9da9df528ab5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d5740a8a-7f9b-45c5-9523-8cac0b8ff59b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_7f074e7b-8dec-4269-bda0-a6907c0f0c12" xlink:to="loc_us-gaap_NetIncomeLoss_d5740a8a-7f9b-45c5-9523-8cac0b8ff59b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_753d2580-38b2-459e-952a-a70644ba44cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_7f074e7b-8dec-4269-bda0-a6907c0f0c12" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_753d2580-38b2-459e-952a-a70644ba44cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Investments_603a0757-ce94-42b3-919e-038ea49c0461" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Investments"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_7f074e7b-8dec-4269-bda0-a6907c0f0c12" xlink:to="loc_us-gaap_Investments_603a0757-ce94-42b3-919e-038ea49c0461" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/RevenueNarrativeDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#RevenueNarrativeDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/RevenueNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_7e84d12c-4bda-4f75-a72b-f1c779156ca7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RisksAndUncertaintiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_ee00fc9a-d782-408b-a41d-42eedd32585e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_7e84d12c-4bda-4f75-a72b-f1c779156ca7" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_ee00fc9a-d782-408b-a41d-42eedd32585e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_4a65b5b0-ffdc-4f3d-8345-1184c5279828" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_ee00fc9a-d782-408b-a41d-42eedd32585e" xlink:to="loc_srt_CounterpartyNameAxis_4a65b5b0-ffdc-4f3d-8345-1184c5279828" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b735303e-1114-4f3d-bfc7-51f1e209a2d9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_4a65b5b0-ffdc-4f3d-8345-1184c5279828" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b735303e-1114-4f3d-bfc7-51f1e209a2d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_MediWoundLtdMember_596a24f7-1dd7-4c72-99ca-483a6d077bc6" xlink:href="vcel-20230331.xsd#vcel_MediWoundLtdMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b735303e-1114-4f3d-bfc7-51f1e209a2d9" xlink:to="loc_vcel_MediWoundLtdMember_596a24f7-1dd7-4c72-99ca-483a6d077bc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_3be8572c-9540-4db5-a16e-713b7942bf45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_ee00fc9a-d782-408b-a41d-42eedd32585e" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_3be8572c-9540-4db5-a16e-713b7942bf45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_4d631665-9243-40be-9de6-ac0507d0aa2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_3be8572c-9540-4db5-a16e-713b7942bf45" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_4d631665-9243-40be-9de6-ac0507d0aa2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_8d2ac205-d809-4538-89c4-7b09d136be43" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_4d631665-9243-40be-9de6-ac0507d0aa2a" xlink:to="loc_us-gaap_SubsequentEventMember_8d2ac205-d809-4538-89c4-7b09d136be43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_1321ebb7-b606-40df-821d-6d86df8f3672" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_ee00fc9a-d782-408b-a41d-42eedd32585e" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_1321ebb7-b606-40df-821d-6d86df8f3672" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_NumberOfContractedSpecialtyPharmacies_968726c6-092b-4e0e-aa4d-f98fcc4620e9" xlink:href="vcel-20230331.xsd#vcel_NumberOfContractedSpecialtyPharmacies"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_1321ebb7-b606-40df-821d-6d86df8f3672" xlink:to="loc_vcel_NumberOfContractedSpecialtyPharmacies_968726c6-092b-4e0e-aa4d-f98fcc4620e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulOtherReceivablesCurrent_74365f63-477f-4bf1-ae13-8fb85ca54305" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllowanceForDoubtfulOtherReceivablesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_1321ebb7-b606-40df-821d-6d86df8f3672" xlink:to="loc_us-gaap_AllowanceForDoubtfulOtherReceivablesCurrent_74365f63-477f-4bf1-ae13-8fb85ca54305" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_RevenueRevenueRecognizedChangeinUncollectibleAnalysisPercentage_c85039c1-1b5f-43dd-97f3-d877d58a15c4" xlink:href="vcel-20230331.xsd#vcel_RevenueRevenueRecognizedChangeinUncollectibleAnalysisPercentage"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_1321ebb7-b606-40df-821d-6d86df8f3672" xlink:to="loc_vcel_RevenueRevenueRecognizedChangeinUncollectibleAnalysisPercentage_c85039c1-1b5f-43dd-97f3-d877d58a15c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_RevenueRevenueRecognizedEffectOf0.5ChangeInTheEstimatedUncollectiblePercentageAmount_daf33926-ddef-49b7-8cc9-641086ad82c3" xlink:href="vcel-20230331.xsd#vcel_RevenueRevenueRecognizedEffectOf0.5ChangeInTheEstimatedUncollectiblePercentageAmount"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_1321ebb7-b606-40df-821d-6d86df8f3672" xlink:to="loc_vcel_RevenueRevenueRecognizedEffectOf0.5ChangeInTheEstimatedUncollectiblePercentageAmount_daf33926-ddef-49b7-8cc9-641086ad82c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LicenseAgreementAdditionalFunding_74dc6369-5147-480b-9531-825f5e44ec42" xlink:href="vcel-20230331.xsd#vcel_LicenseAgreementAdditionalFunding"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_1321ebb7-b606-40df-821d-6d86df8f3672" xlink:to="loc_vcel_LicenseAgreementAdditionalFunding_74dc6369-5147-480b-9531-825f5e44ec42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/RevenueSummaryofDisaggregationofRevenueDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#RevenueSummaryofDisaggregationofRevenueDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/RevenueSummaryofDisaggregationofRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_2709b1bd-a580-4121-a15d-b0624d7b43b6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RisksAndUncertaintiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_83773fbe-1e0d-4b66-ac53-7c00c4907627" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_2709b1bd-a580-4121-a15d-b0624d7b43b6" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_83773fbe-1e0d-4b66-ac53-7c00c4907627" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerSalesChannelAxis_e51cb6f3-de24-4e94-b509-a640a515c4ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerSalesChannelAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_83773fbe-1e0d-4b66-ac53-7c00c4907627" xlink:to="loc_us-gaap_ContractWithCustomerSalesChannelAxis_e51cb6f3-de24-4e94-b509-a640a515c4ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerSalesChannelDomain_9380a369-a448-4ebf-9405-05c9dd02c789" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerSalesChannelDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelAxis_e51cb6f3-de24-4e94-b509-a640a515c4ec" xlink:to="loc_us-gaap_ContractWithCustomerSalesChannelDomain_9380a369-a448-4ebf-9405-05c9dd02c789" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesChannelThroughIntermediaryMember_0619342a-3729-47ae-b6a2-f5e940833755" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SalesChannelThroughIntermediaryMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_9380a369-a448-4ebf-9405-05c9dd02c789" xlink:to="loc_us-gaap_SalesChannelThroughIntermediaryMember_0619342a-3729-47ae-b6a2-f5e940833755" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeAndMaterialsContractMember_005a1be6-54e6-4ced-92df-13a45a8307a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TimeAndMaterialsContractMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_9380a369-a448-4ebf-9405-05c9dd02c789" xlink:to="loc_us-gaap_TimeAndMaterialsContractMember_005a1be6-54e6-4ced-92df-13a45a8307a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_ProviderorFacilityMember_9c28f746-f1e6-4c01-b72e-73d6c3ba1d68" xlink:href="vcel-20230331.xsd#vcel_ProviderorFacilityMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_9380a369-a448-4ebf-9405-05c9dd02c789" xlink:to="loc_vcel_ProviderorFacilityMember_9c28f746-f1e6-4c01-b72e-73d6c3ba1d68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesChannelDirectlyToConsumerMember_b6210b76-f033-483d-b523-72ac6b95b782" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SalesChannelDirectlyToConsumerMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_9380a369-a448-4ebf-9405-05c9dd02c789" xlink:to="loc_us-gaap_SalesChannelDirectlyToConsumerMember_b6210b76-f033-483d-b523-72ac6b95b782" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_960fcf06-6298-4c02-8aa6-c8aa5a6c8147" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_83773fbe-1e0d-4b66-ac53-7c00c4907627" xlink:to="loc_srt_ProductOrServiceAxis_960fcf06-6298-4c02-8aa6-c8aa5a6c8147" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_fc26aa5b-c1e2-43bd-9998-ad90f4e76a89" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_960fcf06-6298-4c02-8aa6-c8aa5a6c8147" xlink:to="loc_srt_ProductsAndServicesDomain_fc26aa5b-c1e2-43bd-9998-ad90f4e76a89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_ImplantsMember_db0c68e3-4555-44b2-8040-5c08f2a1578b" xlink:href="vcel-20230331.xsd#vcel_ImplantsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_fc26aa5b-c1e2-43bd-9998-ad90f4e76a89" xlink:to="loc_vcel_ImplantsMember_db0c68e3-4555-44b2-8040-5c08f2a1578b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_BiopsyKitsMember_0a2b95c5-5e69-4b80-96db-aadca99c55a3" xlink:href="vcel-20230331.xsd#vcel_BiopsyKitsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_fc26aa5b-c1e2-43bd-9998-ad90f4e76a89" xlink:to="loc_vcel_BiopsyKitsMember_0a2b95c5-5e69-4b80-96db-aadca99c55a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_MACIImplantsAndKitsMember_fc4d835b-3667-4fca-b3d5-a4f8d16c82ae" xlink:href="vcel-20230331.xsd#vcel_MACIImplantsAndKitsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_fc26aa5b-c1e2-43bd-9998-ad90f4e76a89" xlink:to="loc_vcel_MACIImplantsAndKitsMember_fc4d835b-3667-4fca-b3d5-a4f8d16c82ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_EpicelMember_b8f9a43b-3119-41e5-9b03-5ae987aaf918" xlink:href="vcel-20230331.xsd#vcel_EpicelMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_fc26aa5b-c1e2-43bd-9998-ad90f4e76a89" xlink:to="loc_vcel_EpicelMember_b8f9a43b-3119-41e5-9b03-5ae987aaf918" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_NexoBridMember_f56bd0ae-400c-4b9c-a407-fabd885e3369" xlink:href="vcel-20230331.xsd#vcel_NexoBridMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_fc26aa5b-c1e2-43bd-9998-ad90f4e76a89" xlink:to="loc_vcel_NexoBridMember_f56bd0ae-400c-4b9c-a407-fabd885e3369" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerBasisOfPricingAxis_08ec92d3-fc5c-4858-be65-574212cfcab0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerBasisOfPricingAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_83773fbe-1e0d-4b66-ac53-7c00c4907627" xlink:to="loc_us-gaap_ContractWithCustomerBasisOfPricingAxis_08ec92d3-fc5c-4858-be65-574212cfcab0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_74ea46ab-62e3-48e5-84dc-1d82ce5c5ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerBasisOfPricingDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerBasisOfPricingAxis_08ec92d3-fc5c-4858-be65-574212cfcab0" xlink:to="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_74ea46ab-62e3-48e5-84dc-1d82ce5c5ce0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FixedPriceContractMember_62bf2fd2-e12f-4107-adff-499298b31338" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FixedPriceContractMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_74ea46ab-62e3-48e5-84dc-1d82ce5c5ce0" xlink:to="loc_us-gaap_FixedPriceContractMember_62bf2fd2-e12f-4107-adff-499298b31338" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeAndMaterialsContractMember_1feaefc9-c7e0-4ab4-a011-ad3cf3a32a7a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TimeAndMaterialsContractMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_74ea46ab-62e3-48e5-84dc-1d82ce5c5ce0" xlink:to="loc_us-gaap_TimeAndMaterialsContractMember_1feaefc9-c7e0-4ab4-a011-ad3cf3a32a7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_144f9824-51f2-4312-9c40-1381df528c77" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_83773fbe-1e0d-4b66-ac53-7c00c4907627" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_144f9824-51f2-4312-9c40-1381df528c77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_13ecc3fc-df6f-4e9c-8f59-46c1af84b2e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_144f9824-51f2-4312-9c40-1381df528c77" xlink:to="loc_us-gaap_TypeOfAdoptionMember_13ecc3fc-df6f-4e9c-8f59-46c1af84b2e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_5cb072a3-74ca-48cc-87a7-9eb4241cd9a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingStandardsUpdate201409Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_13ecc3fc-df6f-4e9c-8f59-46c1af84b2e5" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_5cb072a3-74ca-48cc-87a7-9eb4241cd9a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_69cd3402-a464-4668-9305-717e239293d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ChangeInAccountingEstimateByTypeAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_83773fbe-1e0d-4b66-ac53-7c00c4907627" xlink:to="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_69cd3402-a464-4668-9305-717e239293d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_3bd1a6a2-89bb-4c49-9519-b7afa018108a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ChangeInAccountingEstimateTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingEstimateByTypeAxis_69cd3402-a464-4668-9305-717e239293d0" xlink:to="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_3bd1a6a2-89bb-4c49-9519-b7afa018108a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInAccountingMethodAccountedForAsChangeInEstimateMember_d1e1d1d4-da19-49a9-8f86-c9589a00153e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ChangeInAccountingMethodAccountedForAsChangeInEstimateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingEstimateTypeDomain_3bd1a6a2-89bb-4c49-9519-b7afa018108a" xlink:to="loc_us-gaap_ChangeInAccountingMethodAccountedForAsChangeInEstimateMember_d1e1d1d4-da19-49a9-8f86-c9589a00153e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_75648229-aad9-422f-8337-0487269a062d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_83773fbe-1e0d-4b66-ac53-7c00c4907627" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_75648229-aad9-422f-8337-0487269a062d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e9de5e44-d94d-454b-be2d-0b44dbf560b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_75648229-aad9-422f-8337-0487269a062d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e9de5e44-d94d-454b-be2d-0b44dbf560b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomerOther_dde62a36-a01c-4ce7-ae80-c352aae31258" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueNotFromContractWithCustomerOther"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_75648229-aad9-422f-8337-0487269a062d" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomerOther_dde62a36-a01c-4ce7-ae80-c352aae31258" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_29f7159a-539c-4526-89b5-ec1df2d9dda0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_75648229-aad9-422f-8337-0487269a062d" xlink:to="loc_us-gaap_Revenues_29f7159a-539c-4526-89b5-ec1df2d9dda0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsSummaryofinventoryDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#SelectedBalanceSheetComponentsSummaryofinventoryDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsSummaryofinventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6b019843-eda3-463a-9258-e1b3f832da68" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNetAbstract_f23c6e2a-0968-417a-922e-75b4a3241a5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNetAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6b019843-eda3-463a-9258-e1b3f832da68" xlink:to="loc_us-gaap_InventoryNetAbstract_f23c6e2a-0968-417a-922e-75b4a3241a5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_20b520f8-3b21-4654-97ba-189d4bc68a71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryRawMaterials"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_f23c6e2a-0968-417a-922e-75b4a3241a5b" xlink:to="loc_us-gaap_InventoryRawMaterials_20b520f8-3b21-4654-97ba-189d4bc68a71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_3ec5dea3-c5a8-4dd9-98e0-725bb04dc8cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_f23c6e2a-0968-417a-922e-75b4a3241a5b" xlink:to="loc_us-gaap_InventoryWorkInProcess_3ec5dea3-c5a8-4dd9-98e0-725bb04dc8cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_a6cdb973-bba3-43f3-8709-b01b59660387" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_f23c6e2a-0968-417a-922e-75b4a3241a5b" xlink:to="loc_us-gaap_InventoryFinishedGoods_a6cdb973-bba3-43f3-8709-b01b59660387" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_007fa0f4-f1ff-4d1e-a535-b41838124dd7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_f23c6e2a-0968-417a-922e-75b4a3241a5b" xlink:to="loc_us-gaap_InventoryNet_007fa0f4-f1ff-4d1e-a535-b41838124dd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofpropertyandequipmentnetDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#SelectedBalanceSheetComponentsScheduleofpropertyandequipmentnetDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofpropertyandequipmentnetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_887cf879-43a8-4236-878d-6fb7af5e296b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2a971e62-d588-4fc8-845d-b2446f97b32e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_887cf879-43a8-4236-878d-6fb7af5e296b" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2a971e62-d588-4fc8-845d-b2446f97b32e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_03ed67ec-570b-48d5-86d2-b6bd70ae103d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2a971e62-d588-4fc8-845d-b2446f97b32e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_03ed67ec-570b-48d5-86d2-b6bd70ae103d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_46e4d047-821b-4554-bced-3a99fdbd2a72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_03ed67ec-570b-48d5-86d2-b6bd70ae103d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_46e4d047-821b-4554-bced-3a99fdbd2a72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_99f63103-3989-455c-b636-7e3981e8caa3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_46e4d047-821b-4554-bced-3a99fdbd2a72" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_99f63103-3989-455c-b636-7e3981e8caa3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_1c10b0f2-98e7-49f4-a5c9-bccb8587af0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_46e4d047-821b-4554-bced-3a99fdbd2a72" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_1c10b0f2-98e7-49f4-a5c9-bccb8587af0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_ComputerEquipmentAndComputerSoftwareIntangibleAssetMember_e5a689c5-669f-44c4-8e4f-5f1f30f1d061" xlink:href="vcel-20230331.xsd#vcel_ComputerEquipmentAndComputerSoftwareIntangibleAssetMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_46e4d047-821b-4554-bced-3a99fdbd2a72" xlink:to="loc_vcel_ComputerEquipmentAndComputerSoftwareIntangibleAssetMember_e5a689c5-669f-44c4-8e4f-5f1f30f1d061" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_107ce3f0-4e40-4f63-8272-da7adcec8692" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_46e4d047-821b-4554-bced-3a99fdbd2a72" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_107ce3f0-4e40-4f63-8272-da7adcec8692" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_85cbc07b-dafc-4b80-8f16-256d9b441208" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_46e4d047-821b-4554-bced-3a99fdbd2a72" xlink:to="loc_us-gaap_ConstructionInProgressMember_85cbc07b-dafc-4b80-8f16-256d9b441208" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_05308d79-65fe-41dc-9eae-ee51af82bea5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2a971e62-d588-4fc8-845d-b2446f97b32e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_05308d79-65fe-41dc-9eae-ee51af82bea5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_02788893-4dec-4be8-ba39-966d28d0a0af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_05308d79-65fe-41dc-9eae-ee51af82bea5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_02788893-4dec-4be8-ba39-966d28d0a0af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetBeforeAccumulatedAmortization_38ec804c-730e-49a5-86a7-0f77de655211" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseRightOfUseAssetBeforeAccumulatedAmortization"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_05308d79-65fe-41dc-9eae-ee51af82bea5" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetBeforeAccumulatedAmortization_38ec804c-730e-49a5-86a7-0f77de655211" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_089dd50f-e7dd-4e80-9e80-5ecbb46b693c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_05308d79-65fe-41dc-9eae-ee51af82bea5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_089dd50f-e7dd-4e80-9e80-5ecbb46b693c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_d4691ff3-f77b-431d-bb47-32724f25c49e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_05308d79-65fe-41dc-9eae-ee51af82bea5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_d4691ff3-f77b-431d-bb47-32724f25c49e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_43c3ba97-a971-455e-b0f3-b1597bddd3ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_05308d79-65fe-41dc-9eae-ee51af82bea5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_43c3ba97-a971-455e-b0f3-b1597bddd3ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsNarrativeDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#SelectedBalanceSheetComponentsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_97f33294-d485-4627-8390-e18717e45e0b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_eb5857d3-7f67-4d5e-97e0-d0690f8e5f3f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_97f33294-d485-4627-8390-e18717e45e0b" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_eb5857d3-7f67-4d5e-97e0-d0690f8e5f3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_a8af8c43-df3a-40df-9e6b-13bb050e9e37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_eb5857d3-7f67-4d5e-97e0-d0690f8e5f3f" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_a8af8c43-df3a-40df-9e6b-13bb050e9e37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ce174d98-9fc3-4526-b63e-943a47f9e5be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_a8af8c43-df3a-40df-9e6b-13bb050e9e37" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ce174d98-9fc3-4526-b63e-943a47f9e5be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_16e8cf84-8141-46e5-813a-af0cadd18da6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ce174d98-9fc3-4526-b63e-943a47f9e5be" xlink:to="loc_us-gaap_LicensingAgreementsMember_16e8cf84-8141-46e5-813a-af0cadd18da6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_dfcd2977-1053-41d2-8139-0f289870b195" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_eb5857d3-7f67-4d5e-97e0-d0690f8e5f3f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_dfcd2977-1053-41d2-8139-0f289870b195" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_6ec1ae7f-69e6-4c0d-a2b3-f80b814c2634" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Depreciation"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_dfcd2977-1053-41d2-8139-0f289870b195" xlink:to="loc_us-gaap_Depreciation_6ec1ae7f-69e6-4c0d-a2b3-f80b814c2634" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_14209f48-b3a4-47f2-8472-7861b8696071" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_dfcd2977-1053-41d2-8139-0f289870b195" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_14209f48-b3a4-47f2-8472-7861b8696071" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleoffinitelivedintangibleassetsDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#SelectedBalanceSheetComponentsScheduleoffinitelivedintangibleassetsDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleoffinitelivedintangibleassetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_13913b52-2d1d-45f7-9223-c334e4f2bbb1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_87088f0b-7f4e-419e-a04b-70780defe4a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_13913b52-2d1d-45f7-9223-c334e4f2bbb1" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_87088f0b-7f4e-419e-a04b-70780defe4a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_d92af639-ee0b-4a0f-b68e-b80ed4de15be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_87088f0b-7f4e-419e-a04b-70780defe4a6" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_d92af639-ee0b-4a0f-b68e-b80ed4de15be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4dc1e776-7401-4a88-aecb-dab4738eb19b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_d92af639-ee0b-4a0f-b68e-b80ed4de15be" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4dc1e776-7401-4a88-aecb-dab4738eb19b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_b74e508f-9ac6-4d80-b026-1d4cb6b1b009" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_4dc1e776-7401-4a88-aecb-dab4738eb19b" xlink:to="loc_us-gaap_LicensingAgreementsMember_b74e508f-9ac6-4d80-b026-1d4cb6b1b009" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_fe4e1aa0-b949-4a03-8b4f-3a9164dac143" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_87088f0b-7f4e-419e-a04b-70780defe4a6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_fe4e1aa0-b949-4a03-8b4f-3a9164dac143" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_30956e37-599e-494d-a3bd-a18f4cd8a976" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_fe4e1aa0-b949-4a03-8b4f-3a9164dac143" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_30956e37-599e-494d-a3bd-a18f4cd8a976" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_2158fb60-643b-40d4-a443-6f34ade4c278" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_fe4e1aa0-b949-4a03-8b4f-3a9164dac143" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_2158fb60-643b-40d4-a443-6f34ade4c278" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_9fa34cd4-8958-405f-a872-a2a4ad477e55" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_fe4e1aa0-b949-4a03-8b4f-3a9164dac143" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_9fa34cd4-8958-405f-a872-a2a4ad477e55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_362ba83d-3cc8-457a-b3a1-15c106a84689" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_fe4e1aa0-b949-4a03-8b4f-3a9164dac143" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_362ba83d-3cc8-457a-b3a1-15c106a84689" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleoffinitelivedintangibleassetsfutureamortizationexpenseDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#SelectedBalanceSheetComponentsScheduleoffinitelivedintangibleassetsfutureamortizationexpenseDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleoffinitelivedintangibleassetsfutureamortizationexpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6d237f99-05a5-4825-acc1-9605ce1d0b74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_16c43925-5650-4594-baa7-8949b483bc5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6d237f99-05a5-4825-acc1-9605ce1d0b74" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_16c43925-5650-4594-baa7-8949b483bc5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_60218c3f-2d29-45a3-96e1-3f69ce9eb376" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_16c43925-5650-4594-baa7-8949b483bc5a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_60218c3f-2d29-45a3-96e1-3f69ce9eb376" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_df8590a0-3930-46c7-b2a0-b76e5b70addc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_60218c3f-2d29-45a3-96e1-3f69ce9eb376" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_df8590a0-3930-46c7-b2a0-b76e5b70addc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_8f449f5c-da35-474e-8bad-1c284dd5f130" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_df8590a0-3930-46c7-b2a0-b76e5b70addc" xlink:to="loc_us-gaap_LicensingAgreementsMember_8f449f5c-da35-474e-8bad-1c284dd5f130" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29bee76b-7344-43e0-b0f2-9f191594301c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_16c43925-5650-4594-baa7-8949b483bc5a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29bee76b-7344-43e0-b0f2-9f191594301c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_a2f10eef-a0e6-4117-935c-115eac863ffc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29bee76b-7344-43e0-b0f2-9f191594301c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_a2f10eef-a0e6-4117-935c-115eac863ffc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_5148284d-e50a-4623-806d-4342ae167fee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29bee76b-7344-43e0-b0f2-9f191594301c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_5148284d-e50a-4623-806d-4342ae167fee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_794af1ee-cf43-483d-ae3a-b3212d63979c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29bee76b-7344-43e0-b0f2-9f191594301c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_794af1ee-cf43-483d-ae3a-b3212d63979c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_8abb831f-24de-4fcf-beac-d818dd1cdfd2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29bee76b-7344-43e0-b0f2-9f191594301c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_8abb831f-24de-4fcf-beac-d818dd1cdfd2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_93f4e407-f2c7-47d7-a22d-51cd45c8ffec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29bee76b-7344-43e0-b0f2-9f191594301c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_93f4e407-f2c7-47d7-a22d-51cd45c8ffec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_c552ebe9-c58c-4292-ad95-e3c2ba8717a2" xlink:href="vcel-20230331.xsd#vcel_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29bee76b-7344-43e0-b0f2-9f191594301c" xlink:to="loc_vcel_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_c552ebe9-c58c-4292-ad95-e3c2ba8717a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_d56d55d8-8fa5-4c39-8daa-f2a88638adf5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_29bee76b-7344-43e0-b0f2-9f191594301c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_d56d55d8-8fa5-4c39-8daa-f2a88638adf5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofaccruedexpensesDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#SelectedBalanceSheetComponentsScheduleofaccruedexpensesDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SelectedBalanceSheetComponentsScheduleofaccruedexpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_850e4252-1573-4a81-95d3-1e2f01ae4e82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_245f9401-6e7f-4c6a-b5bc-1a04b9ce7273" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_850e4252-1573-4a81-95d3-1e2f01ae4e82" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_245f9401-6e7f-4c6a-b5bc-1a04b9ce7273" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedBonusesCurrent_acc2b1ea-eba7-4c06-a760-2c84696a2e08" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedBonusesCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_245f9401-6e7f-4c6a-b5bc-1a04b9ce7273" xlink:to="loc_us-gaap_AccruedBonusesCurrent_acc2b1ea-eba7-4c06-a760-2c84696a2e08" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_406607f4-9a36-45ac-822e-43630c5eca49" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_245f9401-6e7f-4c6a-b5bc-1a04b9ce7273" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_406607f4-9a36-45ac-822e-43630c5eca49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedInsuranceCurrent_8bdc0bf1-3306-4c5a-ba9d-8298c5773abf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedInsuranceCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_245f9401-6e7f-4c6a-b5bc-1a04b9ce7273" xlink:to="loc_us-gaap_AccruedInsuranceCurrent_8bdc0bf1-3306-4c5a-ba9d-8298c5773abf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_AccruedExpensesOtherCurrent_e07fb7bc-373a-45c1-a6f6-5c72d47e4184" xlink:href="vcel-20230331.xsd#vcel_AccruedExpensesOtherCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_245f9401-6e7f-4c6a-b5bc-1a04b9ce7273" xlink:to="loc_vcel_AccruedExpensesOtherCurrent_e07fb7bc-373a-45c1-a6f6-5c72d47e4184" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_43d6eec1-0048-4db7-9b9d-30a028c22b0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_245f9401-6e7f-4c6a-b5bc-1a04b9ce7273" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_43d6eec1-0048-4db7-9b9d-30a028c22b0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#LeasesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/LeasesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_3658119a-5674-4135-8449-c22fe56bb55b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_b0b8ecdf-7336-46aa-9898-c7ece36e7375" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_3658119a-5674-4135-8449-c22fe56bb55b" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_b0b8ecdf-7336-46aa-9898-c7ece36e7375" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f6bca12e-352c-4531-9292-60fa9639e1d1" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_b0b8ecdf-7336-46aa-9898-c7ece36e7375" xlink:to="loc_srt_RangeAxis_f6bca12e-352c-4531-9292-60fa9639e1d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_68709184-f32f-4024-8a8c-83b7906a2078" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_f6bca12e-352c-4531-9292-60fa9639e1d1" xlink:to="loc_srt_RangeMember_68709184-f32f-4024-8a8c-83b7906a2078" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_6262d618-4510-43ad-ad8e-c2cdf6a55915" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_68709184-f32f-4024-8a8c-83b7906a2078" xlink:to="loc_srt_MinimumMember_6262d618-4510-43ad-ad8e-c2cdf6a55915" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_a2692428-0a6f-4e39-b06a-ed89ec00dbc8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_68709184-f32f-4024-8a8c-83b7906a2078" xlink:to="loc_srt_MaximumMember_a2692428-0a6f-4e39-b06a-ed89ec00dbc8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_c4d019d9-3e50-4396-9421-9f35b38a9e33" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_b0b8ecdf-7336-46aa-9898-c7ece36e7375" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_c4d019d9-3e50-4396-9421-9f35b38a9e33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_72fc9442-3b0a-431a-a0f7-dfe9220213f5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_c4d019d9-3e50-4396-9421-9f35b38a9e33" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_72fc9442-3b0a-431a-a0f7-dfe9220213f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_A25NetworkDriveBurlingtonMassachusettsMember_41a65884-74d9-4f7c-90da-7f3d7ba8390c" xlink:href="vcel-20230331.xsd#vcel_A25NetworkDriveBurlingtonMassachusettsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_72fc9442-3b0a-431a-a0f7-dfe9220213f5" xlink:to="loc_vcel_A25NetworkDriveBurlingtonMassachusettsMember_41a65884-74d9-4f7c-90da-7f3d7ba8390c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_AnnArborMichiganMember_442a2975-973d-431d-9e60-69a23d918cae" xlink:href="vcel-20230331.xsd#vcel_AnnArborMichiganMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_72fc9442-3b0a-431a-a0f7-dfe9220213f5" xlink:to="loc_vcel_AnnArborMichiganMember_442a2975-973d-431d-9e60-69a23d918cae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_b0b8ecdf-7336-46aa-9898-c7ece36e7375" xlink:to="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LesseeOperatingLeaseMonthlyContractualPayments_0e43e5ec-f72f-4049-b107-8f52b07f69bf" xlink:href="vcel-20230331.xsd#vcel_LesseeOperatingLeaseMonthlyContractualPayments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LesseeOperatingLeaseMonthlyContractualPayments_0e43e5ec-f72f-4049-b107-8f52b07f69bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AreaOfRealEstateProperty_582a9d72-6962-417b-a578-eae5a4750c67" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AreaOfRealEstateProperty"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_us-gaap_AreaOfRealEstateProperty_582a9d72-6962-417b-a578-eae5a4750c67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LesseeLeaseCommencementRentPaymentStartDateTerm_08db0c73-7ab1-4185-aaaa-cf5fc662b9d1" xlink:href="vcel-20230331.xsd#vcel_LesseeLeaseCommencementRentPaymentStartDateTerm"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LesseeLeaseCommencementRentPaymentStartDateTerm_08db0c73-7ab1-4185-aaaa-cf5fc662b9d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_70a537b5-31e4-425f-92a4-bfbcbfc1258d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseTermOfContract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_70a537b5-31e4-425f-92a4-bfbcbfc1258d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LesseeOperatingLeaseNumberOfRenewalOptions_bfd46600-7cf6-46e5-b0fd-2aba5b59f322" xlink:href="vcel-20230331.xsd#vcel_LesseeOperatingLeaseNumberOfRenewalOptions"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LesseeOperatingLeaseNumberOfRenewalOptions_bfd46600-7cf6-46e5-b0fd-2aba5b59f322" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LeaseOptionToExtendTerm_d761b35d-0220-466f-8a6b-7b381fbecb2c" xlink:href="vcel-20230331.xsd#vcel_LeaseOptionToExtendTerm"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LeaseOptionToExtendTerm_d761b35d-0220-466f-8a6b-7b381fbecb2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LesseeOperatingLeaseAnnualLeasePerSquareFoot_06df7cea-4e72-4255-9120-0c3ff0c6c4d1" xlink:href="vcel-20230331.xsd#vcel_LesseeOperatingLeaseAnnualLeasePerSquareFoot"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LesseeOperatingLeaseAnnualLeasePerSquareFoot_06df7cea-4e72-4255-9120-0c3ff0c6c4d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LesseeOperatingLeaseAnnualLeaseIncreaseLimitPercentage_e22576c1-e54e-4c42-b24b-eb2ce1d2ddb3" xlink:href="vcel-20230331.xsd#vcel_LesseeOperatingLeaseAnnualLeaseIncreaseLimitPercentage"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LesseeOperatingLeaseAnnualLeaseIncreaseLimitPercentage_e22576c1-e54e-4c42-b24b-eb2ce1d2ddb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LesseeOperatingLeaseTenantImprovementAllowancePerSquareFoot_0cc21374-2be0-4ac0-ad54-4b5a096c5236" xlink:href="vcel-20230331.xsd#vcel_LesseeOperatingLeaseTenantImprovementAllowancePerSquareFoot"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LesseeOperatingLeaseTenantImprovementAllowancePerSquareFoot_0cc21374-2be0-4ac0-ad54-4b5a096c5236" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LesseeOperatingLeaseTenantImprovementAllowance_f69b4f8e-ccf0-43d8-9057-43a6dd3384ac" xlink:href="vcel-20230331.xsd#vcel_LesseeOperatingLeaseTenantImprovementAllowance"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LesseeOperatingLeaseTenantImprovementAllowance_f69b4f8e-ccf0-43d8-9057-43a6dd3384ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LetterOfCreditCashDeposit_345b0448-e88a-47ca-a620-fefba6235a30" xlink:href="vcel-20230331.xsd#vcel_LetterOfCreditCashDeposit"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LetterOfCreditCashDeposit_345b0448-e88a-47ca-a620-fefba6235a30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LetterOfCreditCashDepositLeaseYearThree_b240fc40-7356-44fa-9d03-d4727e5ccbc5" xlink:href="vcel-20230331.xsd#vcel_LetterOfCreditCashDepositLeaseYearThree"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LetterOfCreditCashDepositLeaseYearThree_b240fc40-7356-44fa-9d03-d4727e5ccbc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LetterOfCreditCashDepositLeaseYearFour_f8ebfb0e-eacc-4653-835b-83e2adc1fe75" xlink:href="vcel-20230331.xsd#vcel_LetterOfCreditCashDepositLeaseYearFour"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_vcel_LetterOfCreditCashDepositLeaseYearFour_f8ebfb0e-eacc-4653-835b-83e2adc1fe75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_36f6fe3c-1fd0-4a24-b623-bf7fa486434d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_us-gaap_ShortTermLeaseCost_36f6fe3c-1fd0-4a24-b623-bf7fa486434d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_417f2f7a-e198-4a98-9062-0d0ee9768b75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_us-gaap_OperatingLeaseExpense_417f2f7a-e198-4a98-9062-0d0ee9768b75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestExpense_7d085807-cb3a-47a0-88a7-6cd881c262f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseInterestExpense"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_39855b75-e150-44ac-a4be-1b10c6c3542d" xlink:to="loc_us-gaap_FinanceLeaseInterestExpense_7d085807-cb3a-47a0-88a7-6cd881c262f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/LeasesSummaryofassetsandliabilitiesDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#LeasesSummaryofassetsandliabilitiesDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/LeasesSummaryofassetsandliabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_8202d27d-3581-4192-8c77-8c389de72e45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_48c97f7d-04a8-442c-9654-fb09568c8c51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_8202d27d-3581-4192-8c77-8c389de72e45" xlink:to="loc_us-gaap_AssetsAbstract_48c97f7d-04a8-442c-9654-fb09568c8c51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_f3357fa1-5fa1-42b1-8aa8-0a027094b0cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_48c97f7d-04a8-442c-9654-fb09568c8c51" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_f3357fa1-5fa1-42b1-8aa8-0a027094b0cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_866e8b67-9508-4975-a5a9-bdaf09e30a2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_48c97f7d-04a8-442c-9654-fb09568c8c51" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_866e8b67-9508-4975-a5a9-bdaf09e30a2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_RightOfUseAsset_3a52ea3d-0018-41c5-a30d-cf33561692bb" xlink:href="vcel-20230331.xsd#vcel_RightOfUseAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_48c97f7d-04a8-442c-9654-fb09568c8c51" xlink:to="loc_vcel_RightOfUseAsset_3a52ea3d-0018-41c5-a30d-cf33561692bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAbstract_8ced7f55-4c42-421c-91ae-9231cba755a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_8202d27d-3581-4192-8c77-8c389de72e45" xlink:to="loc_us-gaap_LiabilitiesAbstract_8ced7f55-4c42-421c-91ae-9231cba755a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_d5a462e7-e5e8-4078-a580-be71922bd7b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_8ced7f55-4c42-421c-91ae-9231cba755a4" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_d5a462e7-e5e8-4078-a580-be71922bd7b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_5b973cba-3d12-4e3f-a1d7-c31de8975278" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_d5a462e7-e5e8-4078-a580-be71922bd7b5" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_5b973cba-3d12-4e3f-a1d7-c31de8975278" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_6e59a3d1-c226-450b-bdc9-75c7393be1d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_d5a462e7-e5e8-4078-a580-be71922bd7b5" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_6e59a3d1-c226-450b-bdc9-75c7393be1d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrentAbstract_93cace4a-308b-4373-9acd-a2737df1820e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesNoncurrentAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_8ced7f55-4c42-421c-91ae-9231cba755a4" xlink:to="loc_us-gaap_LiabilitiesNoncurrentAbstract_93cace4a-308b-4373-9acd-a2737df1820e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4c8364c0-61a5-4f1d-b63a-7e3e59a965c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_93cace4a-308b-4373-9acd-a2737df1820e" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4c8364c0-61a5-4f1d-b63a-7e3e59a965c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LeaseLiabilityNoncurrent_83fae118-2467-49b1-bdd2-78c90cece2fb" xlink:href="vcel-20230331.xsd#vcel_LeaseLiabilityNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_93cace4a-308b-4373-9acd-a2737df1820e" xlink:to="loc_vcel_LeaseLiabilityNoncurrent_83fae118-2467-49b1-bdd2-78c90cece2fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_4a5b1327-af78-4e78-85be-4a2f31a984f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_8202d27d-3581-4192-8c77-8c389de72e45" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_4a5b1327-af78-4e78-85be-4a2f31a984f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList_9b304832-adb2-45a3-b80f-b95ad019d826" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_8202d27d-3581-4192-8c77-8c389de72e45" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList_9b304832-adb2-45a3-b80f-b95ad019d826" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/RevolvingCreditAgreementDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#RevolvingCreditAgreementDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/RevolvingCreditAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_c87b5e17-6722-4af5-911c-35ce959fc0f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_327b0beb-57d8-460c-a530-c514b0c18bc8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_c87b5e17-6722-4af5-911c-35ce959fc0f3" xlink:to="loc_us-gaap_DebtInstrumentTable_327b0beb-57d8-460c-a530-c514b0c18bc8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_8029737d-dd7d-4844-92b7-821056d9d608" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_327b0beb-57d8-460c-a530-c514b0c18bc8" xlink:to="loc_us-gaap_CreditFacilityAxis_8029737d-dd7d-4844-92b7-821056d9d608" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_3db8cd35-60fc-4c6c-9248-5d591bf08d86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityAxis_8029737d-dd7d-4844-92b7-821056d9d608" xlink:to="loc_us-gaap_CreditFacilityDomain_3db8cd35-60fc-4c6c-9248-5d591bf08d86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_fe53b469-bf89-4ff8-a0a7-dcd91dc3442b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_3db8cd35-60fc-4c6c-9248-5d591bf08d86" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_fe53b469-bf89-4ff8-a0a7-dcd91dc3442b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LetterOfCreditMember_5041e643-8e48-4112-a581-4495d41f5a9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LetterOfCreditMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_3db8cd35-60fc-4c6c-9248-5d591bf08d86" xlink:to="loc_us-gaap_LetterOfCreditMember_5041e643-8e48-4112-a581-4495d41f5a9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_45e57ba3-2222-41ac-bf9b-346673a38ba3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_327b0beb-57d8-460c-a530-c514b0c18bc8" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_45e57ba3-2222-41ac-bf9b-346673a38ba3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_f5b8ac8a-8d59-4ccd-b9e1-61d7892ecbc4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_45e57ba3-2222-41ac-bf9b-346673a38ba3" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_f5b8ac8a-8d59-4ccd-b9e1-61d7892ecbc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_38d6f8f1-77a1-44ea-aef0-7ed2a78a143a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_f5b8ac8a-8d59-4ccd-b9e1-61d7892ecbc4" xlink:to="loc_us-gaap_LineOfCreditMember_38d6f8f1-77a1-44ea-aef0-7ed2a78a143a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_18bb4c33-f110-4b06-bc7f-a0a50fed672b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_327b0beb-57d8-460c-a530-c514b0c18bc8" xlink:to="loc_us-gaap_VariableRateAxis_18bb4c33-f110-4b06-bc7f-a0a50fed672b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_ede31462-73d5-4915-8dca-ad81fe76e2f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_18bb4c33-f110-4b06-bc7f-a0a50fed672b" xlink:to="loc_us-gaap_VariableRateDomain_ede31462-73d5-4915-8dca-ad81fe76e2f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember_83f23127-c30a-4c7c-8e58-20745710a1ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_ede31462-73d5-4915-8dca-ad81fe76e2f0" xlink:to="loc_us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember_83f23127-c30a-4c7c-8e58-20745710a1ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BaseRateMember_fe38a746-df90-42d4-8cf8-2e738e073ecd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BaseRateMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_ede31462-73d5-4915-8dca-ad81fe76e2f0" xlink:to="loc_us-gaap_BaseRateMember_fe38a746-df90-42d4-8cf8-2e738e073ecd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_14fd0f7a-b084-42b5-b4f4-4706a1caf7f2" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_327b0beb-57d8-460c-a530-c514b0c18bc8" xlink:to="loc_srt_RangeAxis_14fd0f7a-b084-42b5-b4f4-4706a1caf7f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_d8740406-2191-4924-b456-9df9a2bf6d14" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_14fd0f7a-b084-42b5-b4f4-4706a1caf7f2" xlink:to="loc_srt_RangeMember_d8740406-2191-4924-b456-9df9a2bf6d14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_31872f37-b8be-4519-b083-dc492d885a95" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_d8740406-2191-4924-b456-9df9a2bf6d14" xlink:to="loc_srt_MinimumMember_31872f37-b8be-4519-b083-dc492d885a95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_3f8f8a4a-358b-4b98-8cb4-95a1abe2f626" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_d8740406-2191-4924-b456-9df9a2bf6d14" xlink:to="loc_srt_MaximumMember_3f8f8a4a-358b-4b98-8cb4-95a1abe2f626" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_327b0beb-57d8-460c-a530-c514b0c18bc8" xlink:to="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_59c83864-0bef-4fb6-a704-9c5555150369" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_59c83864-0bef-4fb6-a704-9c5555150369" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_04f9c5d8-f245-4add-9036-ed85e9a91cef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:to="loc_us-gaap_DebtInstrumentTerm_04f9c5d8-f245-4add-9036-ed85e9a91cef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_a0456314-e995-4180-bd65-b9bf1aa826ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_a0456314-e995-4180-bd65-b9bf1aa826ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_693f438b-95fa-4450-a8a9-7c6947ec9ed1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_693f438b-95fa-4450-a8a9-7c6947ec9ed1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_10341409-cda9-4e39-ac28-05c1ca89b89b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_10341409-cda9-4e39-ac28-05c1ca89b89b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_e3c67a0f-61f3-48fa-b5d8-d8f94eeb5d71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityCommitmentFeePercentage"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:to="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_e3c67a0f-61f3-48fa-b5d8-d8f94eeb5d71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_5ec26510-d387-4795-8430-92012a42fcac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCredit"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:to="loc_us-gaap_LineOfCredit_5ec26510-d387-4795-8430-92012a42fcac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_DebtInstrumentCovenantLeverageRatioMaximum_52399bca-94c2-4312-869d-8393d8552091" xlink:href="vcel-20230331.xsd#vcel_DebtInstrumentCovenantLeverageRatioMaximum"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:to="loc_vcel_DebtInstrumentCovenantLeverageRatioMaximum_52399bca-94c2-4312-869d-8393d8552091" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_DebtInstrumentCovenantIncreaseOptionLeverageRatioMaximum_0d4c708f-f91b-4d50-87db-247dd55e8016" xlink:href="vcel-20230331.xsd#vcel_DebtInstrumentCovenantIncreaseOptionLeverageRatioMaximum"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_747445ca-1b8c-434b-8270-11829f302124" xlink:to="loc_vcel_DebtInstrumentCovenantIncreaseOptionLeverageRatioMaximum_0d4c708f-f91b-4d50-87db-247dd55e8016" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#StockBasedCompensationExpenseDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/StockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_82a1fff9-6fd8-455c-90f9-5352733758e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_7bd44177-3045-40b7-a972-3772a6e4840d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_82a1fff9-6fd8-455c-90f9-5352733758e1" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_7bd44177-3045-40b7-a972-3772a6e4840d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_dd9c26b4-ff42-4e59-a045-af84b49aff75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_7bd44177-3045-40b7-a972-3772a6e4840d" xlink:to="loc_us-gaap_AwardTypeAxis_dd9c26b4-ff42-4e59-a045-af84b49aff75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5d56acaf-b717-4092-8437-8ed3c8f6147d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_dd9c26b4-ff42-4e59-a045-af84b49aff75" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5d56acaf-b717-4092-8437-8ed3c8f6147d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_EmployeeStockAndEmployeeStockOptionMember_43205498-b187-467c-91be-dae415edfbae" xlink:href="vcel-20230331.xsd#vcel_EmployeeStockAndEmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5d56acaf-b717-4092-8437-8ed3c8f6147d" xlink:to="loc_vcel_EmployeeStockAndEmployeeStockOptionMember_43205498-b187-467c-91be-dae415edfbae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_c5f3565c-d22c-41c1-b0ee-2c31f07b4ece" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_7bd44177-3045-40b7-a972-3772a6e4840d" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_c5f3565c-d22c-41c1-b0ee-2c31f07b4ece" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_9fb3181b-e8b9-4ad5-a69c-0f838acbfd11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_c5f3565c-d22c-41c1-b0ee-2c31f07b4ece" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_9fb3181b-e8b9-4ad5-a69c-0f838acbfd11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_c3f7791a-1a39-48d7-bfaa-0af47ce2bbe3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfSalesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_9fb3181b-e8b9-4ad5-a69c-0f838acbfd11" xlink:to="loc_us-gaap_CostOfSalesMember_c3f7791a-1a39-48d7-bfaa-0af47ce2bbe3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_bc886658-5456-4a9e-bf2c-7d03394aaa70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_9fb3181b-e8b9-4ad5-a69c-0f838acbfd11" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_bc886658-5456-4a9e-bf2c-7d03394aaa70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_80393ab5-8f44-4294-835d-b56cf7aa4b6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_9fb3181b-e8b9-4ad5-a69c-0f838acbfd11" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_80393ab5-8f44-4294-835d-b56cf7aa4b6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e04d3e68-e609-4e8c-9d43-d8b887e0b0f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_7bd44177-3045-40b7-a972-3772a6e4840d" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e04d3e68-e609-4e8c-9d43-d8b887e0b0f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_4c2810dd-a69e-42c0-a8f5-c259d9ba8310" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_e04d3e68-e609-4e8c-9d43-d8b887e0b0f1" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_4c2810dd-a69e-42c0-a8f5-c259d9ba8310" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/StockBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#StockBasedCompensationNarrativeDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/StockBasedCompensationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_8011273a-4641-4fd1-9fc1-0abc57ed0e9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2a937f96-269f-405a-8813-dadc10139f42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_8011273a-4641-4fd1-9fc1-0abc57ed0e9f" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2a937f96-269f-405a-8813-dadc10139f42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_8d722f25-c11e-4142-b2b1-f3dc15490a4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2a937f96-269f-405a-8813-dadc10139f42" xlink:to="loc_us-gaap_AwardTypeAxis_8d722f25-c11e-4142-b2b1-f3dc15490a4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7531c789-da73-44ae-a3d4-8c26d867a2e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_8d722f25-c11e-4142-b2b1-f3dc15490a4e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7531c789-da73-44ae-a3d4-8c26d867a2e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_a24574d7-5b22-4dc6-96d7-8162a19d39d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7531c789-da73-44ae-a3d4-8c26d867a2e2" xlink:to="loc_us-gaap_EmployeeStockOptionMember_a24574d7-5b22-4dc6-96d7-8162a19d39d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_52cab6ac-75d0-49f0-a1a4-4331e8a2af22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7531c789-da73-44ae-a3d4-8c26d867a2e2" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_52cab6ac-75d0-49f0-a1a4-4331e8a2af22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_66a24ea5-3bc9-4c8e-b146-28ad19b1c443" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2a937f96-269f-405a-8813-dadc10139f42" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_66a24ea5-3bc9-4c8e-b146-28ad19b1c443" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_08cf7a32-4c28-4c0e-a1bf-78f54c934518" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_66a24ea5-3bc9-4c8e-b146-28ad19b1c443" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_08cf7a32-4c28-4c0e-a1bf-78f54c934518" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_1b1ceeaf-6bbd-4315-aad7-e3838bca24e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_66a24ea5-3bc9-4c8e-b146-28ad19b1c443" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_1b1ceeaf-6bbd-4315-aad7-e3838bca24e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_35fb0b62-5de3-4ef2-9831-88ab7129975e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_66a24ea5-3bc9-4c8e-b146-28ad19b1c443" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_35fb0b62-5de3-4ef2-9831-88ab7129975e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_a3c4d266-5401-46a8-a053-cf5500c0cf2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_66a24ea5-3bc9-4c8e-b146-28ad19b1c443" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_a3c4d266-5401-46a8-a053-cf5500c0cf2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/InvestmentsDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#InvestmentsDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/InvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_a5a704c1-a932-47c6-8a62-197243c3174c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesTable_f2b8dc21-4293-444d-863d-6f2063db7add" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_a5a704c1-a932-47c6-8a62-197243c3174c" xlink:to="loc_us-gaap_MarketableSecuritiesTable_f2b8dc21-4293-444d-863d-6f2063db7add" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_74692ad8-3950-495e-b47c-52deff40caa5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesTable_f2b8dc21-4293-444d-863d-6f2063db7add" xlink:to="loc_us-gaap_FinancialInstrumentAxis_74692ad8-3950-495e-b47c-52deff40caa5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_c0a983f3-e137-4bf0-8e50-861bf8a1c202" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_74692ad8-3950-495e-b47c-52deff40caa5" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_c0a983f3-e137-4bf0-8e50-861bf8a1c202" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_6d3bc5eb-3366-41aa-aaa5-5216863e1b33" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_c0a983f3-e137-4bf0-8e50-861bf8a1c202" xlink:to="loc_us-gaap_CommercialPaperMember_6d3bc5eb-3366-41aa-aaa5-5216863e1b33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_a146521c-5cbf-4094-9dcf-e4b10523ad89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_c0a983f3-e137-4bf0-8e50-861bf8a1c202" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_a146521c-5cbf-4094-9dcf-e4b10523ad89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_9317cf92-8b1e-4da6-85bc-ee6b43fbccfa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_c0a983f3-e137-4bf0-8e50-861bf8a1c202" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_9317cf92-8b1e-4da6-85bc-ee6b43fbccfa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_a0df1fa2-3e3e-4d01-9ab7-24d54ed31abe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_c0a983f3-e137-4bf0-8e50-861bf8a1c202" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_a0df1fa2-3e3e-4d01-9ab7-24d54ed31abe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_2c250e8e-24ce-4878-bb30-62c437973c14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesTable_f2b8dc21-4293-444d-863d-6f2063db7add" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_2c250e8e-24ce-4878-bb30-62c437973c14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_aab6b09f-5397-4e37-81b5-e9e0dd3ce60e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_2c250e8e-24ce-4878-bb30-62c437973c14" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_aab6b09f-5397-4e37-81b5-e9e0dd3ce60e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_7342327f-a94d-4746-9f5d-c1c17e2db966" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_aab6b09f-5397-4e37-81b5-e9e0dd3ce60e" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_7342327f-a94d-4746-9f5d-c1c17e2db966" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LongtermInvestmentsMember_d0be0fd1-0de1-4701-8a2c-15e03ade2509" xlink:href="vcel-20230331.xsd#vcel_LongtermInvestmentsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_aab6b09f-5397-4e37-81b5-e9e0dd3ce60e" xlink:to="loc_vcel_LongtermInvestmentsMember_d0be0fd1-0de1-4701-8a2c-15e03ade2509" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesLineItems_fef2daa8-5532-42bc-a0ff-8e2916ebc309" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesTable_f2b8dc21-4293-444d-863d-6f2063db7add" xlink:to="loc_us-gaap_MarketableSecuritiesLineItems_fef2daa8-5532-42bc-a0ff-8e2916ebc309" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_3a79ba26-ed4e-4ba4-9e54-0132b8ee8beb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_fef2daa8-5532-42bc-a0ff-8e2916ebc309" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_3a79ba26-ed4e-4ba4-9e54-0132b8ee8beb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_9b9241e8-09f3-4220-bd36-c3416068ca27" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_fef2daa8-5532-42bc-a0ff-8e2916ebc309" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_9b9241e8-09f3-4220-bd36-c3416068ca27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_fb080dc7-3bdf-4f94-9e6f-e5593c4c5850" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_fef2daa8-5532-42bc-a0ff-8e2916ebc309" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_fb080dc7-3bdf-4f94-9e6f-e5593c4c5850" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss_72df8908-5925-40f5-bbd0-b466db681f9e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_fef2daa8-5532-42bc-a0ff-8e2916ebc309" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss_72df8908-5925-40f5-bbd0-b466db681f9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_39a239c1-7d42-4195-92e8-3685b6d35043" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_fef2daa8-5532-42bc-a0ff-8e2916ebc309" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_39a239c1-7d42-4195-92e8-3685b6d35043" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_DebtSecuritiesAvailableForSaleContractualMaturityPeriod_cf605d3f-d32d-418a-b3ef-22ccf05394d1" xlink:href="vcel-20230331.xsd#vcel_DebtSecuritiesAvailableForSaleContractualMaturityPeriod"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_fef2daa8-5532-42bc-a0ff-8e2916ebc309" xlink:to="loc_vcel_DebtSecuritiesAvailableForSaleContractualMaturityPeriod_cf605d3f-d32d-418a-b3ef-22ccf05394d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_acce3beb-7bd7-4e55-90a3-4ad7e43856d7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_fef2daa8-5532-42bc-a0ff-8e2916ebc309" xlink:to="loc_us-gaap_AssetImpairmentCharges_acce3beb-7bd7-4e55-90a3-4ad7e43856d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#FairValueMeasurementsDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_864a1021-9996-4e8f-87ab-305508dc0682" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_661eedd6-3945-41da-8ec9-57bafe35813f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_864a1021-9996-4e8f-87ab-305508dc0682" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_661eedd6-3945-41da-8ec9-57bafe35813f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_d9d4608a-1faf-47fa-8fac-120fbf84af9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_661eedd6-3945-41da-8ec9-57bafe35813f" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_d9d4608a-1faf-47fa-8fac-120fbf84af9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_d1d341c5-02ac-4498-881b-aceda68c99b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_d9d4608a-1faf-47fa-8fac-120fbf84af9b" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_d1d341c5-02ac-4498-881b-aceda68c99b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_199ce8c2-7463-4467-a16a-eef01f04d41d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_d1d341c5-02ac-4498-881b-aceda68c99b5" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_199ce8c2-7463-4467-a16a-eef01f04d41d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_75c72b22-2145-4fd8-950a-6f42ce1bbbe5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_661eedd6-3945-41da-8ec9-57bafe35813f" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_75c72b22-2145-4fd8-950a-6f42ce1bbbe5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2a41bb62-9579-471c-9d7f-b64e0ad81576" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_75c72b22-2145-4fd8-950a-6f42ce1bbbe5" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2a41bb62-9579-471c-9d7f-b64e0ad81576" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_18cacb86-97f9-4fe5-b11e-783be72ae26a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2a41bb62-9579-471c-9d7f-b64e0ad81576" xlink:to="loc_us-gaap_MoneyMarketFundsMember_18cacb86-97f9-4fe5-b11e-783be72ae26a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_a52a783a-c52a-45e1-bc36-1d3d3df803c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_661eedd6-3945-41da-8ec9-57bafe35813f" xlink:to="loc_us-gaap_FinancialInstrumentAxis_a52a783a-c52a-45e1-bc36-1d3d3df803c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b771f716-83f5-4dcf-9e40-781fb0b42dae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_a52a783a-c52a-45e1-bc36-1d3d3df803c4" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b771f716-83f5-4dcf-9e40-781fb0b42dae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_a8fe6f82-1a16-4124-a2a7-d53af1fe39f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b771f716-83f5-4dcf-9e40-781fb0b42dae" xlink:to="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_a8fe6f82-1a16-4124-a2a7-d53af1fe39f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNoteSecuritiesMember_241aebe6-d1d3-4eed-920f-c53a14f4a719" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateNoteSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b771f716-83f5-4dcf-9e40-781fb0b42dae" xlink:to="loc_us-gaap_CorporateNoteSecuritiesMember_241aebe6-d1d3-4eed-920f-c53a14f4a719" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_36c9e979-bc85-4323-baf5-27df38156fa4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b771f716-83f5-4dcf-9e40-781fb0b42dae" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_36c9e979-bc85-4323-baf5-27df38156fa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_27b992d0-1ca5-400e-bd03-e65c1577ce75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b771f716-83f5-4dcf-9e40-781fb0b42dae" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_27b992d0-1ca5-400e-bd03-e65c1577ce75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c8ca32aa-fdad-481b-8fea-008ec1151460" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_661eedd6-3945-41da-8ec9-57bafe35813f" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c8ca32aa-fdad-481b-8fea-008ec1151460" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_c70da20b-d7eb-48e8-977a-81837c2438f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c8ca32aa-fdad-481b-8fea-008ec1151460" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_c70da20b-d7eb-48e8-977a-81837c2438f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_6005316a-3e52-4e4e-af20-2fb99982abfd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_c70da20b-d7eb-48e8-977a-81837c2438f6" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_6005316a-3e52-4e4e-af20-2fb99982abfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_21d345ca-34f9-46bd-8ca2-5e4969100df8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_c70da20b-d7eb-48e8-977a-81837c2438f6" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_21d345ca-34f9-46bd-8ca2-5e4969100df8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_416908ac-6e83-45c9-99c1-79ed34bbb2c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_c70da20b-d7eb-48e8-977a-81837c2438f6" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_416908ac-6e83-45c9-99c1-79ed34bbb2c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_464a0595-5794-44ff-8ff4-24e2c32cba9c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_661eedd6-3945-41da-8ec9-57bafe35813f" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_464a0595-5794-44ff-8ff4-24e2c32cba9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_16d210a7-2119-4119-b82e-5f8c85c21faf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_464a0595-5794-44ff-8ff4-24e2c32cba9c" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_16d210a7-2119-4119-b82e-5f8c85c21faf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsMember_55fbf50d-912d-4a6f-9342-6ad012be0b74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_16d210a7-2119-4119-b82e-5f8c85c21faf" xlink:to="loc_us-gaap_CashAndCashEquivalentsMember_55fbf50d-912d-4a6f-9342-6ad012be0b74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_397a46be-d91f-40e2-8197-0ac63e7ee071" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_661eedd6-3945-41da-8ec9-57bafe35813f" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_397a46be-d91f-40e2-8197-0ac63e7ee071" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_d034484a-e02f-420e-9609-c0c678c7bf27" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_397a46be-d91f-40e2-8197-0ac63e7ee071" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_d034484a-e02f-420e-9609-c0c678c7bf27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4fe88066-c6e4-4a21-9ca0-7b660a4e5410" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_397a46be-d91f-40e2-8197-0ac63e7ee071" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4fe88066-c6e4-4a21-9ca0-7b660a4e5410" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_d806eb37-c52f-4173-854d-810e89bfac44" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_397a46be-d91f-40e2-8197-0ac63e7ee071" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_d806eb37-c52f-4173-854d-810e89bfac44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/NetLossPerCommonShareDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#NetLossPerCommonShareDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/NetLossPerCommonShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_d0d00b81-dfc1-4b37-b84c-6eab602715c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_06f7c9a0-490b-496e-9933-e31c0876d3c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_d0d00b81-dfc1-4b37-b84c-6eab602715c5" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_06f7c9a0-490b-496e-9933-e31c0876d3c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_83ad2ed0-00c8-4269-8826-72c21210f2a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_06f7c9a0-490b-496e-9933-e31c0876d3c8" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_83ad2ed0-00c8-4269-8826-72c21210f2a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_aaf4fd89-2e76-406d-b0ea-e5e72d5ef974" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_83ad2ed0-00c8-4269-8826-72c21210f2a8" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_aaf4fd89-2e76-406d-b0ea-e5e72d5ef974" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_2e513704-958f-4a33-b095-1ed8b305f07b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_aaf4fd89-2e76-406d-b0ea-e5e72d5ef974" xlink:to="loc_us-gaap_EmployeeStockOptionMember_2e513704-958f-4a33-b095-1ed8b305f07b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_29fe12fa-88ce-47c4-9036-1c9a834c53ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_aaf4fd89-2e76-406d-b0ea-e5e72d5ef974" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_29fe12fa-88ce-47c4-9036-1c9a834c53ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_ef3513d7-e4ea-416a-bee9-2e5a9b9d3f44" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_06f7c9a0-490b-496e-9933-e31c0876d3c8" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_ef3513d7-e4ea-416a-bee9-2e5a9b9d3f44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAbstract_1edc5b0f-33d8-4dc0-901b-c5a2d8b5eef8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_ef3513d7-e4ea-416a-bee9-2e5a9b9d3f44" xlink:to="loc_us-gaap_NetIncomeLossAbstract_1edc5b0f-33d8-4dc0-901b-c5a2d8b5eef8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e1b7977f-821c-4781-bc2a-43c7f6434f94" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_1edc5b0f-33d8-4dc0-901b-c5a2d8b5eef8" xlink:to="loc_us-gaap_NetIncomeLoss_e1b7977f-821c-4781-bc2a-43c7f6434f94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_91634e4a-6fa6-4ea5-82b6-645923073e01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_1edc5b0f-33d8-4dc0-901b-c5a2d8b5eef8" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_91634e4a-6fa6-4ea5-82b6-645923073e01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_05be10b8-e67a-4c4c-97f0-3905c5590a82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_1edc5b0f-33d8-4dc0-901b-c5a2d8b5eef8" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_05be10b8-e67a-4c4c-97f0-3905c5590a82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ddb1a12e-78bf-4a39-9464-e1b0605d7b9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_1edc5b0f-33d8-4dc0-901b-c5a2d8b5eef8" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ddb1a12e-78bf-4a39-9464-e1b0605d7b9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_e2f493a6-c2e7-4170-a4e2-b8a2310f4fce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_1edc5b0f-33d8-4dc0-901b-c5a2d8b5eef8" xlink:to="loc_us-gaap_EarningsPerShareBasic_e2f493a6-c2e7-4170-a4e2-b8a2310f4fce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_2b96decc-9f48-4f42-9dc3-ca43d557346b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_1edc5b0f-33d8-4dc0-901b-c5a2d8b5eef8" xlink:to="loc_us-gaap_EarningsPerShareDiluted_2b96decc-9f48-4f42-9dc3-ca43d557346b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_e8a206a5-8d82-4623-8d3b-0fabed5e876b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_ef3513d7-e4ea-416a-bee9-2e5a9b9d3f44" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_e8a206a5-8d82-4623-8d3b-0fabed5e876b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_b5aa50eb-1bdd-4544-b5e4-4dd35e43c0f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_e8a206a5-8d82-4623-8d3b-0fabed5e876b" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_b5aa50eb-1bdd-4544-b5e4-4dd35e43c0f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/NexoBridLicenseandSupplyAgreementsDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#NexoBridLicenseandSupplyAgreementsDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/NexoBridLicenseandSupplyAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_ba1ce11a-0d7b-480b-acae-cc9fe558b5eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_e9c8401c-4c91-4502-b115-3b54ef52b84d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_ba1ce11a-0d7b-480b-acae-cc9fe558b5eb" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_e9c8401c-4c91-4502-b115-3b54ef52b84d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_fe036542-1f24-4e54-907e-ef6209e2ccdb" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_e9c8401c-4c91-4502-b115-3b54ef52b84d" xlink:to="loc_srt_CounterpartyNameAxis_fe036542-1f24-4e54-907e-ef6209e2ccdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_914d56c9-46ae-4cdd-a11b-df6dbf1fc9ee" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_fe036542-1f24-4e54-907e-ef6209e2ccdb" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_914d56c9-46ae-4cdd-a11b-df6dbf1fc9ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_MediWoundLtdMember_eda81e59-f65f-4c9f-a74c-13c4631f484d" xlink:href="vcel-20230331.xsd#vcel_MediWoundLtdMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_914d56c9-46ae-4cdd-a11b-df6dbf1fc9ee" xlink:to="loc_vcel_MediWoundLtdMember_eda81e59-f65f-4c9f-a74c-13c4631f484d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_1199a1ce-7aab-4854-bef1-60b1dd399eed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_e9c8401c-4c91-4502-b115-3b54ef52b84d" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_1199a1ce-7aab-4854-bef1-60b1dd399eed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_f29e3ca6-9e32-464d-8ce0-c91c48b631de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_1199a1ce-7aab-4854-bef1-60b1dd399eed" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_f29e3ca6-9e32-464d-8ce0-c91c48b631de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_0cd5c3bf-1543-4192-ab30-e1c1e65fd162" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_f29e3ca6-9e32-464d-8ce0-c91c48b631de" xlink:to="loc_us-gaap_SubsequentEventMember_0cd5c3bf-1543-4192-ab30-e1c1e65fd162" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_122c4a8a-8fb2-4572-be31-726f8ffae33f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_e9c8401c-4c91-4502-b115-3b54ef52b84d" xlink:to="loc_us-gaap_RelatedPartyTransactionLineItems_122c4a8a-8fb2-4572-be31-726f8ffae33f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LicenseAgreementConsideration_490d376e-ffeb-4514-a392-521bf838ca55" xlink:href="vcel-20230331.xsd#vcel_LicenseAgreementConsideration"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_122c4a8a-8fb2-4572-be31-726f8ffae33f" xlink:to="loc_vcel_LicenseAgreementConsideration_490d376e-ffeb-4514-a392-521bf838ca55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LicenseAgreementContingentConsideration_0ceb9aa0-8093-44de-9e3d-6c4adf385a3d" xlink:href="vcel-20230331.xsd#vcel_LicenseAgreementContingentConsideration"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_122c4a8a-8fb2-4572-be31-726f8ffae33f" xlink:to="loc_vcel_LicenseAgreementContingentConsideration_0ceb9aa0-8093-44de-9e3d-6c4adf385a3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LicenseAgreementContingentConsiderationMaximum_8c91ef17-3093-43ed-9950-daa2f0c757fd" xlink:href="vcel-20230331.xsd#vcel_LicenseAgreementContingentConsiderationMaximum"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_122c4a8a-8fb2-4572-be31-726f8ffae33f" xlink:to="loc_vcel_LicenseAgreementContingentConsiderationMaximum_8c91ef17-3093-43ed-9950-daa2f0c757fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LicenseAgreementInitialMilestoneSales_e1ff6a33-fcb6-45ea-9053-8ff20d41b3f7" xlink:href="vcel-20230331.xsd#vcel_LicenseAgreementInitialMilestoneSales"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_122c4a8a-8fb2-4572-be31-726f8ffae33f" xlink:to="loc_vcel_LicenseAgreementInitialMilestoneSales_e1ff6a33-fcb6-45ea-9053-8ff20d41b3f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LicenseAgreementSupplyAgreementTerm_dcec3ce6-1cab-4df8-a896-b6b896d6e08f" xlink:href="vcel-20230331.xsd#vcel_LicenseAgreementSupplyAgreementTerm"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_122c4a8a-8fb2-4572-be31-726f8ffae33f" xlink:to="loc_vcel_LicenseAgreementSupplyAgreementTerm_dcec3ce6-1cab-4df8-a896-b6b896d6e08f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LicenseAgreementSupplyAgreementRenewalTerm_485fb5eb-0755-47d9-bee0-9e6bfd1ed635" xlink:href="vcel-20230331.xsd#vcel_LicenseAgreementSupplyAgreementRenewalTerm"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_122c4a8a-8fb2-4572-be31-726f8ffae33f" xlink:to="loc_vcel_LicenseAgreementSupplyAgreementRenewalTerm_485fb5eb-0755-47d9-bee0-9e6bfd1ed635" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_LicenseAgreementAdditionalFunding_1a9bff28-a74b-4ef3-9856-7b4bec7ae9ea" xlink:href="vcel-20230331.xsd#vcel_LicenseAgreementAdditionalFunding"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_122c4a8a-8fb2-4572-be31-726f8ffae33f" xlink:to="loc_vcel_LicenseAgreementAdditionalFunding_1a9bff28-a74b-4ef3-9856-7b4bec7ae9ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vcel.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="vcel-20230331.xsd#SubsequentEventsDetails"/>
  <link:presentationLink xlink:role="http://vcel.com/role/SubsequentEventsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsAbstract_17ba905b-5011-4620-b470-b1f3f2fd8d48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_634ef35d-5dff-429c-8664-dca49dacf0f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_17ba905b-5011-4620-b470-b1f3f2fd8d48" xlink:to="loc_us-gaap_SubsequentEventTable_634ef35d-5dff-429c-8664-dca49dacf0f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_7d0fca7b-8a78-4c79-a9e6-922012f01994" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_634ef35d-5dff-429c-8664-dca49dacf0f8" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_7d0fca7b-8a78-4c79-a9e6-922012f01994" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_fc3e5168-654c-45e8-9156-1481161ef67a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_7d0fca7b-8a78-4c79-a9e6-922012f01994" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_fc3e5168-654c-45e8-9156-1481161ef67a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_cbc1e709-d84f-4c7c-ae43-419375ba77c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_fc3e5168-654c-45e8-9156-1481161ef67a" xlink:to="loc_us-gaap_SubsequentEventMember_cbc1e709-d84f-4c7c-ae43-419375ba77c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_2d5e4cb6-4460-4006-b3ff-27eb2f98533e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_634ef35d-5dff-429c-8664-dca49dacf0f8" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_2d5e4cb6-4460-4006-b3ff-27eb2f98533e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_5aca200e-fde9-4aa5-b8e3-b901caf7ec11" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_2d5e4cb6-4460-4006-b3ff-27eb2f98533e" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_5aca200e-fde9-4aa5-b8e3-b901caf7ec11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_A25NetworkDriveBurlingtonMassachusettsMember_91ed3639-874b-49e4-8825-c9f062786e6c" xlink:href="vcel-20230331.xsd#vcel_A25NetworkDriveBurlingtonMassachusettsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_5aca200e-fde9-4aa5-b8e3-b901caf7ec11" xlink:to="loc_vcel_A25NetworkDriveBurlingtonMassachusettsMember_91ed3639-874b-49e4-8825-c9f062786e6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_452e76b8-e8cc-4e50-8477-52d37ec806e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_634ef35d-5dff-429c-8664-dca49dacf0f8" xlink:to="loc_us-gaap_SubsequentEventLineItems_452e76b8-e8cc-4e50-8477-52d37ec806e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_EscrowDepositPercentContributed_de2d51c7-69a2-45b1-84cc-5d70b07c7c9c" xlink:href="vcel-20230331.xsd#vcel_EscrowDepositPercentContributed"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_452e76b8-e8cc-4e50-8477-52d37ec806e1" xlink:to="loc_vcel_EscrowDepositPercentContributed_de2d51c7-69a2-45b1-84cc-5d70b07c7c9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EscrowDeposit_60eaa0aa-23b0-47f6-834f-32aaf1b81e28" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EscrowDeposit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_452e76b8-e8cc-4e50-8477-52d37ec806e1" xlink:to="loc_us-gaap_EscrowDeposit_60eaa0aa-23b0-47f6-834f-32aaf1b81e28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vcel_EscrowDepositRemainingPercentToBeContributed_47f56653-5d87-46bc-ae1f-b3a460f4decf" xlink:href="vcel-20230331.xsd#vcel_EscrowDepositRemainingPercentToBeContributed"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_452e76b8-e8cc-4e50-8477-52d37ec806e1" xlink:to="loc_vcel_EscrowDepositRemainingPercentToBeContributed_47f56653-5d87-46bc-ae1f-b3a460f4decf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
