Income Tax Reconciliation Tax Repeal
Michigan business tax repeal
The portion of the difference between total income tax expense or benefit as reported in the Income Statement and the expected income tax expense or benefit computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations, which is attributable to the taxes repealed during the period.
Convertible Preferred Stock Conversion Ratio
Conversion ratio, the number of shares of common stock received per share of convertible preferred stock
Represents, in the form of a ratio, the number of shares of common stock received in conversion per share of convertible preferred stock.
Class of Warrant or Right Warrants Issued to Underwriter for Exercise of Over Allotment Option
Warrants issued to the underwriter pursuant to the exercise of its over-allotment option
Represents the warrants issued to the underwriter pursuant to the exercise of its over-allotment option.
Non Employee [Member]
Non-employee
Represents the non-employee director of the entity.
Warrants Issued in October 2007 [Member]
October 2007 Warrants
Represents the October 2007 Warrants issued by the entity.
January 2010 Class A Warrants
Represents the Class A warrants issued by the entity in January 2010.
Class A Warrants Issued in January 2010 [Member]
Warrants Issued in December 2010 [Member]
December 2010 Warrants
Represents the warrants issued by the entity in December 2010.
Series B 2 Preferred Stock [Member]
Convertible preferred shares with voting rights, reported as temporary equity not forming the part of equity.
Series B-2 voting convertible preferred stock
Series B-2 Preferred Stock
Series B 1 Preferred Stock [Member]
Convertible preferred shares with no voting rights, reported as temporary equity not forming the part of equity.
Series B-1 non-voting convertible preferred stock
Series B-1 preferred stock
Document and Entity Information
Amendment Description
Convertible preferred stock, shares reserved
Temporary Equity Shares Reserved for Future Issuance
Aggregate number of securities classified as temporary equity reserved for future issuance.
Amendment Flag
Research and Development Agreements
Research and development agreements
Revenue from Research And Development Agreements when the scientific or clinical results stipulated in the agreement have been met and there are no ongoing obligations on the part of the company.
Organizational Costs Activity
Start-up activities include those one-time activities related to opening a new facility, introducing a new product or service, conducting business in a new territory, conducting business with a new class of customer or beneficiary, initiating a new process in an existing facility, or commencing some new operation. Start-up activities include activities related to organizing a new entity (commonly referred to as organization costs).
Organizational costs
Basis of Presentation
Basis of Presentation
The entire disclosure for warrants including description, amounts outstanding, fair value calculation and estimates.
Warrants and Rights Note Disclosure [Text Block]
Stock Purchase Warrants
Schedule of Class of Warrant or Right Valuation Assumptions [Table Text Block]
Schedule of assumptions used in calculating estimated fair value of warrants
Tabular disclosure of the significant assumptions used during the period to estimate the fair value of warrant liabilities, including, but not limited to: (a) expected term of instruments, (b) expected volatility of the entity's shares, (c) closing stock price, (d) risk-free rate, and (e) dividend rate.
Summary of change in estimated fair value of warrant liabilities
Tabular disclosure of change in the estimated fair value of the warrant liabilities.
Schedule of Change in Estimated Fair Value of Warrant Liabilities [Table Text Block]
Minimum Period of Uncertainty Regarding Entity's, Ability to Maintain Liquidity Sufficient to Operate Business Effectively
Minimum period of uncertainty regarding the entity's ability to maintain liquidity sufficient to operate business effectively
Represents the minimum period of uncertainty regarding the entity's ability to maintain liquidity sufficient to operate business effectively.
Weighted Average Exercise Price
Share Based Compensation Arrangement by Share Based Payment Award Options Outstanding, Weighted Average Exercise Price [Abstract]
Share Based Compensation Arrangement by Share Based Payment Award Options, Weighted Average Remaining Contractual Term [Abstract]
Weighted Average Remaining Contractual Term (Years)
Share Based Compensation Arrangement by Share Based Payment Award Options, Aggregate Intrinsic Value [Abstract]
Aggregate Intrinsic Value
Warrants and Rights [Roll Forward]
Change in the estimated fair value of warrant liabilities
A roll forward is a reconciliation of a concept from the beginning of a period to the end of the period.
Offering price per share (in dollars per share)
Represents the offering price per share of preferred stock issued during the period.
Stock Issued During Period Offering Price Per Share
Period of closing of offering after which shares are convertible
Represents the period of closing of offering after which shares are convertible.
Preferred Stock, Period of Closing of Offering after which Shares are Convertible
Preferred Stock Conversion Price Per Share
Conversion price per share (in dollars per share)
Represents the conversion price per share of convertible preferred stock.
Preferred Stock, Cumulative Dividend Rate, Percentage
Percentage of cumulative dividend rate
Represents the cumulative percentage rate used to calculate dividend payments on preferred stock.
Preferred Stock, Period for Accrual of Dividend
Period for accrual of dividend
Represents the period during which dividends will accrue on preferred stock.
Current Fiscal Year End Date
Award Type [Axis]
Series I Convertible Preferred Stock [Member]
1998 Series I Convertible Preferred Stock
A Series I Convertible Preferred Stock that may be exchanged into common shares or other types of securities at the owner's option as long as it is in accordance with the issuer's terms. Classified within stockholders' equity if nonredeemable or redeemable solely at the option of the issuer. Classified within temporary equity if redemption is outside the control of the issuer.
Series III Convertible Preferred Stock [Member]
1999 Series III Convertible Preferred Stock
A Series III Convertible Preferred Stock that may be exchanged into common shares or other types of securities at the owner's option as long as it is in accordance with the issuer's terms. Classified within stockholders' equity if nonredeemable or redeemable solely at the option of the issuer. Classified within temporary equity if redemption is outside the control of the issuer.
Adjustments to Additional Paid in Capital, Payment Received under Shareholder Note Receivable
Principal payment received under shareholder note Receivable
Adjustments to additional paid in capital resulting from the principal payment received under the shareholder note receivable.
Expected proceeds from sale of common stock
Expected Proceeds from Issuance or Sale of Equity
The expected cash inflow from the issuance of common stock under at the Market Sales Agreement.
Percentage of Gross Proceeds Payable as Commission
Percentage of gross proceeds payable as commission
Represents the percentage of gross proceeds payable as commission.
Represents details pertaining to McNicoll, Lewis & Vlak LLC with whom the entity entered into an At the Market Sales Agreement.
McNicoll Lewis and Vlak LLC [Member]
MLV
The additional number of rights distributed to shareholders per share of common stock issued between close of business date and distribution date.
Class of Warrant or Right, Additional Number of Rights Distributed Per Common Share
Additional number of rights per common share
Represents the percentage of the entity's outstanding common stock that must be acquired for rights to become exercisable by an individual or group.
Class of Warrant or Right, Condition on Exercise of Rights Percentage of Common Stock Acquired
Percentage of common stock to be acquired for rights to be exercisable by an individual or group
Percentage of common stock to be owned for rights to be exercisable by an individual or group commencing a tender offer
Represents the percentage of the entity's outstanding common stock that must be owned for rights to become exercisable by an individual or group commencing a tender offer.
Class of Warrant or Right, Condition on Exercise of Rights, Percentage of Common Stock Owned by Person or Group Commencing Tender Offer
Represents the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.
Share Based Compensation Arrangement by Share Based Payment Award Options Cancelled in Period
Cancelled (in shares)
Cancelled (in dollars per share)
Represents the weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were cancelled.
Share Based Compensation Arrangements by Share Based Payment Award Options Cancelled in Period Weighted Average Exercise Price
Document Period End Date
Diversity of Credit Risk [Policy Text Block]
Diversity of Credit Risk
Disclosure of accounting policy guidelines for diversification and maturity of investments.
Warrants
Disclosure of accounting policy for warrants.
Warrants [Policy Text Block]
Tabular disclosure of the components of accrued employee benefits.
Schedule of Accrued Employee Benefits [Table Text Block]
Schedule of accrued employee benefits
Warrants
The portion of the difference between total income tax expense or benefit as reported in the Income Statement for the period and the expected income tax expense or benefit computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations attributable to warrant expenses under enacted tax laws.
Income Tax Reconciliation Warrants
Income Tax Reconciliation Net Operating Loss (Benefit)
Michigan NOL benefit
The sum of the differences between total income tax expense (benefit) as reported in the income statement for the period and the expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations attributable to net operating loss benefit.
Income Tax Reconciliation Net Operating Loss Expirations
Net operating loss expirations
The sum of the differences between total income tax expense (benefit) as reported in the income statement for the period and the expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations attributable to net operating loss expirations.
Operating Loss Carryforwards and Tax Credit Carryforwards [Table]
Schedule reflecting pertinent information, such as tax authority, amounts, and expiration dates, of net operating loss carryforwards and tax credit carryforwards.
Net operating loss and tax credit carryforwards
Net Operating Loss Carryforwards and Tax Credit Carryforwards [Line Items]
Operating Lease Area Leased
Area leased
Represents the area leased under the operating lease agreement.
Entity [Domain]
Represents the term of the operating lease agreement.
Operating Lease Term
Lease term
Number of five-year market value renewals
Represents the number of five-year market value renewals under the operating lease agreement.
Operating Lease Number of Five Year Market Value Renewals
Operating Lease Period of Market Value Renewals
Period of market value renewals
Represents the period of market value renewals under the operating lease agreement.
Arrangements and Non-arrangement Transactions [Domain]
Operating Lease Rating Class of Modular Manufacturing Clean Room Laboratories and Office Space Leased
Rating class of modular manufacturing clean room, laboratories and office space leased
Represents the rating class of modular manufacturing clean room, laboratories and office space leased under the operating lease agreement.
Represents the number of rights for each outstanding share of common stock.
Class of Warrant or Right Number of Rights Per Common Stock Share
Number of rights for each outstanding share of common stock
Class of Right Condition on Exercise of Rights Number of Multiples of Exercise Price Holder Can Receive in Common Stock Value
Multiple of the value of common stock acquired (after conversion from preferred) to the exercise price of stock purchase right in the event of an acquiring person event
Represents the number of multiples of the exercise price of the right that the right holder will receive in value of the entity's common stock when an acquiring person event occurs.
Represents the number of multiples of the exercise price of the right that the right holder will receive in value of the entity's common stock when a merger of the entity occurs.
Multiple of the value of common stock acquired to the exercise price of stock purchase right in the event of a merger of the entity
Class of Right Condition on Exercise of Rights Number of Multiples of Exercise Price Holder Can Receive in Common Stock Value in Event of Merger
The minimum cumulative percentage change of ownership positions of certain stockholders that results in change in control.
Minimum Cumulative Percentage Change of Ownership over which Change in Control is Considered
Minimum cumulative percentage change of ownership over which change in control is considered
The rolling period over which cumulative percentage change of ownership positions is required for change in control.
Period over which Cumulative Change of Ownership Required for Change in Control
Rolling period over which cumulative change of ownership is required for change in control
Represents the reduction in income tax expense (benefit) resulting from gross unrecognized tax benefits recognized due to valuation allowance.
Income Tax Expense (Benefit) Reduction Resulting from Gross Unrecognized Tax Benefits Recognized Due to Valuation Allowance
Reduction in income tax expense if gross unrecognized tax benefits have been recognized due to valuation allowance
Collaborative Arrangement Royalty Revenue as Percentage of Net Sales of Products
Royalty revenue as a percentage of net sales of products
Represents the amount of royalty revenue as a percentage of net sales of products under the collaborative arrangement.
Maximum Period before Cash and Cash Equivalents are Fully Depleted
Maximum period before cash and cash equivalents are not sufficient to sustain operations
Represents the maximum period of time before cash and cash equivalents are fully depleted.
2009 Plan
Represents the information pertaining to 2009 Omnibus Incentive Plan.
Omnibus Incentive Plan 2009 [Member]
Prior Plans [Member]
2004, 2001 and 1992 PLANS
Represents the information pertaining to the Prior Plans consisting of 1992 Stock Option Plan, the 2001 Stock Option Plan and the Amended and Restated 2004 Equity Incentive Plan.
Consideration to be received on issuance of convertible securities or shares depending upon which warrants contain anti-dilution provisions
Represents the consideration to be received on issuance of convertible securities or shares depending upon which warrants contain anti-dilution provisions.
Proceeds from Issuance of Convertible Securities Depending upon which Warrants Contain Antidilution Provisions
Class of Warrant or Right Number of Warrants Issued
Number of warrants issued.
Number of warrants issued
Corning
Sublicense Agreement [Member]
Represents the details pertaining to sublicense agreement relating to the entity's cell transfection technology.
Warrants Issued in August 2013 [Member]
August 2013 warrants
Represents the warrants issued by the entity in August 2013.
Represents the number of warrant holders.
Number of Warrant Holders
Number of warrant holders
Warrant issuance
Represents the value of warrants issued during the period.
Class of Warrant or Right Warrants Issued Value
Fair market value of the warrants
Class of Warrant or Right Warrants Exercised Value
Warrant exercise
Represents the value of warrants exercised during the period.
Error of Classification of Carrying Value of Series B1 Preferred Stock [Member]
Classification error for Series B-1 preferred stock carrying value
Represents the classification error regarding its previous reporting for the Series B-1 preferred stock carrying value.
Earnings Per Share Basic and Diluted [Line Items]
Net Loss Per Common Share
Net Proceeds from Issuance or Sale of Equity
Represents the net amount of cash inflow from the issuance of common stock, preferred stock, treasury stock, stock options, and other types of equity.
Net proceeds raised from sale of shares under ATM
Stock Issued to Underwriter for Exercise of Over Allotment Option
Represents the shares issued to the underwriter pursuant to the exercise of its over-allotment option.
Common stock issued to the underwriter pursuant to the exercise of its over-allotment option (in shares)
Correction of Error [Member]
Correction of error determined to be immaterial to the prior reporting periods.
Correction of error
Accumulated Undeclared Dividends
Accumulated but undeclared dividends
Represents the amount of accumulated but undeclared dividends related to convertible preferred stock.
Stock Issued During Period Value Preferred Stock Issues
Issuance of preferred stock
Represents the equity impact of the value of new preferred stock issued during the period.
Issuance of preferred stock (in shares)
Stock Issued During Period Shares Preferred Stock Issues
Represents the number of new preferred stocks issued during the period.
Class of Warrant or Rights Redemption Price Per Right
Redemption price per right (in dollars per right)
Represents the redemption price per right, which will expire unless earlier redeemed.
Convertible Preferred Stock 5.5 [Member]
5.5% Convertible Preferred Stock
Represents information pertaining to 5.5% Convertible Preferred Stock.
Linco in Park Capital Fund LLC [Member]
Lincoln Park
Represents information pertaining to Lincoln Park Capital Fund, LLC.
Value of Shares of Common Stock to be Sold
Value of shares of common stock to be sold
Represents the value of shares of common stock to be sold as per the purchase agreement entered into by the entity.
Value of shares of common stock under obligation to purchase
Represents the value of shares of common stock to be purchased as per the purchase agreement entered into by the entity.
Value of Shares of Common Stock to be Purchased
Period over which Shares of Common Stock to be Purchased
Period over which shares of common stock to be purchased
Represents the period over which shares of common stock to be purchased as per the purchase agreement entered into by the entity.
Number of Shares of Common Stock to be Purchased in Regular Purchases
Number of shares of common stock to be purchased in regular purchases
Represents the number of shares of common stock to be purchased in regular purchases, if directed by the entity as per the purchase agreement.
Number of Shares of Common Stock to be Purchased Based on Closing Sale Price of Common Stock
Number of shares of common stock to be purchased depending upon the closing sale price of the common stock
Represents the number of shares of common stock to be purchased depending upon the closing sale price of the common stock, if directed by the entity as per the purchase agreement.
Threshold Closing Sale Price of Common Stock on Date of Regular Purchase to Trigger Accelerated Purchases of Additional Common Stock
Threshold closing sale price of the common stock on the date of a regular purchase to trigger purchase of additional amounts as accelerated purchases (in dollars per share)
Represents the threshold closing sale price of the common stock on the date of a regular purchase to trigger accelerated purchases of additional shares of common stock, if directed by the entity as per the purchase agreement.
Period of Business Days over which Purchase Price of Shares of Common Stock will be Determined
Period of business days over which purchase price of shares of common stock will be determined
Represents the period of business days over which purchase price of shares of common stock will be determined as per the purchase agreement entered into by the entity.
Floor Price for Sale of Shares of Common Stock
Floor price for sale of shares of common stock (in dollars per share)
Represents the floor price for the sale of shares of common stock as per the purchase agreement entered into by the entity.
Reverse stock split common stock in lieu of fractional shares
Represents the value of shares issued during the period in lieu of fractional shares as a result of reverse stock split.
Stock Issued During Period Value Reverse Stock Split in Lieu of Fractional Shares
Stock Issued During Period Shares Reverse Stock Split in Lieu of Fractional Shares
Reverse stock split common stock in lieu of fractional shares (in shares)
Represents the number of shares issued during the period in lieu of fractional shares as a result of reverse stock split.
Cumulative Proceeds from Issuance of Common Stock
Total gross proceeds
Represents the cumulative proceeds from issuance of common stock.
Reverse Stock Split [Policy Text Block]
Reverse Stock Split
Disclosure of accounting policy for reverse stock spilt.
Entity Well-known Seasoned Issuer
Reverse Stock Split [Abstract]
Reverse Stock Split
Entity Voluntary Filers
Operating Loss Carryforwards Amount understated
Amount of net operating loss carryforward understated
Represents the amount of operating loss carryforward understated during the period.
Entity Current Reporting Status
Operating Loss Carryforwards Valuation Allowance Amount Understated
Amount of valuation allowance associated with operating loss carryforward understated
Represents the amount of the valuation allowance associated with operating loss carryforward understated during the period.
Entity Filer Category
Error in Income Tax Disclosure [Member]
Error in income tax disclosure
Represents information pertaining to the error in income tax disclosure.
Entity Public Float
Stock Issued During Period Value Common Stock Issues IPO
Initial public offering of common stock at $1,120 per share, net of issuance costs of $2,865
Equity impact of the value of new stock issued during the period. Includes shares issued in an initial public offering.
Entity Registrant Name
Number of new stock issued during the period in an initial public offering.
Initial public offering of common stock at $1,120 per share, net of issuance costs of $2,865 (in shares)
Stock Issued During Period Shares Common Stock Issues IPO
Entity Central Index Key
Eastern Capital Limited and Affiliates [Member]
Eastern Capital Limited and its affiliates
Represents information pertaining to Eastern Capital Limited and its affiliates.
Represents the percentage of common stock approved to be purchased.
Class of Warrant or Right Percentage of Common Stock Approved to be Purchased
Percentage of common stock approved to be purchased
Class of Warrant or Right Number of Rights Deemed to be Delivered Per Common Stock Share Issued or Transferred
Number of rights deemed to be delivered for each share of common stock issued or transferred
Represents the number of rights deemed to be delivered for each share of common stock issued or transferred by the entity.
Operating Loss Carryforwards Amount Overstated
Amount of net operating loss carryforward overstated
Represents the amount of operating loss carryforward overstated during the period.
Entity Common Stock, Shares Outstanding
Represents the equity impact of the value of preferred stock reclassified from temporary equity during the period.
Stock Issued During Period Value Conversion of Temporary Equity
Reclassification of Series B-2 Preferred Stock
Stock Issued During Period Shares Conversion of Temporary Equity
Reclassification of Series B-2 Preferred Stock (in shares)
Represents the number of shares of preferred stock reclassified from temporary equity during the period.
Net Income (Loss) Available to Common Stockholders Basic before Dividends
NET LOSS ATTRIBUTABLE TO COMMON SHAREHOLDERS
Net income before adjustments for dividends on preferred stock (declared in the period) and/or cumulative preferred stock (accumulated for the period).
Sanofi [Member]
Sanofi
Represents information pertaining to Sanofi.
Number of Patents and Patent Applications to be Acquired
Number of patents and patents applications to be acquired
Represents the number of patents and patent applications to be acquired by the entity.
Organization and Summary of Significant Accounting Policies [Line Items]
Organization and summary of significant accounting policies
Threshold on percentage of outstanding shares of the common stock that can be beneficially owned by counterparty
Represents the threshold on percentage of outstanding shares of the common stock that can be beneficially owned by counterparty to the agreement.
Threshold on Percentage of Outstanding Shares of Common Stock that can be Beneficially Owned by Counterparty
Threshold Percentage of Outstanding Equity Securities for Prepayment of Promissory Note Due
Percentage of outstanding equity securities
Represents the percentage of outstanding equity securities as a covenant for prepayment and due of promissory note.
Document Fiscal Year Focus
Document Fiscal Period Focus
Legal Entity [Axis]
Document Type
Organization and Summary of Significant Accounting Policies
Accounts payable and accrued expenses
Accounts payable and accrued expenses
Accounts Payable and Accrued Liabilities, Current
Accounts Payable and Accrued Expenses
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable
Accounts Payable, Current
Vacation pay and other
Accrued Vacation, Current
Accrued employee benefits
Accrued employee benefits
Accrued Employee Benefits, Current
Accrued expenses
Accrued Liabilities, Current
Bonus
Accrued Bonuses, Current
Less accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Issuance of Stock Purchase Rights for cash in September 1995 and March 1996
Adjustments to Additional Paid in Capital, Warrant Issued
Adjustments to reconcile net loss to net cash used for operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Compensation expense related to stock options, restricted stock, and warrants granted
Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition
Issuance of stock, issuance cost
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Net compensation expense related to employees and directors (in dollars)
Allocated Share-based Compensation Expense
Amortization of discounts and premiums on investments
Amortization of Financing Costs and Discounts
Aggregate number of common equivalent shares (related to options, warrants and preferred stock) that have been excluded from computations of diluted net loss per common share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Total assets
Total assets
Assets
Current assets:
Assets, Current [Abstract]
ASSETS
Assets [Abstract]
Total current assets
Total current assets
Assets, Current
Selected Balance Sheet Information
Basis of Presentation
Basis of Accounting [Text Block]
Total consideration
Business Combination, Consideration Transferred
Counterparty Name [Axis]
2014
Capital Leases, Future Minimum Payments Due in Two Years
Total
Capital Leases, Future Minimum Payments Due
2015
Capital Leases, Future Minimum Payments Due in Three Years
2016
Capital Leases, Future Minimum Payments Due in Four Years
Capital leases
Capital Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract]
Equipment acquired under capital lease obligations
Capital Lease Obligations Incurred
More than 5 Years
Capital Leases, Future Minimum Payments Due Thereafter
2014
Capital Leases, Future Minimum Payments Due, Next Twelve Months
Cash
Cash
Cash at beginning of period
Cash at end of period
Cash
Cash at beginning of period
Cash at end of period
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Warrants outstanding
Class of Warrant or Right, Outstanding
Shareholders' Equity
Series B Convertible Preferred Stock
Class of Stock [Line Items]
Class of Warrant or Right [Axis]
Class of Warrant or Right [Domain]
Total shares issuable on exercise
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrants sold (in shares)
Number of preferred share purchase rights for each outstanding share of the entity's common stock
Exercise price per share (in dollars per share)
Public offering price (in dollars per share)
Cash exercise prices (in dollars per unit)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Stock Purchase Warrants
Shareholder Rights Plan
Class of Warrant or Right [Line Items]
Class of Stock [Domain]
Class of Warrant or Right [Table]
Licenses, Royalties and Collaborative Agreements and Commitments
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Licenses, Royalties and Collaborative Agreements and Commitments
Collaborative Arrangement Disclosure [Text Block]
Commitments, Contingencies and Debt
COMMITMENTS AND CONTINGENCIES (Notes 8 and 9)
Commitments and Contingencies
Commitments, Contingencies and Debt
Commitments and Contingencies Disclosure [Text Block]
Initial public offering of common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Common Stock
Common Stock [Member]
Common stock, no par value; shares authorized - 15,000; shares issued and outstanding - 4,723 and 6,245, respectively
Common Stock, Value, Issued
Common Stock, shares issued
Common stock issued
Common Stock, Shares, Issued
Number of shares of common stock sold
Common Stock, shares authorized
Common Stock, Shares Authorized
Par value of common stock (in dollars per share)
Common Stock, No Par Value
Common Stock, shares outstanding
Common Stock, Shares, Outstanding
Employee Savings Plan
Computer software
Computer Software, Intangible Asset [Member]
Computer equipment
Computer Equipment [Member]
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Contractual Obligation, Fiscal Year Maturity Schedule [Abstract]
Future minimum payments
2015
Contractual Obligation, Due in Second Year
2018
Contractual Obligation, Due in Fifth Year
Schedule of future minimum payments related to operating and capital leases
Contractual Obligation, Fiscal Year Maturity Schedule [Table Text Block]
2017
Contractual Obligation, Due in Fourth Year
2014
Contractual Obligation, Due in Next Twelve Months
2016
Contractual Obligation, Due in Third Year
More than 5 Years
Contractual Obligation, Due after Fifth Year
Contractual Obligations
Contractual Obligation, Fiscal Year Maturity [Abstract]
Total
Contractual Obligation
Exercise of stock purchase warrants (in shares)
Conversion of Stock, Shares Issued
Exercise of stock purchase warrants
Conversion of Stock, Amount Issued
Convertible Preferred Stock [Member]
Series B-2 voting convertible preferred stock
Convertible preferred stock, shares reserved
Convertible Preferred Stock, Shares Reserved for Future Issuance
Cost of product sales and rentals
Cost of Goods Sold
Costs and expenses:
Costs and Expenses [Abstract]
Total costs and expenses
Costs and Expenses
Amount of consideration payable in the form of a promissory note
Debt Instrument, Face Amount
Initial public offering of common stock, issuance costs
Deferred Offering Costs
Total deferred tax assets
Deferred Tax Assets, Gross
Other, net
Deferred Tax Assets, Other
Research and development credit carryforwards
Deferred Tax Assets, Tax Credit Carryforwards, Research
Deferred tax assets
Deferred Tax Assets, Net [Abstract]
Employee benefits and stock compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Contributions made under 401(k) savings plan
Defined Contribution Plan, Cost Recognized
Depreciation and amortization
Depreciation, Depletion and Amortization
Stock-Based Compensation
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
Stock-Based Compensation
Cash dividends declared and paid
Dividends, Common Stock, Cash
Net loss per share attributable to common shareholders (Basic and Diluted) (see note 7) (in dollars per share)
Net loss per share attributable to common shareholders (basic and diluted) (in dollars per share)
Earnings Per Share, Basic and Diluted
Net Loss Per Share Attributable to Common Shareholders
Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items]
Net Loss Per Common Share
Earnings Per Share [Text Block]
Net Loss Per Share Attributable to Common Shareholders'
Earnings Per Share, Policy [Policy Text Block]
Net loss per share
Net Loss Per Common Share
Federal statutory rate (as a percent)
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Service-based stock options
Employee Stock Option [Member]
Weighted average period over which unrecognized compensation is expected to be recognized
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Total unrecognized compensation cost (in dollars)
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options
Accrued Employee Benefits
Employee-related Liabilities, Current [Abstract]
Series B Convertible Preferred Stock
Equity Component [Domain]
Measurement Frequency [Axis]
Expected stock price volatility (as a percent)
Fair Value Assumptions, Expected Volatility Rate
Decrease in fair value
Fair Value, Liabilities Measured on Recurring Basis, Change in Unrealized Gain (Loss)
Increase in fair value
Fair Value Measurements, Recurring and Nonrecurring [Table]
Fair Value, Hierarchy [Axis]
Liability Class [Axis]
Transfers to level 2
Fair Value, Measurement with Unobservable Inputs Reconciliation, Liability, Transfers out of Level 3
Transfers to level 2
Warrant exercises
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements
Warrant exercises
Recurring
Fair Value, Measurements, Recurring [Member]
Fair Value, Measurement Frequency [Domain]
Risk-free interest rate (as a percent)
Fair Value Assumptions, Risk Free Interest Rate
Fair Value Measurements
Fair Value Measurement, Policy [Policy Text Block]
(Increase) decrease in fair value of warrants
Change in fair value of warrants
Increase in fair value
Fair Value Adjustment of Warrants
Fair Value by Liability Class [Domain]
Expected life
Fair Value Assumptions, Expected Term
Assumptions used in calculating the estimated fair value of the warrants
Fair Value Assumptions and Methodology for Assets and Liabilities [Abstract]
Liabilities that are measured at fair value on a recurring basis
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Warrant issuance
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Issuances
Expected dividend rate (as a percent)
Fair Value Assumptions, Expected Dividend Rate
Beginning balance
Ending balance
Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value
Fair Value Hierarchy [Domain]
Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Schedule of reconciliation of beginning and ending balances for the Company's fair value measurements using Level 3 inputs
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Level 3
Fair Value, Inputs, Level 3 [Member]
Reconciliation of beginning and ending balances for the company's fair value measurements using Level 3 inputs
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Reconciliation of beginning and ending balances for the company's fair value measurements using Level 3 inputs
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Level 2
Fair Value, Inputs, Level 2 [Member]
Schedule of Company's liabilities that are measured at fair value on a recurring basis
Fair Value, Liabilities Measured on Recurring Basis [Table Text Block]
Furniture and fixtures
Furniture and Fixtures [Member]
Loss on property held for resale
Gain (Loss) on Disposition of Property Plant Equipment
Correction of a classification error
Immaterial Error Correction
Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
Loss before income taxes
Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest
Income Taxes
Income Tax Authority [Domain]
Income Tax Authority [Axis]
Income Taxes
Income Tax Disclosure [Text Block]
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Reconciliation of income taxes computed using the federal statutory rate to the taxes reported in consolidated statements of operations
Effective Income Tax Rate Reconciliation, Amount [Abstract]
Nondeductible stock compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Compensation Cost, Amount
Uncertain tax positions
Income Tax Uncertainties [Abstract]
Taxes computed at federal statutory rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Income Taxes
Income Tax, Policy [Policy Text Block]
Other
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Loss attributable to foreign operations
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Other current assets
Increase (Decrease) in Other Current Assets
Accounts payable and accrued expenses
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Amount of errors corrected
Reclassification of Series B-2 Preferred Stock
Increase in Carrying Amount of Redeemable Preferred Stock
Inventories
Increase (Decrease) in Inventories
Accrued employee benefits
Increase (Decrease) in Employee Related Liabilities
Receivables
Increase (Decrease) in Receivables
Increase (Decrease) in Shareholders' Equity
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Interest expense
Interest Expense
Interest paid
Interest Paid
Federal
Internal Revenue Service (IRS) [Member]
Inventory write downs
Inventory Write-down
Interest income
Investment Income, Interest
Stock issued pursuant to license agreement
Issuance of Stock and Warrants for Services or Claims
Leasehold improvements
Leasehold Improvements [Member]
Total current liabilities
Total current liabilities
Liabilities, Current
Total liabilities and shareholders' equity
Total liabilities and shareholders' equity (deficit)
Liabilities and Equity
Current liabilities:
Liabilities, Current [Abstract]
Total liabilities
Liabilities
LIABILITIES AND SHAREHOLDERS' EQUITY
Liabilities and Equity [Abstract]
Current portion of long-term debt
Long-term Debt, Current Maturities
Long-term debt
Long-term Debt, Excluding Current Maturities
Machinery and equipment
Machinery and Equipment [Member]
Maximum
Maximum [Member]
Minimum
Minimum [Member]
Nature of Error [Domain]
Financing activities:
Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract]
Operating activities:
Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract]
Net increase (decrease) in cash
Net Cash Provided by (Used in) Continuing Operations
Numerator of basic and diluted EPS
Net loss
Net loss attributable to common shareholders
Net Income (Loss) Available to Common Stockholders, Basic
Net cash used for operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations
Numerator:
Net Income (Loss) Attributable to Parent [Abstract]
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations
Net cash used for investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations
Investing activities:
Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract]
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Total other income (expense)
Nonoperating Income (Expense)
Number of reportable segments
Number of Reportable Segments
Office equipment
Office Equipment [Member]
More than 5 Years
Operating Leases, Future Minimum Payments, Due Thereafter
Operating leases
Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract]
2017
Operating Leases, Future Minimum Payments, Due in Four Years
2018
Operating Leases, Future Minimum Payments, Due in Five Years
2016
Operating Leases, Future Minimum Payments, Due in Three Years
Rent expense
Operating Leases, Rent Expense, Net
2014
Operating Leases, Future Minimum Payments Due, Next Twelve Months
Loss from operations
Loss from operations
Operating Income (Loss)
Operating Loss Carryforwards [Table]
2015
Operating Leases, Future Minimum Payments, Due in Two Years
Total
Operating Leases, Future Minimum Payments Due
Net operating loss carryforwards
Operating Loss Carryforwards
Licenses, Royalties and Collaborative Agreements and Commitments
Organization and Summary of Significant Accounting Policies
Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block]
Other current assets
Other Assets, Current
Other income
Other Nonoperating Income
Other income (expense):
Other Nonoperating Income (Expense) [Abstract]
MBT net operating loss has been derecognized as a result of repeal
Other Tax Expense (Benefit)
Other Tax Expense (Benefit)
Cash paid for warrant exercise
Payments for Repurchase of Warrants
Amount of consideration to be paid in cash
Payments to Acquire Businesses, Gross
Property and equipment purchases
Payments to Acquire Property, Plant, and Equipment
Purchase of short-term investments
Payments to Acquire Short-term Investments
Employee Savings Plan
Pension and Other Postretirement Benefits Disclosure [Text Block]
Plan Name [Domain]
Plan Name [Axis]
Par value per share (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Convertible Preferred Stock, par value (in dollars per share)
Dividends and yields on preferred stock (in shares)
Preferred Stock Dividends, Shares
Par value of convertible preferred stock (in dollars per share)
Preferred Stock, No Par Value
Convertible Preferred Stock, rate of interest (as a percent)
Percentage of accrued dividend rate
Preferred Stock, Dividend Rate, Percentage
Total convertible preferred stock
Preferred Stock, Value, Outstanding
Accretion of convertible preferred stock
Preferred Stock, Accretion of Redemption Discount
Series B Convertible Preferred Stock
Preferred Stock [Text Block]
Preferred stock, shares issued
Preferred Stock, Shares Issued
Convertible preferred stock, shares issued
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Convertible preferred stock, shares authorized
Redemption price (in dollars per share)
Preferred Stock, Redemption Price Per Share
Less: earnings attributable to convertible preferred stock
Preferred Stock Dividends, Income Statement Impact
Convertible preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock
Preferred Stock [Member]
Net proceeds from exercise of warrants
Proceeds from Warrant Exercises
Maturities of short-term investments
Proceeds from Sale, Maturity and Collection of Short-term Investments
Restricted cash used as compensating balance
Proceeds from (Repayments of) Restricted Cash, Financing Activities
Other, net
Proceeds from (Payments for) Other Financing Activities
Net proceeds from issuance of common stock and warrants
Net proceeds from issuance of common stock and warrants
Proceeds from Issuance or Sale of Equity
Proceeds from sale of common stock
Payments received for stock purchase rights and other, net
Proceeds from Issuance of Warrants
Net proceeds from issuance of preferred stock
Net proceeds from the sale of preferred stock
Proceeds from Issuance of Preferred Stock and Preference Stock
Proceeds from long-term debt
Proceeds from Issuance of Long-term Debt
Net Proceeds raised by utilizing Equity Line
Proceeds from Issuance of Common Stock
Proceeds from sale of property held for resale
Proceeds from Sale of Property, Plant, and Equipment
Estimated useful life
Property, Plant and Equipment, Useful Life
Property and equipment, gross
Property, Plant and Equipment, Gross
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Schedule of property and equipment
Property, Plant and Equipment [Table Text Block]
Property, Plant and Equipment, Type [Domain]
Property, Plant and Equipment, Type [Axis]
Property and Equipment
Property, Plant and Equipment [Line Items]
Provision for losses on accounts receivable
Provision for Doubtful Accounts
Correction of error
Quantifying Misstatement in Current Year Financial Statements [Line Items]
Nature of Error [Axis]
Range [Axis]
Range [Domain]
Series A Junior Participating Cumulative Preferred Stock
Rights [Member]
Receivables
Receivables, Net, Current
Principal payments under long-term debt obligations
Repayments of Long-term Debt
Counterparty Name [Domain]
Research and development
Research and Development Expense
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Restructuring charge
Restructuring Charges
Restructuring reserve related to severance payments
Restructuring Reserve
Restructuring
Restructuring
Restructuring and Related Activities Disclosure [Text Block]
Deficit Accumulated During the Development Stage
Retained Earnings [Member]
Deficit accumulated during the development stage
Retained Earnings (Accumulated Deficit)
Grants
Revenue from Grants
Revenue Recognition
Revenue Recognition, Policy [Policy Text Block]
Revenues:
Revenues [Abstract]
University Of Michigan
Royalty Agreement Terms [Member]
Future royalty revenue
Royalty Revenue
Total fair value of options vested (in dollars)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value
Expected life
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Expiration period
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period
Exercisable at the end of the period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Outstanding at the beginning of the period
Outstanding at the end of the period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Product sales and rentals
Sales Revenue, Goods, Net
Total revenues
Revenues
Revenue, Net
Actual
Scenario, Actual [Member]
Scenario, Unspecified [Domain]
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
Summary of activity for service-based stock options
Schedule of weighted average assumptions used to estimate fair value of each service-based stock option grant
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of reconciliation of income taxes computed using the federal statutory rate to the taxes reported in consolidated statements of operations
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of deferred tax assets
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Summary of the Company's quarterly consolidated results of operations
Schedule of Quarterly Financial Information [Table Text Block]
Schedule of Capital Units [Table]
Schedule of net loss attributable to common shareholders and share data used in the basic and diluted earnings per share computations using the two class method
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of accounts payable and accrued expenses
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table]
Schedule of Earnings Per Share, Basic, by Common Class, Including Two Class Method [Table]
Property, Plant and Equipment [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Quantifying Prior Year Misstatement Corrected in Current Year Financial Statements [Table]
Schedule of Stock by Class [Table]
Schedule of warrants outstanding
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Selling, general and administrative
Selling, General and Administrative Expense
Series A Preferred Stock
Series A Preferred Stock [Member]
Series E Preferred Stock
Series E Preferred Stock [Member]
Series B preferred stock
Series B Preferred Stock [Member]
Series B voting convertible preferred stock
Series B-2 voting convertible preferred stock
Granted (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Forfeited (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Stock compensation expense
Share-based Compensation
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Vesting period
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Stock-Based Compensation
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-Based Compensation
Share-based Compensation [Abstract]
Closing stock price (in dollars per share)
Share Price
Public offering price (in dollars per share)
Expired (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Exercised (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Exercisable at the end of the period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend rate (as a percent)
Anticipated dividend rate (as a percent)
Expired (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Exercisable at the end of the period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Additional disclosures
Awards available for future grant under the Plan (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Expected stock price volatility (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Risk-free interest rate (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Weighted average assumptions used to estimate fair value of each service-based stock option grant
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Weighted average grant-date fair value (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Forfeited or expired (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Forfeited or expired (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period
Outstanding at the beginning of the period (in dollars per share)
Outstanding at the end of the period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Stock-Based Compensation
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Outstanding at the beginning of the period (in shares)
Outstanding at the end of the period (in shares)
Outstanding at the beginning of the period
Outstanding at the end of the period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Equity Award [Domain]
Shares, Outstanding
BALANCE (in shares)
BALANCE (in shares)
State
State and Local Jurisdiction [Member]
Michigan
Scenario [Axis]
Statement [Table]
Statement
Statement [Line Items]
CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY (DEFICIT)
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
Equity Components [Axis]
CONDENSED CONSOLIDATED BALANCE SHEETS
Class of Stock [Axis]
Stock Issued During Period, Shares, Period Increase (Decrease)
Stock Issued During Period, Shares, Period Increase (Decrease)
Issuance of common stock for cash, services and license rights (in shares)
Stock Issued During Period, Shares, Issued for Services
Repurchase and retirement of common shares outstanding
Stock Repurchased and Retired During Period, Value
Issuance of restricted stock, net of cancellations (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Warrants exchanged for common stock
Warrants exchanged for common stock
Stock and Warrants Issued During Period, Value, Preferred Stock and Warrants
Conversion of preferred stock
Stock Issued During Period, Value, Conversion of Convertible Securities
Issuance of common stock for cash, services and license rights
Stock Issued During Period, Value, Issued for Services
Repurchase and retirement of common shares outstanding (in shares)
Stock Repurchased and Retired During Period, Shares
Issuance of stock under Direct Stock Purchase Plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Warrants exchanged for common stock
Exercise of stock options and stock purchase warrants, and issuance of stock under Employee Stock Purchase Plan (in shares)
Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures
Exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Forfeiture adjustments included in compensation costs due to restructuring activities (in dollars)
Stock Issued During Period, Value, Share-based Compensation, Forfeited
Issuance of stock under Direct Stock Purchase Plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of common stock, net of issuance costs of $980, $147, $13,424 during the period ended December 31, 2013, December 31, 2012 and December 31, 2010 respectively (in shares)
Shares of common stock sold
Number of shares sold
Stock Issued During Period, Shares, New Issues
Initial public offering of common stock at $1,120 per share, net of issuance costs of $2,865 (in shares)
Conversion of preferred stock (in shares)
Stock Issued During Period, Shares, Conversion of Convertible Securities
Exercise of stock options and stock purchase warrants, and issuance of stock under Employee Stock Purchase Plan
Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures
Dividends and yields on preferred stock
Stock Issued During Period, Value, Stock Dividend
Issuance of common stock, net of issuance costs of $980, $147, $13,424 during the period ended December 31, 2013, December 31, 2012 and December 31, 2010 respectively
Initial public offering of common stock at $1,120 per share, net of issuance costs of $2,865
Stock Issued During Period, Value, New Issues
Shareholders' equity:
Stockholders' Equity Attributable to Parent [Abstract]
Stockholders' Equity, Period Increase (Decrease)
Stockholders' Equity, Period Increase (Decrease)
Total shareholders' equity
BALANCE
BALANCE
Total shareholders' equity (deficit)
Stockholders' Equity Attributable to Parent
Shareholders' Equity
Shareholders' Equity
Stockholders' Equity Note Disclosure [Text Block]
Stockholders' Equity Note, Stock Split, Conversion Ratio
Reverse stock split ratio
Subsequent Event
Subsequent Events [Text Block]
Subsequent Event
Subsequent Event [Table]
Subsequent event
Subsequent Event [Line Items]
Subsequent Event
Subsequent event
Subsequent Event [Member]
Subsequent Event Type [Domain]
Subsequent Event Type [Axis]
Selected Balance Sheet Information
Supplemental Balance Sheet Disclosures [Text Block]
Supplemental cash flow information (non-cash):
Supplemental Cash Flow Information [Abstract]
Tax credit carryforwards
Tax Credit Carryforward, Amount
Income taxes
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward [Table]
Convertible preferred stock, shares outstanding
Preferred stock, shares outstanding
Temporary Equity, Shares Outstanding
Par value of convertible preferred stock (in dollars per share)
Temporary Equity, Par or Stated Value Per Share
Total convertible preferred stock
Carrying value of convertible preferred stock
Temporary Equity, Carrying Amount, Attributable to Parent
Convertible preferred stock, shares authorized
Temporary Equity, Shares Authorized
Convertible preferred stock, shares issued
Temporary Equity, Shares Issued
Reclassification of Series B preferred stock
Temporary Equity, Carrying Amount, Period Increase (Decrease)
Title of Individual [Axis]
Relationship to Entity [Domain]
Type of Arrangement and Non-arrangement Transactions [Axis]
Unrecognized tax benefit associated with research and development tax credits
Unrecognized Tax Benefits
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Warrants
Warrant [Member]
Stock Purchase Warrants
Warrant liabilities
Warrants outstanding
Balance at the beginning of the period
Balance at the end of the period
Warrants and Rights Outstanding
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Weighted average number of common shares outstanding (Basic and Diluted)
Weighted Average Number of Shares Outstanding, Basic and Diluted
Denominator for basic and diluted EPS: Weighted-average common shares outstanding