Statement of Financial Position [Abstract] ASSETS Assets [Abstract] Current assets: Assets, Current [Abstract] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Short term investments Short-term Investments Accounts receivable (net of allowance for doubtful accounts of $286 and $249, respectively) Accounts Receivable, Net, Current Inventory Inventory, Net Other current assets Other Assets, Current Total current assets Assets, Current Property and equipment, net Property, Plant and Equipment, Net Total assets Assets LIABILITIES AND SHAREHOLDERS’ EQUITY Liabilities and Equity [Abstract] Current liabilities: Liabilities, Current [Abstract] Accounts payable Accounts Payable, Current Accrued expenses Accounts Payable and Accrued Liabilities, Current Deferred rent Contract with Customer, Liability, Current Current portion of term loan credit agreement (net of deferred costs of $69 and $67, respectively) Line of Credit and Term Loan Credit Agreement, Current, Net of Deferred Costs Line of Credit and Term Loan Credit Agreement, Current, Net of Deferred Costs Warrant liabilities Derivative Liability, Current Other Other Liabilities, Current Total current liabilities Liabilities, Current Revolving and term loan credit agreement (net of deferred costs of $150 and $196, respectively) Long-term Debt, Excluding Current Maturities Deferred rent Deferred Rent Credit, Noncurrent Total liabilities Liabilities COMMITMENTS AND CONTINGENCIES (Note 13) Commitments and Contingencies Shareholders’ equity: Stockholders' Equity Attributable to Parent [Abstract] Common stock, no par value; shares authorized — 75,000; shares issued and outstanding — 43,170 and 35,861, respectively Common Stock, Value, Issued Other comprehensive loss Accumulated Other Comprehensive Income (Loss), Net of Tax Warrants Warrants and Rights Outstanding Accumulated deficit Retained Earnings (Accumulated Deficit) Total shareholders’ equity Stockholders' Equity Attributable to Parent Total liabilities and shareholders’ equity Liabilities and Equity Revenue from Contract with Customer [Abstract] Concentration Risk [Table] Concentration Risk [Table] Concentration Risk Type [Axis] Concentration Risk Type [Axis] Concentration Risk Type [Domain] Concentration Risk Type [Domain] Customer concentration Customer Concentration Risk [Member] Customer [Axis] Customer [Axis] Customer [Domain] Customer [Domain] MACI and Carticel Carticel And MACI Distributor [Member] Carticel And MACI Distributor [Member] Epicel Epicel [Member] Epicel [Member] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Revenue Concentration Sales Revenue, Net [Member] Accounts Receivable Concentration Accounts Receivable [Member] Range [Axis] Range [Axis] Range [Domain] Range [Domain] Maximum Maximum [Member] CONCENTRATION Concentration Risk [Line Items] Concentration risk Concentration Risk, Percentage Investments, Debt and Equity Securities [Abstract] Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-sale [Table] Financial Instrument [Axis] Financial Instrument [Axis] Financial Instruments [Domain] Financial Instruments [Domain] Money market funds Money Market Funds [Member] Repurchase agreements Repurchase Agreements [Member] Commercial paper Commercial Paper [Member] Corporate notes Corporate Debt Securities [Member] U.S. government securities US Government Agencies Debt Securities [Member] U.S. asset-backed securities Asset-backed Securities [Member] Balance Sheet Location [Axis] Balance Sheet Location [Axis] Balance Sheet Location [Domain] Balance Sheet Location [Domain] Cash equivalents Cash Equivalents [Member] Short-term investments Short-term Investments [Member] Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-sale [Line Items] Amortized Cost Debt Securities, Available-for-sale, Amortized Cost Gains Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Losses Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Fair Value Debt Securities, Available-for-sale Debt Disclosure [Abstract] Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Lender Name [Axis] Lender Name [Axis] Line of Credit Facility, Lender [Domain] Line of Credit Facility, Lender [Domain] Silicon Valley Bank and MidCap Financial Services Silicon Valley Bank And MidCap Financial Services [Member] Silicon Valley Bank And MidCap Financial Services [Member] Silicon Valley Bank Silicon Valley Bank [Member] Silicon Valley Bank [Member] Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Debt Financing Agreement Debt Financing Agreement [Member] Debt Financing Agreement [Member] Term Loan Term Loan [Member] Term Loan [Member] Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Line of Credit Line of Credit [Member] Credit Facility [Axis] Credit Facility [Axis] Credit Facility [Domain] Credit Facility [Domain] Revolving Credit Facility Revolving Credit Facility [Member] Variable Rate [Axis] Variable Rate [Axis] Variable Rate [Domain] Variable Rate [Domain] Prime Rate Prime Rate [Member] Minimum Minimum [Member] Debt Instrument [Line Items] Debt Instrument [Line Items] Maximum borrowing capacity (up to) Debt Financing Agreement, Maximum Borrowing Capacity Debt Financing Agreement, Maximum Borrowing Capacity Debt instrument, face amount Debt Instrument, Face Amount Line of credit facility, maximum borrowing capacity Line of Credit Facility, Maximum Borrowing Capacity Basis spread on variable rate Debt Instrument, Basis Spread on Variable Rate Number of installments Debt Instrument, Number of Installments Debt Instrument, Number of Installments Short-term bank loans and notes payable Short-term Bank Loans and Notes Payable Line of credit, current Line of Credit, Current Deferred costs Debt Issuance Costs, Net Weighted average interest rate Debt, Weighted Average Interest Rate Interest rate, stated percentage, final payment due upon maturity Debt Instrument, Interest Rate, Stated Percentage, Final Payment Due Upon Maturity Debt Instrument, Interest Rate, Stated Percentage, Final Payment Due Upon Maturity Remaining borrowing capacity Line of Credit Facility, Remaining Borrowing Capacity Payments to acquire investment funds and securities Payments to Acquire Debt Securities, Available-for-sale Fair Value Disclosures [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Schedule of annual principal payments on debt Contractual Obligation, Fiscal Year Maturity Schedule [Table Text Block] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Stock-based Compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Earnings Per Share [Abstract] Schedule of net loss attributable to common shareholders and share data used in the basic and diluted earnings per share computations using the two class method Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Related Party Transactions [Abstract] License Agreement Collaborative Arrangement Disclosure [Text Block] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Balance Sheet Related Disclosures [Abstract] Inventory: Inventory, Net [Abstract] Raw materials Inventory, Raw Materials, Gross Work-in-process Inventory, Work in Process, Gross Finished goods Inventory, Finished Goods, Gross Inventory Summary of valuation of the Company's investments and financial instruments that are measured at fair value on a recurring basis Fair Value, Liabilities Measured on Recurring Basis [Table Text Block] Summary of change in estimated fair value of warrant liabilities Schedule of Change in Estimated Fair Value of Warrant Liabilities [Table Text Block] Tabular disclosure of change in the estimated fair value of the warrant liabilities. Line of Credit Facility [Table] Line of Credit Facility [Table] Line of Credit Facility [Line Items] Line of Credit Facility [Line Items] 2018 Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months 2019 Long-term Debt, Maturities, Repayments of Principal in Year Two 2020 Long-term Debt, Maturities, Repayments of Principal in Year Three 2021 Long-term Debt, Maturities, Repayments of Principal in Year Four 2022 Long-term Debt, Maturities, Repayments of Principal in Year Five Thereafter Long-term Debt, Maturities, Repayments of Principal after Year Five Total principal payments on debt Long-term Debt Schedule of non-cash stock-based compensation expense Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Schedule of weighted average assumptions used to estimate fair value of each service-based stock option grant Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Award Type [Axis] Award Type [Axis] Equity Award [Domain] Equity Award [Domain] Service-Based Stock Options Employee Stock Option [Member] Employee Stock Employee Stock [Member] Plan Name [Axis] Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] 2004, 2001, 1992, and 2009 Plans Prior Plans [Member] Represents the information pertaining to the Prior Plans consisting of 1992 Stock Option Plan, the 2001 Stock Option Plan and the Amended and Restated 2004 Equity Incentive Plan. 2017 Plan Omnibus Incentive Plan 2017 [Member] Omnibus Incentive Plan 2017 [Member] Subsequent Event Type [Axis] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Subsequent Event Subsequent Event [Member] Stock-Based Compensation Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Expiration period Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period Vesting period Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Number of shares available for grant (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Employee Stock Purchase Plan, number of shares authorized (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Employee Stock Purchase Plan, grants since inception (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Granted Employee Stock Purchase Plan, stock issued during period (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Employee Stock Purchase Plan, stock issued during period, value Stock Issued During Period, Value, Employee Stock Purchase Plan Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Grant date fair value (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Stock-based compensation expense Allocated Share-based Compensation Expense Weighted average assumptions used to estimate fair value of each service-based stock option grant Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract] Expected dividend rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Expected stock price volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Risk-free interest rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Expected life Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Organization, Consolidation and Presentation of Financial Statements [Abstract] Number of reportable segments Number of Reportable Segments Accumulated deficit Net loss Net Income (Loss) Attributable to Parent Incentive from landlord Incentive from Lessor Deferred rent credit Deferred Rent Credit Operating leases Operating Leases Leased Office Space Future Minimum Payments Due [Abstract] Total Operating Leases, Future Minimum Payments Due 2018 Operating Leases, Future Minimum Payments, Remainder of Fiscal Year 2019 Operating Leases, Future Minimum Payments, Due in Two Years 2020 Operating Leases, Future Minimum Payments, Due in Three Years 2021 Operating Leases, Future Minimum Payments, Due in Four Years 2022 Operating Leases, Future Minimum Payments, Due in Five Years More than 5 years Operating Leases, Future Minimum Payments, Due Thereafter Debt and interest related payments Contractual Obligation, Fiscal Year Maturity [Abstract] Total Contractual Obligation 2018 Contractual Obligation, Due in Next Fiscal Year 2019 Contractual Obligation, Due in Second Year 2020 Contractual Obligation, Due in Third Year 2021 Contractual Obligation, Due in Fourth Year 2022 Contractual Obligation, Due in Fifth Year More than 5 years Contractual Obligation, Due after Fifth Year Purchase commitments Purchase Obligation, Fiscal Year Maturity [Abstract] Total Purchase Obligation 2018 Purchase Obligation, Due in Next Twelve Months 2019 Purchase Obligation, Due in Second Year 2020 Purchase Obligation, Due in Third Year 2021 Purchase Obligation, Due in Fourth Year 2022 Purchase Obligation, Due in Fifth Year More than 5 years Purchase Obligation, Due after Fifth Year Total Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract] Total Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due 2018 Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due, Current Operating and Capital Leases and Purchase Commitments, Future Minimum Payments Due, Current 2019 Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Two Years Operating and Capital Leases and Purchase Commitments, Due In Two Years 2020 Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Three Years Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Three Years 2021 Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Four Years Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due In Four Years 2022 Minimum Lease Payments, Sale Leaseback Transactions, Due in Rolling after Year Five More than 5 years Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due Thereafter Operating and Capital Leases and Purchase Commitments, Future Minimum Payments, Due Thereafter Rent expense Operating Leases, Rent Expense, Net Revenue Revenue from Contract with Customer [Text Block] Allowance for doubtful accounts Allowance for Doubtful Accounts Receivable Current portion of term loan credit agreement, deferred costs Debt Issuance Costs, Current, Net Revolving and term loan credit agreement, deferred costs Debt Issuance Costs, Noncurrent, Net Common stock, authorized (in shares) Common Stock, Shares Authorized Common stock, issued (in shares) Common Stock, Shares, Issued Common stock, outstanding (in shares) Common Stock, Shares, Outstanding Numerator: Net Income (Loss) Attributable to Parent [Abstract] Net loss Denominator for basic and diluted EPS: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Weighted-average common shares outstanding (in shares) Weighted Average Number of Shares Outstanding, Basic and Diluted Net loss per share attributable to common shareholders (basic and diluted) (in dollars per share) Earnings Per Share, Basic and Diluted Aggregate number of common equivalent shares (related to options, warrants and preferred stock) excluded from diluted net loss per common share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Warrants and Rights Note Disclosure [Abstract] Class of Warrant or Right [Table] Class of Warrant or Right [Table] Class of Warrant or Right [Axis] Class of Warrant or Right [Axis] Class of Warrant or Right [Domain] Class of Warrant or Right [Domain] September 2016 Warrants Warrants Issued In September 2016 [Member] Warrants Issued In September 2016 [Member] December 2017 Warrants Warrants Issued On December 7, 2017 [Member] Warrants Issued In December 2017 [Member] August 2013 Warrants Warrants Issued In August2013 [Member] Represents the warrants issued by the entity in August 2013. Equity Components [Axis] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock Common Stock [Member] Measurement Input Type [Axis] Measurement Input Type [Axis] Measurement Input Type [Domain] Measurement Input Type [Domain] Measurement Input, Expected Dividend Rate Measurement Input, Expected Dividend Rate [Member] Stock Purchase Warrants Class of Warrant or Right [Line Items] Exercise price (in dollars per share) Class of Warrant or Right, Exercise Price of Warrants or Rights Total shares issuable on exercise (in shares) Class of Warrant or Right, Number of Securities Called by Warrants or Rights Shares issued upon the exercise of warrants (in shares) Stock Issued During Period, Shares, Conversion of Convertible Securities Shares issued upon the exercise of warrants, value Stock Issued During Period, Value, Conversion of Convertible Securities Warrants outstanding (in shares) Class of Warrant or Right, Outstanding Warrants and Rights Outstanding, Measurement Input Warrants and Rights Outstanding, Measurement Input Schedule of inventory Schedule of Inventory, Current [Table Text Block] Schedule of property and equipment, net Property, Plant and Equipment [Table Text Block] Schedule of accounts payable and accrued expenses Schedule of Accounts Payable and Accrued Liabilities [Table Text Block] Net Loss Per Common Share Earnings Per Share [Text Block] Basis of Presentation [Abstract] Basis of Presentation [Abstract] Schedule of cash flow, supplemental disclosures Schedule of Cash Flow, Supplemental Disclosures [Table Text Block] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value Measurements, Recurring and Nonrecurring [Table] Warrants Warrant [Member] Measurement Frequency [Axis] Measurement Frequency [Axis] Fair Value, Measurement Frequency [Domain] Fair Value, Measurement Frequency [Domain] Recurring Fair Value, Measurements, Recurring [Member] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Level 1 Fair Value, Inputs, Level 1 [Member] Level 2 Fair Value, Inputs, Level 2 [Member] Level 3 Fair Value, Inputs, Level 3 [Member] Debt Financing Agreement and Term Loan Debt Financing Agreement And Term Loan [Member] Debt Financing Agreement And Term Loan [Member] Assets and liabilities that are measured at fair value on a recurring basis Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Assets: Assets, Fair Value Disclosure [Abstract] Assets, fair value Assets, Fair Value Disclosure Liabilities: Liabilities, Fair Value Disclosure [Abstract] Warrant liabilities Change in the estimated fair value of warrant liabilities Warrants and Rights [Roll Forward] A roll forward is a reconciliation of a concept from the beginning of a period to the end of the period. Balance at December 31, 2017 Increase in fair value (net of expired warrants) Fair Value Adjustment of Warrants Warrant exercise Stock Issued Balance at September 30, 2018 Debt instrument, fair value Debt Instrument, Fair Value Disclosure Accounting Policies [Abstract] Recent Accounting Pronouncements Significant Accounting Policies [Text Block] Cash Equivalents and Investments Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Stockholders' Equity Note [Abstract] Schedule of Stock by Class [Table] Schedule of Stock by Class [Table] Counterparty Name [Axis] Counterparty Name [Axis] Counterparty Name [Domain] Counterparty Name [Domain] Cowen Cowen and Company, LLC [Member] Cowen and Company, LLC [Member] Class of Stock [Axis] Class of Stock [Axis] Class of Stock [Domain] Class of Stock [Domain] Common Class A Common Class A [Member] Product and Service [Axis] Product and Service [Axis] Product and Service [Domain] Product and Service [Domain] Financial Service Financial Service [Member] Sale of Stock [Axis] Sale of Stock [Axis] Sale of Stock [Domain] Sale of Stock [Domain] Public Stock Offering Public Stock Offering [Member] Public Stock Offering [Member] Class of Stock [Line Items] Class of Stock [Line Items] At-the-market sales agreement, maximum aggregate proceeds At-The-Market Sales Agreement, Maximum Aggregate Proceeds At-The-Market Sales Agreement, Maximum Aggregate Proceeds Percentage of gross proceeds payable as commission Percentage of Gross Proceeds Payable as Commission Represents the percentage of gross proceeds payable as commission. At-the-market sales agreement, shares issued (in shares) At-the-Market Sales Agreement, Shares Issued At-the-Market Sales Agreement, Shares Issued At-the-market sales agreement, proceeds from issuance of common stock At-The-Market-Sales Agreement, Proceeds From Issuance Of Common Stock At-The-Market-Sales Agreement, Proceeds From Issuance Of Common Stock Product sales, net Revenue from Contract with Customer, Excluding Assessed Tax Number of shares sold (in shares) Sale of Stock, Number of Shares Issued in Transaction Sale of stock, price per share (in dollars per share) Sale of Stock, Price Per Share Consideration received on sale of stock Sale of Stock, Consideration Received on Transaction Payments of stock issuance costs Payments of Stock Issuance Costs Basis of Presentation Basis of Accounting [Text Block] Warrants exercised for common stock Warrants Exercised For Common Stock Warrants Exercised For Common Stock Interest paid (net of interest capitalized) Interest Paid, Excluding Capitalized Interest, Operating Activities Shares converted to common from preferred stock Additions to equipment in process included in accounts payable Capital Expenditures Incurred but Not yet Paid Debt Debt Disclosure [Text Block] Document and Entity Information Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Document Type Document Type Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Amendment Flag Amendment Flag Entity Common Stock, Shares Outstanding (in shares) Entity Common Stock, Shares Outstanding Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Cost of goods sold Cost of Sales [Member] Research and development Research and Development Expense [Member] Selling, general and administrative Selling, General and Administrative Expenses [Member] Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Non-cash stock-based compensation expense Selected Balance Sheet Components Supplemental Balance Sheet Disclosures [Text Block] Income Statement [Abstract] Statement [Table] Statement [Table] Product Product [Member] Statement [Line Items] Statement [Line Items] Cost of product sales Cost of Goods and Services Sold Gross profit Gross Profit Research and development Research and Development Expense Selling, general and administrative Selling, General and Administrative Expense Total operating expenses Operating Expenses Loss from operations Operating Income (Loss) Other income (expense): Other Nonoperating Income (Expense) [Abstract] Decrease (increase) in fair value of warrants Foreign currency translation loss Foreign Currency Transaction Gain (Loss), Realized Interest income Investment Income, Interest Interest expense Interest Expense Other income Other Nonoperating Income (Expense) Total other income (expense) Nonoperating Income (Expense) Net loss Net loss per share attributable to common shareholders (Basic and Diluted) (in dollars per share) Weighted average number of common shares outstanding (Basic and Diluted) (in shares) Statement of Comprehensive Income [Abstract] Other comprehensive loss: Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Net change in unrealized loss on investments Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Schedule of revenue by product and customer Disaggregation of Revenue [Table Text Block] Schedules of concentration of risk Schedules of Concentration of Risk, by Risk Factor [Table Text Block] Stock Purchase Warrants Warrants and Rights Note Disclosure [Text Block] The entire disclosure for warrants including description, amounts outstanding, fair value calculation and estimates. Organization Nature of Operations [Text Block] Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Investments Investment, Policy [Policy Text Block] Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Revenue Recognition and Net Product Sales and Revenue Recognition for License Grants, Milestone and Royalty Payments Revenue from Contract with Customer [Policy Text Block] Schedule of warrants outstanding Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] Shareholders' Equity Stockholders' Equity Note Disclosure [Text Block] Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Machinery and equipment Machinery and Equipment [Member] Furniture, fixtures and office equipment Furniture and Fixtures [Member] Computer equipment and software Computer Equipment [Member] Leasehold improvements Leasehold Improvements [Member] Construction in process Construction in Progress [Member] Property and equipment, net: Property, Plant and Equipment [Line Items] Total property and equipment, gross Property, Plant and Equipment, Gross Less: Accumulated depreciation Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Total, net Depreciation and amortization Depreciation, Depletion and Amortization, Excluding Intangible Assets Depreciation, Depletion and Amortization, Excluding Intangible Assets Statement of Cash Flows [Abstract] Operating activities: Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Adjustments to reconcile net loss to net cash used for operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Depreciation and amortization expense Depreciation, Depletion and Amortization Stock compensation expense Share-based Compensation Change in fair value of warrants Inventory provision Inventory Write-down Loss on sale of fixed assets Gain (Loss) on Disposition of Assets Foreign currency translation loss Foreign Currency Transaction Gain (Loss), before Tax Change in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Inventory Increase (Decrease) in Inventories Deferred rent Increase (Decrease) in Prepaid Rent Accounts receivable Increase (Decrease) in Receivables Prepaid and other current assets Increase (Decrease) in Other Current Assets Accounts payable Increase (Decrease) in Accounts Payable and Accrued Liabilities Accrued expenses Increase (Decrease) in Employee Related Liabilities Other assets and liabilities, net Increase (Decrease) in Other Operating Assets and Liabilities, Net Net cash used for operating activities Net Cash Provided by (Used in) Operating Activities Investing activities: Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Purchases of short term investments Payments to Acquire Businesses, Net of Cash Acquired Expenditures for property, plant and equipment Payments to Acquire Property, Plant, and Equipment Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities Financing activities: Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Net proceeds from equity offering Proceeds from Issuance of Preferred Stock and Preference Stock Net proceeds from common stock issuance due to stock option exercises Proceeds from Stock Options Exercised Proceeds from exercise of warrants Proceeds from Warrant Exercises Other Proceeds from (Payments for) Other Financing Activities Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Net increase (decrease) in cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) Cash and cash equivalents at beginning of period Cash Cash and cash equivalents at end of period Schedule of fair value of securities, not including cash Debt Securities, Available-for-sale [Table Text Block] Accounts payable and accrued expenses: Accounts Payable and Accrued Liabilities, Current [Abstract] Bonus related compensation Accrued Bonuses Employee related accruals Employee-related Liabilities, Current Other accrued expenses Other Accrued Liabilities, Current Total Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Loss Contingency Nature [Axis] Loss Contingency Nature [Axis] Loss Contingency, Nature [Domain] Loss Contingency, Nature [Domain] Agreement with Orsini, Potential Payment if Minimum Payment Obligations Not Achieved Agreement With Orsini, Potential Payment If Minimum Payment Obligations Not Achieved [Member] Agreement With Orsini, Potential Payment If Minimum Payment Obligations Not Achieved [Member] Implants Implants [Member] Implants [Member] Biopsy kits Biopsy Kits [Member] Biopsy Kits [Member] Epicel License Grants, Milestone and Royalty Payments License Grants, Milestone And Royalty Payments [Member] License Grants, Milestone And Royalty Payments [Member] Contract with Customer, Basis of Pricing [Axis] Contract with Customer, Basis of Pricing [Axis] Contract with Customer, Basis of Pricing [Domain] Contract with Customer, Basis of Pricing [Domain] Contracted rate Fixed-price Contract [Member] Third party reimbursement Time-and-materials Contract [Member] Contract with Customer, Sales Channel [Axis] Contract with Customer, Sales Channel [Axis] Contract with Customer, Sales Channel [Domain] Contract with Customer, Sales Channel [Domain] Third party distributor Sales Channel, Through Intermediary [Member] Direct bill Sales Channel, Directly to Consumer [Member] Adjustments for New Accounting Pronouncements [Axis] Adjustments for New Accounting Pronouncements [Axis] Type of Adoption [Domain] Type of Adoption [Domain] Accounting Standards Update 2014-09 Accounting Standards Update 2014-09 [Member] Initial Application Period Cumulative Effect Transition [Axis] Initial Application Period Cumulative Effect Transition [Axis] Initial Application Period Cumulative Effect Transition [Domain] Initial Application Period Cumulative Effect Transition [Domain] Difference between Revenue Guidance in Effect before and after Topic 606 Difference between Revenue Guidance in Effect before and after Topic 606 [Member] Innovative Cellular Therapeutics Innovative Cellular Therapeutics [Member] Innovative Cellular Therapeutics [Member] Disaggregation of Revenue [Line Items] Disaggregation of Revenue [Line Items] Incremental service fee Other Commitment Schedule of future minimum payments related to leases Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]