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  <xsd:element id="astm_ScheduleOfChangeInEstimatedFairValueOfWarrantLiabilitiesTableTextBlock" name="ScheduleOfChangeInEstimatedFairValueOfWarrantLiabilitiesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="astm_ScheduleOfClassOfWarrantOrRightValuationAssumptionsTableTextBlock" name="ScheduleOfClassOfWarrantOrRightValuationAssumptionsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="astm_ScheduleOfFutureMinimumRentalPaymentsForOperatingAndCapitalLeasesTableTextBlock" name="ScheduleOfFutureMinimumRentalPaymentsForOperatingAndCapitalLeasesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="astm_ScheduleOfIncomeLossBeforeIncomeTaxesTableTextBlock" name="ScheduleOfIncomeLossBeforeIncomeTaxesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_SeriesB1PreferredStockMember" name="SeriesB1PreferredStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="astm_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsCancelledInPeriodWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsCancelledInPeriodWeightedAverageExercisePrice" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_SiliconValleyBankMember" name="SiliconValleyBankMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="astm_StockIssuedDuringPeriodOfferingPricePerShare" name="StockIssuedDuringPeriodOfferingPricePerShare" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="duration" />
  <xsd:element id="astm_StockIssuedToUnderwriterForExerciseOfOverAllotmentOption" name="StockIssuedToUnderwriterForExerciseOfOverAllotmentOption" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_SublicenseAgreementMember" name="SublicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_SupplementaryQuarterlyFinancialInformationunauditedAbstract" name="SupplementaryQuarterlyFinancialInformationunauditedAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_TermLoanMember" name="TermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="astm_ThresholdClosingSalePriceOfCommonStockOnDateOfRegularPurchaseToTriggerAcceleratedPurchasesOfAdditionalCommonStock" name="ThresholdClosingSalePriceOfCommonStockOnDateOfRegularPurchaseToTriggerAcceleratedPurchasesOfAdditionalCommonStock" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="instant" />
  <xsd:element id="astm_ThresholdOnPercentageOfOutstandingSharesOfCommonStockThatCanBeBeneficiallyOwnedByCounterparty" name="ThresholdOnPercentageOfOutstandingSharesOfCommonStockThatCanBeBeneficiallyOwnedByCounterparty" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="astm_UnderwritersDiscount" name="UnderwritersDiscount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="astm_ValueOfRemainingSharesOfCommonStockToBeSold" name="ValueOfRemainingSharesOfCommonStockToBeSold" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="astm_ValueOfSharesOfCommonStockToBeSold" name="ValueOfSharesOfCommonStockToBeSold" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="astm_WarrantsAndRightsNoteDisclosureTextBlock" name="WarrantsAndRightsNoteDisclosureTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_WarrantsAndRightsRollForward" name="WarrantsAndRightsRollForward" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_WarrantsIssuedInAugust2013Member" name="WarrantsIssuedInAugust2013Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="astm_WarrantsIssuedInDecember2010Member" name="WarrantsIssuedInDecember2010Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="astm_WarrantsPolicyTextBlock" name="WarrantsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
</xsd:schema>





