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<!--Created on: 11/13/2014 7:44:50 AM-->
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  <xsd:element name="OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDueInFourYears" id="astm_OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDueInFourYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDueInFiveYears" id="astm_OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDueInFiveYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDue" id="astm_OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="GenzymeBiosurgeryApsMember" id="astm_GenzymeBiosurgeryApsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element id="astm_OneThirdPartyCustomerInUSMember" name="OneThirdPartyCustomerInUSMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <xsd:element name="ClassAWarrantsIssuedInJanuary2010Member" id="astm_ClassAWarrantsIssuedInJanuary2010Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantsIssuedInDecember2010Member" id="astm_WarrantsIssuedInDecember2010Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SeriesB1PreferredStockMember" id="astm_SeriesB1PreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DocumentAndEntityInformationAbstract" id="astm_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BasisOfPresentationDisclosureAbstract" id="astm_BasisOfPresentationDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantsAndRightsNoteDisclosureTextBlock" id="astm_WarrantsAndRightsNoteDisclosureTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfClassOfWarrantOrRightValuationAssumptionsTableTextBlock" id="astm_ScheduleOfClassOfWarrantOrRightValuationAssumptionsTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfChangeInEstimatedFairValueOfWarrantLiabilitiesTableTextBlock" id="astm_ScheduleOfChangeInEstimatedFairValueOfWarrantLiabilitiesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceAbstract" id="astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" id="astm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantsAndRightsRollForward" id="astm_WarrantsAndRightsRollForward" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockIssuedDuringPeriodOfferingPricePerShare" id="astm_StockIssuedDuringPeriodOfferingPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockPeriodOfClosingOfOfferingAfterWhichSharesAreConvertible" id="astm_PreferredStockPeriodOfClosingOfOfferingAfterWhichSharesAreConvertible" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockConversionPricePerShare" id="astm_PreferredStockConversionPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockCumulativeDividendRatePercentage" id="astm_PreferredStockCumulativeDividendRatePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="McNicollLewisAndVlakLLCMember" id="astm_McNicollLewisAndVlakLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeaseTerm" id="astm_OperatingLeaseTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeaseNumberOfFiveYearMarketValueRenewals" id="astm_OperatingLeaseNumberOfFiveYearMarketValueRenewals" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasePeriodOfMarketValueRenewals" id="astm_OperatingLeasePeriodOfMarketValueRenewals" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeaseRatingClassOfModularManufacturingCleanRoomLaboratoriesAndOfficeSpaceLeased" id="astm_OperatingLeaseRatingClassOfModularManufacturingCleanRoomLaboratoriesAndOfficeSpaceLeased" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantsIssuedInAugust2013Member" id="astm_WarrantsIssuedInAugust2013Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfWarrantHolders" id="astm_NumberOfWarrantHolders" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ClassOfWarrantOrRightWarrantsExercisedValue" id="astm_ClassOfWarrantOrRightWarrantsExercisedValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element id="astm_AccumulatedUndeclaredDividends" name="AccumulatedUndeclaredDividends" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <xsd:element name="LincolnParkCapitalFundLLCMember" id="astm_LincolnParkCapitalFundLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ValueOfSharesOfCommonStockToBeSold" id="astm_ValueOfSharesOfCommonStockToBeSold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="ValueOfSharesOfCommonStockToBePurchased" id="astm_ValueOfSharesOfCommonStockToBePurchased" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="PeriodOverWhichSharesOfCommonStockToBePurchased" id="astm_PeriodOverWhichSharesOfCommonStockToBePurchased" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfSharesOfCommonStockToBePurchasedInRegularPurchases" id="astm_NumberOfSharesOfCommonStockToBePurchasedInRegularPurchases" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfSharesOfCommonStockToBePurchasedBasedOnClosingSalePriceOfCommonStock" id="astm_NumberOfSharesOfCommonStockToBePurchasedBasedOnClosingSalePriceOfCommonStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ThresholdClosingSalePriceOfCommonStockOnDateOfRegularPurchaseToTriggerAcceleratedPurchasesOfAdditionalCommonStock" id="astm_ThresholdClosingSalePriceOfCommonStockOnDateOfRegularPurchaseToTriggerAcceleratedPurchasesOfAdditionalCommonStock" type="num:perShareItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="PeriodOfBusinessDaysOverWhichPurchasePriceOfSharesOfCommonStockWillBeDetermined" id="astm_PeriodOfBusinessDaysOverWhichPurchasePriceOfSharesOfCommonStockWillBeDetermined" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FloorPriceForSaleOfSharesOfCommonStock" id="astm_FloorPriceForSaleOfSharesOfCommonStock" type="num:perShareItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="SanofiMember" id="astm_SanofiMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OrganizationAndSummaryOfSignificantAccountingPoliciesLineItems" id="astm_OrganizationAndSummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ThresholdOnPercentageOfOutstandingSharesOfCommonStockThatCanBeBeneficiallyOwnedByCounterparty" id="astm_ThresholdOnPercentageOfOutstandingSharesOfCommonStockThatCanBeBeneficiallyOwnedByCounterparty" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LiquidityDisclosureAbstract" id="astm_LiquidityDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EquipmentAndComputersMember" id="astm_EquipmentAndComputersMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BuildingImprovementsAndLeaseholdImprovementsMember" id="astm_BuildingImprovementsAndLeaseholdImprovementsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesSalesForceLeasedAutoFleetFutureMinimumPaymentsDueAbstract" id="astm_OperatingLeasesSalesForceLeasedAutoFleetFutureMinimumPaymentsDueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesSalesForceLeasedAutoFleetFutureMinimumPaymentsRemainderOfFiscalYear" id="astm_OperatingLeasesSalesForceLeasedAutoFleetFutureMinimumPaymentsRemainderOfFiscalYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDueInTwoYears" id="astm_OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDueInTwoYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDueInThreeYears" id="astm_OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDueInThreeYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDueInFourYears" id="astm_OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDueInFourYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDueInFiveYears" id="astm_OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDueInFiveYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDue" id="astm_OperatingLeasesSalesForceLeasedAutoFleetPaymentsFutureMinimumPaymentsDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ScheduleOfBusinessCombinationConsiderationTransferredTableTextBlock" id="astm_ScheduleOfBusinessCombinationConsiderationTransferredTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfPatentsAndPatentApplicationsAcquired" id="astm_NumberOfPatentsAndPatentApplicationsAcquired" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="BusinessAcquisitionProFormaEarningsPerShareBasicAndDiluted" id="astm_BusinessAcquisitionProFormaEarningsPerShareBasicAndDiluted" type="num:perShareItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CellTherapyAndRegenerativeMedicineBusinessMember" id="astm_CellTherapyAndRegenerativeMedicineBusinessMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OrganizationConsolidationAndPresentationOfFinancialStatementsTable" id="astm_OrganizationConsolidationAndPresentationOfFinancialStatementsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems" id="astm_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDueAbstract" id="astm_OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsRemainderOfFiscalYear" id="astm_OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsRemainderOfFiscalYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDueInTwoYears" id="astm_OperatingLeasesLeasedOfficeSpaceFutureMinimumPaymentsDueInTwoYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ValueOfRemainingSharesOfCommonStockToBeSold" id="astm_ValueOfRemainingSharesOfCommonStockToBeSold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <element id="astm_CommonStockRemainingCapacity" name="CommonStockRemainingCapacity" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_UnderwritersDiscount" name="UnderwritersDiscount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_OperatingLeasesLeasedComputerEquipmentFutureMinimumPaymentsDueAbstract" name="OperatingLeasesLeasedComputerEquipmentFutureMinimumPaymentsDueAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_OperatingLeasesLeasedComputerEquipmentFutureMinimumPaymentsRemainderOfFiscalYear" name="OperatingLeasesLeasedComputerEquipmentFutureMinimumPaymentsRemainderOfFiscalYear" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDueInTwoYears" name="OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDueInTwoYears" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDueInThreeYears" name="OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDueInThreeYears" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDueInFourYears" name="OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDueInFourYears" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDueInFiveYears" name="OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDueInFiveYears" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDue" name="OperatingLeasesLeasedComputerEquipmentPaymentsFutureMinimumPaymentsDue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_PeriodWithinWhichSharesOfCommonStockToBePurchased" name="PeriodWithinWhichSharesOfCommonStockToBePurchased" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_MaximumNumberOfSharesOfCommonStockToBePurchasedOnCertainBusinessDays" name="MaximumNumberOfSharesOfCommonStockToBePurchasedOnCertainBusinessDays" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_VerigenMember" name="VerigenMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_RestructuringReserveCurrentAndAssetRetirementObligation" name="RestructuringReserveCurrentAndAssetRetirementObligation" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_IncreaseDecreaseInRestructuringReserveAndAssetRetirementObligations" name="IncreaseDecreaseInRestructuringReserveAndAssetRetirementObligations" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_RestructuringReserveAndAssetRetirementObligationAbstract" name="RestructuringReserveAndAssetRetirementObligationAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_NumberOfCustomers" name="NumberOfCustomers" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_BusinessCombinationCashPaymentMadeToSecureFutureDevelopmentRights" name="BusinessCombinationCashPaymentMadeToSecureFutureDevelopmentRights" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_RegistrationOfSecuritiesForPublicSale" name="RegistrationOfSecuritiesForPublicSale" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_ScheduleOfRestructuringReserveByTypeOfCostAndAssetRetirementObligationsTableTextBlock" name="ScheduleOfRestructuringReserveByTypeOfCostAndAssetRetirementObligationsTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="astm_PeriodForWhichCashIsSufficientToSustainOperations" name="PeriodForWhichCashIsSufficientToSustainOperations" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>