

<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.vcel.com/role/BasisOfPresentation" xlink:href="astm-20190331.xsd#BasisOfPresentation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/BasisOfPresentationDetails" xlink:href="astm-20190331.xsd#BasisOfPresentationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/BasisOfPresentationTables" xlink:href="astm-20190331.xsd#BasisOfPresentationTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CashEquivalentsAndInvestments" xlink:href="astm-20190331.xsd#CashEquivalentsAndInvestments" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CashEquivalentsAndInvestmentsDetails" xlink:href="astm-20190331.xsd#CashEquivalentsAndInvestmentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CashEquivalentsAndInvestmentsScheduleOfFairValueOfSecuritiesDetails" xlink:href="astm-20190331.xsd#CashEquivalentsAndInvestmentsScheduleOfFairValueOfSecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CashEquivalentsAndInvestmentsTables" xlink:href="astm-20190331.xsd#CashEquivalentsAndInvestmentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CommitmentsAndContingencies" xlink:href="astm-20190331.xsd#CommitmentsAndContingencies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CommitmentsAndContingenciesDetails" xlink:href="astm-20190331.xsd#CommitmentsAndContingenciesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:href="astm-20190331.xsd#CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CondensedConsolidatedBalanceSheetsUnauditedParenthetical" xlink:href="astm-20190331.xsd#CondensedConsolidatedBalanceSheetsUnauditedParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:href="astm-20190331.xsd#CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CondensedConsolidatedStatementsOfComprehensiveLossUnaudited" xlink:href="astm-20190331.xsd#CondensedConsolidatedStatementsOfComprehensiveLossUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/CondensedConsolidatedStatementsOfOperationsUnaudited" xlink:href="astm-20190331.xsd#CondensedConsolidatedStatementsOfOperationsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/ConsolidatedStatementsOfShareholdersEquity" xlink:href="astm-20190331.xsd#ConsolidatedStatementsOfShareholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/DocumentAndEntityInformation" xlink:href="astm-20190331.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/FairValueMeasurements" xlink:href="astm-20190331.xsd#FairValueMeasurements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/FairValueMeasurementsRecurringBasisDetails" xlink:href="astm-20190331.xsd#FairValueMeasurementsRecurringBasisDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/FairValueMeasurementsTables" xlink:href="astm-20190331.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/LeasesAssetsAndLiabilitiesDetails" xlink:href="astm-20190331.xsd#LeasesAssetsAndLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/LeasesDetails" xlink:href="astm-20190331.xsd#LeasesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/LeasesLeaseTermAndDiscountRateDetails" xlink:href="astm-20190331.xsd#LeasesLeaseTermAndDiscountRateDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/LeasesMaturitiesOfLeaseLiabilitiesDetails" xlink:href="astm-20190331.xsd#LeasesMaturitiesOfLeaseLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/LeasesNotes" xlink:href="astm-20190331.xsd#LeasesNotes" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/LeasesSchedulePriorToAdoptionDetails" xlink:href="astm-20190331.xsd#LeasesSchedulePriorToAdoptionDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/LeasesTables" xlink:href="astm-20190331.xsd#LeasesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/NetLossPerCommonShare" xlink:href="astm-20190331.xsd#NetLossPerCommonShare" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/NetLossPerCommonShareDetails" xlink:href="astm-20190331.xsd#NetLossPerCommonShareDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/NetLossPerCommonShareTables" xlink:href="astm-20190331.xsd#NetLossPerCommonShareTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/Organization" xlink:href="astm-20190331.xsd#Organization" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/OrganizationDetails" xlink:href="astm-20190331.xsd#OrganizationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/RecentAccountingPronouncements" xlink:href="astm-20190331.xsd#RecentAccountingPronouncements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/RecentAccountingPronouncementsPolicies" xlink:href="astm-20190331.xsd#RecentAccountingPronouncementsPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/Revenue" xlink:href="astm-20190331.xsd#Revenue" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/RevenueConcentrationOfCreditRiskDetails" xlink:href="astm-20190331.xsd#RevenueConcentrationOfCreditRiskDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/RevenueRevenueByProductAndCustomerDetails" xlink:href="astm-20190331.xsd#RevenueRevenueByProductAndCustomerDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/RevenueTables" xlink:href="astm-20190331.xsd#RevenueTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/SelectedBalanceSheetComponents" xlink:href="astm-20190331.xsd#SelectedBalanceSheetComponents" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/SelectedBalanceSheetComponentsAccruedExpensesDetails" xlink:href="astm-20190331.xsd#SelectedBalanceSheetComponentsAccruedExpensesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/SelectedBalanceSheetComponentsInventoryDetails" xlink:href="astm-20190331.xsd#SelectedBalanceSheetComponentsInventoryDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/SelectedBalanceSheetComponentsPropertyAndEquipmentDetails" xlink:href="astm-20190331.xsd#SelectedBalanceSheetComponentsPropertyAndEquipmentDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/SelectedBalanceSheetComponentsTables" xlink:href="astm-20190331.xsd#SelectedBalanceSheetComponentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/StockBasedCompensation" xlink:href="astm-20190331.xsd#StockBasedCompensation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/StockBasedCompensationDetails" xlink:href="astm-20190331.xsd#StockBasedCompensationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/StockBasedCompensationNonCashStockBasedCompensationExpenseDetails" xlink:href="astm-20190331.xsd#StockBasedCompensationNonCashStockBasedCompensationExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/StockBasedCompensationTables" xlink:href="astm-20190331.xsd#StockBasedCompensationTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/StockPurchaseWarrants" xlink:href="astm-20190331.xsd#StockPurchaseWarrants" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/StockPurchaseWarrantsDetails" xlink:href="astm-20190331.xsd#StockPurchaseWarrantsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/StockPurchaseWarrantsTables" xlink:href="astm-20190331.xsd#StockPurchaseWarrantsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/SubsequentEvents" xlink:href="astm-20190331.xsd#SubsequentEvents" xlink:type="simple" />
  <link:roleRef roleURI="http://www.vcel.com/role/SubsequentEventsDetails" xlink:href="astm-20190331.xsd#SubsequentEventsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <link:presentationLink xlink:role="http://www.vcel.com/role/BasisOfPresentation" xlink:type="extended">
    <link:loc xlink:href="astm-20190331.xsd#astm_BasisofPresentationAbstract" xlink:label="loc_astm_BasisofPresentationAbstract_FEB8A707E58E59C493F9ABD27F088662" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BasisOfAccounting" xlink:label="loc_us-gaap_BasisOfAccounting_C81D43CEE6E75BF398389F2379752805" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_BasisofPresentationAbstract_FEB8A707E58E59C493F9ABD27F088662" xlink:to="loc_us-gaap_BasisOfAccounting_C81D43CEE6E75BF398389F2379752805" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/BasisOfPresentationDetails" xlink:type="extended">
    <link:loc xlink:href="astm-20190331.xsd#astm_BasisofPresentationAbstract" xlink:label="loc_astm_BasisofPresentationAbstract_EF531FB9014148B85FB68F439C10DBCF" xlink:type="locator" />
    <link:loc xlink:href="astm-20190331.xsd#astm_WarrantsExercisedForCommonStock" xlink:label="loc_astm_WarrantsExercisedForCommonStock_2C880D2AA0E38A382B0E8F439C1044CF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_BasisofPresentationAbstract_EF531FB9014148B85FB68F439C10DBCF" xlink:to="loc_astm_WarrantsExercisedForCommonStock_2C880D2AA0E38A382B0E8F439C1044CF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestPaidNet" xlink:label="loc_us-gaap_InterestPaidNet_851A8E96325F08729E868F439C10DE0E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_BasisofPresentationAbstract_EF531FB9014148B85FB68F439C10DBCF" xlink:to="loc_us-gaap_InterestPaidNet_851A8E96325F08729E868F439C10DE0E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalExpendituresIncurredButNotYetPaid" xlink:label="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_5BD3DDD9CF9AF335786C8F439C100144" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_BasisofPresentationAbstract_EF531FB9014148B85FB68F439C10DBCF" xlink:to="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_5BD3DDD9CF9AF335786C8F439C100144" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_74358FF3C74F42C3C10F8F4D07CBBEF2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_BasisofPresentationAbstract_EF531FB9014148B85FB68F439C10DBCF" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_74358FF3C74F42C3C10F8F4D07CBBEF2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/BasisOfPresentationTables" xlink:type="extended">
    <link:loc xlink:href="astm-20190331.xsd#astm_BasisofPresentationAbstract" xlink:label="loc_astm_BasisofPresentationAbstract_0B9FF86C59AB52C6B987B0F92AE17C4C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock_A81EA2E09B675E7BAE11001DFD099C51" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_BasisofPresentationAbstract_0B9FF86C59AB52C6B987B0F92AE17C4C" xlink:to="loc_us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock_A81EA2E09B675E7BAE11001DFD099C51" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CashEquivalentsAndInvestments" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_08A94AC467C85920ACAF503292E8E0E4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock" xlink:label="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_0ABB99BDEFCB585C9031E61DE477734F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_08A94AC467C85920ACAF503292E8E0E4" xlink:to="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_0ABB99BDEFCB585C9031E61DE477734F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CashEquivalentsAndInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_D338BF5054A852619AFC3255A80729DE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_9EADFBD7609F5EEEAB493A6E58AE75E1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_D338BF5054A852619AFC3255A80729DE" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_9EADFBD7609F5EEEAB493A6E58AE75E1" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CashEquivalentsAndInvestmentsScheduleOfFairValueOfSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_4694BC6716DFEE072961791EABC50918" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_A564D46BE99E41D562C5791EABC54841" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_4694BC6716DFEE072961791EABC50918" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_A564D46BE99E41D562C5791EABC54841" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_135A9DA7EA0E4A8C6BB6791EABC574E1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_A564D46BE99E41D562C5791EABC54841" xlink:to="loc_us-gaap_FinancialInstrumentAxis_135A9DA7EA0E4A8C6BB6791EABC574E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12185AC03ECE97825E75791EABC5C4F6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_135A9DA7EA0E4A8C6BB6791EABC574E1" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12185AC03ECE97825E75791EABC5C4F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MoneyMarketFundsMember" xlink:label="loc_us-gaap_MoneyMarketFundsMember_FFB74142DC03D987FFF2791EABC6B2F8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12185AC03ECE97825E75791EABC5C4F6" xlink:to="loc_us-gaap_MoneyMarketFundsMember_FFB74142DC03D987FFF2791EABC6B2F8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_0C8605EA9EEF7632B9AF791EABC6D077" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12185AC03ECE97825E75791EABC5C4F6" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_0C8605EA9EEF7632B9AF791EABC6D077" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommercialPaperMember" xlink:label="loc_us-gaap_CommercialPaperMember_051223D4259D59FE74FA791EABC61195" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12185AC03ECE97825E75791EABC5C4F6" xlink:to="loc_us-gaap_CommercialPaperMember_051223D4259D59FE74FA791EABC61195" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_878623A1F2B7CC66A447791EABC63CC5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12185AC03ECE97825E75791EABC5C4F6" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_878623A1F2B7CC66A447791EABC63CC5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_9B82B593DFB19BF7B4C1791EABC6020D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12185AC03ECE97825E75791EABC5C4F6" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_9B82B593DFB19BF7B4C1791EABC6020D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_91ED60F27D55B3E19659791EABC769E9" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12185AC03ECE97825E75791EABC5C4F6" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_91ED60F27D55B3E19659791EABC769E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_F36E7B70782D844B4F40791EABC70535" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_A564D46BE99E41D562C5791EABC54841" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_F36E7B70782D844B4F40791EABC70535" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_89692E95BD04059FC159791EABC72B76" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_F36E7B70782D844B4F40791EABC70535" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_89692E95BD04059FC159791EABC72B76" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashEquivalentsMember" xlink:label="loc_us-gaap_CashEquivalentsMember_E071B9C3295961A27AFE791EABC7F727" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_89692E95BD04059FC159791EABC72B76" xlink:to="loc_us-gaap_CashEquivalentsMember_E071B9C3295961A27AFE791EABC7F727" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestmentsMember" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_2C21FCA88D42CE96466A791EABC7CC1D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_89692E95BD04059FC159791EABC72B76" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_2C21FCA88D42CE96466A791EABC7CC1D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_2799A03D873635C11AC4791EABC8770C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_A564D46BE99E41D562C5791EABC54841" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_2799A03D873635C11AC4791EABC8770C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_5E647D7ED1D98FF079667984B8CFF4EE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_2799A03D873635C11AC4791EABC8770C" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_5E647D7ED1D98FF079667984B8CFF4EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_BF03C781E6659A6C122F791EABC881D4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_2799A03D873635C11AC4791EABC8770C" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_BF03C781E6659A6C122F791EABC881D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_E41E4A1212316AA5F852791EABC8C061" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_2799A03D873635C11AC4791EABC8770C" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_E41E4A1212316AA5F852791EABC8C061" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_7EC3C9756D2112E1D399791EABC8FA08" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_2799A03D873635C11AC4791EABC8770C" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_7EC3C9756D2112E1D399791EABC8FA08" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_064C12E4D411123E867D791EABC8F7B7" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_2799A03D873635C11AC4791EABC8770C" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_064C12E4D411123E867D791EABC8F7B7" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CashEquivalentsAndInvestmentsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_FB7194EFCCB55B998F9D72CD4B35E518" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_47C654BAD53156B38CCDA1F1DBDF95A2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_FB7194EFCCB55B998F9D72CD4B35E518" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_47C654BAD53156B38CCDA1F1DBDF95A2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CommitmentsAndContingencies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_15EEEDF910FA58AE9A83E8DE782F9AC7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_C8C8348F895D5326B5F82704FA1ECEAD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_15EEEDF910FA58AE9A83E8DE782F9AC7" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_C8C8348F895D5326B5F82704FA1ECEAD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CommitmentsAndContingenciesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_991B22903529A7A18DDA8F2B9CD9DD2A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncentiveFromLessor" xlink:label="loc_us-gaap_IncentiveFromLessor_F8E4C835058753CEC4728F2B9D6BDAD4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_991B22903529A7A18DDA8F2B9CD9DD2A" xlink:to="loc_us-gaap_IncentiveFromLessor_F8E4C835058753CEC4728F2B9D6BDAD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredRentCredit" xlink:label="loc_us-gaap_DeferredRentCredit_7B1510172B0BC42A85BB8F2B9D73A14F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_991B22903529A7A18DDA8F2B9CD9DD2A" xlink:to="loc_us-gaap_DeferredRentCredit_7B1510172B0BC42A85BB8F2B9D73A14F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_5E04C1CCDFAEE9F5B4618F233BA95749" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_A9237EF0283ADEF200DD8F233BA940D8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5E04C1CCDFAEE9F5B4618F233BA95749" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_A9237EF0283ADEF200DD8F233BA940D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_660CF82FD3986ADA2F828F233BA9D80B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5E04C1CCDFAEE9F5B4618F233BA95749" xlink:to="loc_us-gaap_AssetsAbstract_660CF82FD3986ADA2F828F233BA9D80B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_0EB8557D309CFD8640088F233BA98BFF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_660CF82FD3986ADA2F828F233BA9D80B" xlink:to="loc_us-gaap_AssetsCurrentAbstract_0EB8557D309CFD8640088F233BA98BFF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_636DEE43F30D2E2FBE098F233BAA2FEA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0EB8557D309CFD8640088F233BA98BFF" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_636DEE43F30D2E2FBE098F233BAA2FEA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_573716C0530FD3DAC9048F233BAAB5F7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0EB8557D309CFD8640088F233BA98BFF" xlink:to="loc_us-gaap_ShortTermInvestments_573716C0530FD3DAC9048F233BAAB5F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_F72A239AC7FA6EF6836F8F233BAA3316" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0EB8557D309CFD8640088F233BA98BFF" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_F72A239AC7FA6EF6836F8F233BAA3316" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_58E3E721C9FA6AB129CF8F233BAAC97D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0EB8557D309CFD8640088F233BA98BFF" xlink:to="loc_us-gaap_InventoryNet_58E3E721C9FA6AB129CF8F233BAAC97D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaap_OtherAssetsCurrent_0C58855E25F59D565CE38F233BAB1842" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0EB8557D309CFD8640088F233BA98BFF" xlink:to="loc_us-gaap_OtherAssetsCurrent_0C58855E25F59D565CE38F233BAB1842" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_594687A7C01AAA7C38D58F233BAB5638" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_0EB8557D309CFD8640088F233BA98BFF" xlink:to="loc_us-gaap_AssetsCurrent_594687A7C01AAA7C38D58F233BAB5638" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_E733D8F5976BAA49DFB08F233BAB1F8E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_660CF82FD3986ADA2F828F233BA9D80B" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_E733D8F5976BAA49DFB08F233BAB1F8E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_9F999BDDC525FD4BF26B8F233BAB3F19" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_660CF82FD3986ADA2F828F233BA9D80B" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_9F999BDDC525FD4BF26B8F233BAB3F19" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_81E9B25C84753586AB468F233BAB0551" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_660CF82FD3986ADA2F828F233BA9D80B" xlink:to="loc_us-gaap_Assets_81E9B25C84753586AB468F233BAB0551" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E16013616F6D323D513F8F233BAB22BA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5E04C1CCDFAEE9F5B4618F233BA95749" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E16013616F6D323D513F8F233BAB22BA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_689B2AFF7ABF61F8949B8F233BAC6A0D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E16013616F6D323D513F8F233BAB22BA" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_689B2AFF7ABF61F8949B8F233BAC6A0D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_EA3297948BED958AC6F08F233BAC2115" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_689B2AFF7ABF61F8949B8F233BAC6A0D" xlink:to="loc_us-gaap_AccountsPayableCurrent_EA3297948BED958AC6F08F233BAC2115" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_75EB1F5C74D580674B558F233BACACB8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_689B2AFF7ABF61F8949B8F233BAC6A0D" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_75EB1F5C74D580674B558F233BACACB8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_78EED6B9E3EA1DF31DD88F233BACDB5F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_689B2AFF7ABF61F8949B8F233BAC6A0D" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_78EED6B9E3EA1DF31DD88F233BACDB5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_80CA55CC443234CC15F18F233BADB418" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_689B2AFF7ABF61F8949B8F233BAC6A0D" xlink:to="loc_us-gaap_LiabilitiesCurrent_80CA55CC443234CC15F18F233BADB418" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4DDEC650DCED087945648F233BAD0672" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E16013616F6D323D513F8F233BAB22BA" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4DDEC650DCED087945648F233BAD0672" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredRentCreditNoncurrent" xlink:label="loc_us-gaap_DeferredRentCreditNoncurrent_EE19D24071187907715B8F233BAD448D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E16013616F6D323D513F8F233BAB22BA" xlink:to="loc_us-gaap_DeferredRentCreditNoncurrent_EE19D24071187907715B8F233BAD448D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_80188CE9BD0F3BD8412C8F233BADE48D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E16013616F6D323D513F8F233BAB22BA" xlink:to="loc_us-gaap_Liabilities_80188CE9BD0F3BD8412C8F233BADE48D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaap_CommitmentsAndContingencies_944CEC3D7FFD92D39AA48F233BAD8FE7" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E16013616F6D323D513F8F233BAB22BA" xlink:to="loc_us-gaap_CommitmentsAndContingencies_944CEC3D7FFD92D39AA48F233BAD8FE7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_8173F764D2E05A0577E68F233BAD4092" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E16013616F6D323D513F8F233BAB22BA" xlink:to="loc_us-gaap_StockholdersEquityAbstract_8173F764D2E05A0577E68F233BAD4092" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_71E52ADBDB184740811E8F233BAE1265" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_8173F764D2E05A0577E68F233BAD4092" xlink:to="loc_us-gaap_CommonStockValue_71E52ADBDB184740811E8F233BAE1265" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_9F7755E7472C7A8731A88F233BAE7AD3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_8173F764D2E05A0577E68F233BAD4092" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_9F7755E7472C7A8731A88F233BAE7AD3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_272DF7A14E216163BC798F233BAE56B1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_8173F764D2E05A0577E68F233BAD4092" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_272DF7A14E216163BC798F233BAE56B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3AC477BD4C02CB7ED22E8F233BAEE902" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_8173F764D2E05A0577E68F233BAD4092" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3AC477BD4C02CB7ED22E8F233BAEE902" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_D057F391123F305611468F233BAE7978" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_8173F764D2E05A0577E68F233BAD4092" xlink:to="loc_us-gaap_StockholdersEquity_D057F391123F305611468F233BAE7978" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_584B13BF5D8B3A6EF0818F233BAF6A8D" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_E16013616F6D323D513F8F233BAB22BA" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_584B13BF5D8B3A6EF0818F233BAF6A8D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CondensedConsolidatedBalanceSheetsUnauditedParenthetical" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_A962E01030EB2A2EAF2B371DF46EF6DF" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_4060FF8F5ED33264A4B5371DF47241D5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_A962E01030EB2A2EAF2B371DF46EF6DF" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_4060FF8F5ED33264A4B5371DF47241D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_E7C19E5D594CF64DED8A371DF473C8A2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_A962E01030EB2A2EAF2B371DF46EF6DF" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_E7C19E5D594CF64DED8A371DF473C8A2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_9BE03FF3FA24EC02D7E2371DF473EFE8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_A962E01030EB2A2EAF2B371DF46EF6DF" xlink:to="loc_us-gaap_CommonStockSharesIssued_9BE03FF3FA24EC02D7E2371DF473EFE8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_22362EC52768DB3106BE371DF473A636" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_A962E01030EB2A2EAF2B371DF46EF6DF" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_22362EC52768DB3106BE371DF473A636" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_3C12C2F12C465ABF1D2B931AAE10BD39" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_5A00383A27B80E9C0BD0931AAE10C1A0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_3C12C2F12C465ABF1D2B931AAE10BD39" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_5A00383A27B80E9C0BD0931AAE10C1A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_D47778AD6CA37C7E7CE0931AAE116DF1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_5A00383A27B80E9C0BD0931AAE10C1A0" xlink:to="loc_us-gaap_NetIncomeLoss_D47778AD6CA37C7E7CE0931AAE116DF1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_5A00383A27B80E9C0BD0931AAE10C1A0" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_74C4B05BDDF09BD162EB931AAE111851" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_74C4B05BDDF09BD162EB931AAE111851" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_F16B2C49A2716F76D7D9931AAE1198AF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:to="loc_us-gaap_ShareBasedCompensation_F16B2C49A2716F76D7D9931AAE1198AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_D7E31EBFF8BB1AB23802931AAE11BFAB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_D7E31EBFF8BB1AB23802931AAE11BFAB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnDispositionOfAssets1" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_38697C56E9F42A033449931AAE121B54" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_38697C56E9F42A033449931AAE121B54" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_7A1A7B65806612CC3CBB931AAE122EBB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_7A1A7B65806612CC3CBB931AAE122EBB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_3258311B65D1F12D409A931AAE1297A1" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_3258311B65D1F12D409A931AAE1297A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_8C968411533042DA1265931AAE12BBB7" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_8C968411533042DA1265931AAE12BBB7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_2001FF6B66561D4A08EF931AAE12DC44" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_C5CDAD94DB1513DC57A5931AAE1126CC" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_2001FF6B66561D4A08EF931AAE12DC44" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_BBCA08455C6FE187B117931AAE121B7A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_2001FF6B66561D4A08EF931AAE12DC44" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_BBCA08455C6FE187B117931AAE121B7A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInReceivables" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_11B8FEDF2B7DE5FF7040931AAE13F453" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_2001FF6B66561D4A08EF931AAE12DC44" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_11B8FEDF2B7DE5FF7040931AAE13F453" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherCurrentAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_E632C3EC819FF5AB412A931AAE13112F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_2001FF6B66561D4A08EF931AAE12DC44" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentAssets_E632C3EC819FF5AB412A931AAE13112F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_AE7EBE780E33EE635895931AAE13164E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_2001FF6B66561D4A08EF931AAE12DC44" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_AE7EBE780E33EE635895931AAE13164E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_EBB441BDB489DCF3BD0D931AAE13E807" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_2001FF6B66561D4A08EF931AAE12DC44" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_EBB441BDB489DCF3BD0D931AAE13E807" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_IncreaseDecreaseInLeaseLiabilities" xlink:label="loc_astm_IncreaseDecreaseInLeaseLiabilities_881670F7BB771B9F5531931AAE14E03D" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_2001FF6B66561D4A08EF931AAE12DC44" xlink:to="loc_astm_IncreaseDecreaseInLeaseLiabilities_881670F7BB771B9F5531931AAE14E03D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_65CEFEE776B4C41723B3931AAE147B73" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_2001FF6B66561D4A08EF931AAE12DC44" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_65CEFEE776B4C41723B3931AAE147B73" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1A4F2E38A662420FA5FE931AAE1430B5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperationsAbstract_5A00383A27B80E9C0BD0931AAE10C1A0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1A4F2E38A662420FA5FE931AAE1430B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_08DB7AC00524CA767693931AAE14944C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_3C12C2F12C465ABF1D2B931AAE10BD39" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_08DB7AC00524CA767693931AAE14944C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_EE1CAB14695263C3C7F9931AAE14BE78" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_08DB7AC00524CA767693931AAE14944C" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_EE1CAB14695263C3C7F9931AAE14BE78" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_7F78FAFC060392403E18931AAE1466E8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_08DB7AC00524CA767693931AAE14944C" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments_7F78FAFC060392403E18931AAE1466E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_17353D1D8EBDA1F1D009931AAE158074" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_08DB7AC00524CA767693931AAE14944C" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_17353D1D8EBDA1F1D009931AAE158074" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_70A3D5343BBA69935F84931AAE15FEBE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperationsAbstract_08DB7AC00524CA767693931AAE14944C" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_70A3D5343BBA69935F84931AAE15FEBE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_CAA28F49A700210E7CB5931AAE153EF4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_3C12C2F12C465ABF1D2B931AAE10BD39" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_CAA28F49A700210E7CB5931AAE153EF4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_352CB13FDF8B15091359931AAE15C467" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_CAA28F49A700210E7CB5931AAE153EF4" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_352CB13FDF8B15091359931AAE15C467" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromWarrantExercises" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_D3BF9FDEEB7F2FA7368E931AAE15558B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_CAA28F49A700210E7CB5931AAE153EF4" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_D3BF9FDEEB7F2FA7368E931AAE15558B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_BE4015B87F53E6B658EE931AAE16DBA9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_CAA28F49A700210E7CB5931AAE153EF4" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_BE4015B87F53E6B658EE931AAE16DBA9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_473B11C75E964662CF59931AAE16BA09" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_CAA28F49A700210E7CB5931AAE153EF4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_473B11C75E964662CF59931AAE16BA09" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_B385C23DA8EAF9E1D112931AAE167707" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_3C12C2F12C465ABF1D2B931AAE10BD39" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_B385C23DA8EAF9E1D112931AAE167707" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Cash" xlink:label="loc_us-gaap_Cash_BB5449E81B47611ACC03931AAE16A04C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_3C12C2F12C465ABF1D2B931AAE10BD39" xlink:to="loc_us-gaap_Cash_BB5449E81B47611ACC03931AAE16A04C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Cash" xlink:label="loc_us-gaap_Cash_D6BEE738EBE896E216B1931AAE16A502" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_3C12C2F12C465ABF1D2B931AAE10BD39" xlink:to="loc_us-gaap_Cash_D6BEE738EBE896E216B1931AAE16A502" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CondensedConsolidatedStatementsOfComprehensiveLossUnaudited" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_A071559DCD5F7D4203777598CE62E728" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_E4EE8FF7CF8EA3EEDCE27598CE631BB4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_A071559DCD5F7D4203777598CE62E728" xlink:to="loc_us-gaap_NetIncomeLoss_E4EE8FF7CF8EA3EEDCE27598CE631BB4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_31D5696244698EE931677598CE63D717" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_A071559DCD5F7D4203777598CE62E728" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_31D5696244698EE931677598CE63D717" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_D5DEC5DC7F9019319FC27598CE630893" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_31D5696244698EE931677598CE63D717" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_D5DEC5DC7F9019319FC27598CE630893" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_AE4BAEF60E82D20E4FE17598CE635056" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_A071559DCD5F7D4203777598CE62E728" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_AE4BAEF60E82D20E4FE17598CE635056" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/CondensedConsolidatedStatementsOfOperationsUnaudited" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_0C467E39362112DAB6B68F233B9B1007" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_EFB26DD3C8A482D106848F233B9BA795" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0C467E39362112DAB6B68F233B9B1007" xlink:to="loc_us-gaap_StatementTable_EFB26DD3C8A482D106848F233B9BA795" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_F759C09A90B1A4C3F1A78F233B9CD547" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_EFB26DD3C8A482D106848F233B9BA795" xlink:to="loc_srt_ProductOrServiceAxis_F759C09A90B1A4C3F1A78F233B9CD547" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_E486DD85645A79D217EC8F233B9CC10F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_F759C09A90B1A4C3F1A78F233B9CD547" xlink:to="loc_srt_ProductsAndServicesDomain_E486DD85645A79D217EC8F233B9CC10F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProductMember" xlink:label="loc_us-gaap_ProductMember_425627CABFB97C7042818F233B9CD31B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_E486DD85645A79D217EC8F233B9CC10F" xlink:to="loc_us-gaap_ProductMember_425627CABFB97C7042818F233B9CD31B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_EFB26DD3C8A482D106848F233B9BA795" xlink:to="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_D38E54682E48ABF9971C8F233B9D94B7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_D38E54682E48ABF9971C8F233B9D94B7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_3073FE908B39DBC064C98F233B9DE201" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_3073FE908B39DBC064C98F233B9DE201" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GrossProfit" xlink:label="loc_us-gaap_GrossProfit_80E5E661595A271B1E068F233B9DA22C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_GrossProfit_80E5E661595A271B1E068F233B9DA22C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_15B421687C24D39E9CA28F233B9D120F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_15B421687C24D39E9CA28F233B9D120F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_68C3946C548A982E95558F233B9ED83D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_68C3946C548A982E95558F233B9ED83D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_E008B41EC385A0D3B8A18F233B9E6FDA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_OperatingExpenses_E008B41EC385A0D3B8A18F233B9E6FDA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_F2DD058984EB694F85FC8F233B9E52EA" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_OperatingIncomeLoss_F2DD058984EB694F85FC8F233B9E52EA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_9DB0142D652F6B90AFC88F233B9EE764" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_9DB0142D652F6B90AFC88F233B9EE764" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_688C9C5320B74A4A40678F233B9EEE1E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_9DB0142D652F6B90AFC88F233B9EE764" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_688C9C5320B74A4A40678F233B9EEE1E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_us-gaap_InvestmentIncomeInterest_2C436925646A96A786E98F233B9FF43A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_9DB0142D652F6B90AFC88F233B9EE764" xlink:to="loc_us-gaap_InvestmentIncomeInterest_2C436925646A96A786E98F233B9FF43A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_163EDF575822C7FEB4C58F233B9F2849" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_9DB0142D652F6B90AFC88F233B9EE764" xlink:to="loc_us-gaap_InterestExpense_163EDF575822C7FEB4C58F233B9F2849" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_8FF776591BFE7A0BCF4C8F233B9FFACB" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_9DB0142D652F6B90AFC88F233B9EE764" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_8FF776591BFE7A0BCF4C8F233B9FFACB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_CA7090BEB76ABD7AB6108F233B9F2A88" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_9DB0142D652F6B90AFC88F233B9EE764" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_CA7090BEB76ABD7AB6108F233B9F2A88" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_39096185929CEDF54A4C8F233B9FA4E0" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_NetIncomeLoss_39096185929CEDF54A4C8F233B9FA4E0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_CB36808084679ADBD2A18F233BA0B2E3" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_CB36808084679ADBD2A18F233BA0B2E3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xlink:label="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_6B5B2DDD4CAB55AAE2998F233BA05946" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0D55737EB3B134B505A08F233B9DEE1C" xlink:to="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_6B5B2DDD4CAB55AAE2998F233BA05946" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/ConsolidatedStatementsOfShareholdersEquity" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_994DA0ECA83268FC30BE93673B2F9049" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_DC061D2B978EA543A80393673B302F08" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_994DA0ECA83268FC30BE93673B2F9049" xlink:to="loc_us-gaap_StatementTable_DC061D2B978EA543A80393673B302F08" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_7FE1F8D5CB711D28206593673B305B52" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_DC061D2B978EA543A80393673B302F08" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_7FE1F8D5CB711D28206593673B305B52" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_184A956CE773159235D993673B311F05" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_7FE1F8D5CB711D28206593673B305B52" xlink:to="loc_us-gaap_EquityComponentDomain_184A956CE773159235D993673B311F05" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_D008D1130F7EA311CBD593673B31BA5E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_184A956CE773159235D993673B311F05" xlink:to="loc_us-gaap_CommonStockMember_D008D1130F7EA311CBD593673B31BA5E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_847106F7E613565ADA8A93673B31B518" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_184A956CE773159235D993673B311F05" xlink:to="loc_us-gaap_WarrantMember_847106F7E613565ADA8A93673B31B518" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_DD239F9C429D7BD198DF93673B314B16" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_184A956CE773159235D993673B311F05" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_DD239F9C429D7BD198DF93673B314B16" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_BD4901296B1D2453B8BB93673B322C4C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_184A956CE773159235D993673B311F05" xlink:to="loc_us-gaap_RetainedEarningsMember_BD4901296B1D2453B8BB93673B322C4C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_61E59EAC7FB07325B5F893673B32984F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_DC061D2B978EA543A80393673B302F08" xlink:to="loc_us-gaap_StatementLineItems_61E59EAC7FB07325B5F893673B32984F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_61E59EAC7FB07325B5F893673B32984F" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_DD47AF6E478D7DB69ED393673B325EE4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_SharesOutstanding_DD47AF6E478D7DB69ED393673B325EE4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_AFFDE9F652E6B2FE969293673B33CAE4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_StockholdersEquity_AFFDE9F652E6B2FE969293673B33CAE4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_DF91CC97CC343FE1553593673B331675" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_NetIncomeLoss_DF91CC97CC343FE1553593673B331675" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_73F4680BFD9F4C582CFB93673B3342D2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_73F4680BFD9F4C582CFB93673B3342D2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_2077E7C2425CCB9D960A93673B33B4CE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_2077E7C2425CCB9D960A93673B33B4CE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_1406CDAA7E42587F9D8F93673B33810B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_1406CDAA7E42587F9D8F93673B33810B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_5CC893CED3F9154CFB4D93673B34082B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_5CC893CED3F9154CFB4D93673B34082B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_CDFB62EDAA17A127330F93673B348B29" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_CDFB62EDAA17A127330F93673B348B29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TradingSecuritiesUnrealizedHoldingGainLoss" xlink:label="loc_us-gaap_TradingSecuritiesUnrealizedHoldingGainLoss_AA8906E1D04A702496DA93673F640277" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_TradingSecuritiesUnrealizedHoldingGainLoss_AA8906E1D04A702496DA93673F640277" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_StockIssuedDuringPeriodSharesExerciseOfWarrants" xlink:label="loc_astm_StockIssuedDuringPeriodSharesExerciseOfWarrants_A43FCBC5C9EAE23AE9ED93673B34E834" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_astm_StockIssuedDuringPeriodSharesExerciseOfWarrants_A43FCBC5C9EAE23AE9ED93673B34E834" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_StockIssuedDuringPeriodValueExerciseOfWarrants" xlink:label="loc_astm_StockIssuedDuringPeriodValueExerciseOfWarrants_5F6A9A6457830153426493673B34A10C" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_astm_StockIssuedDuringPeriodValueExerciseOfWarrants_5F6A9A6457830153426493673B34A10C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrealizedLossOnSecurities" xlink:label="loc_us-gaap_UnrealizedLossOnSecurities_221FE11943ED104DB0F893673B347F97" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_UnrealizedLossOnSecurities_221FE11943ED104DB0F893673B347F97" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_3B42F5D5F7A60AC24B6693673B34CB58" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_SharesOutstanding_3B42F5D5F7A60AC24B6693673B34CB58" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_63DA7498C79FF666DB4B93673B35CEF3" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_21486E419E5DFADB455D93673B32334B" xlink:to="loc_us-gaap_StockholdersEquity_63DA7498C79FF666DB4B93673B35CEF3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/DocumentAndEntityInformation" xlink:type="extended">
    <link:loc xlink:href="astm-20190331.xsd#astm_DocumentAndEntityInformationAbstract" xlink:label="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_140DCA8C03D1578DB0D73312DFAB6856" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_EntityRegistrantName_140DCA8C03D1578DB0D73312DFAB6856" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_349D09FA393C5ADA1EB93312DFAC32BA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_EntityCentralIndexKey_349D09FA393C5ADA1EB93312DFAC32BA" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_7F684249EB42AC925F763312DFACFC6E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_CurrentFiscalYearEndDate_7F684249EB42AC925F763312DFACFC6E" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_9A0465A0F7E4D76D98F33312DFAC4086" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_EntityFilerCategory_9A0465A0F7E4D76D98F33312DFAC4086" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntitySmallBusiness" xlink:label="loc_dei_EntitySmallBusiness_8688C15F28BA2762D4833312DFAC2DDB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_EntitySmallBusiness_8688C15F28BA2762D4833312DFAC2DDB" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_dei_EntityEmergingGrowthCompany_9D7252C8CB2F28A90EBF3312DFACF767" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_EntityEmergingGrowthCompany_9D7252C8CB2F28A90EBF3312DFACF767" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_F04A7AAB7D570687E1343312DFAD3A54" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_DocumentType_F04A7AAB7D570687E1343312DFAD3A54" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_F9E10CD1B44E1EAECD5D3312DFAD8E99" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_DocumentPeriodEndDate_F9E10CD1B44E1EAECD5D3312DFAD8E99" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_BFDA5D71BB6746FADA523312DFAD296D" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_DocumentFiscalYearFocus_BFDA5D71BB6746FADA523312DFAD296D" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_A99B5F7FFF5108ADADF33312DFAD2A5A" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_DocumentFiscalPeriodFocus_A99B5F7FFF5108ADADF33312DFAD2A5A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_DADC99B4203EFB7910B73312DFAD6077" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_AmendmentFlag_DADC99B4203EFB7910B73312DFAD6077" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_27D074642D59249621273312DFAD772C" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_DocumentAndEntityInformationAbstract_0EB420BD0AA2CEA82E0C3312DFAB10B9" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_27D074642D59249621273312DFAD772C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_5E8D8EC97516518A8209E8090E68B8D1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_B6EBF6B61BB75C9D968D72224B87FF1C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_5E8D8EC97516518A8209E8090E68B8D1" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_B6EBF6B61BB75C9D968D72224B87FF1C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/FairValueMeasurementsRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_51809C002FC4CBBC50CF4590D7D4FDDE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_F03EC078BB5C8D9E02794590D7D563A4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_51809C002FC4CBBC50CF4590D7D4FDDE" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_F03EC078BB5C8D9E02794590D7D563A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_0B4BD2C326D968D393E14590D7D5DFCA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_F03EC078BB5C8D9E02794590D7D563A4" xlink:to="loc_us-gaap_FinancialInstrumentAxis_0B4BD2C326D968D393E14590D7D5DFCA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5EB9997DDEB30E7513EE4590D7D61CD9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0B4BD2C326D968D393E14590D7D5DFCA" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5EB9997DDEB30E7513EE4590D7D61CD9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MoneyMarketFundsMember" xlink:label="loc_us-gaap_MoneyMarketFundsMember_2EE24261BAF2270196FB4590D7D6CC9E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5EB9997DDEB30E7513EE4590D7D61CD9" xlink:to="loc_us-gaap_MoneyMarketFundsMember_2EE24261BAF2270196FB4590D7D6CC9E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepurchaseAgreementsMember" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_34841E092EFE120DCA874590D7D69BCF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5EB9997DDEB30E7513EE4590D7D61CD9" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_34841E092EFE120DCA874590D7D69BCF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommercialPaperMember" xlink:label="loc_us-gaap_CommercialPaperMember_6732963F28516F4AC3CB4590D7D75906" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5EB9997DDEB30E7513EE4590D7D61CD9" xlink:to="loc_us-gaap_CommercialPaperMember_6732963F28516F4AC3CB4590D7D75906" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_7CE0E7B09D86A105E3A94590D7D764B5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5EB9997DDEB30E7513EE4590D7D61CD9" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_7CE0E7B09D86A105E3A94590D7D764B5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_31B8C78156F16F7A2C5C4590D7D7ECF6" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5EB9997DDEB30E7513EE4590D7D61CD9" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_31B8C78156F16F7A2C5C4590D7D7ECF6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetBackedSecuritiesMember" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_77CFD1A2BA84905078374590D7D7CCD4" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_5EB9997DDEB30E7513EE4590D7D61CD9" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_77CFD1A2BA84905078374590D7D7CCD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_0FC00226C3C54E3B90C84590D7D7D678" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_F03EC078BB5C8D9E02794590D7D563A4" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_0FC00226C3C54E3B90C84590D7D7D678" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_9C77DD392C0C0207023A4590D7D82AC7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_0FC00226C3C54E3B90C84590D7D7D678" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_9C77DD392C0C0207023A4590D7D82AC7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_86ECE11F9201554F9FDA4590D7D8C242" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_9C77DD392C0C0207023A4590D7D82AC7" xlink:to="loc_us-gaap_WarrantMember_86ECE11F9201554F9FDA4590D7D8C242" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_2119E95ED1E36A9A366D4590D7D9C840" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_F03EC078BB5C8D9E02794590D7D563A4" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_2119E95ED1E36A9A366D4590D7D9C840" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_AC22FEA6D99E0EACEF374590D7D93D8D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_2119E95ED1E36A9A366D4590D7D9C840" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_AC22FEA6D99E0EACEF374590D7D93D8D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_EA258D6C16CFEDC6A4034590D7D984AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_AC22FEA6D99E0EACEF374590D7D93D8D" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_EA258D6C16CFEDC6A4034590D7D984AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_DA5D1A3AE60454D2417E4590D7D9F25C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_F03EC078BB5C8D9E02794590D7D563A4" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_DA5D1A3AE60454D2417E4590D7D9F25C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F45BA31DF22857F85DE14590D7DAD52D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_DA5D1A3AE60454D2417E4590D7D9F25C" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F45BA31DF22857F85DE14590D7DAD52D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_0CB2759FBE32592C692A4590D7DA516D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F45BA31DF22857F85DE14590D7DAD52D" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_0CB2759FBE32592C692A4590D7DA516D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_7C1FCDD7ED480C9109B34590D7DB6E8B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F45BA31DF22857F85DE14590D7DAD52D" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_7C1FCDD7ED480C9109B34590D7DB6E8B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_BBBA33810363D2CF88D04590D7DBC248" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_F45BA31DF22857F85DE14590D7DAD52D" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_BBBA33810363D2CF88D04590D7DBC248" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_293AD079DE441AA6B7F84590D7DDEACB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_F03EC078BB5C8D9E02794590D7D563A4" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_293AD079DE441AA6B7F84590D7DDEACB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsFairValueDisclosureAbstract" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_4C4202F71961A43E213A4590D7DDB591" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_293AD079DE441AA6B7F84590D7DDEACB" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_4C4202F71961A43E213A4590D7DDB591" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_A4C4504ABCCAC315017F4590D7DE960F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_4C4202F71961A43E213A4590D7DDB591" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_A4C4504ABCCAC315017F4590D7DE960F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_AFB14951A83E4F03884B4590D7E5C60F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_C15EFCA3CA94811BC1544590D7E68C8F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_AFB14951A83E4F03884B4590D7E5C60F" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisTextBlock_C15EFCA3CA94811BC1544590D7E68C8F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/LeasesAssetsAndLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract" xlink:label="loc_us-gaap_LeasesAbstract_6173D99ED0BA8B6A74D9792390692C18" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_AA005C2DF20CC843D4DC792EC017F703" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_6173D99ED0BA8B6A74D9792390692C18" xlink:to="loc_us-gaap_AssetsAbstract_AA005C2DF20CC843D4DC792EC017F703" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_B7FE6F6D1B704A00C8647923DCAA2CE8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_AA005C2DF20CC843D4DC792EC017F703" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_B7FE6F6D1B704A00C8647923DCAA2CE8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAsset" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_D1D55FF7E01F5D3A1F6F792421BE9260" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_AA005C2DF20CC843D4DC792EC017F703" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_D1D55FF7E01F5D3A1F6F792421BE9260" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_RightOfUseAsset" xlink:label="loc_astm_RightOfUseAsset_617D63B27B591EE4D972792593636AA4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_AA005C2DF20CC843D4DC792EC017F703" xlink:to="loc_astm_RightOfUseAsset_617D63B27B591EE4D972792593636AA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAbstract" xlink:label="loc_us-gaap_LiabilitiesAbstract_B81FC14A91D03CDF915F792FF0E21C9E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_6173D99ED0BA8B6A74D9792390692C18" xlink:to="loc_us-gaap_LiabilitiesAbstract_B81FC14A91D03CDF915F792FF0E21C9E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_41899E7BC67BE61C0A15793126E4B90B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_B81FC14A91D03CDF915F792FF0E21C9E" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_41899E7BC67BE61C0A15793126E4B90B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_CEBE80E337B6025F75BB7929E01D0304" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_41899E7BC67BE61C0A15793126E4B90B" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_CEBE80E337B6025F75BB7929E01D0304" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityCurrent" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_0167791D28EA9FC2E947792A7CC07428" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_41899E7BC67BE61C0A15793126E4B90B" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_0167791D28EA9FC2E947792A7CC07428" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityCurrent" xlink:label="loc_astm_LeaseLiabilityCurrent_051436AA2B9A85EE873A792D42F96E24" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_41899E7BC67BE61C0A15793126E4B90B" xlink:to="loc_astm_LeaseLiabilityCurrent_051436AA2B9A85EE873A792D42F96E24" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesNoncurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E489F7181A32AF4211E7930D0A06A6F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_B81FC14A91D03CDF915F792FF0E21C9E" xlink:to="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E489F7181A32AF4211E7930D0A06A6F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_6B9AFABD0977CF755FA6792A297C060B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E489F7181A32AF4211E7930D0A06A6F" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_6B9AFABD0977CF755FA6792A297C060B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_2C4397821308C107C09F792B3C9B8716" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E489F7181A32AF4211E7930D0A06A6F" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_2C4397821308C107C09F792B3C9B8716" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityNoncurrent" xlink:label="loc_astm_LeaseLiabilityNoncurrent_4CA27B30C6109367123B792E197E1BFE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesNoncurrentAbstract_6E489F7181A32AF4211E7930D0A06A6F" xlink:to="loc_astm_LeaseLiabilityNoncurrent_4CA27B30C6109367123B792E197E1BFE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/LeasesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract" xlink:label="loc_us-gaap_LeasesAbstract_D262A32FCB3E05DF5841935EB0024B9C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermLeaseCost" xlink:label="loc_us-gaap_ShortTermLeaseCost_E4697FAFA055F513B3AF935EB0026A02" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_D262A32FCB3E05DF5841935EB0024B9C" xlink:to="loc_us-gaap_ShortTermLeaseCost_E4697FAFA055F513B3AF935EB0026A02" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_RightOfUseAsset" xlink:label="loc_astm_RightOfUseAsset_3BDB2B454D988033E4CD935EB00236EF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_D262A32FCB3E05DF5841935EB0024B9C" xlink:to="loc_astm_RightOfUseAsset_3BDB2B454D988033E4CD935EB00236EF" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiability" xlink:label="loc_astm_LeaseLiability_13C85AE6580F33D2DE08935EB0032196" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_D262A32FCB3E05DF5841935EB0024B9C" xlink:to="loc_astm_LeaseLiability_13C85AE6580F33D2DE08935EB0032196" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseExpense" xlink:label="loc_us-gaap_OperatingLeaseExpense_1FDAA871F7D3EFF318B3935EB003ADE9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_D262A32FCB3E05DF5841935EB0024B9C" xlink:to="loc_us-gaap_OperatingLeaseExpense_1FDAA871F7D3EFF318B3935EB003ADE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseInterestExpense" xlink:label="loc_us-gaap_FinanceLeaseInterestExpense_BEC0702E3B8BB0363F10935EB0033ED5" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_D262A32FCB3E05DF5841935EB0024B9C" xlink:to="loc_us-gaap_FinanceLeaseInterestExpense_BEC0702E3B8BB0363F10935EB0033ED5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesIncomeStatementInterestExpense" xlink:label="loc_us-gaap_CapitalLeasesIncomeStatementInterestExpense_17A5CE9D4F839D2DC082935EB0034BF6" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_D262A32FCB3E05DF5841935EB0024B9C" xlink:to="loc_us-gaap_CapitalLeasesIncomeStatementInterestExpense_17A5CE9D4F839D2DC082935EB0034BF6" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/LeasesLeaseTermAndDiscountRateDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract" xlink:label="loc_us-gaap_LeasesAbstract_75805A32179D6F03CF0E461A816CFDD9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_6EA820027B64F37BDBF1461E6982D8F1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_75805A32179D6F03CF0E461A816CFDD9" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_6EA820027B64F37BDBF1461E6982D8F1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseWeightedAverageRemainingLeaseTerm1" xlink:label="loc_us-gaap_FinanceLeaseWeightedAverageRemainingLeaseTerm1_0FBC723BA871CF4DE706461AA7EC5CB4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_75805A32179D6F03CF0E461A816CFDD9" xlink:to="loc_us-gaap_FinanceLeaseWeightedAverageRemainingLeaseTerm1_0FBC723BA871CF4DE706461AA7EC5CB4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_4E5CC1DCD1029B47FE25461E877A3EA3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_75805A32179D6F03CF0E461A816CFDD9" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_4E5CC1DCD1029B47FE25461E877A3EA3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseWeightedAverageDiscountRatePercent" xlink:label="loc_us-gaap_FinanceLeaseWeightedAverageDiscountRatePercent_913A7AD00C09A9ED319E461AE621680E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_75805A32179D6F03CF0E461A816CFDD9" xlink:to="loc_us-gaap_FinanceLeaseWeightedAverageDiscountRatePercent_913A7AD00C09A9ED319E461AE621680E" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/LeasesMaturitiesOfLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract" xlink:label="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract" xlink:label="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_F5D443428123343222048F439BD245B3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_F5D443428123343222048F439BD245B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_49A628F9771620286C268F439BD24FE2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_49A628F9771620286C268F439BD24FE2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_7748D1042B12FD182FE38F439BD263F4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_7748D1042B12FD182FE38F439BD263F4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_F9AB676CFBBD72B7DF5E8F439BD2A188" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_F9AB676CFBBD72B7DF5E8F439BD2A188" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_13EE24781A0D131840ED8F439BD250B3" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_13EE24781A0D131840ED8F439BD250B3" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LesseeOperatingLeaseLiabilityPaymentsDueYearSix" xlink:label="loc_astm_LesseeOperatingLeaseLiabilityPaymentsDueYearSix_93B3BD10E8032CE995778F439BD26610" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_astm_LesseeOperatingLeaseLiabilityPaymentsDueYearSix_93B3BD10E8032CE995778F439BD26610" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LesseeOperatingLeaseLiabilityPaymentsDueafterYearSix" xlink:label="loc_astm_LesseeOperatingLeaseLiabilityPaymentsDueafterYearSix_492BA7BCB8379C0AD0418F439BD2871C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_astm_LesseeOperatingLeaseLiabilityPaymentsDueafterYearSix_492BA7BCB8379C0AD0418F439BD2871C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_DA2ADCE6E115F73977158F439BD299A2" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_DA2ADCE6E115F73977158F439BD299A2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_1CB8B32618D60EB739EE8F439BD20AC0" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_1CB8B32618D60EB739EE8F439BD20AC0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiability" xlink:label="loc_us-gaap_OperatingLeaseLiability_9D2C93FF6794F524A18D8F439BD2FDD4" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_27F74588E702A384DE6C8F439BD208EB" xlink:to="loc_us-gaap_OperatingLeaseLiability_9D2C93FF6794F524A18D8F439BD2FDD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract" xlink:label="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_14B9617EB7F4EBE23E488F439BD2E0D6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_14B9617EB7F4EBE23E488F439BD2E0D6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_889F31A31026363E73358F439BD275E5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_889F31A31026363E73358F439BD275E5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_18C2D2BE2E5C0DE898458F439BD2D949" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_18C2D2BE2E5C0DE898458F439BD2D949" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_BF42DF85CD66D6D612158F439BD2E1F2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_BF42DF85CD66D6D612158F439BD2E1F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_4881EA7E35641122400A8F439BD2710D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_4881EA7E35641122400A8F439BD2710D" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_FinanceLeaseLiabilityPaymentsDueYearSix" xlink:label="loc_astm_FinanceLeaseLiabilityPaymentsDueYearSix_C2CFF3108BC348C5B0678F439BD2EDD7" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_astm_FinanceLeaseLiabilityPaymentsDueYearSix_C2CFF3108BC348C5B0678F439BD2EDD7" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_FinanceLeaseLiabilityPaymentsDueafterYearSix" xlink:label="loc_astm_FinanceLeaseLiabilityPaymentsDueafterYearSix_14F85EA812B59AA8B6088F439BD278A8" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_astm_FinanceLeaseLiabilityPaymentsDueafterYearSix_14F85EA812B59AA8B6088F439BD278A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_F10A2E0E06D2EE3894948F439BD2432E" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_F10A2E0E06D2EE3894948F439BD2432E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_77B6A01306D5C1BDD8A88F439BD2DE57" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_77B6A01306D5C1BDD8A88F439BD2DE57" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiability" xlink:label="loc_us-gaap_FinanceLeaseLiability_F34C7CFE175A9E983E7A8F439BD289A6" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinanceLeaseLiabilitiesPaymentsDueAbstract_8DF75D8B9F8FB08894BE8F439BD22D07" xlink:to="loc_us-gaap_FinanceLeaseLiability_F34C7CFE175A9E983E7A8F439BD289A6" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityPaymentsDueRemainderOfFiscalYear" xlink:label="loc_astm_LeaseLiabilityPaymentsDueRemainderOfFiscalYear_0320C0074A84D4CD9B6B8F439BD2DA61" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiabilityPaymentsDueRemainderOfFiscalYear_0320C0074A84D4CD9B6B8F439BD2DA61" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityPaymentsDueYearTwo" xlink:label="loc_astm_LeaseLiabilityPaymentsDueYearTwo_A0AFC5485E6F963628F38F439BD2EC8C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiabilityPaymentsDueYearTwo_A0AFC5485E6F963628F38F439BD2EC8C" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityPaymentsDueYearThree" xlink:label="loc_astm_LeaseLiabilityPaymentsDueYearThree_BF4F881291C309F518968F439BD2DFBD" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiabilityPaymentsDueYearThree_BF4F881291C309F518968F439BD2DFBD" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityPaymentsDueYearFour" xlink:label="loc_astm_LeaseLiabilityPaymentsDueYearFour_7C0584425FEB5F4AEFD98F439BD2A52B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiabilityPaymentsDueYearFour_7C0584425FEB5F4AEFD98F439BD2A52B" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityPaymentsDueYearFive" xlink:label="loc_astm_LeaseLiabilityPaymentsDueYearFive_C8CAEA14D877C4A74B4D8F439BD27E53" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiabilityPaymentsDueYearFive_C8CAEA14D877C4A74B4D8F439BD27E53" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityPaymentsDueYearSix" xlink:label="loc_astm_LeaseLiabilityPaymentsDueYearSix_38A0EA0043814915E2BC8F439BD23F01" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiabilityPaymentsDueYearSix_38A0EA0043814915E2BC8F439BD23F01" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityPaymentsDueAfterYearSix" xlink:label="loc_astm_LeaseLiabilityPaymentsDueAfterYearSix_779EAE2AED5FD70734508F439BD274FC" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiabilityPaymentsDueAfterYearSix_779EAE2AED5FD70734508F439BD274FC" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityPaymentsDue" xlink:label="loc_astm_LeaseLiabilityPaymentsDue_D411D81A6AA58A6E2F7D8F439BD239D4" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiabilityPaymentsDue_D411D81A6AA58A6E2F7D8F439BD239D4" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiabilityUndiscountedExcessAmount" xlink:label="loc_astm_LeaseLiabilityUndiscountedExcessAmount_DAA6BED4870EBF0974008F439BD2D555" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiabilityUndiscountedExcessAmount_DAA6BED4870EBF0974008F439BD2D555" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LeaseLiability" xlink:label="loc_astm_LeaseLiability_DAB481C15806CD5A07348F439BD2775E" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_CA8C88BABCD5C6000E448F439BD26B55" xlink:to="loc_astm_LeaseLiability_DAB481C15806CD5A07348F439BD2775E" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/LeasesNotes" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract" xlink:label="loc_us-gaap_LeasesAbstract_07F4D27EE07FEBD8B9E8791EABF6AE54" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeasesTextBlock" xlink:label="loc_us-gaap_LesseeOperatingLeasesTextBlock_F7172F5F44746172A39B794506030160" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_07F4D27EE07FEBD8B9E8791EABF6AE54" xlink:to="loc_us-gaap_LesseeOperatingLeasesTextBlock_F7172F5F44746172A39B794506030160" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeFinanceLeasesTextBlock" xlink:label="loc_us-gaap_LesseeFinanceLeasesTextBlock_4EE2EE025368EF5C86FA7945A6DBE382" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_07F4D27EE07FEBD8B9E8791EABF6AE54" xlink:to="loc_us-gaap_LesseeFinanceLeasesTextBlock_4EE2EE025368EF5C86FA7945A6DBE382" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/LeasesSchedulePriorToAdoptionDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract" xlink:label="loc_us-gaap_LeasesAbstract_5B49AD2D76FBCFC36E4D8E553BA451A6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesOperatingAbstract" xlink:label="loc_us-gaap_LeasesOperatingAbstract_0E3AAAB3CC986E61A12A8E584377303F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_5B49AD2D76FBCFC36E4D8E553BA451A6" xlink:to="loc_us-gaap_LeasesOperatingAbstract_0E3AAAB3CC986E61A12A8E584377303F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_0190DC293DACD021B1588E5569C35E3F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_0E3AAAB3CC986E61A12A8E584377303F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_0190DC293DACD021B1588E5569C35E3F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_F4707E6198286D1108CB8E55C5087327" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_0E3AAAB3CC986E61A12A8E584377303F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_F4707E6198286D1108CB8E55C5087327" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_3820AA8552D3E09D4E8B8E55C66A4EA4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_0E3AAAB3CC986E61A12A8E584377303F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_3820AA8552D3E09D4E8B8E55C66A4EA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_602802E032B2E49A108D8E55C7526206" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_0E3AAAB3CC986E61A12A8E584377303F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_602802E032B2E49A108D8E55C7526206" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_F6344CA149451534D1BF8E55C87E1A76" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_0E3AAAB3CC986E61A12A8E584377303F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_F6344CA149451534D1BF8E55C87E1A76" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_D7C4BF5AB89723BF7C868E55C99824AC" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_0E3AAAB3CC986E61A12A8E584377303F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_D7C4BF5AB89723BF7C868E55C99824AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_C67FC288E676650502598E55CAC61406" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_0E3AAAB3CC986E61A12A8E584377303F" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_C67FC288E676650502598E55CAC61406" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesCapitalAbstract" xlink:label="loc_us-gaap_LeasesCapitalAbstract_0B028C67742819CAEA7E8E5A289FD0F7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_5B49AD2D76FBCFC36E4D8E553BA451A6" xlink:to="loc_us-gaap_LeasesCapitalAbstract_0B028C67742819CAEA7E8E5A289FD0F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDue_B284813DE7F345DE027F8E55FA6B4B0A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesCapitalAbstract_0B028C67742819CAEA7E8E5A289FD0F7" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDue_B284813DE7F345DE027F8E55FA6B4B0A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent_D768187E290D87BC16418E55FB9AD251" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesCapitalAbstract_0B028C67742819CAEA7E8E5A289FD0F7" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent_D768187E290D87BC16418E55FB9AD251" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears_4C6404CEC4E9148A0D2B8E55FCB684E3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesCapitalAbstract_0B028C67742819CAEA7E8E5A289FD0F7" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears_4C6404CEC4E9148A0D2B8E55FCB684E3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears_99E7DAF4B19F647C80798E55FDE7CC13" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesCapitalAbstract_0B028C67742819CAEA7E8E5A289FD0F7" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears_99E7DAF4B19F647C80798E55FDE7CC13" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears_05EC1DD1B4D76F14961C8E55FEFEA0A6" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesCapitalAbstract_0B028C67742819CAEA7E8E5A289FD0F7" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears_05EC1DD1B4D76F14961C8E55FEFEA0A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears_BBEA7B69BA015BEEDF5F8E5600279227" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesCapitalAbstract_0B028C67742819CAEA7E8E5A289FD0F7" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears_BBEA7B69BA015BEEDF5F8E5600279227" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter_15339E4120E30780073A8E56016982C4" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesCapitalAbstract_0B028C67742819CAEA7E8E5A289FD0F7" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter_15339E4120E30780073A8E56016982C4" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_OperatingAndCapitalLeasesAbstract" xlink:label="loc_astm_OperatingAndCapitalLeasesAbstract_84CA1CFD0F0C9E4AF98E8E5BC625C145" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_5B49AD2D76FBCFC36E4D8E553BA451A6" xlink:to="loc_astm_OperatingAndCapitalLeasesAbstract_84CA1CFD0F0C9E4AF98E8E5BC625C145" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDue" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDue_202789FA5C45012BF61C8E5634AFF793" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesAbstract_84CA1CFD0F0C9E4AF98E8E5BC625C145" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDue_202789FA5C45012BF61C8E5634AFF793" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueCurrent" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueCurrent_2E78C7A0B99FFDB7A4C58E56361D8D4F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesAbstract_84CA1CFD0F0C9E4AF98E8E5BC625C145" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueCurrent_2E78C7A0B99FFDB7A4C58E56361D8D4F" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInTwoYears_9DB7B09E6918C8DD8F0C8E563732C2DE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesAbstract_84CA1CFD0F0C9E4AF98E8E5BC625C145" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInTwoYears_9DB7B09E6918C8DD8F0C8E563732C2DE" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInThreeYears_E1FFEF01498D546BDCFB8E5638A02929" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesAbstract_84CA1CFD0F0C9E4AF98E8E5BC625C145" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInThreeYears_E1FFEF01498D546BDCFB8E5638A02929" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInFourYears" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInFourYears_774D689BC928642F4C9C8E5639DCBB20" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesAbstract_84CA1CFD0F0C9E4AF98E8E5BC625C145" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueInFourYears_774D689BC928642F4C9C8E5639DCBB20" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueinFiveYears" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueinFiveYears_42DC23E351F1AAB3A02A8E563B2D1204" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesAbstract_84CA1CFD0F0C9E4AF98E8E5BC625C145" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueinFiveYears_42DC23E351F1AAB3A02A8E563B2D1204" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueThereafter" xlink:label="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueThereafter_B3D351CEC6794F3BE3338E563CD5329F" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_astm_OperatingAndCapitalLeasesAbstract_84CA1CFD0F0C9E4AF98E8E5BC625C145" xlink:to="loc_astm_OperatingandCapitalLeasesandPurchaseCommitmentsFutureMinimumPaymentsDueThereafter_B3D351CEC6794F3BE3338E563CD5329F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/LeasesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract" xlink:label="loc_us-gaap_LeasesAbstract_7DA363842C2E55580C9C8E4A9A107080" xlink:type="locator" />
    <link:loc xlink:href="astm-20190331.xsd#astm_AssetsAndLiabilitiesLeasesTableTextBlock" xlink:label="loc_astm_AssetsAndLiabilitiesLeasesTableTextBlock_6FF5F90DF60922DB7F9A8E4A9A10D943" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_7DA363842C2E55580C9C8E4A9A107080" xlink:to="loc_astm_AssetsAndLiabilitiesLeasesTableTextBlock_6FF5F90DF60922DB7F9A8E4A9A10D943" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseLiabilityMaturityTableTextBlock" xlink:label="loc_us-gaap_FinanceLeaseLiabilityMaturityTableTextBlock_8A8C800AEB2F7F548E228E4A9A1019C2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_7DA363842C2E55580C9C8E4A9A107080" xlink:to="loc_us-gaap_FinanceLeaseLiabilityMaturityTableTextBlock_8A8C800AEB2F7F548E228E4A9A1019C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_16920FB9297B4407C28F8E4A9A10CC93" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_7DA363842C2E55580C9C8E4A9A107080" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_16920FB9297B4407C28F8E4A9A10CC93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseCostTableTextBlock" xlink:label="loc_us-gaap_LeaseCostTableTextBlock_27B5EB2BCAE79079AB998E4A9A11D79F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_7DA363842C2E55580C9C8E4A9A107080" xlink:to="loc_us-gaap_LeaseCostTableTextBlock_27B5EB2BCAE79079AB998E4A9A11D79F" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_ScheduleOfFutureMinimumRentalPaymentsForOperatingAndCapitalLeasesTableTextBlock" xlink:label="loc_astm_ScheduleOfFutureMinimumRentalPaymentsForOperatingAndCapitalLeasesTableTextBlock_33166CABDFD33A32E8C38E5451629A73" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_7DA363842C2E55580C9C8E4A9A107080" xlink:to="loc_astm_ScheduleOfFutureMinimumRentalPaymentsForOperatingAndCapitalLeasesTableTextBlock_33166CABDFD33A32E8C38E5451629A73" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/NetLossPerCommonShare" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_313F6B1BC6275801A611FA2F74AAFE6A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_46788439E1935FF69CF75D82B04381AD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_313F6B1BC6275801A611FA2F74AAFE6A" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_46788439E1935FF69CF75D82B04381AD" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/NetLossPerCommonShareDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_BA9AF3C8C1C0170690638F233A7111DA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_A85B2A7B5B2DAE3AEDBB8F2517FB13BF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_BA9AF3C8C1C0170690638F233A7111DA" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_A85B2A7B5B2DAE3AEDBB8F2517FB13BF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_3C7CBF9FCC0C37B354BD8F2528677F31" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_A85B2A7B5B2DAE3AEDBB8F2517FB13BF" xlink:to="loc_us-gaap_StatementClassOfStockAxis_3C7CBF9FCC0C37B354BD8F2528677F31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_4F5B927DAB655C962F3D8F25286F748C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_3C7CBF9FCC0C37B354BD8F2528677F31" xlink:to="loc_us-gaap_ClassOfStockDomain_4F5B927DAB655C962F3D8F25286F748C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OptionMember" xlink:label="loc_us-gaap_OptionMember_62741CB46B2FF13ED9B58F25840B3727" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4F5B927DAB655C962F3D8F25286F748C" xlink:to="loc_us-gaap_OptionMember_62741CB46B2FF13ED9B58F25840B3727" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_E43D972B4A5BDB3BDE2C8F25E2721634" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4F5B927DAB655C962F3D8F25286F748C" xlink:to="loc_us-gaap_RestrictedStockMember_E43D972B4A5BDB3BDE2C8F25E2721634" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_37775094430F0AFC27148F264096A6CA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4F5B927DAB655C962F3D8F25286F748C" xlink:to="loc_us-gaap_WarrantMember_37775094430F0AFC27148F264096A6CA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_A00611CF63316BE8D41A8F2517FB201C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_A85B2A7B5B2DAE3AEDBB8F2517FB13BF" xlink:to="loc_us-gaap_ClassOfStockLineItems_A00611CF63316BE8D41A8F2517FB201C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLossAbstract" xlink:label="loc_us-gaap_NetIncomeLossAbstract_316C8326A544B554C8F48F233A71C2CD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_A00611CF63316BE8D41A8F2517FB201C" xlink:to="loc_us-gaap_NetIncomeLossAbstract_316C8326A544B554C8F48F233A71C2CD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_04B6624A6ACBD2874BBB8F233A711824" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_316C8326A544B554C8F48F233A71C2CD" xlink:to="loc_us-gaap_NetIncomeLoss_04B6624A6ACBD2874BBB8F233A711824" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_31E8864B2E978F76EF538F233A72D704" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_A00611CF63316BE8D41A8F2517FB201C" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_31E8864B2E978F76EF538F233A72D704" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xlink:label="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_0940DE8C9358B3C7ADA18F233A72E770" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" priority="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_31E8864B2E978F76EF538F233A72D704" xlink:to="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_0940DE8C9358B3C7ADA18F233A72E770" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_A346156F6E039AC37B438F233A725E09" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_31E8864B2E978F76EF538F233A72D704" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_A346156F6E039AC37B438F233A725E09" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_4421B07CAF6AD298196E8F233A72F537" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_A00611CF63316BE8D41A8F2517FB201C" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_4421B07CAF6AD298196E8F233A72F537" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/NetLossPerCommonShareTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_96AE377B81EB5DBCB38FDC1DC3A54A17" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_B0EEB8F7BA6E5AA39DD4CAC060C863BB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_96AE377B81EB5DBCB38FDC1DC3A54A17" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_B0EEB8F7BA6E5AA39DD4CAC060C863BB" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/Organization" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_A746BCB8240953CD8FA7E9FBBF736D72" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NatureOfOperations" xlink:label="loc_us-gaap_NatureOfOperations_E275DB04C84D5F72A3AA116C2FC05E39" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_A746BCB8240953CD8FA7E9FBBF736D72" xlink:to="loc_us-gaap_NatureOfOperations_E275DB04C84D5F72A3AA116C2FC05E39" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/OrganizationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_C87EF21DF04F5BEFAF356EE606C17BC6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_9B82BA02149E570BB9EBB72036EA6B9D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" priority="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_C87EF21DF04F5BEFAF356EE606C17BC6" xlink:to="loc_us-gaap_NumberOfReportableSegments_9B82BA02149E570BB9EBB72036EA6B9D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4ACE7217255759A39D2803CA6E050F3F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_C87EF21DF04F5BEFAF356EE606C17BC6" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4ACE7217255759A39D2803CA6E050F3F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_596B01FAF06E5CE8A6CF7D4F355509BD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_C87EF21DF04F5BEFAF356EE606C17BC6" xlink:to="loc_us-gaap_NetIncomeLoss_596B01FAF06E5CE8A6CF7D4F355509BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_7AE5AE247A6853EEB47A61A297C0B05D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_C87EF21DF04F5BEFAF356EE606C17BC6" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_7AE5AE247A6853EEB47A61A297C0B05D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestments" xlink:label="loc_us-gaap_ShortTermInvestments_04C6FA8F0EBD532EAFF7715DEBAA43A1" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_C87EF21DF04F5BEFAF356EE606C17BC6" xlink:to="loc_us-gaap_ShortTermInvestments_04C6FA8F0EBD532EAFF7715DEBAA43A1" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/RecentAccountingPronouncements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_AE5E6DCB956C5CA99A71F7BDE903AB27" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_6B246D5433795D518F8AB08DF9BF009F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_AE5E6DCB956C5CA99A71F7BDE903AB27" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_6B246D5433795D518F8AB08DF9BF009F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/RecentAccountingPronouncementsPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_89DA38CC37467E2AF01245BC8A3768A3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_A8AED09F2BC1ADE8C96245BC8A3AFE95" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_89DA38CC37467E2AF01245BC8A3768A3" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_A8AED09F2BC1ADE8C96245BC8A3AFE95" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/Revenue" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_93A7B7AF47E358EFAF0621458C36ACA2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerTextBlock" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_5668DBB7EC9156B0A3EF837A6025ADF8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_93A7B7AF47E358EFAF0621458C36ACA2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_5668DBB7EC9156B0A3EF837A6025ADF8" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/RevenueConcentrationOfCreditRiskDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_06AE376EC5B2CE6EC2244BE539319991" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTable" xlink:label="loc_us-gaap_ConcentrationRiskTable_22F1D9E141C0F55BE9304BE539315986" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_06AE376EC5B2CE6EC2244BE539319991" xlink:to="loc_us-gaap_ConcentrationRiskTable_22F1D9E141C0F55BE9304BE539315986" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_FCE7CEFB534F86A13BFD4BE539315F76" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_22F1D9E141C0F55BE9304BE539315986" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_FCE7CEFB534F86A13BFD4BE539315F76" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_75C73EF8976DA00C2F974BE539311E23" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_FCE7CEFB534F86A13BFD4BE539315F76" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_75C73EF8976DA00C2F974BE539311E23" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_7649BE4E5F54E4BCE1D64BE539311C90" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_75C73EF8976DA00C2F974BE539311E23" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_7649BE4E5F54E4BCE1D64BE539311C90" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis" xlink:label="loc_srt_MajorCustomersAxis_57C15D8A63E0999219334BE539312554" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_22F1D9E141C0F55BE9304BE539315986" xlink:to="loc_srt_MajorCustomersAxis_57C15D8A63E0999219334BE539312554" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_512196B50E4504CFC6EE4BE539316B91" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_MajorCustomersAxis_57C15D8A63E0999219334BE539312554" xlink:to="loc_srt_NameOfMajorCustomerDomain_512196B50E4504CFC6EE4BE539316B91" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_CarticelAndMACIDistributorMember" xlink:label="loc_astm_CarticelAndMACIDistributorMember_2EDAF2E5649140B680D84BE53931DB67" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_512196B50E4504CFC6EE4BE539316B91" xlink:to="loc_astm_CarticelAndMACIDistributorMember_2EDAF2E5649140B680D84BE53931DB67" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_EpicelMember" xlink:label="loc_astm_EpicelMember_EA21B99541A724AEA5E44BE539318326" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_512196B50E4504CFC6EE4BE539316B91" xlink:to="loc_astm_EpicelMember_EA21B99541A724AEA5E44BE539318326" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_93103F1FF2BA44F9139C4BE539315E2C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_22F1D9E141C0F55BE9304BE539315986" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_93103F1FF2BA44F9139C4BE539315E2C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_D732169E86505C187EA24BE53931BF9E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_93103F1FF2BA44F9139C4BE539315E2C" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_D732169E86505C187EA24BE53931BF9E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesRevenueNetMember" xlink:label="loc_us-gaap_SalesRevenueNetMember_BFB668262FFBF49C02954BE53931AE2B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_D732169E86505C187EA24BE53931BF9E" xlink:to="loc_us-gaap_SalesRevenueNetMember_BFB668262FFBF49C02954BE53931AE2B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_4C37D197FEE12A1037D34BE5393140FA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_D732169E86505C187EA24BE53931BF9E" xlink:to="loc_us-gaap_AccountsReceivableMember_4C37D197FEE12A1037D34BE5393140FA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_C2F5A52F7983FBA548064BE53931610B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_22F1D9E141C0F55BE9304BE539315986" xlink:to="loc_srt_RangeAxis_C2F5A52F7983FBA548064BE53931610B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_E672DEE8FB68334C6A294BE539316E31" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_C2F5A52F7983FBA548064BE53931610B" xlink:to="loc_srt_RangeMember_E672DEE8FB68334C6A294BE539316E31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_2F7ADCA0539CAD9DD7F64BE5393100E4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_E672DEE8FB68334C6A294BE539316E31" xlink:to="loc_srt_MaximumMember_2F7ADCA0539CAD9DD7F64BE5393100E4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskLineItems" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_712AD44FA9438ABECFA04BE539313D50" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_22F1D9E141C0F55BE9304BE539315986" xlink:to="loc_us-gaap_ConcentrationRiskLineItems_712AD44FA9438ABECFA04BE539313D50" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_815F40B52A4C2E8961954BE5393138E0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_712AD44FA9438ABECFA04BE539313D50" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_815F40B52A4C2E8961954BE5393138E0" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/RevenueRevenueByProductAndCustomerDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_8E3FABC6DB76E638AD158F233B5AEFF0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_8E3FABC6DB76E638AD158F233B5AEFF0" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_AA104919565CFB90B5418F233B5A2E60" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_AA104919565CFB90B5418F233B5A2E60" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingencyNatureDomain" xlink:label="loc_us-gaap_LossContingencyNatureDomain_2C9B8BED6DCD6109D8D38F233B5B3662" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_AA104919565CFB90B5418F233B5A2E60" xlink:to="loc_us-gaap_LossContingencyNatureDomain_2C9B8BED6DCD6109D8D38F233B5B3662" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_DCB1D4653944092B88478F233B5B5453" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:to="loc_srt_ProductOrServiceAxis_DCB1D4653944092B88478F233B5B5453" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_32288415911EA467BB5A8F233B5B5028" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_DCB1D4653944092B88478F233B5B5453" xlink:to="loc_srt_ProductsAndServicesDomain_32288415911EA467BB5A8F233B5B5028" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_ImplantsMember" xlink:label="loc_astm_ImplantsMember_9F9263A725B64A0DED218F233B5C92C7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_32288415911EA467BB5A8F233B5B5028" xlink:to="loc_astm_ImplantsMember_9F9263A725B64A0DED218F233B5C92C7" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_BiopsyKitsMember" xlink:label="loc_astm_BiopsyKitsMember_18086E5ED0ECCFA3DF608F233B5C7C74" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_32288415911EA467BB5A8F233B5B5028" xlink:to="loc_astm_BiopsyKitsMember_18086E5ED0ECCFA3DF608F233B5C7C74" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_EpicelMember" xlink:label="loc_astm_EpicelMember_D85B0F471F92CCDBB0BB8F233B5C75AB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_32288415911EA467BB5A8F233B5B5028" xlink:to="loc_astm_EpicelMember_D85B0F471F92CCDBB0BB8F233B5C75AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerBasisOfPricingAxis" xlink:label="loc_us-gaap_ContractWithCustomerBasisOfPricingAxis_2C89491F1849DC75C8338F233B5C45D4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:to="loc_us-gaap_ContractWithCustomerBasisOfPricingAxis_2C89491F1849DC75C8338F233B5C45D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerBasisOfPricingDomain" xlink:label="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_BB8D978041A4CD60BC5C8F233B5C3BFA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerBasisOfPricingAxis_2C89491F1849DC75C8338F233B5C45D4" xlink:to="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_BB8D978041A4CD60BC5C8F233B5C3BFA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FixedPriceContractMember" xlink:label="loc_us-gaap_FixedPriceContractMember_DF59E79FD328369D491C8F233B5D94AC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_BB8D978041A4CD60BC5C8F233B5C3BFA" xlink:to="loc_us-gaap_FixedPriceContractMember_DF59E79FD328369D491C8F233B5D94AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TimeAndMaterialsContractMember" xlink:label="loc_us-gaap_TimeAndMaterialsContractMember_1F1C588F5BA11E4791768F233B5D7690" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerBasisOfPricingDomain_BB8D978041A4CD60BC5C8F233B5C3BFA" xlink:to="loc_us-gaap_TimeAndMaterialsContractMember_1F1C588F5BA11E4791768F233B5D7690" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerSalesChannelAxis" xlink:label="loc_us-gaap_ContractWithCustomerSalesChannelAxis_35C3A4D3D981916857948F233B5D0A55" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:to="loc_us-gaap_ContractWithCustomerSalesChannelAxis_35C3A4D3D981916857948F233B5D0A55" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerSalesChannelDomain" xlink:label="loc_us-gaap_ContractWithCustomerSalesChannelDomain_FD50A4596D60D1795EBD8F233B5D90E8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelAxis_35C3A4D3D981916857948F233B5D0A55" xlink:to="loc_us-gaap_ContractWithCustomerSalesChannelDomain_FD50A4596D60D1795EBD8F233B5D90E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesChannelThroughIntermediaryMember" xlink:label="loc_us-gaap_SalesChannelThroughIntermediaryMember_147A141967DAF72A3A5F8F233B5EBF7C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_FD50A4596D60D1795EBD8F233B5D90E8" xlink:to="loc_us-gaap_SalesChannelThroughIntermediaryMember_147A141967DAF72A3A5F8F233B5EBF7C" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_ProviderorFacilityMember" xlink:label="loc_astm_ProviderorFacilityMember_752C728B731C715FA9FE8F233B5EA974" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_FD50A4596D60D1795EBD8F233B5D90E8" xlink:to="loc_astm_ProviderorFacilityMember_752C728B731C715FA9FE8F233B5EA974" xlink:type="arc" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_FD50A4596D60D1795EBD8F233B5D90E8" xlink:to="loc_us-gaap_TimeAndMaterialsContractMember_1F1C588F5BA11E4791768F233B5D7690" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesChannelDirectlyToConsumerMember" xlink:label="loc_us-gaap_SalesChannelDirectlyToConsumerMember_751684603E4ADFB385BF8F233B5EE32B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerSalesChannelDomain_FD50A4596D60D1795EBD8F233B5D90E8" xlink:to="loc_us-gaap_SalesChannelDirectlyToConsumerMember_751684603E4ADFB385BF8F233B5EE32B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_073171535A78CFE1BABE8F233B5E9E20" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_073171535A78CFE1BABE8F233B5E9E20" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_6DCE7475E567B002E9498F233B5E9C5E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_073171535A78CFE1BABE8F233B5E9E20" xlink:to="loc_us-gaap_TypeOfAdoptionMember_6DCE7475E567B002E9498F233B5E9C5E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_F78641391509CFC4B3908F233B5F02D6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_6DCE7475E567B002E9498F233B5E9C5E" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_F78641391509CFC4B3908F233B5F02D6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_990704E379A05673354E8F233B5F6D8C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_990704E379A05673354E8F233B5F6D8C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_08A595EE6E69CEB3458F8F233B5FD920" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_990704E379A05673354E8F233B5F6D8C" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_08A595EE6E69CEB3458F8F233B5FD920" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:label="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_4AAA7E97A3D9F922BD1D8F233B5FC0D2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_08A595EE6E69CEB3458F8F233B5FD920" xlink:to="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_4AAA7E97A3D9F922BD1D8F233B5FC0D2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis" xlink:label="loc_srt_MajorCustomersAxis_B8114A50AB2E2BD940818F233B600B6D" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:to="loc_srt_MajorCustomersAxis_B8114A50AB2E2BD940818F233B600B6D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_03547620DCFB524BD9388F233B60F768" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_MajorCustomersAxis_B8114A50AB2E2BD940818F233B600B6D" xlink:to="loc_srt_NameOfMajorCustomerDomain_03547620DCFB524BD9388F233B60F768" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_916ABBA64818362B9CBE8F233B60BD29" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_A2F8BBCF1C48DD5E38BE8F233B5AE930" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_916ABBA64818362B9CBE8F233B60BD29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_F898444B846EF880466A8F233B6155A6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_916ABBA64818362B9CBE8F233B60BD29" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_F898444B846EF880466A8F233B6155A6" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/RevenueTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_D5AA15793009BE4AE55A4590D8925C24" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_2818ED7BAB92B17C2ACD4590D89200A8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_D5AA15793009BE4AE55A4590D8925C24" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_2818ED7BAB92B17C2ACD4590D89200A8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" xlink:label="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_CFB860E25B14064BDDEF4590D892ABE6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_D5AA15793009BE4AE55A4590D8925C24" xlink:to="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_CFB860E25B14064BDDEF4590D892ABE6" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/SelectedBalanceSheetComponents" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_17FA4501481D5E0EA381291ABF4EB9A0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_0D81BD6FE96F55C2AF2833CAB42BB69C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_17FA4501481D5E0EA381291ABF4EB9A0" xlink:to="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_0D81BD6FE96F55C2AF2833CAB42BB69C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/SelectedBalanceSheetComponentsAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_AF2E6879A91D5A029E5A5BD117D7882B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_10C48925AA2F5340A61E22F716707D66" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_AF2E6879A91D5A029E5A5BD117D7882B" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_10C48925AA2F5340A61E22F716707D66" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedBonusesCurrentAndNoncurrent" xlink:label="loc_us-gaap_AccruedBonusesCurrentAndNoncurrent_E9B41EC302E45F60A4C911EB15849D6F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_10C48925AA2F5340A61E22F716707D66" xlink:to="loc_us-gaap_AccruedBonusesCurrentAndNoncurrent_E9B41EC302E45F60A4C911EB15849D6F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_0FB70D1D8B3456418020F676AF39C9D4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_10C48925AA2F5340A61E22F716707D66" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_0FB70D1D8B3456418020F676AF39C9D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_F12CE21492BD525E803F5C194A78A3A9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_10C48925AA2F5340A61E22F716707D66" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_F12CE21492BD525E803F5C194A78A3A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_1568BADCD13459F6BF69FD7D87424AD2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_10C48925AA2F5340A61E22F716707D66" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_1568BADCD13459F6BF69FD7D87424AD2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/SelectedBalanceSheetComponentsInventoryDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_282E04A61735596AB237DBF5775C6682" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNetAbstract" xlink:label="loc_us-gaap_InventoryNetAbstract_17D6DE8267335D6FB851073D7F716286" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_282E04A61735596AB237DBF5775C6682" xlink:to="loc_us-gaap_InventoryNetAbstract_17D6DE8267335D6FB851073D7F716286" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryRawMaterials" xlink:label="loc_us-gaap_InventoryRawMaterials_F9D322BACFBE5E1C8CB04C8A7D7B1B7E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_17D6DE8267335D6FB851073D7F716286" xlink:to="loc_us-gaap_InventoryRawMaterials_F9D322BACFBE5E1C8CB04C8A7D7B1B7E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryWorkInProcess" xlink:label="loc_us-gaap_InventoryWorkInProcess_9494D391C23754FE93BC2A7ACE197878" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_17D6DE8267335D6FB851073D7F716286" xlink:to="loc_us-gaap_InventoryWorkInProcess_9494D391C23754FE93BC2A7ACE197878" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryFinishedGoods" xlink:label="loc_us-gaap_InventoryFinishedGoods_8F0D5CF7132D54008C282D4D19E1F944" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_17D6DE8267335D6FB851073D7F716286" xlink:to="loc_us-gaap_InventoryFinishedGoods_8F0D5CF7132D54008C282D4D19E1F944" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_9A5F463934575F97834E619028BA517A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryNetAbstract_17D6DE8267335D6FB851073D7F716286" xlink:to="loc_us-gaap_InventoryNet_9A5F463934575F97834E619028BA517A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/SelectedBalanceSheetComponentsPropertyAndEquipmentDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_303D4FB052D87C8387528E684A8A8AE0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_113FD803F60FED1A245F8E684A8B8347" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_303D4FB052D87C8387528E684A8A8AE0" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_113FD803F60FED1A245F8E684A8B8347" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1188103C2D78E8ADF1278E684A8BF500" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_113FD803F60FED1A245F8E684A8B8347" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1188103C2D78E8ADF1278E684A8BF500" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ECC570F252FEBD39BA748E684A8BB61A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1188103C2D78E8ADF1278E684A8BF500" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ECC570F252FEBD39BA748E684A8BB61A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MachineryAndEquipmentMember" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_D9928814803806CFC9CF8E684A8CCD4F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ECC570F252FEBD39BA748E684A8BB61A" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_D9928814803806CFC9CF8E684A8CCD4F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_1A1C88C0EFC0BFA702BE8E684A8C0ACB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ECC570F252FEBD39BA748E684A8BB61A" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_1A1C88C0EFC0BFA702BE8E684A8C0ACB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComputerEquipmentMember" xlink:label="loc_us-gaap_ComputerEquipmentMember_67CC48E0F1E9E60BA5D98E684A8C7417" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ECC570F252FEBD39BA748E684A8BB61A" xlink:to="loc_us-gaap_ComputerEquipmentMember_67CC48E0F1E9E60BA5D98E684A8C7417" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_D6C8A50AFEBBCA7838A28E684A8C76A0" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ECC570F252FEBD39BA748E684A8BB61A" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_D6C8A50AFEBBCA7838A28E684A8C76A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConstructionInProgressMember" xlink:label="loc_us-gaap_ConstructionInProgressMember_195E573A4C46B549CF148E684A8C71DA" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ECC570F252FEBD39BA748E684A8BB61A" xlink:to="loc_us-gaap_ConstructionInProgressMember_195E573A4C46B549CF148E684A8C71DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_92178F53995943D1F1258E684A8C63EE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_113FD803F60FED1A245F8E684A8B8347" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_92178F53995943D1F1258E684A8C63EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_5F6D59A592DD84408A9B8E684A8D50FF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_92178F53995943D1F1258E684A8C63EE" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_5F6D59A592DD84408A9B8E684A8D50FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinanceLeaseRightOfUseAsset" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_66E9174DC0DEA73FBC2B8E684A8D6250" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_92178F53995943D1F1258E684A8C63EE" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_66E9174DC0DEA73FBC2B8E684A8D6250" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_E2C80B8F344FB68E49488E684A8D4ED6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_92178F53995943D1F1258E684A8C63EE" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_E2C80B8F344FB68E49488E684A8D4ED6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_942BBFBAF025B54796D98E684A8D35CD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_92178F53995943D1F1258E684A8C63EE" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_942BBFBAF025B54796D98E684A8D35CD" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_DepreciationDepletionandAmortizationExcludingIntangibleAssets" xlink:label="loc_astm_DepreciationDepletionandAmortizationExcludingIntangibleAssets_DAFB7515AE1CAB8BF6548E684A8D9AB0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_92178F53995943D1F1258E684A8C63EE" xlink:to="loc_astm_DepreciationDepletionandAmortizationExcludingIntangibleAssets_DAFB7515AE1CAB8BF6548E684A8D9AB0" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/SelectedBalanceSheetComponentsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_5A8B6C5D25225AD1B655F8E11FBB0D5C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_1EDEE7030AB1579990BDF8A94E838B9C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_5A8B6C5D25225AD1B655F8E11FBB0D5C" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_1EDEE7030AB1579990BDF8A94E838B9C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_0A7EAC4DC71D53B88205114DCD2356BA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_5A8B6C5D25225AD1B655F8E11FBB0D5C" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_0A7EAC4DC71D53B88205114DCD2356BA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_97BF3AF0E7885BB4B6E6C4D981DFFDE0" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_5A8B6C5D25225AD1B655F8E11FBB0D5C" xlink:to="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_97BF3AF0E7885BB4B6E6C4D981DFFDE0" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/StockBasedCompensation" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_5FD9798B9C295CA0A612EA84D74387F6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_34C8392048D85F0BB48A6D566A80BA8C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_5FD9798B9C295CA0A612EA84D74387F6" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_34C8392048D85F0BB48A6D566A80BA8C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/StockBasedCompensationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_557506AC351B68D8FF6C791EABD7A7E2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7077997F137524F7FE5B791EABD71EDA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_557506AC351B68D8FF6C791EABD7A7E2" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7077997F137524F7FE5B791EABD71EDA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_CD0D39E53E8316F93D93791EABD77F30" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7077997F137524F7FE5B791EABD71EDA" xlink:to="loc_us-gaap_AwardTypeAxis_CD0D39E53E8316F93D93791EABD77F30" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_82023C75E7E4F587B96A791EABD7C8C2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_CD0D39E53E8316F93D93791EABD77F30" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_82023C75E7E4F587B96A791EABD7C8C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_09EF231999ADBAA368D4791EABD7A465" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_82023C75E7E4F587B96A791EABD7C8C2" xlink:to="loc_us-gaap_EmployeeStockOptionMember_09EF231999ADBAA368D4791EABD7A465" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_07260844E62AA47C53A6791EABD8A024" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_82023C75E7E4F587B96A791EABD7C8C2" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_07260844E62AA47C53A6791EABD8A024" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockMember" xlink:label="loc_us-gaap_EmployeeStockMember_78F4DA407E0F7F95E7B5791EABD8E4CC" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_82023C75E7E4F587B96A791EABD7C8C2" xlink:to="loc_us-gaap_EmployeeStockMember_78F4DA407E0F7F95E7B5791EABD8E4CC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_94C5F15763859402AA10791EABD87E0A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7077997F137524F7FE5B791EABD71EDA" xlink:to="loc_srt_RangeAxis_94C5F15763859402AA10791EABD87E0A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_B83183DF8F1E29465A3A791EABD857C1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_94C5F15763859402AA10791EABD87E0A" xlink:to="loc_srt_RangeMember_B83183DF8F1E29465A3A791EABD857C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_445B401419FB447CB956791EABD80825" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_B83183DF8F1E29465A3A791EABD857C1" xlink:to="loc_srt_MaximumMember_445B401419FB447CB956791EABD80825" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_C8ED1BED72D33BD068D5791EABD9BF3B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_B83183DF8F1E29465A3A791EABD857C1" xlink:to="loc_srt_MinimumMember_C8ED1BED72D33BD068D5791EABD9BF3B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_92F1516F8F16E64AFB01791EABD9B32A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7077997F137524F7FE5B791EABD71EDA" xlink:to="loc_us-gaap_PlanNameAxis_92F1516F8F16E64AFB01791EABD9B32A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_9C046B3FC5325FFA6CEC791EABD91D78" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_92F1516F8F16E64AFB01791EABD9B32A" xlink:to="loc_us-gaap_PlanNameDomain_9C046B3FC5325FFA6CEC791EABD91D78" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_PriorPlansMember" xlink:label="loc_astm_PriorPlansMember_02BC507420A22A5E42B3791EABD9B9B8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_9C046B3FC5325FFA6CEC791EABD91D78" xlink:to="loc_astm_PriorPlansMember_02BC507420A22A5E42B3791EABD9B9B8" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_OmnibusIncentivePlan2017Member" xlink:label="loc_astm_OmnibusIncentivePlan2017Member_17ABC65FC94DF8A8D6BB791EABDAFCC3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_9C046B3FC5325FFA6CEC791EABD91D78" xlink:to="loc_astm_OmnibusIncentivePlan2017Member_17ABC65FC94DF8A8D6BB791EABDAFCC3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_D14B63D4F346A102BB03791EABDA5F09" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7077997F137524F7FE5B791EABD71EDA" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_D14B63D4F346A102BB03791EABDA5F09" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_684031A97670B3E13ABB791EABDAFF1B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_D14B63D4F346A102BB03791EABDA5F09" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_684031A97670B3E13ABB791EABDAFF1B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_B708C10495F52A48AF2E791EABDA754D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_684031A97670B3E13ABB791EABDAFF1B" xlink:to="loc_us-gaap_SubsequentEventMember_B708C10495F52A48AF2E791EABDA754D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7077997F137524F7FE5B791EABD71EDA" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_0EC10E72C2788A2256C2791EABDB6A58" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_0EC10E72C2788A2256C2791EABDB6A58" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_F8F26E4C641359F3F6B7791EABDB12F8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_F8F26E4C641359F3F6B7791EABDB12F8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_EE7FCC2A737E38C19DEE791EABDBAF87" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_EE7FCC2A737E38C19DEE791EABDBAF87" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_4A54DD2D0075A98BB50A791EABDB7CB2" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_4A54DD2D0075A98BB50A791EABDB7CB2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_08ACEFD0B2E9CB009F9C791EABDBB4EE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_08ACEFD0B2E9CB009F9C791EABDBB4EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_99FD5BCDAC743BAB1F58791EABDC218B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_99FD5BCDAC743BAB1F58791EABDC218B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_3FB1EC73BFDC759959E3791EABDCF158" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_3FB1EC73BFDC759959E3791EABDCF158" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_85712E24B6B24C7F07D6791EABDC4054" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_85712E24B6B24C7F07D6791EABDC4054" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_58DDC8086D0DCE19B78A791EABDCCD13" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_58DDC8086D0DCE19B78A791EABDCCD13" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_C3F497FE67EF28416D02791EABDCF4D3" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_C3F497FE67EF28416D02791EABDCF4D3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_77358D07748747F808B4791EABDC0835" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_77358D07748747F808B4791EABDC0835" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_E4FD4590E0F2296F3370791EABDC1DB6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_77358D07748747F808B4791EABDC0835" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_E4FD4590E0F2296F3370791EABDC1DB6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_23A9A735DDA5E2CD865B791EABDD71F1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_77358D07748747F808B4791EABDC0835" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_23A9A735DDA5E2CD865B791EABDD71F1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_FFCB151FB0D5F925045F791EABDDDD98" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_77358D07748747F808B4791EABDC0835" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_FFCB151FB0D5F925045F791EABDDDD98" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_C9262A896D713FDA0725791EABDD00F3" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_77358D07748747F808B4791EABDC0835" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_C9262A896D713FDA0725791EABDD00F3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockExpense" xlink:label="loc_us-gaap_RestrictedStockExpense_3138290B6694A76C01D7791EABDD1B83" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7A449AB2689886DDEF6F791EABDB26A6" xlink:to="loc_us-gaap_RestrictedStockExpense_3138290B6694A76C01D7791EABDD1B83" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/StockBasedCompensationNonCashStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_9410DB22DBDC5C6696B09B9EBDA917ED" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_AE76C955380C5A08AFB3DC7346889B7C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_9410DB22DBDC5C6696B09B9EBDA917ED" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_AE76C955380C5A08AFB3DC7346889B7C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_758CB0479C9F50018AA58A21FF4FEEA6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_AE76C955380C5A08AFB3DC7346889B7C" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_758CB0479C9F50018AA58A21FF4FEEA6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_BEC73DDEE50E54778DBBBE1058FC70B8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_758CB0479C9F50018AA58A21FF4FEEA6" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_BEC73DDEE50E54778DBBBE1058FC70B8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfSalesMember" xlink:label="loc_us-gaap_CostOfSalesMember_E56370AEAA615A64B8210399179F27AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_BEC73DDEE50E54778DBBBE1058FC70B8" xlink:to="loc_us-gaap_CostOfSalesMember_E56370AEAA615A64B8210399179F27AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_D6AC2C60D7DA5E4B9FB1275B79840F05" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_BEC73DDEE50E54778DBBBE1058FC70B8" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_D6AC2C60D7DA5E4B9FB1275B79840F05" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_D39AE6973DE45F0D8B5670A39B29D91C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_BEC73DDEE50E54778DBBBE1058FC70B8" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_D39AE6973DE45F0D8B5670A39B29D91C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_330CF52DAA745C2F9096AAD372195CE3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_AE76C955380C5A08AFB3DC7346889B7C" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_330CF52DAA745C2F9096AAD372195CE3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_F648670E214A58C19358EE5814F67A4D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_330CF52DAA745C2F9096AAD372195CE3" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_F648670E214A58C19358EE5814F67A4D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/StockBasedCompensationTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_F12EBC2173DC55E09D6E4631C62B027A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_D230BBB621535D0BB697DE8EA248D8F4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_F12EBC2173DC55E09D6E4631C62B027A" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_D230BBB621535D0BB697DE8EA248D8F4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_1D7AA79BA76D5DBC98AA29531A8F2AFE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_F12EBC2173DC55E09D6E4631C62B027A" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_1D7AA79BA76D5DBC98AA29531A8F2AFE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/StockPurchaseWarrants" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsNoteDisclosureAbstract" xlink:label="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_CB8405FEA64853EBB9802D204270AA03" xlink:type="locator" />
    <link:loc xlink:href="astm-20190331.xsd#astm_WarrantsAndRightsNoteDisclosureTextBlock" xlink:label="loc_astm_WarrantsAndRightsNoteDisclosureTextBlock_441516C873C256B9B937DDD01992AA1B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_CB8405FEA64853EBB9802D204270AA03" xlink:to="loc_astm_WarrantsAndRightsNoteDisclosureTextBlock_441516C873C256B9B937DDD01992AA1B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/StockPurchaseWarrantsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsNoteDisclosureAbstract" xlink:label="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_038C190AFCC58E2130AA4590D84D91C6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightTable" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_91673DA0E88F2EBA51644590D84E50A3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_038C190AFCC58E2130AA4590D84D91C6" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_91673DA0E88F2EBA51644590D84E50A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_E579704E4016A2E910244590D84EDACF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_91673DA0E88F2EBA51644590D84E50A3" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_E579704E4016A2E910244590D84EDACF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_4B5DC28B50898B7C33944590D84E1FC3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_E579704E4016A2E910244590D84EDACF" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_4B5DC28B50898B7C33944590D84E1FC3" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_WarrantsIssuedinDecember2017Member" xlink:label="loc_astm_WarrantsIssuedinDecember2017Member_A3F4D87DC35A68ADEF484590D84FE8CF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_4B5DC28B50898B7C33944590D84E1FC3" xlink:to="loc_astm_WarrantsIssuedinDecember2017Member_A3F4D87DC35A68ADEF484590D84FE8CF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_89295D6C1A5D9C9ABAA74590D850C455" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_91673DA0E88F2EBA51644590D84E50A3" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_89295D6C1A5D9C9ABAA74590D850C455" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_3EADF4555E1B1614B2614590D851534E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_89295D6C1A5D9C9ABAA74590D850C455" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_3EADF4555E1B1614B2614590D851534E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputExpectedDividendRateMember" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_8448529C9FBE12DE77FE4590D85143E8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_3EADF4555E1B1614B2614590D851534E" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_8448529C9FBE12DE77FE4590D85143E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightLineItems" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_427164785C8BFCA9A5504590D851F13E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_91673DA0E88F2EBA51644590D84E50A3" xlink:to="loc_us-gaap_ClassOfWarrantOrRightLineItems_427164785C8BFCA9A5504590D851F13E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_26C4ADFC3C400941F2B04590D8510A10" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_427164785C8BFCA9A5504590D851F13E" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_26C4ADFC3C400941F2B04590D8510A10" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_D96C9F5C9FB70D4306E14590D851A491" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_427164785C8BFCA9A5504590D851F13E" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_D96C9F5C9FB70D4306E14590D851A491" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstandingMeasurementInput" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_888E8C779A917166613E4590D85221EC" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_427164785C8BFCA9A5504590D851F13E" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_888E8C779A917166613E4590D85221EC" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/StockPurchaseWarrantsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsNoteDisclosureAbstract" xlink:label="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_91D0A16EE4AD548F91930AC9CCD0B06E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock" xlink:label="loc_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_F528467A0386505B928D8FF68C9DF4BC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_91D0A16EE4AD548F91930AC9CCD0B06E" xlink:to="loc_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_F528467A0386505B928D8FF68C9DF4BC" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/SubsequentEvents" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_EAA4703FC1C66F04231C92E5D4AA05B1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventsTextBlock" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_DF813A7E38AB7D1FB08C92E5D4AAF359" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_EAA4703FC1C66F04231C92E5D4AA05B1" xlink:to="loc_us-gaap_SubsequentEventsTextBlock_DF813A7E38AB7D1FB08C92E5D4AAF359" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.vcel.com/role/SubsequentEventsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_us-gaap_SubsequentEventsAbstract_5CAE4A5751D546E2D061931AAD2FA1C0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="loc_us-gaap_SubsequentEventTable_C09D290EFE7BE952C20E931AAD305171" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_5CAE4A5751D546E2D061931AAD2FA1C0" xlink:to="loc_us-gaap_SubsequentEventTable_C09D290EFE7BE952C20E931AAD305171" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_791150D7FE3C89960274931AAD324D90" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_C09D290EFE7BE952C20E931AAD305171" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_791150D7FE3C89960274931AAD324D90" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_06CEC4280DB2FA65D738931AAD328567" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_791150D7FE3C89960274931AAD324D90" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_06CEC4280DB2FA65D738931AAD328567" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_A16356ADA7C6F2BA07A7931AAD32C31A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_06CEC4280DB2FA65D738931AAD328567" xlink:to="loc_us-gaap_SubsequentEventMember_A16356ADA7C6F2BA07A7931AAD32C31A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis" xlink:label="loc_srt_CounterpartyNameAxis_C169F82CCB2B4768DCD9933703A54553" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_C09D290EFE7BE952C20E931AAD305171" xlink:to="loc_srt_CounterpartyNameAxis_C169F82CCB2B4768DCD9933703A54553" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_151A1D4DB73D377323E0933770408474" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_C169F82CCB2B4768DCD9933703A54553" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_151A1D4DB73D377323E0933770408474" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_MediWoundLtdMember" xlink:label="loc_astm_MediWoundLtdMember_7D266A678004CFCE2C57933703AC1AC6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_151A1D4DB73D377323E0933770408474" xlink:to="loc_astm_MediWoundLtdMember_7D266A678004CFCE2C57933703AC1AC6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="loc_us-gaap_SubsequentEventLineItems_DB079BECB7F7D70695ED931AAD33AE9A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_C09D290EFE7BE952C20E931AAD305171" xlink:to="loc_us-gaap_SubsequentEventLineItems_DB079BECB7F7D70695ED931AAD33AE9A" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LicenseAgreementPayable" xlink:label="loc_astm_LicenseAgreementPayable_244E9634A873CD8D68BB9335C1A559B1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_DB079BECB7F7D70695ED931AAD33AE9A" xlink:to="loc_astm_LicenseAgreementPayable_244E9634A873CD8D68BB9335C1A559B1" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LicenseAgreementContingentConsideration" xlink:label="loc_astm_LicenseAgreementContingentConsideration_7E2F74948E90451B5405933A4C354D90" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_DB079BECB7F7D70695ED931AAD33AE9A" xlink:to="loc_astm_LicenseAgreementContingentConsideration_7E2F74948E90451B5405933A4C354D90" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LicenseAgreementContingentConsiderationMaximum" xlink:label="loc_astm_LicenseAgreementContingentConsiderationMaximum_E9E4BE11019F2E4D0A1A933C31600FE2" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_DB079BECB7F7D70695ED931AAD33AE9A" xlink:to="loc_astm_LicenseAgreementContingentConsiderationMaximum_E9E4BE11019F2E4D0A1A933C31600FE2" xlink:type="arc" />
    <link:loc xlink:href="astm-20190331.xsd#astm_LicenseAgreementInitialMilestoneSales" xlink:label="loc_astm_LicenseAgreementInitialMilestoneSales_4F45DAD2E9588946EF56933F3ADBE69C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_DB079BECB7F7D70695ED931AAD33AE9A" xlink:to="loc_astm_LicenseAgreementInitialMilestoneSales_4F45DAD2E9588946EF56933F3ADBE69C" xlink:type="arc" />
  </link:presentationLink>
</link:linkbase>