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  <xs:element id="vcel_LicenseAgreementAdditionalFunding" abstract="false" name="LicenseAgreementAdditionalFunding" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LicenseAgreementTextBlock" abstract="false" name="LicenseAgreementTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="vcel_LicenseAgreementContingentConsideration" abstract="false" name="LicenseAgreementContingentConsideration" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_NumberOfProducts" abstract="false" name="NumberOfProducts" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="vcel_LetterOfCreditCashDepositLeaseYearThree" abstract="false" name="LetterOfCreditCashDepositLeaseYearThree" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_EmployeeStockAndEmployeeStockOptionMember" abstract="true" name="EmployeeStockAndEmployeeStockOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_IncreaseDecreaseInLeaseLiabilities" abstract="false" name="IncreaseDecreaseInLeaseLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_AnnArborMichiganMember" abstract="true" name="AnnArborMichiganMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_LeaseOptionToExtendTerm" abstract="false" name="LeaseOptionToExtendTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcel_RestrictedStockHeldForEmployeeTaxRemittanceIncludedInAccountsPayable" abstract="false" name="RestrictedStockHeldForEmployeeTaxRemittanceIncludedInAccountsPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LesseeOperatingLeaseNumberOfRenewalOptions" abstract="false" name="LesseeOperatingLeaseNumberOfRenewalOptions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="vcel_LetterOfCreditCashDepositLeaseYearFour" abstract="false" name="LetterOfCreditCashDepositLeaseYearFour" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_EscrowDepositPercentContributed" abstract="false" name="EscrowDepositPercentContributed" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="vcel_LongtermInvestmentsMember" abstract="true" name="LongtermInvestmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_NumberOfContractedSpecialtyPharmacies" abstract="false" name="NumberOfContractedSpecialtyPharmacies" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="vcel_LicenseAgreementSupplyAgreementRenewalTerm" abstract="false" name="LicenseAgreementSupplyAgreementRenewalTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcel_NexoBridMember" abstract="true" name="NexoBridMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_LesseeOperatingLeaseAnnualLeasePerSquareFoot" abstract="false" name="LesseeOperatingLeaseAnnualLeasePerSquareFoot" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="vcel_MediWoundLtdMember" abstract="true" name="MediWoundLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_DebtSecuritiesAvailableForSaleContractualMaturityPeriod" abstract="false" name="DebtSecuritiesAvailableForSaleContractualMaturityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcel_LesseeOperatingLeaseMonthlyContractualPayments" abstract="false" name="LesseeOperatingLeaseMonthlyContractualPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_DebtInstrumentCovenantLeverageRatioMaximum" abstract="false" name="DebtInstrumentCovenantLeverageRatioMaximum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="vcel_AccruedExpensesOtherCurrent" abstract="false" name="AccruedExpensesOtherCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LesseeOperatingLeaseTenantImprovementAllowancePerSquareFoot" abstract="false" name="LesseeOperatingLeaseTenantImprovementAllowancePerSquareFoot" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="vcel_LicenseAgreementContingentConsiderationMaximum" abstract="false" name="LicenseAgreementContingentConsiderationMaximum" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_RevenueRevenueRecognizedChangeinUncollectibleAnalysisPercentage" abstract="false" name="RevenueRevenueRecognizedChangeinUncollectibleAnalysisPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="vcel_AssetsAndLiabilitiesLeasesTableTextBlock" abstract="false" name="AssetsAndLiabilitiesLeasesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="vcel_BiopsyKitsMember" abstract="true" name="BiopsyKitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_LesseeOperatingLeaseAnnualLeaseIncreaseLimitPercentage" abstract="false" name="LesseeOperatingLeaseAnnualLeaseIncreaseLimitPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="vcel_RightOfUseAsset" abstract="false" name="RightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_ComputerEquipmentAndComputerSoftwareIntangibleAssetMember" abstract="false" name="ComputerEquipmentAndComputerSoftwareIntangibleAssetMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_LicenseAgreementConsideration" abstract="false" name="LicenseAgreementConsideration" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_ProviderorFacilityMember" abstract="true" name="ProviderorFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vcel_LesseeOperatingLeaseTenantImprovementAllowance" abstract="false" name="LesseeOperatingLeaseTenantImprovementAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vcel_LesseeLeaseCommencementRentPaymentStartDateTerm" abstract="false" name="LesseeLeaseCommencementRentPaymentStartDateTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vcel_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" abstract="false" name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
