<PAGE>
 
   
AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON DECEMBER 19, 1996     
                                                     REGISTRATION NO. 333-15415
- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549
                               ----------------
                                
                             AMENDMENT NO. 2     
                                      TO
                                   FORM S-1
                            REGISTRATION STATEMENT
                                     UNDER
                          THE SECURITIES ACT OF 1933
                               ----------------
                           AASTROM BIOSCIENCES, INC.
            (Exact name of registrant as specified in its charter)

         MICHIGAN                    2834                    94-3096597
     (State or other          (Primary Standard            (IRS Employer
     jurisdiction of              Industrial            Identification No.)
     incorporation or        Classification Code
      organization)                Number)
                               ----------------

                          24 FRANK LLOYD WRIGHT DRIVE
                                 P.O. BOX 376
                           ANN ARBOR, MICHIGAN 48106
                                (313) 930-5555
  (Address, including zip code, and telephone number, including area code, of
                   registrant's principal executive offices)
                               ----------------

                          R. DOUGLAS ARMSTRONG, PH.D.
                      PRESIDENT, CHIEF EXECUTIVE OFFICER
                           AASTROM BIOSCIENCES, INC.
                          24 FRANK LLOYD WRIGHT DRIVE
                                 P.O. BOX 376
                           ANN ARBOR, MICHIGAN 48106
                                (313) 930-5555
(Name, address, including zip code, and telephone number, including area code,
                             of agent for service)
                               ----------------

                                  COPIES TO:
          T. KNOX BELL, ESQ.                 RICHARD R. PLUMRIDGE, ESQ.
         DOUGLAS J. REIN, ESQ.                 MICHAEL A. CONZA, ESQ.
          MATT KIRMAYER, ESQ.              BROBECK, PHLEGER & HARRISON LLP
         DAYNA J. PINEDA, ESQ.                      1633 BROADWAY
     GRAY CARY WARE & FREIDENRICH             NEW YORK, NEW YORK 10019
   4365 EXECUTIVE DRIVE, SUITE 1600
      SAN DIEGO, CALIFORNIA 92121
                               ----------------
 
  Approximate date of commencement of proposed sale to the public: As soon as
practicable after this Registration Statement becomes effective.
 
  If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, check the following box. [_]
 
  If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, check the following box and
list the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [_]
 
  If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [_]
 
  If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [_]
 
  The Registrant hereby amends this Registration Statement on such date or
dates as may be necessary to delay its effective date until the Registrant
shall file a further amendment which specifically states that this
Registration Statement shall thereafter become effective in accordance with
Section 8(a) of the Securities Act of 1933 or until the Registration Statement
shall become effective on such date as the Commission acting pursuant to said
Section 8(a), may determine.
- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------

<PAGE>
 
++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
+INFORMATION CONTAINED HEREIN IS SUBJECT TO COMPLETION OR AMENDMENT. A         +
+REGISTRATION STATEMENT RELATING TO THESE SECURITIES HAS BEEN FILED WITH THE   +
+SECURITIES AND EXCHANGE COMMISSION. THESE SECURITIES MAY NOT BE SOLD NOR MAY  +
+OFFERS TO BUY BE ACCEPTED PRIOR TO THE TIME THE REGISTRATION STATEMENT        +
+BECOMES EFFECTIVE. THIS PROSPECTUS SHALL NOT CONSTITUTE AN OFFER TO SELL OR   +
+THE SOLICITATION OF AN OFFER TO BUY NOR SHALL THERE BE ANY SALE OF THESE      +
+SECURITIES IN ANY STATE IN WHICH SUCH OFFER, SOLICITATION OR SALE WOULD BE    +
+UNLAWFUL PRIOR TO REGISTRATION OR QUALIFICATION UNDER THE SECURITIES LAWS OF  +
+ANY SUCH STATE.                                                               +
++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
 
PROSPECTUS (Subject to Completion)
   
Dated December 19, 1996     
 
                                3,250,000 Shares
 
                       [LOGO OF AASTROM BIOSCIENCES INC]
 
                                  Common Stock
 
                                --------------
 
  All of the shares of Common Stock, no par value per share (the "Common
Stock"), offered are being sold by Aastrom Biosciences, Inc. ("Aastrom" or the
"Company").
 
  Prior to this offering, there has been no public market for the Common Stock
of the Company. It is currently estimated that the initial public offering
price will be between $8.00 and $10.00 per share. See "Underwriting" for a
discussion of the factors considered in determining the initial public offering
price. The Company has applied for quotation of the Common Stock on the Nasdaq
National Market under the symbol "ASTM."
 
  Cobe Laboratories, Inc. has agreed to purchase $5,000,000 of shares of Common
Stock in this offering at the Price to the Public set forth below. See "Certain
Transactions."
 
                                --------------
 
 THIS OFFERING INVOLVES A HIGH DEGREE OF RISK. SEE "RISK FACTORS" BEGINNING ON
                           PAGE 5 OF THIS PROSPECTUS.
 
                                --------------
 
 THESE   SECURITIES  HAVE  NOT  BEEN   APPROVED  OR
  DISAPPROVED  BY  THE   SECURITIES  AND  EXCHANGE
   COMMISSION OR ANY  STATE SECURITIES COMMISSION
    NOR   HAS   THE   SECURITIES   AND   EXCHANGE
    COMMISSION    OR   ANY   STATE    SECURITIES
     COMMISSION  PASSED  UPON THE  ACCURACY  OR
      ADEQUACY   OF   THIS   PROSPECTUS.   ANY
       REPRESENTATION TO  THE  CONTRARY  IS  A
       CRIMINAL OFFENSE.
 

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------

                                                          Underwriting
                                        Price to          Discounts and        Proceeds to
                                         Public           Commissions(1)        Company(2)
- ------------------------------------------------------------------------------------------
<S>                                <C>                 <C>                 <C>
Per Share........................          $                   $                   $
Total(3).........................         $                   $                   $
- ------------------------------------------------------------------------------------------
</TABLE>

(1) The Company has agreed to indemnify the Underwriters against certain
    liabilities, including liabilities under the Securities Act of 1933. See
    "Underwriting."
(2) Before deducting expenses payable by the Company, estimated to be $900,000.
(3) The Company has granted to the Underwriters an option, exercisable within
    30 days of the date hereof, to purchase an aggregate of up to 487,500
    additional shares at the Price to Public less Underwriting Discounts and
    Commissions to cover over-allotments, if any. If all such additional shares
    are purchased, the total Price to Public, Underwriting Discounts and
    Commissions and Proceeds to Company will be $   , $   and $   ,
    respectively. See "Underwriting."
                                --------------
   
  The Common Stock is offered by the several Underwriters named herein when, as
and if received and accepted by them, subject to their right to reject orders
in whole or in part and subject to certain other conditions. It is expected
that delivery of the certificates for the shares will be made at the offices of
Cowen & Company, New York, New York, on or about   , 1997.     
                                --------------
 
COWEN & COMPANY                                               J.P. MORGAN & CO.
   
    , 1997     

<PAGE>
 
 
     [COLOR FLOW CHART DEPICTING "STEM CELL THERAPY METHODS"
     DESCRIBING STEM CELL THERAPY UTILIZING BONE MARROW HARVEST,
     PROGENITOR BLOOD CELL MOBILIZATION AND THE AASTROM CPS]
 
       [COLOR PHOTOGRAPH OF A PROTOTYPE OF THE AASTROM CPS WITH A
                      CLINICIAN INNOCULATING CELLS]
 
 
 
  A prototype of the Aastrom CPS is currently being used in a clinical trial
and ongoing development activities are directed at completing production level
components of the Aastrom CPS. The Company may not market the Aastrom CPS
unless and until FDA and other necessary regulatory approvals are received.
 
  IN CONNECTION WITH THIS OFFERING, THE UNDERWRITERS MAY OVER-ALLOT OR EFFECT
TRANSACTIONS WHICH STABILIZE OR MAINTAIN THE MARKET PRICE OF THE COMMON STOCK
OFFERED HEREBY AT A LEVEL ABOVE THAT WHICH MIGHT OTHERWISE PREVAIL IN THE OPEN
MARKET. SUCH TRANSACTIONS MAY BE EFFECTED ON THE NASDAQ NATIONAL MARKET, IN
THE OVER-THE-COUNTER MARKET OR OTHERWISE. SUCH STABILIZING, IF COMMENCED, MAY
BE DISCONTINUED AT ANY TIME.
 
                                       2

<PAGE>
 

                               PROSPECTUS SUMMARY
 
  The following summary is qualified in its entirety by the more detailed
information and financial statements, including the notes thereto, appearing
elsewhere in this Prospectus. Prospective investors should carefully consider
the information set forth under the heading "Risk Factors."
 

                                  THE COMPANY
   
  Aastrom Biosciences, Inc. is developing proprietary process technologies and
devices for a range of cell therapy applications, including stem cell therapies
and gene therapy. The Company's lead product under development, the Aastrom
Cell Production System (the "Aastrom CPS") consists of a clinical cell culture
system with disposable cassettes and reagents for use in the rapidly growing
stem cell therapy market. The Company believes that the Aastrom CPS method will
be less costly, less invasive and less time consuming than currently available
stem cell collection methods. The Aastrom CPS is designed as a platform product
which implements the Company's pioneering stem cell replication technology. The
Company also believes that the Aastrom CPS can be modified to produce a wide
variety of other cell types for new, emerging therapies being developed by
others. Prior to commencement of multiple-site pivotal trials, the Company is
conducting a limited "pre-pivotal" trial of the Aastrom CPS under an
Investigational Device Exemption for use in stem cell therapy. The Company has
entered into a strategic collaboration for the development of the Aastrom CPS
in stem cell therapy with Cobe BCT, Inc., a subsidiary of Gambro AB and a
leading provider of blood cell processing products. In ex vivo gene therapy,
the genetic manipulation of cells outside of the body for use in therapy, the
Company is developing proprietary processes and the Aastrom CPS to enable high
efficiency genetic modification and production of cells, respectively.     
   
  Stem cell therapy is a rapidly growing form of cell therapy used to restore
blood and immune system function to cancer patients following chemotherapy or
radiation therapy and, according to an industry source, approximately 32,000
stem cell therapy procedures were completed worldwide in 1995. Other novel cell
therapies are under development by third parties, including stem cell therapy
for the treatment of autoimmune diseases and for augmenting recipient
acceptance of organ transplants. Current stem cell therapy methods, including
bone marrow harvest and peripheral blood progenitor cell mobilization, are
costly, invasive and time-consuming for both medical personnel and patients.
Technologies which facilitate a more readily available source of cells may
contribute to additional growth in cell therapy procedures. Umbilical cord
blood ("UCB") is emerging as a new source of cells for stem cell therapy,
offering additional market opportunity, although the more widespread use of UCB
transplants has been restricted by cell quantity limitations, which the Company
believes may ultimately be addressed by the Aastrom CPS.     
   
  The Company believes that the Aastrom CPS will offer significant advantages
over traditional stem cell collection methods. The Aastrom CPS is intended to
be used to produce cells used for therapy from a small starting volume of bone
marrow cells. Compared with current methods, the Aastrom CPS is expected to
involve two patient care episodes rather than approximately eight to 21 care
episodes, less than three hours of patient procedure time rather than
approximately 16 to 39 hours of patient procedure time and approximately four
to ten needle sticks rather than 22 or more needle sticks over the course of
collection and infusion. The Aastrom CPS may also permit higher and more
frequent doses of chemotherapy to be administered to cancer patients by
enabling the production of multiple doses of cells from patient samples taken
at the initial collection.     
   
  Aastrom is currently conducting a pre-pivotal stem cell therapy trial. The
trial is designed to show that cells produced in the Aastrom CPS can by
themselves safely enable recovery of bone marrow and cells of the blood and
immune systems in accordance with trial endpoints in patients who have received
chemotherapy which has destroyed cells of the blood and immune systems. Based
on the outcome of this and other related trials, the Company intends to seek
FDA approval to begin a multi-center pivotal trial for use of the Aastrom CPS
in stem cell therapy. It is anticipated that the results of this pivotal trial
will be used to support the Company's Pre-Market Approval ("PMA") submission to
the FDA. In the near future, the Company plans to initiate a stem cell therapy
clinical trial in Europe, the results of which are expected to be used for the
CE Mark registration necessary to market the Aastrom CPS in Europe.     
 
  The Company's business strategy is to: (i) establish a consumable-based
business model; (ii) focus initially on the currently-reimbursed stem cell
therapy market; (iii) leverage Aastrom's cell production technology across
multiple cell therapy market opportunities; and (iv) market through
collaborative relationships.
   
  Aastrom has entered into a strategic collaboration with Cobe BCT to support
the development and marketing of the Aastrom CPS in the field of stem cell
therapy. In 1993, the Company entered into a series of agreements in which Cobe
BCT purchased $15,000,000 of the Company's equity securities and acquired the
worldwide distribution rights to the Aastrom CPS for stem cell therapy. Under
the terms of the collaboration, Aastrom retains manufacturing rights and 58% to
60% of all revenue generated by Cobe BCT's sale of the Aastrom CPS, subject to
the Company's obligation to make certain royalty payments. Aastrom also retains
all marketing and distribution rights to the Aastrom CPS for other cell types
and ex vivo gene therapy applications, including stem cells. Cobe Laboratories
Inc., an affiliate of Cobe BCT, has agreed to purchase $5,000,000 of Common
Stock in this offering at the initial public offering price per share.     
 
  The Company's patent portfolio includes patents relating to both stem and
progenitor cell production, processes for the genetic modification of stem and
other cell types, and cell culture devices for human cells. As of September 30,
1996, the Company had exclusive rights to five issued U.S. and three foreign
patents, and a number of U.S. patent applications and certain corresponding
foreign applications.
 
                                       3

<PAGE>
 
                                  THE OFFERING
 

<TABLE>
<S>                        <C>
Common Stock offered...... 3,250,000 shares(1)
Common Stock to be out-    
 standing after this of-
 fering................... 13,235,734 shares(2)
Use of proceeds........... For clinical trials, the development and manufacture
                           of the Aastrom CPS, research and development of
                           other product candidates, working capital and other
                           general corporate purposes.
Proposed Nasdaq National   
 Market symbol............ ASTM
</TABLE>

 
                             SUMMARY FINANCIAL DATA
 

<TABLE>
<CAPTION>
                                                                                                 THREE MONTHS
                                             YEAR ENDED JUNE 30,                             ENDED SEPTEMBER 30,
                         ---------------------------------------------------------------  ---------------------------
                            1992         1993         1994         1995         1996         1995           1996
                         -----------  -----------  -----------  -----------  -----------  -----------  --------------
<S>                      <C>          <C>          <C>          <C>          <C>          <C>          <C>
STATEMENT OF OPERATIONS
 DATA:
Total revenues.......... $       --   $   784,000  $   872,000  $   517,000  $ 1,609,000  $   211,000   $   224,000
Costs and expenses:
 Research and
  development...........   1,090,000    2,600,000    5,627,000    4,889,000   10,075,000    1,195,000     3,160,000
 General and
  administrative........     272,000    1,153,000    1,565,000    1,558,000    2,067,000      446,000       452,000
                         -----------  -----------  -----------  -----------  -----------  -----------   -----------
  Total costs and
   expenses.............   1,362,000    3,753,000    7,192,000    6,447,000   12,142,000    1,641,000     3,612,000
Other income, net.......      94,000      122,000      180,000      213,000      616,000      131,000       115,000
                         -----------  -----------  -----------  -----------  -----------  -----------   -----------
Net loss................ $(1,268,000) $(2,847,000) $(6,140,000) $(5,717,000) $(9,917,000) $(1,299,000)  $(3,273,000)
                         ===========  ===========  ===========  ===========  ===========  ===========   ===========
Pro forma net loss per
 share(3)............... $      (.32) $      (.49) $      (.82) $      (.66) $      (.98) $      (.13)  $      (.32)
                         ===========  ===========  ===========  ===========  ===========  ===========   ===========
Pro forma weighted
 average number of
 shares outstanding(3)..   3,919,000    5,840,000    7,461,000    8,644,000   10,103,000   10,094,000    10,107,000
                         ===========  ===========  ===========  ===========  ===========  ===========   ===========
<CAPTION>
                                                                                              SEPTEMBER 30, 1996
                                                                                          ---------------------------
                                                                                            ACTUAL     AS ADJUSTED(4)
                                                                                          -----------  --------------
<S>                                                                                       <C>          <C>
BALANCE SHEET DATA:
 Cash, cash equivalents and short-term investments..................................      $ 7,108,000   $33,410,500
 Working capital....................................................................        6,540,000    32,842,500
 Total assets.......................................................................        8,931,000    35,233,500
 Deficit accumulated during the development stage...................................      (30,298,000)  (30,298,000)
 Total shareholders' equity.........................................................        7,618,000    33,920,500
</TABLE>

- -------
(1) Includes 555,556 shares which Cobe Laboratories, Inc. has agreed to
    purchase, assuming an initial public offering price of $9.00 per share.
(2) Excludes options and warrants to purchase 1,132,361 shares of Common Stock
    at a weighted average exercise price of $6.50 per share, assuming the
    closing of this offering at an initial public offering price of $9.00 per
    share. See "Management--Stock Option and Employee Benefit Plans" and Notes
    4 and 9 of Notes to Financial Statements.
(3) See Note 1 of Notes to Financial Statements for information concerning the
    computation of pro forma net loss per share and shares used in computing
    pro forma net loss per share.
(4) Adjusted to reflect the sale by the Company of 3,250,000 shares of Common
    Stock offered hereby at an assumed initial public offering price of $9.00
    per share, after deduction of underwriting discounts and commissions and
    estimated offering expenses. See "Use of Proceeds" and "Capitalization."
 
  Unless otherwise indicated, all information contained in this Prospectus (i)
gives effect to a two-for-three reverse stock split to be effected prior to the
closing of this offering, (ii) gives effect to the conversion of all
outstanding shares of the Company's Preferred Stock into 8,098,422 shares of
Common Stock upon the closing of this offering, (iii) gives effect to the
filing of an Amended and Restated Articles of Incorporation upon the closing of
this offering to, among other things, create a new class of undesignated
preferred stock and (iv) assumes no exercise of the Underwriters' over-
allotment option. See "Description of Capital Stock" and "Underwriting." This
Prospectus contains forward-looking statements which involve risks and
uncertainties. The Company's actual results may differ significantly from the
results discussed in the forward-looking statements. Factors that might cause
such differences include, but are not limited to, those discussed in "Risk
Factors."
 
                                       4

<PAGE>
 

                                 RISK FACTORS
 
  In addition to the other information in this Prospectus, prospective
investors should consider the following risk factors in evaluating the Company
and its business before purchasing any of the Common Stock offered hereby.
 
UNCERTAINTIES RELATED TO PRODUCT DEVELOPMENT AND MARKETABILITY
 
  The Company has not completed the development or clinical trials of any of
its cell culture technologies or product candidates and, accordingly, has not
begun to market or generate revenue from their commercialization. Furthermore,
the Company's technologies and product candidates are based on cell culture
processes and methodologies which are not widely employed. Commercialization
of the Company's lead product candidate, the Aastrom CPS, will require
substantial additional research and development by the Company as well as
substantial clinical trials. There can be no assurance that the Company will
successfully complete development of the Aastrom CPS or its other product
candidates, or successfully market its technologies or product candidates,
which lack of success would have a material adverse effect on the Company's
business, financial condition and results of operations.
 
  The Company or its collaborators may encounter problems and delays relating
to research and development, regulatory approval and intellectual property
rights of the Company's technologies and product candidates. There can be no
assurance that the Company's research and development programs will be
successful, that its cell culture technologies and product candidates will
facilitate the ex vivo production of cells with the expected biological
activities in humans, that its technologies and product candidates, if
successfully developed, will prove to be safe and efficacious in clinical
trials, that the necessary regulatory approvals for any of the Company's
technologies or product candidates and the cells produced in such products
will be obtained or, if obtained, will be as broad as sought, that patents
will issue on the Company's patent applications or that the Company's
intellectual property protections will be adequate. The Company's product
development efforts are primarily directed toward obtaining regulatory
approval to market the Aastrom CPS as an alternative to the bone marrow
harvest and peripheral blood progenitor cell ("PBPC") stem cell collection
methods. These stem cell collection methods have been widely practiced for a
number of years, and there can be no assurance that any of the Company's
technologies or product candidates will be accepted by the marketplace as
readily as these or other competing processes and methodologies, or at all.
The failure by the Company to achieve any of the foregoing would have a
material adverse effect on the Company's business, financial condition and
results of operations.
 
UNCERTAINTIES RELATED TO CLINICAL TRIALS
 
  The approval of the United States Food and Drug Administration (the "FDA")
will be required before any commercial sales of the Company's product
candidates may commence in the United States, and approvals from foreign
regulatory authorities will be required before international sales may
commence. Prior to obtaining necessary regulatory approvals, the Company will
be required to demonstrate the safety and efficacy of its processes and
product candidates and the cells produced by such processes and in such
products for application in the treatment of humans through extensive
preclinical studies and clinical trials. To date, the Company has only tested
the safety of cells produced in the cell culture chamber predecessor of the
Aastrom CPS, and only in a limited numbers of patients. The Company is
currently conducting a pre-pivotal clinical trial to demonstrate the safety
and biological activity of patient-derived cells produced in the Company's
cell culture chamber in a limited number of patients with breast cancer and,
if the results from this pre-pivotal trial are successful, the Company intends
to seek clearance from the FDA to commence its pivotal clinical trial. The
results of preclinical studies and clinical trials of the Company's product
candidates, however, may not necessarily be predictive of results that will be
obtained from subsequent or more extensive clinical trials. Further, there can
be no assurance that pre-pivotal or pivotal clinical trials of any of the
Company's product candidates will demonstrate the safety and efficacy of such
products, or of the cells produced in such products, to the extent necessary
to obtain required regulatory approvals or market acceptance.
 
  The ability of the Company to complete its clinical trials in a timely
manner is dependent upon many factors, including the rate of patient
enrollment. Patient enrollment is a function of many factors, including the
size of the patient population, the proximity of suitable patients to clinical
sites and the eligibility criteria for the
 
                                       5

<PAGE>
 
study. The Company has experienced delays in patient accrual in its current
pre-pivotal clinical trial. Further delays in patient accrual, in the
Company's current pre-pivotal clinical trial or in future clinical trials,
could result in increased costs associated with clinical trials or delays in
receiving regulatory approvals and commercialization, if any. Furthermore, the
progress of clinical investigations with the Aastrom CPS and the Company's
other product candidates will be monitored by the FDA, which has the authority
to cease clinical investigations, at any time, due to patient safety or other
considerations. Any of the foregoing would have a material adverse effect on
the Company's business, financial condition and results of operations. See "--
Uncertainty of Regulatory Approval; --Extensive Government Regulation."
 
  The Company's current pre-pivotal trial is designed to demonstrate specific
biological safety and activity of cells produced in the Aastrom CPS, but is
not designed to demonstrate long-term sustained engraftment of such cells. The
patients enrolled in this pre-pivotal trial will have undergone extensive
chemotherapy treatment prior to the infusion of cells produced in the Aastrom
CPS. Such treatments will have substantially weakened these patients and may
have irreparably damaged their hematopoietic systems. Due to these and other
factors, it is possible that one or more of these patients may die or suffer
severe complications during the course of the pre-pivotal trial. Further,
there can be no assurance that patients receiving cells produced with the
Company's technologies and product candidates will demonstrate long-term
engraftment in a manner comparable to cells obtained from current stem cell
therapy procedures, or at all. The failure to adequately demonstrate the
safety or efficacy of the Company's technologies and product candidates,
including long-term sustained engraftment, or the death of, or occurrence of
severe complications in, one or more patients could substantially delay, or
prevent, regulatory approval of such product candidates and have a material
adverse effect on the Company's business, financial condition and results of
operations.
 
MANUFACTURING AND SUPPLY UNCERTAINTIES; DEPENDENCE ON THIRD PARTIES
   
  The Company does not operate and has no current intention to operate
manufacturing facilities for the production of its product candidates. The
Company currently arranges for the manufacture of its product candidates and
their components, including certain cytokines, serum and media, with third
parties, and expects to continue to do so in the forseeable future. The
Company has entered into collaborative product development and supply
agreements with SeaMED Corporation ("SeaMED"), Ethox Corporation ("Ethox") and
Anchor Advanced Products Inc., Mid-State Plastics Division ("MSP") for the
collaborative development and manufacture of certain components of the Aastrom
CPS and is dependent upon those suppliers to manufacture its products. The
Company is also dependent upon Immunex Corporation ("Immunex"), Life
Technologies, Inc. and Biowhittaker for the supply of certain cytokines, serum
and media to be used in conjunction with the Aastrom CPS. With regard to
cytokines that are not commercially available from other sources, Immunex is
currently the Company's sole supplier and few alternative supply sources
exist. Apart from SeaMED, Ethox, MSP and Immunex, the Company currently does
not have contractual commitments from any of these manufacturers or suppliers.
There can be no assurance that the Company's supply of such key cytokines,
components and other materials will not become limited, be interrupted or
become restricted to certain geographic regions. Furthermore, the Company
currently only has the right to distribute cytokines obtained from Immunex in
the United States and there can be no assurance that the Company will be able
to obtain the worldwide right to distribute such cytokines or manufacture such
cytokines by or for itself in the event that the Company's agreement with
Immunex is terminated. There can also be no assurance that the Company will be
able to obtain alternative components and materials from other manufacturers
of acceptable quality, or on terms or in quantities acceptable to the Company
or that the Company will not require additional cytokines, components and
other materials to manufacture or use its product candidates. In the event
that any of the Company's key manufacturers or suppliers fail to perform their
respective obligations or the Company's supply of such cytokines, components
or other materials become limited or interrupted, the Company would not be
able to market its product candidates on a timely and cost-competitive basis,
if at all, which would have a material adverse effect on the Company's
business, financial condition and results of operations.     
   
  Like SeaMED, Ethox and MSP, other suppliers would need to meet FDA
manufacturing requirements and undergo rigorous facility and process
validation tests required by federal and state regulatory authorities. Any
    
                                       6

<PAGE>
 
significant delays in the completion and validation of such facilities could
have a material adverse effect on the ability of the Company to complete
clinical trials and to market its products on a timely and profitable basis,
which in turn would have a material adverse effect on the Company's business,
financial condition and results of operations.
 
  There can also be no assurance that the Company will be able to continue its
present arrangements with its suppliers, supplement existing relationships or
establish new relationships or that the Company will be able to identify and
obtain the ancillary materials that are necessary to develop its product
candidates in the future. The Company's dependence upon third parties for the
supply and manufacture of such items could adversely affect the Company's
ability to develop and deliver commercially feasible products on a timely and
competitive basis.
 
HISTORY OF OPERATING LOSSES; ANTICIPATION OF FUTURE LOSSES
 
  The Company is a development stage company and there can be no assurance
that its product applications for cell therapy will be successful. The Company
has not yet completed the development and clinical trials of any of its
product candidates and, accordingly, has not yet begun to generate revenues
from the commercialization of any of its product candidates. Aastrom was
incorporated in 1989 and has experienced substantial operating losses since
inception. As of September 30, 1996, the Company has incurred net operating
losses totaling approximately $30.3 million. Such losses have resulted
principally from costs incurred in the research and development of the
Company's cell culture technologies and the Aastrom CPS, general and
administrative expenses, and the prosecution of patent applications. The
Company expects to incur significant and increasing operating losses for at
least the next several years, primarily owing to the expansion of its research
and development programs, including preclinical studies and clinical trials.
The amount of future losses and when, if ever, the Company will achieve
profitability, are uncertain. The Company's ability to achieve profitability
will depend, among other things, on successfully completing the development of
its product candidates, obtaining regulatory approvals, establishing
manufacturing, sales and marketing arrangements with third parties, and
raising sufficient funds to finance its activities. No assurance can be given
that the Company's product development efforts will be successful, that
required regulatory approvals will be obtained, that any of the Company's
product candidates will be manufactured at a competitive cost and will be of
acceptable quality, or that the Company will be able to achieve profitability
or that profitability, if achieved, can be sustained.
 
LIMITED SALES AND MARKETING CAPABILITIES; DEPENDENCE ON COLLABORATIVE
RELATIONSHIPS
 
  The Company has limited internal sales, marketing and distribution
capabilities. If any of the Company's product candidates are successfully
developed and the necessary regulatory approvals are obtained, the Company
intends to market such products through collaborative relationships with
companies that have established sales, marketing and distribution
capabilities. The Company has established a strategic alliance with Cobe
Laboratories, Inc. and Cobe BCT, Inc. (collectively, "Cobe") for the worldwide
distribution of the Aastrom CPS for stem cell therapy and related uses. Cobe
has the right to terminate its Distribution Agreement with the Company upon
twelve months' notice upon a change of control of the Company, other than to
Cobe, or at any time after December 31, 1997, if Cobe determines that
commercialization of the Aastrom CPS for stem cell therapy on or prior to
December 31, 1998 is unlikely. See "--Consequences of Cobe Relationship."
 
  The amount and timing of resources that Cobe commits to its strategic
alliance activities with the Company are, to a significant extent, outside of
the control of the Company. There can be no assurance that Cobe will pursue
the marketing and distribution of the Company's products, continue to perform
its obligations under its agreements with the Company or that the Company's
strategic alliance with Cobe will result in the successful commercialization
and distribution of the Company's technologies and product candidates. There
can also be no assurance that Cobe will be successful in its efforts to market
and distribute the Company's products for stem cell therapy. The suspension or
termination of the Company's strategic alliance with Cobe or the failure of
the strategic alliance to be successful would have a material adverse effect
on the Company's business, financial condition and results of operations.
 
                                       7

<PAGE>
 
  Subject to the contractual requirements of the Cobe relationship, the
Company will seek to enter into other agreements relating to the development
and marketing of product candidates and in connection with such agreements may
rely upon corporate partners to conduct clinical trials, seek regulatory
approvals for, manufacture and market its potential products. There can be no
assurance that the Company will be able to establish collaborative
relationships for the development or marketing of the Company's product
candidates on acceptable terms, if at all. The inability of the Company to
establish such collaborative relationships may require the Company to curtail
its development or marketing activities with regard to its potential products
which would have a material adverse effect on the Company's business,
financial condition and results of operations.
 
FUTURE CAPITAL NEEDS; UNCERTAINTY OF ADDITIONAL FUNDING
   
  To date, Aastrom has funded its operations primarily through the sale of
equity securities and corporate collaborations. The Company anticipates that
the net proceeds of this offering, together with the Company's available cash
and expected interest income thereon, will be sufficient to finance its
research and development and other working capital requirements until late
1998. This estimate is based on certain assumptions which could be negatively
impacted by the matters discussed under this heading and elsewhere under the
caption "Risk Factors." In order to grow and expand its business, and to
introduce its product candidates into the marketplace, the Company will need,
among other things, to raise additional funds. The development of the
Company's products for the expansion of additional cell types will require the
Company to raise additional funds or to seek collaborative partners, or both,
to finance related research and development activities.     
 
  The Company's future capital requirements will depend upon many factors,
including, but not limited to, continued scientific progress in its research
and development programs, costs and timing of conducting clinical trials and
seeking regulatory approvals and patent prosecutions, competing technological
and market developments, possible changes in existing collaborative
relationships, the ability of the Company to establish additional
collaborative relationships, and effective commercialization activities and
facilities expansions if and as required. Because of the Company's potential
long-term funding requirements, it may attempt to access the public or private
equity markets if and whenever conditions are favorable, even if it does not
have an immediate need for additional capital at that time. There can be no
assurance that any such additional funding will be available to the Company on
reasonable terms, or at all. If adequate funds are not available, the Company
may be required to delay or terminate research and development programs,
curtail capital expenditures, and reduce business development and other
operating activities. If the Company is not successful in finding, entering
into and maintaining arrangements with collaborative partners, its development
efforts could be delayed. Furthermore, there can be no assurance that the
Company will be able to implement collaborative development agreements under
acceptable terms, if at all. Any of the foregoing capital constraints would
have a material adverse effect on the Company's business, financial condition
and results of operations. See "Management's Discussion and Analysis of
Financial Condition and Results of Operations--Liquidity and Capital
Resources."
 
UNCERTAINTY OF REGULATORY APPROVAL; EXTENSIVE GOVERNMENT REGULATION
 
  The Company's research and development activities, preclinical studies,
clinical trials, and the anticipated manufacturing and marketing of its
product candidates are subject to extensive regulation by the FDA and other
regulatory authorities in the United States. These activities are also
regulated in other countries where the Company intends to test and market its
product candidates. The approval of the FDA will be required before any
commercial sales of the Company's product candidates may commence in the
United States. Additionally, the Company will be required to obtain approvals
from foreign regulatory authorities before international sales may commence.
 
  The Company's products are potentially subject to regulation as medical
devices under the Federal Food, Drug, and Cosmetic Act, or as biological
products under the Public Health Service Act, or both. Different regulatory
requirements may apply to the Company's products depending on how they are
categorized by the FDA under these laws. To date, the FDA has indicated that
it intends to regulate the Aastrom CPS for stem cell
 
                                       8

<PAGE>
 
therapy as a Class III medical device through the Center for Biologics
Evaluation and Research. However, there can be no assurance that the FDA will
ultimately regulate the Aastrom CPS for stem cell therapy as a medical device
or that regulatory approval for such product will be obtained in a timely
fashion or at all.
 
  Further, it is unclear whether the FDA will separately regulate the cell
therapies derived from the Aastrom CPS. The FDA is in the process of
developing its requirements with respect to somatic cell therapy and gene cell
therapy products, and recently proposed a new type of license for autologous
cells manipulated ex vivo and intended for structural repair or
reconstruction; autologous cells are cells obtained from, and administered to,
the same patient. This proposal may indicate that the FDA will impose a
similar approval requirement on other types of autologous cellular therapies,
such as autologous cells for stem cell therapy. Any such additional regulatory
or approval requirement could significantly delay the introduction of the
Company's product candidates to the market, and have a material adverse effect
on the Company's business, financial condition and results of operations.
Until the FDA issues definitive regulations covering the Company's product
candidates, the regulatory requirements for approval of such product
candidates will continue to be subject to significant uncertainty.
 
  Before marketing, the Aastrom CPS or other product candidates developed by
the Company must undergo an extensive regulatory approval process. The
regulatory process, which includes preclinical studies and clinical trials to
establish safety and efficacy, takes many years and requires the expenditure
of substantial resources. Data obtained from preclinical and clinical
activities are susceptible to varying interpretations which could delay, limit
or prevent FDA approval. In addition, delays or rejections may be encountered
based upon changes in FDA policy for medical product approvals during the
period of product development and FDA regulatory review of applications
submitted by the Company for product approval. Similar delays may also be
encountered in foreign countries. There can be no assurance that, even after
the expenditures of substantial time and financial resources, regulatory
approval will be obtained for any products developed by the Company. Moreover,
if regulatory approval of a product is obtained, such approval may be subject
to limitations on the indicated uses for which it may be marketed. Further,
even if such regulatory approval is obtained, a marketed product, its
manufacturer and its manufacturing facilities are subject to continual review
and periodic inspections by the FDA, and later discovery of previously unknown
problems with a product, manufacturer or facility may result in restrictions
on such product or manufacturer, including a withdrawal of the product from
the market. Failure to comply with the applicable regulatory requirements can,
among other things, result in fines, suspensions of regulatory approvals,
product recalls, operating restrictions and criminal prosecution. Further,
additional government regulation may be established which could prevent or
delay regulatory approval of the Company's products. See "Business--Government
Regulation."
 
CONSEQUENCES OF COBE RELATIONSHIP
 
  Following the completion of this offering, Cobe will be the largest single
shareholder of the Company, beneficially owning approximately 23.1% of the
outstanding Common Stock. In addition, Cobe has certain preemptive rights to
maintain its relative percentage ownership and voting interest in the Company
following this offering, and has the option, for a period of three years
following this offering, to purchase from the Company an amount of Common
Stock equal to 30% of the Company's fully diluted shares after the exercise of
such option, at a purchase price equal to 120% of the public market trading
price of the Company's Common Stock. If such option is exercised, Cobe would
significantly increase its ownership interest in the Company and, as a
consequence of such share ownership, obtain effective control of the Company.
Such effective control would include the ability to influence the outcome of
shareholder votes, including votes concerning the election of directors, the
amendment of provisions of the Company's Restated Articles of Incorporation or
Bylaws, and the approval of mergers and other significant transactions. Cobe
also has been granted a "right of first negotiation" in the event that the
Company determines to sell all, or any material portion, of its assets to
another company or to merge with another company. Furthermore, the Company has
agreed to use reasonable and good faith efforts to cause a nominee designated
by Cobe to be elected to the Board of Directors for as long as Cobe owns at
least 15% of the outstanding Common Stock. In addition, Edward C. Wood, Jr.,
the President of Cobe BCT, is a
 
                                       9

<PAGE>
 
director of the Company. The existence of the foregoing rights or the exercise
of such control by Cobe could have the effect of delaying, deterring or
preventing certain takeovers or changes in control of the management of the
Company, including transactions in which shareholders might otherwise receive
a premium for their shares over then current market prices. See "Description
of Capital Stock--Rights of Cobe."
 
UNCERTAINTY REGARDING PATENTS AND PROPRIETARY RIGHTS
 
  Aastrom's success depends in part on its ability, and the ability of its
licensors, to obtain patent protection for its products and processes,
preserve its trade secrets, defend and enforce its rights against infringement
and operate without infringing the proprietary rights of third parties, both
in the United States and in other countries. The validity and breadth of
claims in medical technology patents involve complex legal and factual
questions and, therefore, may be highly uncertain. No assurance can be given
that any patents based on pending patent applications or any future patent
applications of the Company or its licensors will be issued, that the scope of
any patent protection will exclude competitors or provide competitive
advantages to the Company, that any of the patents that have been or may be
issued to the Company or its licensors will be held valid if subsequently
challenged or that others will not claim rights in or ownership of the patents
and other proprietary rights held or licensed by the Company. Furthermore,
there can be no assurance that others have not developed or will not develop
similar products, duplicate any of the Company's products or design around any
patents that have been or may be issued to the Company or its licensors. Since
patent applications in the United States are maintained in secrecy until
patents issue, the Company also cannot be certain that others did not first
file applications for inventions covered by the Company's and its licensors'
pending patent applications, nor can the Company be certain that it will not
infringe any patents that may issue to others on such applications. The
Company relies on certain licenses granted by the University of Michigan and
Dr. Cremonese for the majority of its patent rights. If the Company breaches
such agreements or otherwise fails to comply with such agreements, or if such
agreements expire or are otherwise terminated, the Company may lose its rights
under the patents held by the University of Michigan and Dr. Cremonese, which
would have a material adverse effect on the Company's business, financial
condition and results of operation. See "Business--Patents and Proprietary
Rights--University of Michigan Research Agreement and License Agreement" and
"--Patents and Proprietary Rights--License Agreement with J.G. Cremonese." The
Company also relies on trade secrets and unpatentable know-how which it seeks
to protect, in part, by confidentiality agreements with its employees,
consultants, suppliers and licensees. There can be no assurance that these
agreements will not be breached, that the Company would have adequate remedies
for any breach, or that the Company's trade secrets or unpatentable know-how
will not otherwise become known or be independently developed by competitors.
 
  The Company's success will also depend in part on its ability to develop
commercially viable products without infringing the proprietary rights of
others. The Company has not conducted freedom of use patent searches and no
assurance can be given that patents do not exist or could not be filed which
would have an adverse effect on the Company's ability to market its products
or maintain its competitive position with respect to its products. If the
Company's technology components, devices, designs, products, processes or
other subject matter are claimed under other existing United States or foreign
patents or are otherwise protected by third party proprietary rights, the
Company may be subject to infringement actions. In such event, the Company may
challenge the validity of such patents or other proprietary rights or be
required to obtain licenses from such companies in order to develop,
manufacture or market its products. There can be no assurance that the Company
would be able to obtain such licenses or that such licenses, if available,
could be obtained on commercially reasonable terms. Furthermore, the failure
to either develop a commercially viable alternative or obtain such licenses
could result in delays in marketing the Company's proposed products or the
inability to proceed with the development, manufacture or sale of products
requiring such licenses, which could have a material adverse effect on the
Company's business, financial condition and results of operations. If the
Company is required to defend itself against charges of patent infringement or
to protect its own proprietary rights against third parties, substantial costs
will be incurred regardless of whether the Company is successful. Such
proceedings are typically protracted with no certainty of success. An adverse
outcome could subject the Company to significant liabilities to third parties,
and force the Company to curtail or cease its development and sale of its
products and processes. See "Business--Patents and Proprietary Rights."
 
                                      10

<PAGE>
 
NO ASSURANCE OF THIRD PARTY REIMBURSEMENT
 
  The Company's ability to successfully commercialize its product candidates
will depend in part on the extent to which payment for the Company's products
and related treatments will be available from government healthcare programs,
such as Medicare and Medicaid, as well as private health insurers, health
maintenance organizations and other third party payors. Government and other
third-party payors are increasingly attempting to contain health care costs,
in part by challenging the price of medical products and services.
Reimbursement by third-party payors depend on a number of factors, including
the payor's determination that use of the product is safe and effective, not
experimental or investigational, medically necessary, appropriate for the
specific patient and cost-effective. Since reimbursement approval is required
from each payor individually, seeking such approvals is a time-consuming and
costly process which will require the Company to provide scientific and
clinical support for the use of each of the Company's products to each payor
separately. Significant uncertainty exists as to the payment status of newly
approved medical products, and there can be no assurance that adequate third-
party payments will be available to enable the Company to establish or
maintain price levels sufficient to realize an appropriate return on its
investment in product development. If adequate payment levels are not provided
by government and third-party payors for use of the Company's products, the
market acceptance of those products will be adversely affected.
 
  There can be no assurance that reimbursement in the United States or foreign
countries will be available for any of the Company's product candidates, that
any reimbursement granted will be maintained, or that limits on reimbursement
available from third-party payors will not reduce the demand for, or
negatively affect the price of, the Company's products. The unavailability or
inadequacy of third-party reimbursement for the Company's product candidates
would have a material adverse effect on the Company. Finally, the Company is
unable to forecast what additional legislation or regulation relating to the
healthcare industry or third-party coverage and reimbursement may be enacted
in the future, or what effect such legislation or regulation would have on the
Company's business.
 
COMPETITION AND TECHNOLOGICAL CHANGE
 
  The Company is engaged in the development of medical products and processes
which will face competition in a marketplace characterized by rapid
technological change. Many of the Company's competitors have significantly
greater resources than the Company, and have developed and may develop product
candidates and processes that directly compete with the Company's products.
Moreover, competitors that are able to achieve patent protection, obtain
regulatory approvals and commence commercial sales of their products before
the Company, and competitors that have already done so, may enjoy a
significant competitive advantage. The Company's product development efforts
are primarily directed toward obtaining regulatory approval to market the
Aastrom CPS for stem cell therapy. That market is currently dominated by the
bone marrow harvest and PBPC collection methods. The Company's clinical data,
although early, is inconclusive as to whether or not cells expanded in the
Aastrom CPS will enable hematopoietic recovery within the time frames
currently achieved by the bone marrow harvest and PBPC collection methods. In
addition, the bone marrow harvest and PBPC collection methods have been widely
practiced for a number of years and, recently, the patient costs associated
with these procedures have begun to decline. There can be no assurance that
the Aastrom CPS method, if approved for marketing, will prove to be
competitive with these established collection methods on the basis of
hematopoietic recovery time, cost or otherwise. The Company also is aware of
certain other products manufactured or under development by competitors that
are used for the prevention or treatment of certain diseases and health
conditions which the Company has targeted for product development. In
particular, the Company is aware that competitors such as Amgen, Inc.,
CellPro, Incorporated, Systemix, Inc., Baxter Healthcare Corp. and Rhone-
Poulenc Rorer Inc. ("RPR") are in advanced stages of development of
technologies and products for use in stem cell therapy and other market
applications currently being pursued by the Company. In addition, Cobe, a
significant shareholder of the Company, is a market leader in the blood cell
processing products industry and, accordingly, a potential competitor of the
Company. There can be no assurance that developments by others will not render
the Company's product candidates or technologies obsolete or noncompetitive,
that the Company will be able to keep pace with new technological developments
or that the
 
                                      11

<PAGE>
 
Company's product candidates will be able to supplant established products and
methodologies in the therapeutic areas that are targeted by the Company. The
foregoing factors could have a material adverse effect on the Company's
business, financial condition and results of operations.
 
HAZARDOUS MATERIALS
 
  The Company's research and development activities involve the controlled use
of hazardous materials, chemicals and various radioactive compounds. The
Company is subject to federal, state and local laws and regulations governing
the use, manufacture, storage, handling and disposal of such materials and
certain waste products. In the event of any contamination or injury from these
materials, the Company could be held liable for any damages that result and
any such liability could exceed the resources of the Company. Furthermore, the
failure to comply with current or future regulations could result in the
imposition of substantial fines against the Company, suspension of production,
alteration of its manufacturing processes or cessation of operations. There
can be no assurance that the Company will not be required to incur significant
costs to comply with any such laws and regulations in the future, or that such
laws or regulations will not have a material adverse effect on the Company's
business, financial condition and results of operations. Any failure by the
Company to control the use, disposal, removal or storage of, or to adequately
restrict the discharge of, or assist in the cleanup of, hazardous chemicals or
hazardous, infectious or toxic substances could subject the Company to
significant liabilities, including joint and several liability under certain
statutes. The imposition of such liabilities would have a material adverse
effect on the Company's business, financial condition and results of
operations.
 
POTENTIAL PRODUCT LIABILITY; AVAILABILITY OF INSURANCE
 
  The Company is, and will continue to be, subject to the risk of product
liability claims alleging that the use of its products has adverse effects on
patients. This risk exists for product candidates tested in human clinical
trials as well as products that are sold commercially, if any. Further, given
the medical conditions for which the Aastrom CPS is expected to be utilized,
any product liability claim could entail substantial compensatory and punitive
damages. The assertion of product liability claims against the Company could
result in a substantial cost to, and diversion of efforts by, the Company.
There can be no assurance that the Company would prevail in any such
litigation or that product liability claims, if made, would not result in a
recall of the Company's products or a change in the indications for which they
may be used. The Company maintains product liability insurance coverage in the
aggregate of $5,000,000 for claims arising from the use of its product
candidates in clinical trials. There can be no assurance that the Company will
be able to maintain such insurance or obtain product liability insurance in
the future to cover any of its product candidates which are commercialized or
that such existing or any future insurance and the resources of the Company
would be sufficient to satisfy any liability resulting from product liability
claims. Consequently, a product liability claim or other claim with respect to
uninsured or underinsured liabilities could have a material adverse effect on
the Company's business, financial condition and results of operations.
 
DEPENDENCE ON KEY PERSONNEL
 
  The success of the Company depends in large part upon the Company's ability
to attract and retain highly qualified scientific and management personnel.
The Company faces competition for such personnel from other companies,
research and academic institutions and other entities. There can be no
assurance that the Company will be successful in hiring or retaining key
personnel. See "Business--Employees" and "Management."
 
SHARES ELIGIBLE FOR FUTURE SALE
 
  Sales of substantial amounts of Common Stock in the public market following
this offering could adversely affect the prevailing market price of the Common
Stock and the Company's ability to raise capital in the future. Upon
completion of this offering, the Company will have a total of 13,235,734
shares of Common Stock outstanding, of which the 3,250,000 shares offered
hereby will be freely tradeable without restriction under the Securities Act
of 1933, as amended (the "Securities Act") by persons other than "affiliates"
of the Company,
 
                                      12

<PAGE>
 
as defined under the Securities Act. The remaining 9,985,734 shares of Common
Stock outstanding are "restricted securities" as the term is defined by Rule
144 promulgated under the Securities Act (the "Restricted Shares"). Of the
9,985,734 Restricted Shares, 6,996,920 shares may be sold under Rule 144,
subject in some cases to certain volume restrictions and other conditions
imposed thereby. An additional 152,056 shares will become eligible for sale 90
days after completion of the offering pursuant to Rule 144 and 701. The
remaining 2,836,758 shares will be eligible for sale upon the expiration of
their respective holding periods as set forth in Rule 144. The Securities and
Exchange Commission has proposed certain amendments to Rule 144 that would
reduce by one year the holding periods required for shares subject to Rule 144
to become eligible for resale in the public market. This proposal, if adopted,
would permit earlier resale of shares of Common Stock currently subject to
holding periods under Rule 144. No assurance can be given concerning whether
or when the proposal will be adopted by the Securities and Exchange
Commission. Furthermore, 9,947,757 of the Restricted Shares are subject to
lock-up agreements expiring 180 days following the date of this Prospectus.
Such agreements provide that Cowen & Company may, in its sole discretion and
at any time without notice, release all or a portion of the shares subject to
these lock-up agreements. Upon the expiration of the lock-up agreements,
7,148,976 of the 9,985,734 Restricted Shares may be sold pursuant to Rule 144
or 701, subject in some cases to certain volume restrictions imposed thereby.
Certain existing shareholders have rights to include shares of Common Stock
owned by them in future registrations by the Company for the sale of Common
Stock or to request that the Company register their shares under the
Securities Act. See "Description of Capital Stock--Registration Rights."
Following the date of this Prospectus, the Company intends to register on one
or more registration statements on Form S-8 approximately 1,837,160 shares of
Common Stock issuable under its stock option and stock purchase plans. Of the
1,837,160 shares issuable under its stock option and stock purchase plans,
336,254 shares are subject to outstanding options as of September 30, 1996,
all of which shares are subject to lock-up agreements. Shares covered by such
registration statements will immediately be eligible for sale in the public
market upon the filing of such registration statements. The Company also has
issued warrants to purchase 69,444 shares of Common Stock which become
exercisable 90 days after the closing of this offering and, upon the effective
date of this offering, will grant an immediately exercisable option to
purchase 333,333 shares of Common Stock. The shares issuable upon exercise of
such warrants and the shares issuable upon exercise of such option will be
subject to lock-up agreements. In addition, Cobe has agreed to purchase
$5,000,000 of Common Stock in this offering at the initial public offering
price per share, all of which shares will be subject to a lock-up agreement.
See "Management--Benefit Plans," "Certain Transactions" and "Shares Eligible
for Future Sale."
 
CONTROL BY EXISTING MANAGEMENT AND SHAREHOLDERS
 
  Upon completion of this offering, the Company's directors, executive
officers, and certain principal shareholders, including Cobe, affiliated with
members of the Board of Directors and their affiliates will beneficially own
approximately 44% of the Common Stock (approximately 42% if the Underwriters'
over-allotment option is exercised in full). Accordingly, such shareholders,
acting together, may have the ability to exert significant influence over the
election of the Company's Board of Directors and other matters submitted to
the Company's shareholders for approval. The voting power of these holders may
discourage or prevent certain takeovers or changes in control of the
management of the Company unless the terms are approved by such holders. See
"Principal Shareholders."
 
NO PRIOR PUBLIC MARKET; POSSIBLE STOCK PRICE VOLATILITY
 
  Prior to this offering there has been no public market for the Common Stock,
and an active public market for the Common Stock may not develop or be
sustained. The initial public offering price will be determined through
negotiation between the Company and the Representatives of the Underwriters
based on several factors that may not be indicative of future market prices.
See "Underwriting" for a discussion of the factors considered in determining
the initial public offering price. The trading price of the Common Stock and
the price at which the Company may sell securities in the future could be
subject to wide fluctuations in response to announcements of clinical results,
research activities, technological innovations or new products by the Company
or competitors,
 
                                      13

<PAGE>
 
changes in government regulation, developments concerning proprietary rights,
variations in the Company's operating results, announcements by the Company of
regulatory developments, litigation, disputes concerning patents or
proprietary rights or public concern regarding the safety, efficacy or other
implications of the products or methodologies to be developed by the Company
or its collaborators or enabled by the Company's technology, general market
conditions, the liquidity of the Company or its ability to raise additional
funds, and other factors or events. In addition, the stock market has
experienced extreme fluctuations in price and volume. This volatility has
significantly affected the market prices for securities of emerging
biotechnology companies for reasons frequently unrelated to or
disproportionate to the operating performance of the specific companies. These
market fluctuations as well as general fluctuations in the stock markets may
adversely affect the market price of the Common Stock.
 
ANTI-TAKEOVER EFFECT OF CHARTER AND BY-LAW PROVISIONS AND MICHIGAN LAW
 
  The Company's Restated Articles of Incorporation authorize the Board of
Directors to issue, without shareholder approval, 5,000,000 shares of
Preferred Stock with voting, conversion, and other rights and preferences that
could materially and adversely affect the voting power or other rights of the
holders of Common Stock. The issuance of Preferred Stock or of rights to
purchase Preferred Stock could be used to discourage an unsolicited
acquisition proposal. The Company's Bylaws contain procedural restrictions on
director nominations by shareholders and the submission of other proposals for
consideration at shareholder meetings. The possible issuance of Preferred
Stock and the procedures required for director nominations and shareholder
proposals could discourage a proxy contest, make more difficult the
acquisition of a substantial block of Common Stock, or limit the price that
investors might be willing to pay in the future for shares of Common Stock. In
addition, certain provisions of Michigan law applicable to the Company could
also delay or make more difficult a merger, tender offer, or proxy contest
involving the Company. See "Description of Capital Stock."
 
IMMEDIATE AND SUBSTANTIAL DILUTION; ABSENCE OF DIVIDENDS
 
  Purchasers of the Common Stock in this offering will experience immediate
and substantial dilution in the net tangible book value of the Common Stock.
Additional dilution is likely to occur upon the exercise of outstanding
options granted by the Company. The Company has never paid cash dividends and
does not anticipate paying any cash dividends in the foreseeable future. See
"Dilution" and "Dividend Policy."
 
                                      14

<PAGE>
 

                                  THE COMPANY
 
  Aastrom was incorporated in Michigan in March 1989 under the name Ann Arbor
Stromal, Inc. In 1991, the Company changed its name to Aastrom Biosciences,
Inc. The Company's principal executive offices are located at 24 Frank Lloyd
Wright Drive, P.O. Box 376, Ann Arbor, Michigan 48106 and its telephone number
is
(313) 930-5555. Aastrom(TM) and the Company's stylized logo are trademarks of
the Company. Leukine and Neupogen are registered trademarks of Immunex
Corporation and Amgen, Inc., respectively.
 

                                USE OF PROCEEDS
 
  The net proceeds to the Company from the sale of the 3,250,000 shares of
Common Stock offered hereby are estimated to be $26,302,500 ($30,382,875 if
the Underwriters exercise their over-allotment option in full), at an assumed
initial public offering price of $9.00 per share and after deducting
underwriting discounts and commissions and estimated offering expenses payable
by the Company.
   
  The Company currently intends to use approximately $16,000,000 of the net
proceeds from the offering to fund product and clinical development activities
for the Aastrom CPS, including pre-pivotal and pivotal clinical trials and
approximately $7,000,000 for other research activities with the remaining
amount being used for working capital and other general corporate purposes,
including scheduled repayments of obligations under equipment leases. The
Company has $339,000 of outstanding equipment lease commitments as of
September 30, 1996 with final payments due between November 1996 and May 1999
and bear interest ranging from 9.7% to 12.1%.     
   
   Based on its current operating plan, the Company anticipates that the net
proceeds of this offering, together with the Company's available cash and
expected interest income thereon, should be sufficient to finance the
Company's research and development and other working capital requirements
until late 1998. This estimate is based on certain assumptions which could be
negatively impacted by the matters discussed in "Risk Factors" and
"Management's Discussion and Analysis of Financial Condition and Results of
Operations--Liquidity and Capital Resources." Pending such uses, the net
proceeds will be invested in short-term, interest bearing investment grade
securities.     
 

                                DIVIDEND POLICY
 
  The Company has never declared or paid any cash dividends on its Common
Stock and does not anticipate paying such cash dividends in the foreseeable
future. The Company currently anticipates that it will retain all future
earnings, if any, for use in the development of its business.
 
                                      15

<PAGE>
 

                                CAPITALIZATION
 
  The following table sets forth the capitalization of the Company (i) as of
September 30, 1996, and (ii) on a pro forma as adjusted basis to reflect the
conversion of all outstanding shares of Preferred Stock into Common Stock upon
the closing of this offering and the receipt of the estimated net proceeds
from the Company's sale of 3,250,000 shares of Common Stock pursuant to this
offering. See "Use of Proceeds" and "Certain Transactions."
 

<TABLE>
<CAPTION>
                                                         SEPTEMBER 30, 1996
                                                      -------------------------
                                                                    PRO FORMA
                                                        ACTUAL     AS ADJUSTED
                                                      -----------  ------------
<S>                                                   <C>          <C>
Long-term portion of capital lease obligations(1).... $   147,000  $    147,000
Shareholders' equity(2):
 Preferred stock, no par value: 10,157,647 shares au-
    thorized, 9,657,648 shares issued and outstand-
    ing, actual; 5,000,000 shares authorized, no
    shares issued and outstanding, as adjusted.......  37,718,000           --
 Common stock, no par value: 18,500,000 shares autho-
    rized, 1,887,312 shares issued and outstanding,
    actual; 40,000,000 shares authorized, 13,235,734
    issued and outstanding, as adjusted, in each case
    net of shareholder notes receivable..............     198,000    64,218,500
Deficit accumulated during the development stage..... (30,298,000)  (30,298,000)
                                                      -----------  ------------
Total shareholders' equity...........................   7,618,000    33,920,500
                                                      -----------  ------------
Total capitalization................................. $ 7,765,000  $ 34,067,500
                                                      ===========  ============
</TABLE>

- --------
(1) See Note 7 of Notes to Financial Statements.
(2) Excludes options and warrants to purchase 1,132,361 shares of Common Stock
    at a weighted average exercise price of $6.50 per share, assuming the
    closing of this offering at an initial public offering price of $9.00 per
    share. See "Management--Stock Option and Employee Benefit Plans" and Notes
    4 and 9 of Notes to Financial Statements.
 
                                      16

<PAGE>
 
                                   DILUTION
 
  The Company's pro forma net tangible book value at September 30, 1996 was
approximately $7,618,000 or $.76 per share. Pro forma net tangible book value
per share represents the amount of the Company's shareholders' equity, less
intangible assets, divided by 9,985,734, the number of shares of Common Stock
outstanding as of September 30, 1996, after giving effect to the automatic
conversion of all Preferred Stock into Common Stock upon the closing of this
offering.
 
  After giving effect to the sale of 3,250,000 shares of Common Stock in this
offering at an assumed initial public offering price of $9.00 per share and
after deducting underwriting discounts and commissions and estimated offering
expenses payable by the Company, the pro forma net tangible book value of the
Company as of September 30, 1996 would have been $33,920,500, or $2.56 per
share. This represents an immediate increase in pro forma net tangible book
value of $1.80 per share to existing shareholders and an immediate dilution in
pro forma net tangible book value of $6.44 per share to purchasers of Common
Stock in this offering, as illustrated in the following table:
 

<TABLE>
     <S>                                                            <C>   <C>
     Assumed initial public offering price per share...............       $9.00
      Pro forma net tangible book value per share as of September
       30, 1996.................................................... $ .76
      Increase per share attributable to new investors.............  1.80
                                                                    -----
     Pro forma net tangible book value per share after this offer-
      ing..........................................................        2.56
                                                                          -----
     Dilution per share to new investors...........................       $6.44
                                                                          =====
</TABLE>

 
  Utilizing the foregoing assumptions, the following table summarizes the
total consideration paid to the Company and the average price per share paid
by the existing shareholders and by purchasers of shares of Common Stock in
this offering:
 

<TABLE>
<CAPTION>
                           SHARES PURCHASED     TOTAL CONSIDERATION
                         --------------------- ---------------------- AVERAGE PRICE
                           NUMBER   PERCENTAGE   AMOUNT    PERCENTAGE   PER SHARE
                         ---------- ---------- ----------- ---------- -------------
<S>                      <C>        <C>        <C>         <C>        <C>
Existing shareholders...  9,985,734     75%    $38,083,000     57%        $3.81
New investors...........  3,250,000     25%     29,250,000     43%         9.00
                         ----------    ---     -----------    ---
  Total................. 13,235,734    100%    $67,333,000    100%
                         ==========    ===     ===========    ===
</TABLE>

- --------
  The foregoing excludes options and warrants to purchase 1,132,361 shares of
Common Stock at a weighted average exercise price of $6.50 per share, assuming
the closing of this offering at an initial public offering price of $9.00 per
share. In the event such options and warrants are exercised, investors may
experience further dilution. See "Management--Stock Option and Employee
Benefit Plans" and Notes 4 and 9 of Notes to Financial Statements.
 
                                      17

<PAGE>
 
                            SELECTED FINANCIAL DATA
   
  The statement of operations data for the fiscal years ended June 30, 1994,
1995 and 1996, for the period from Inception to June 30, 1996 and the balance
sheet data at June 30, 1995 and 1996, are derived from, and are qualified by
reference to, the audited financial statements included elsewhere in the
Prospectus and should be read in conjunction with those financial statements
and notes thereto. The statement of operations data for the fiscal years ended
June 30, 1992 and 1993, and the balance sheet data at June 30, 1992, 1993 and
1994, are derived from audited financial statements not included herein. The
information presented below for the three-month periods ended September 30,
1995 and 1996, for the period from Inception to September 30, 1996 and as of
September 30, 1996, have been derived from the unaudited financial statements
of the Company. In the opinion of the Company's management, the unaudited
financial statements have been prepared by the Company on a basis consistent
with the Company's audited financial statements and include all adjustments,
consisting of only normal recurring accruals, necessary for a fair
presentation of the financial position and the results of operations for those
periods. Operating results for the three-month period ended September 30, 1996
are not necessarily indicative of the results that will be achieved for the
entire year ended June 30, 1997. The data set forth below are qualified by
reference to, and should be read in conjunction with, the financial statements
and notes thereto, and Management's Discussion and Analysis of Financial
Condition and Results of Operations.     
 

<TABLE>   
<CAPTION>
                                                   YEAR ENDED JUNE 30,                           INCEPTION TO
                               ----------------------------------------------------------------    JUNE 30,
                                  1992         1993         1994         1995          1996          1996
                               -----------  -----------  -----------  -----------  ------------  ------------
<S>                            <C>          <C>          <C>          <C>          <C>           <C>
STATEMENT OF OPERATIONS DATA:
Revenues:
 Research and
  development
  agreements....               $       --   $       --   $    49,000  $   396,000  $  1,342,000  $  1,787,000
 Grants.........                       --       784,000      823,000      121,000       267,000     1,995,000
                               -----------  -----------  -----------  -----------  ------------  ------------
 Total revenues.                       --       784,000      872,000      517,000     1,609,000     3,782,000
Costs and ex-
 penses:
 Research and
  development...                 1,090,000    2,600,000    5,627,000    4,889,000    10,075,000    25,075,000
 General and
  administrative.                  272,000    1,153,000    1,565,000    1,558,000     2,067,000     7,089,000
                               -----------  -----------  -----------  -----------  ------------  ------------
 Total costs
  and expenses..                 1,362,000    3,753,000    7,192,000    6,447,000    12,142,000    32,164,000
                               -----------  -----------  -----------  -----------  ------------  ------------
Loss before
 other income
 and expense....                (1,362,000)  (2,969,000)  (6,320,000)  (5,930,000)  (10,533,000)  (28,382,000)
                               -----------  -----------  -----------  -----------  ------------  ------------
Other income
 (expense):
 Interest in-
  come..........                    94,000      148,000      245,000      279,000       678,000     1,576,000
 Interest ex-
  pense.........                       --       (26,000)     (65,000)     (66,000)      (62,000)     (219,000)
                               -----------  -----------  -----------  -----------  ------------  ------------
Net loss........               $(1,268,000) $(2,847,000) $(6,140,000) $(5,717,000) $ (9,917,000) $(27,025,000)
                               ===========  ===========  ===========  ===========  ============  ============
Pro forma net
 loss per
 share(1).......               $      (.32) $      (.49) $      (.82) $      (.66) $       (.98)
                               ===========  ===========  ===========  ===========  ============
Pro forma
 weighted
 average number
 of shares
 outstanding(1).                 3,919,000    5,840,000    7,461,000    8,644,000    10,103,000
                               ===========  ===========  ===========  ===========  ============
<CAPTION>
                                    THREE MONTHS
                                 ENDED SEPTEMBER 30,     INCEPTION TO
                               ------------------------- SEPTEMBER 30,
                                  1995         1996          1996
                               ------------ ------------ --------------
<S>                            <C>          <C>          <C>
STATEMENT OF OPERATIONS DATA:
Revenues:
 Research and
  development
  agreements....               $   172,000  $   195,000  $  1,982,000
 Grants.........                    39,000       29,000     2,024,000
                               ------------ ------------ --------------
 Total revenues.                   211,000      224,000     4,006,000
Costs and ex-
 penses:
 Research and
  development...                 1,195,000    3,160,000    28,235,000
 General and
  administrative.                  446,000      452,000     7,541,000
                               ------------ ------------ --------------
 Total costs
  and expenses..                 1,641,000    3,612,000    35,776,000
                               ------------ ------------ --------------
Loss before
 other income
 and expense....                (1,430,000)  (3,388,000)  (31,770,000)
                               ------------ ------------ --------------
Other income
 (expense):
 Interest in-
  come..........                   149,000      126,000     1,702,000
 Interest ex-
  pense.........                   (18,000)     (11,000)     (230,000)
                               ------------ ------------ --------------
Net loss........               $(1,299,000) $(3,273,000) $(30,298,000)
                               ============ ============ ==============
Pro forma net
 loss per
 share(1).......               $      (.13) $      (.32)
                               ============ ============
Pro forma
 weighted
 average number
 of shares
 outstanding(1).                10,094,000   10,107,000
                               ============ ============
</TABLE>
    
 

<TABLE>   
<CAPTION>
                                                 JUNE 30,
                         -------------------------------------------------------------  SEPTEMBER 30,
                            1992        1993        1994         1995         1996          1996
                         ----------  ----------  -----------  -----------  -----------  -------------
<S>                      <C>         <C>         <C>          <C>          <C>          <C>
BALANCE SHEET DATA:
 Cash, cash equivalents
  and short-term invest-
  ments................. $5,640,000  $3,085,000  $ 6,730,000  $11,068,000  $10,967,000   $ 7,108,000
 Working capital........  5,399,000   2,744,000    6,187,000   10,319,000    9,851,000     6,540,000
 Total assets...........  6,414,000   4,156,000    8,227,000   12,551,000   12,673,000     8,931,000
 Long-term capital lease
  obligations...........        --      311,000      425,000      412,000      189,000       147,000
 Deficit accumulated
  during the development
  stage................. (2,404,000) (5,251,000) (11,391,000) (17,108,000) (27,025,000)  (30,298,000)
 Total shareholders' eq-
  uity..................  6,104,000   3,268,000    6,985,000   11,186,000   10,850,000     7,618,000
</TABLE>
    
- -------
(1) See Note 1 of Notes to Financial Statements for information concerning the
    computation of pro forma net loss per share and shares used in computing
    pro forma net loss per share.
 
                                      18

<PAGE>
 

                    MANAGEMENT'S DISCUSSION AND ANALYSIS OF
                 FINANCIAL CONDITION AND RESULTS OF OPERATIONS
 
OVERVIEW
   
  Since inception, the Company has been in the development stage and engaged
in research and product development, conducted both on its own behalf and in
connection with various collaborative research and development agreements with
other entities. The Company expects that its revenue sources for at least the
next several years will continue to be limited to grant revenues and research
funding, milestone payments and licensing fees from potential future corporate
collaborators. The timing and amount of such future cash payments and
revenues, if any, will be subject to significant fluctuations, based in part
on the success of the Company's research activities, the timing of the
achievement of certain milestones and the extent to which associated costs are
reimbursed under grant or other arrangements. Substantially all of the
Company's revenues from product sales, if any, will be subject to royalty
payments ranging from 2% to 5%. Further, under the Company's Distribution
Agreement with Cobe, Cobe will perform marketing and distribution activities
and in exchange will receive from 38% to 42% of the Company's product sales in
the area of stem cell therapy, subject to negotiated discounts and volume-
based adjustments. Research and development expenses may fluctuate due to the
timing of expenditures for the varying stages of the Company's research and
clinical development programs. Research and development expenses will increase
as product development programs and applications of the Company's products
progress through research and development stages. Under the Company's License
Agreement with Immunex, annual renewal fees of $1,000,000 are payable in each
of the next four years. Under the Company's Distribution Agreement with Cobe,
regulatory approval activities for the Company's products for stem cell
therapies outside of the United States will be conducted, and paid for, by
Cobe. As a result of these factors, the Company's results of operations have
fluctuated and are expected to continue to fluctuate significantly from year
to year and from quarter to quarter and therefore may not be comparable to or
indicative of the results of operations for other periods.     
 
  Over the past several years, the Company's net loss has primarily increased,
consistent with the growth in the Company's scope and size of operations. In
the near term, the Company plans additional moderate growth in employee
headcount necessary to address increasing requirements in the areas of product
development, research, clinical and regulatory affairs and administration.
Assuming capital is available to finance such growth, the Company's operating
expenses will continue to increase as a result. At least until such time as
the Company enters into arrangements providing research and development
funding, the net loss will continue to increase as well. The Company has been
unprofitable since its inception and does not anticipate having net income for
several years. Through September 30, 1996, the Company had an accumulated
deficit of $30,298,000. There can be no assurance that the Company will be
able to achieve profitability on a sustained basis, if at all.
 
  This Prospectus contains, in addition to historical information, forward-
looking statements that involve risks and uncertainties. The Company's actual
results could differ materially from the results discussed in the forward-
looking statements. Factors that could cause or contribute to such differences
include those discussed under this caption, as well as those discussed under
the caption "Risk Factors" and elsewhere in this Prospectus.
 
RESULTS OF OPERATIONS
 
  THREE MONTHS ENDED SEPTEMBER 30, 1996 AND 1995
 
  Total revenues were $224,000 for the three months ended September 30, 1996
compared to $211,000 for the same period in 1995. These revenues consist
primarily of research and development revenue under the Company's research
collaboration with RPR, which was terminated in September 1996. See "Certain
Transactions."
 
  Total costs and expenses were $3,612,000 for the three months ended
September 30, 1996 compared to $1,641,000 for the same period in 1995. The
increase in costs and expenses in 1996 is primarily the result of an increase
in research and development expenses to $3,160,000 in 1996 from $1,195,000 in
1995 and to a lesser extent by general and administrative expenses, which
increased to $452,000 for the three months ended September 30, 1996 from
$446,000 for the same period in 1995.
 
                                      19

<PAGE>
 
  Interest income was $126,000 for the three months ended September 30, 1996
compared to $149,000 for the same period in 1995 and reflects a decrease in
the levels of cash, cash equivalents and short-term investments in 1996.
 
  The Company's net loss increased to $3,273,000 for the three months ended
September 30, 1996 from $1,299,000 for the same period in 1995, primarily as a
result of increased costs and expenses in 1996.
 
  YEARS ENDED JUNE 30, 1996, 1995 AND 1994
   
  Total revenues were $1,609,000 in 1996, $517,000 in 1995, and $872,000 in
1994. Grant revenues increased to $267,000 in 1996 from $121,000 in 1995,
which had decreased from $823,000 in 1994, reflecting the timing of grant
awards and related research activities, to the extent that such associated
costs are reimbursed under the grants. Grant revenues accounted for 17%, 23%
and 94% of total revenues for the years ended June 30, 1996, 1995 and 1994,
respectively. Revenues from research and development agreements totaled
$1,342,000 in 1996, $396,000 in 1995 and $49,000 in 1994, reflecting research
funding received by the Company under its collaboration with RPR which
commenced in September 1995. Revenues from RPR accounted for 83% and 48% of
such revenue in 1996 and 1995, respectively. In September 1996, the Company's
research collaboration with RPR terminated.     
 
  Total costs and expenses were $12,142,000 in 1996, $6,447,000 in 1995, and
$7,192,000 in 1994. The increase in 1996 costs and expenses, compared with
1995, is primarily the result of an increase in research and development
expense to $10,075,000 in 1996 from $4,889,000 in 1995. The increase in
research and development expense reflects an increase in research, clinical
development and product development activities. The decrease in costs and
expenses in 1995, compared with 1994, is primarily the result of a decrease in
research and development expense to $4,889,000 in 1995 from $5,627,000 in
1994. General and administrative expenses were $2,067,000 in 1996, $1,558,000
in 1995 and $1,565,000 in 1994. The increase in general and administrative
expenses in 1996 is the result of increasing finance, legal and other
administrative and marketing expenses which are expected to continue to
increase in support of the Company's increasing product development and
research activities. The decrease in general and administrative expense in
1995 is reflective of generally lower spending in 1995 as compared to 1994.
 
  Interest income was $678,000 in 1996, $279,000 in 1995, and $245,000 in
1994. The increases in interest income in 1996 and 1995 are due primarily to
corresponding increases in the levels of cash, cash equivalents and short-term
investments for such periods. Interest expense was $62,000 in 1996, $66,000 in
1995, and $65,000 in 1994, reflecting varying amounts outstanding under
capital leases during the periods.
 
  The Company's net loss was $9,917,000 in 1996, $5,717,000 in 1995, and
$6,140,000 in 1994. The Company expects to report substantial net losses for
at least the next several years.
 
  The Company has not generated any net income to date and therefore has not
paid any federal income taxes since inception. At June 30, 1996, the Company
had deferred tax assets totaling $9,650,000 consisting primarily of net
operating loss and research tax credits that begin to expire from 2004 through
2011, if not utilized. A full valuation allowance for deferred tax assets has
been provided. Utilization of federal income tax carryforwards is subject to
certain limitations under Section 382 of the Internal Revenue Code of 1986, as
amended. The completion of this offering is likely to limit the Company's
ability to utilize federal income tax carryforwards under Section 382. The
annual limitation could result in expiration of net operating losses and
research and development credits before their complete utilization.
 
LIQUIDITY AND CAPITAL RESOURCES
 
  The Company has financed its operations since inception primarily through
private placements of Preferred Stock and other equity investments, which from
inception, have totaled approximately $37,916,000, and to a lesser degree,
through grant funding, payments received under research agreements and
collaborations, interest
 
                                      20

<PAGE>
 
earned on cash, cash equivalents, and short-term investments, and funding
under equipment leasing agreements. These financing sources have historically
allowed the Company to maintain adequate levels of cash and other liquid
investments.
 
  The Company's combined cash, cash equivalents and short-term investments
totaled $10,967,000 at June 30, 1996, a decrease of $101,000 from June 30,
1995. The primary uses of cash, cash equivalents and short-term investments
during the year ended June 30, 1996 included $8,967,000 to finance the
Company's operations and working capital requirements, $445,000 in capital
equipment additions and $270,000 in scheduled debt payments. During the year
ended June 30, 1996, the Company received $3,500,000 in equity payments from
RPR and $5,965,000 in net proceeds from the sale of Series E Convertible
Preferred Stock. The Company plans to continue its policy of investing excess
funds in short-term, investment-grade, interest-bearing instruments.
 
  The Company's combined cash, cash equivalents and short-term investments
totaled $7,108,000 as of September 30, 1996 compared to $10,967,000 at June
30, 1996. The decrease was primarily attributable to the use of $3,614,000 to
fund operations and working capital requirements during the period and to a
lesser degree by $173,000 in capital equipment purchases and $73,000 in
scheduled debt payments.
   
  In October 1996, the Company executed a financing commitment to provide the
Company with up to $5,000,000 in additional equity funding from Cobe and
$5,000,000 under a convertible loan agreement with another current investor.
In connection with the convertible loan agreement, the Company has issued
warrants to purchase 69,444 shares of Common Stock for securing the
commitment. The warrants expire on October 15, 2000 if not exercised, and may
be exercised, in whole or in part, at a price equal to the lesser of (a) $9.00
per share, which price increases by $3.00 per share on each anniversary of the
closing of the offering being made hereby; or (b) 85% of the fair market value
of the Company's Common Stock at the time of exercise. As of the date of this
Prospectus, the Company has not obtained any financing under these
commitments. These funding commitments expire upon the closing of this
offering. On December 10, 1996, the Company issued to Cobe a notice to sell to
Cobe 500,000 shares of Series F Preferred Stock for an aggregate purchase
price of $3,000,000. Such sale is scheduled to close on March 19, 1997. In the
event that this offering closes prior to March 19, 1997, Cobe's obligation to
purchase Series F Preferred Stock under the equity commitment will terminate.
In the event that this offering closes after March 19, 1997, Cobe's
participation in this offering will be reduced by $3,000,000, the amount of
its purchase of Series F Preferred Stock pursuant to the equity commitment.
       
  The Company's future cash requirements will depend on many factors,
including continued scientific progress in its research and development
programs, the scope and results of clinical trials, the time and costs
involved in obtaining regulatory approvals, the costs involved in filing,
prosecuting and enforcing patents, competing technological and market
developments and the cost of product commercialization. The Company does not
expect to generate a positive cash flow from operations for several years, if
at all, due to the expected increase in spending for research and development
programs and the expected cost of commercializing its product candidates. The
Company may seek additional funding through research and development
agreements with suitable corporate collaborators and through public or private
financing transactions. The Company anticipates that the net proceeds of this
offering, together with the Company's available cash and expected interest
income thereon, will be sufficient to finance its research and development and
other working capital requirements until late 1998. This estimate is based on
certain assumptions which could be negatively impacted by the matters
discussed under this heading and elsewhere under the caption "Risk Factors."
The Company expects that its primary sources of capital for the foreseeable
future will be through collaborative arrangements and through the public or
private sale of its equity securities. There can be no assurance that such
collaboration arrangements, or any public or private financing transaction,
will be available on acceptable terms, if at all, or can be sustained on a
long-term basis. If adequate funds are not available, the Company may be
required to delay, reduce the scope of, or eliminate one or more of its
research and development programs, which may have a material adverse effect on
the Company's business. See "Risk Factors--Future Capital Needs; Uncertainty
of Additional Funding" and Notes to Financial Statements.     
 
                                      21

<PAGE>
 
RECENT PRONOUNCEMENTS
 
  During October 1995, the Financial Accounting Standards Board issued
Statement No. 123, "Accounting for Stock-Based Compensation," which
establishes a fair value based method of accounting for stock-based
compensation and incentive plans and requires additional disclosures for those
companies that elect not to adopt the new method of accounting. Adoption of
the new accounting pronouncement is required for the Company's fiscal year
beginning July 1, 1996 and the Company intends to provide the additional
disclosures required by the pronouncement in its financial statements for the
year ended June 30, 1997.
   
  During March 1995, the Financial Accounting Standards Board issued Statement
No. 121, ("SFAS 121") "Accounting for the Impairment of Long-Lived Assets and
for Long-Lived Assets to Be Disposed Of," which requires the Company to review
for impairment of long-lived assets, certain identifiable intangibles, and
goodwill related to those assets whenever events or changes in circumstances
indicate that the carrying amount of an asset might not be recoverable. In
certain situations, an impairment loss would be recognized. SFAS 121 will
become effective for the Company's fiscal year beginning July 1, 1996.
Management has studied the effect of implementing SFAS 121 and, based upon its
evaluation, has determined that the impact on the Company's financial
condition and results of operations is not significant for the period ended
September 30, 1996.     
 
                                      22

<PAGE>
 

 
                                  BUSINESS
 
OVERVIEW
   
  Aastrom is developing proprietary process technologies and devices for a
range of cell therapy applications, including stem cell therapies and gene
therapy. The Company's lead product under development, the Aastrom Cell
Production System (the "Aastrom CPS"), consists of a clinical cell culture
system with disposable cassettes and reagents for use in the rapidly growing
stem cell therapy market. The Company believes that the Aastrom CPS method
will be less costly, less invasive and less time consuming than currently
available stem cell collection methods. The Aastrom CPS is designed as a
platform product which implements the Company's pioneering stem cell
replication technology. The Company also believes that the Aastrom CPS can be
modified to produce a wide variety of other cell types for new, emerging
therapies being developed by others. Prior to commencement of multiple-site
pivotal trials, the Company is conducting a limited "pre-pivotal" trial of the
Aastrom CPS under an Investigational Device Exemption for use in stem cell
therapy. The Company has entered into a strategic collaboration for the
development of the Aastrom CPS in stem cell therapy with Cobe BCT, Inc., a
subsidiary of Gambro AB and a leading provider of blood cell processing
products. Additionally, Aastrom is developing products and processes for the
delivery of ex vivo gene therapy that are designed to address the production
of gene-modified cells.     
 
CELL THERAPY
 
  Cell therapy is the use of human cells to treat a medical disorder. The most
common types of cell therapy, blood and platelet transfusions, have been
widely used for many decades. More recently, bone marrow-derived cells have
been used to restore the bone marrow and the blood and immune system cells
which are damaged by chemotherapy and radiation therapy during the treatment
of many cancers. Transplantation of these cells is known as stem cell therapy.
Other cell therapies have recently been used for generating skin and cartilage
tissue and additional cell therapies are being developed by various companies
and researchers to restore immune system cells as well as bone, kidney, liver,
vascular and neuronal tissues.
 
  Cell therapies require the collection of cells, either from the patient or a
suitably matched donor. These cells are typically processed and stored for
administration to the patient. Although cell therapy is being developed for
use in an increasing number of diseases, widespread application of new cell
therapies remains limited by the difficulties and expense associated with
current cell collection and processing procedures. The problems of current
cell collection techniques are exemplified in the area of stem cell therapy
where the patient or donor undergoes invasive, time-consuming and costly
procedures to collect the large volume of cells currently required for
effective treatment. The Company believes an alternative to collecting the
required therapeutic dose of cells is to grow these cells ex vivo from a small
starting volume. However, ex vivo cell expansion, when biologically possible,
has typically required costly techniques, facilities and operations to comply
with FDA good manufacturing practices ("GMP"), which are not generally
available in hospitals. As a result, cells needed for such therapies often
require specialized cell production facilities which use labor-intensive,
manual cell culture techniques.
 
  There are numerous forms of cell therapy at an early stage of development.
One such example is ex vivo gene therapy, in which genes are introduced into
target cells in order to selectively correct or modulate disease conditions,
or to modify cells for production of a therapeutic protein. The Company
believes that the successful practice of ex vivo gene therapy will require the
development of processes and products for the reliable, high-efficiency
transfer of genes into cells and a means to produce the necessary dose of the
genetically modified cells under GMP conditions.
 
STEM CELL THERAPY
 
  Stem cell therapy is used to treat cancer patients who undergo chemotherapy
or radiation therapy at dose levels that are toxic to the hematopoietic
system, which is comprised of the bone marrow and cells of the blood and
immune systems. The objective of stem cell therapy is to restore the
hematopoietic system via the infusion and subsequent engraftment of healthy
cells to replace bone marrow and result in the rapid recovery of neutrophils
and platelets that have been destroyed by chemotherapy and radiation therapy.
Stem cell therapy
 
                                      23

<PAGE>
 
reduces the risk of life-threatening infections and bleeding episodes
following cancer treatments. In order to treat many cancers, high intensity
chemotherapy or radiation is often required, which may severely destroy
("myeloablation") or partially destroy ("myelosuppression") the patient's
hematopoietic system.
 
  Cells required for effective stem cell therapy include stem cells, to
replenish depleted bone marrow and provide a long-term ongoing source of the
multilineage progenitor cells of the blood and immune systems, and early and
late stage hematopoietic progenitor cells, to provide for rapid neutrophil and
platelet recoveries. Stromal accessory cells are believed to further augment
the growth of bone marrow. In the adult, all of these cell types originate in
the bone marrow. These cells are currently collected from the donor or patient
directly through multiple syringe aspirations under anesthesia, known as bone
marrow collection, or through blood apheresis following treatment with drugs
which cause cells to be released or mobilized from the bone marrow into the
blood. This latter technique is known as a peripheral blood progenitor cell
("PBPC") collection. See "--Current Stem Cell Collection Methods." Recently,
it has been demonstrated that the blood cells found in the umbilical cord of
newborn infants include cells effective for stem cell therapy. This source of
cells is being explored by physicians as a major new direction in stem cell
therapy, but is currently limited by difficulties in obtaining sufficient
quantities of these cells.
 
  Once collected, the stem cell mixture is infused intravenously and the stem
and stromal accessory cells migrate into the bone cavity where they engraft to
form a new marrow. The hematopoietic progenitor cell components of the cell
mixture provide early restoration of circulating white blood cells and
platelets. The replenished bone marrow will normally provide long-term
hematopoietic function, but complete restoration of bone marrow may take years
following myeloablative cancer therapy. When the patient's hematopoietic
system is malignant, such as in the case of leukemia, cells from a suitable
donor are generally required in order to avoid reintroducing the disease
during cell infusion. Such donor derived transplants are termed "allogeneic"
transplants. Procedures using cells derived from the patient are termed
"autologous" transplants.
 
  STEM CELL THERAPY MARKET OPPORTUNITY
 
  The benefits of stem cell therapy in the treatment of cancer patients have
been well established over the past two decades. Stem cell therapy, in the
form of bone marrow transplantation, was originally used in patients who had
received treatment for blood and bone marrow cancers such as leukemia, and
genetic diseases of the blood. However, because stem cell therapy has been
shown to promote the rapid recovery of hematopoietic function, it is now being
increasingly used to enable patients with other forms of cancer to receive
high dose or multicycle chemotherapy and radiation treatments. These high-
intensity therapies have a greater probability of eradicating dose-sensitive
cancers but, because of their hematopoietic toxicity, cannot generally be
given without stem cell therapy. As a result, some patients are treated with
lower and less effective doses, and fewer cycles, of therapy than might
otherwise be used.
   
  According to an industry source, approximately 32,000 stem cell therapy
procedures were completed worldwide in 1995, and, according to another
industry source, the number of such procedures utilizing donor-derived and
patient-derived cells has been growing annually by approximately 15% and 20%,
respectively. This growth has been driven by encouraging clinical results in
the treatment of dose-sensitive solid tumors, such as breast and ovarian
cancers. The Company expects that stem cell therapy procedures will continue
to grow due to increased incidence and prevalence of cancer, continued
clinical demand for myelotoxic cancer treatment, and the increased cost
effectiveness of stem cell therapy treatments.     
 
  Stem cell therapy may also enhance the effectiveness of blood cell growth
factors. The timing and extent of additional cycles of chemotherapy is often
limited by the recovery of a patient's white blood cells and platelets because
a delayed recovery of these cells can leave the patient susceptible to life-
threatening infection and bleeding episodes, and this limitation may allow for
the regrowth of residual tumor cells. Many cancer patients are routinely
treated with growth factors including G-CSF, such as Neupogen and GM-CSF, such
as Leukine, which enhance the development of mature circulating white blood
cells and platelets from the early progenitor bone-marrow derived cells,
thereby decreasing the time between cycles of therapy and the probability of
infection. However, during high dose or multicycle therapy, the stem and
progenitor cells on which these growth
 
                                      24

<PAGE>
 
factors act are often depleted. Without these cells, growth factors have a
limited or negligible effect. Stem cell therapy generally enhances the
effectiveness of growth factors by introducing target stem and progenitor
cells for growth factors to act upon such that patients generally exhibit a
more rapid and consistent hematopoietic recovery.
 
  CURRENT STEM CELL COLLECTION METHODS
 
  Currently, the bone marrow-derived cells required for stem cell therapy are
collected primarily either through the bone marrow harvest method or the PBPC
collection method.
 
  Bone Marrow Harvest
 
  A traditional bone marrow harvest is a costly and invasive surgical
procedure in which a physician removes approximately one liter of bone marrow
from a patient or donor. This volume of bone marrow is removed using needles
inserted into the cavity of the hip bone. The bone marrow harvest procedure
typically requires between two to four hours of operating room time, with the
physician often making more than 90 separate puncture sites in the hip bone to
collect the necessary amount of bone marrow. Due to the length of the
procedure and the trauma to the patient, general surgical anesthesia is
administered and the patient is often hospitalized for a day. Frequently, the
patient suffers pain from the procedure for several days after being
discharged from the hospital. Furthermore, complications resulting from the
general anesthesia or invasive nature of the procedure occur in a small
percentage of patients. Bone marrow harvest provides a reliable source of stem
and stromal accessory cells and has been the preferred source of cells in
allogeneic transplants.
 
  PBPC Mobilization and Collection
 
  PBPC mobilization is a newer technique in which bone marrow-derived cells
are harvested from a patient's or donor's circulating blood, rather than from
bone marrow. In a PBPC mobilization procedure, the patient receives multiple
injections of growth factors or cytotoxic drugs, or both, over the course of a
week or more, which cause stem and progenitor cells resident in the bone
marrow to mobilize into the circulating blood. The mobilized cells are then
collected by connecting the patient to a blood apheresis device, which draws
and returns large volumes of the patient's or donor's blood in order to
selectively remove the therapeutic volume of stem and progenitor cells. Each
collection procedure typically lasts for two to six hours and is typically
repeated on two to eight consecutive days. Specialized laboratory testing over
the period of mobilization and cell harvesting is necessary to determine that
a sufficient quantity of desired cells has been collected, adding to the cost
of the procedure. The PBPC process has become the predominant procedure in
autologous stem cell therapy.
 
  Procedure Considerations
 
  Although stem cell therapy is being utilized to treat more patients for a
broader range of diseases, its availability continues to be limited by the
high costs of procuring cells, the invasive nature of traditional cell
procurement techniques, and by the technical difficulties related to those
collection procedures. The Company believes that current charges for bone
marrow harvest, processing and infusion are approximately $10,000 to $15,000
per procedure, with considerable variability between institutions. The Company
believes that current charges for PBPC collection, including mobilization and
infusion, are approximately $12,000 to $20,000 for a two to three cycle
procedure, with considerable variability between institutions depending on the
mobilization regimen and the total volume, time and number of aphereses
required.
 
  Overall costs of stem cell therapy include the costs of the cell collection
and infusion procedures, and the costs associated with supporting the patient
during post-transplant recovery. Post-transplant costs include hospitalization
time, antibiotic support, management of adverse reactions to the large volume
cell infusions, and infusions of platelets and red blood cells. Any new stem
cell therapy process will generally need to provide similar recovery endpoints
to be competitive with the current procedures. In this regard, PBPC procedures
have gained popularity compared with bone marrow harvests because the number
of platelet transfusions is reduced for some patients.
 
                                      25

<PAGE>
 
  Recently, products to implement a cell isolation method known as CD34
selection have been developed by other companies in conjunction with bone
marrow harvest and PBPC collections. CD34 selection is a process designed to
isolate specific types of cells in order to decrease storage and infusion
problems associated with the large volume of fluids collected in bone marrow
or multiple apheresis procedures. CD34 selection is used after the initial
collection of stem and progenitor cells and, therefore, does not address the
difficulties or costs associated with the basic cell collection procedures. To
date, the CD34 selection procedure has demonstrated limited therapeutic
benefit to the patient, but substantially increases the costs of the
procedure. A future objective of CD34 selection is to assist in depleting
tumor cells from the transplant cells collected, thereby expanding the
availability of stem cell therapy to new patient populations.
 
  UMBILICAL CORD BLOOD
 
  Umbilical cord blood ("UCB"), which is collected directly from the umbilical
cord after delivery, without pain or risk to the infant or the mother, is
emerging as a new source of cells for stem cell therapy. UCB has been reported
to have stem cell concentrations that are much higher than that typically
obtained from traditional bone marrow and PBPC collection methods. After
collection, UCB is typically frozen for later use in a stem cell therapy
procedure. Storage of UCB samples involves small volumes of cells, compared to
typical bone marrow or PBPC storage. Accordingly, the costs of collection and
storage of UCB cells are comparatively low. This source of cells is also
"tumor-free," such that UCB would be preferred for many current stem cell
therapy procedures in metastatic cancer patients. Before UCB can become a
major supply source for stem cell therapy, a coordinated UCB banking system
must emerge. In this regard, several organized UCB banking institutions have
been established to date, and the group is growing in both number and size.
 
  One current disadvantage of UCB is the relatively low number of available
cells. Unlike bone marrow or PBPC harvest, where the collection of more cells
to meet a particular treatment is typically achievable, the number of cells
available from a UCB donor is limited. This problem is exacerbated by the
required cryopreservation of the cells, which causes significant cell loss.
The resultant low cell number is believed to be responsible for the longer
hematopoietic recovery times observed with UCB transplants, as compared with
bone marrow or PBPC transplants. Further, because of the low cell number, UCB
transplants are typically restricted to small patients. Therefore, increasing
the number of therapeutic cells from a UCB sample would facilitate the more
widespread use of UCB transplants. Aastrom believes that providing the
transplant site with the capability to carry out the UCB cell expansion will
be a major factor in the increased use of UCB for stem cell therapy and a
significant business opportunity.
 
AASTROM TECHNOLOGY
 
  Aastrom is developing proprietary process technologies that are pioneering
the ex vivo production of human stem and progenitor cells. The Company has
also developed a proprietary cell culture device that mimics the biological
and physical environment necessary for the growth of certain human cells and
tissues, including bone marrow. The Company's initial product candidate, the
Aastrom CPS, utilizes the Company's process technology and is designed to
enable the ex vivo production of human stem and progenitor cells as an
alternative to the bone marrow harvest and PBPC mobilization methods and as an
enhancement to the UCB collection method. The Company believes that the
Aastrom CPS may be used for other cell production processes which are being
developed by third parties and, in combination with the Company's proprietary
gene transfer process, may have application in the developing field of ex vivo
gene therapy.
 
  CORE TECHNOLOGY
 
  Stem Cell Growth Process
 
  Aastrom has developed proprietary process technologies for ex vivo
production of therapeutic stem and progenitor cells as well as other key cells
found in human bone marrow. The Company's proprietary process entails the
placement of a stem cell mixture in a culture environment that mimics the
biology and physiology of
 
                                      26

<PAGE>
 
natural bone marrow. This process enables the stem and early and late-stage
progenitor cells needed for an effective stem cell therapy procedure to be
concurrently expanded. Growth factors can be added to stimulate specific cell
lineages to grow or to increase cell growth to meet a particular therapeutic
objective. The stem cell growth process can best be completed with little or
no additional stem cell selection or purification procedures. This stem cell
replication process can also enable or augment the genetic modification of
cells by providing the cell division step needed for new genes to integrate
into the stem cell DNA. Currently available cell culture methods tend to
result in a loss of stem cells, either through death or through
differentiation into mature cells. The Company has exclusive licenses to two
U.S. patents and additional applications that cover these processes. See "--
Additional Stem Cell and Other Cell Therapies."
 
  Aastrom Cell Culture Chamber
 
  Aastrom has developed a proprietary cell culture chamber to implement the
Company's process technology. The culture chamber produces cells on a clinical
scale, and allow for simple, sterile recovery of the cells for therapeutic
use. The Company believes that the Aastrom cell culture chamber may also be
used for growing other human therapeutic cells, such as T-Cells used for
lymphocyte therapies, chondrocytes for cartilage replacement, and mesenchymal
tissues for bone and cartilage replacement. The Company holds exclusive
licenses to two U.S. patents and additional applications for its cell culture
chamber device technology. See "--Additional Stem Cell and Other Cell
Therapies."
 
  Efficient Gene Transfer
   
  Aastrom has developed proprietary processes and device technology that may
enable increased efficiency of vector-mediated gene transfer into cells as
compared to conventional procedures. This directed-motion gene transfer or
gene loading technology is being pursued by the Company for application in
most cell and tissue types and most vector technologies. The Company intends
to develop products based upon its gene loading technology. If successfully
developed into products, the Company believes that such products would
facilitate the advancement of numerous gene therapy protocols into the clinic
and ultimately the market. The Company is the exclusive licensee of a U.S.
Patent, and has additional applications pending, for this technology. See
"Aastrom Product Candidates For Ex Vivo Gene Therapy."     
 
  THE AASTROM CPS
 
  The Aastrom CPS is the Company's lead product under development for multiple
cell therapy applications, including stem cell therapy. The Aastrom CPS is a
proprietary system that the Company believes will enable the large scale ex
vivo production of a variety of therapeutic cells at health care facilities,
independent laboratories, transplant centers and blood banks, and has been
designed to implement Aastrom's stem cell growth process as well as processes
for the production of other cell types.
 
  The Aastrom CPS is comprised of several components, including single-use
disposable cassettes and reagents and microprocessor-controlled instruments,
which are at various stages of development. The Cell Cassette is a single-use
disposable cartridge which contains the Aastrom cell culture chamber and the
related media supply waste reservoirs and harvest bag. The microprocessor-
controlled instruments include the Incubator which controls the culture
conditions for the operation of the Cell Cassette, and the Processor which
automates the priming and harvesting of the cells from the Cell Cassette. The
System Manager is a user interface computer that is being developed to
simultaneously track and monitor the cell production process in over thirty
CPS Incubators and record relevant process variables and operator actions.
Prototype components of the Aastrom CPS are currently being used in a clinical
trial and ongoing development activities are directed at completing other
production level components of the Aastrom CPS.
 
  The Aastrom CPS is designed to be operated with minimal operator activity by
a medical or laboratory technician and can implement clinical scale cell
production at the patient care site. The end product of the Aastrom process is
a blood-bag container with the cell product. The control and documentation
features of the Aastrom CPS have been designed to meet GMP requirements for
the therapeutic production of cells.
 
                                      27

<PAGE>
 
  AASTROM CPS FOR STEM CELL THERAPY
   
  The Company's initial application for the Aastrom CPS is expected to be in
the growing field of stem cell therapy, where the Company believes that the
Aastrom CPS may address many of the limitations of existing procedures. The
Aastrom CPS is based on a comparatively simple process in which a small volume
of bone marrow cells are collected from the patient or donor using a needle
aspiration procedure typically under a local anesthetic or sedative. This cell
mixture is quantified, and an appropriate volume of cells is then inoculated
into one or more Cell Cassettes with the necessary growth media. Growth-
factor-stimulated cells are produced using the Aastrom CPS in approximately 12
to 13 days, with no further patient involvement. Depending upon the cell
quantity necessary for a therapeutic application, single or multiple Cell
Cassettes may be required, with a different volume requirement of starting
cells taken from the patient at the initial visit. The Aastrom CPS has been
designed to minimize operator involvement during the cell production process,
and the steps required before and after the Aastrom CPS are standard
laboratory procedures.     
   
  Potential Advantages of Aastrom CPS     
   
  The Company believes that the Aastrom CPS, if approved for commercial sale
by the FDA and foreign regulatory agencies, may provide certain improvements
and efficiencies over traditional cell collection and infusion processes. The
following table, which sets forth the Company's estimates based on a 1996
survey conducted by the Company of 11 stem cell transplant physicians at
different transplant institutions throughout the United States, compares
estimated patient care episodes, procedure time and needle sticks for
currently established cell collection and infusion techniques with the Aastrom
CPS method of cell procurement:     
 

<TABLE>
<CAPTION>
                                       CARE     PROCEDURE TIME
CELL SOURCE                         EPISODES(1)   (HOURS)(1)   NEEDLE STICKS(2)
- -----------                         ----------- -------------- ----------------
<S>                                 <C>         <C>            <C>
Bone Marrow Harvest(3).............       8           16              103
PBPC Mobilization and Collec-
 tion(4)...........................      21           39               22
Aastrom CPS(5).....................       2          1-3             4-10
</TABLE>

 --------
 (1) Includes all outpatient, inpatient, and home care episodes.
 (2) Includes bone marrow aspirates, blood samples, catheter placements and
     other venous access, and subcutaneous injections.
 (3) Includes operating room procedure and all preparatory and recovery
     procedures.
 (4) Based on an average of three rounds of apheresis following cell
     mobilization injections.
    
 (5) Projections, based on data accumulated during the Company's pre-clinical
     research and clinical trials.     
 
  Reduced Cost. The Company believes the Aastrom CPS has the potential to
replace more costly, labor intensive and invasive cell collection and infusion
procedures currently employed for stem cell therapy and to reduce physician,
staff and patient time requirements.
 
  Reduced Patient and Physician Burden. Cell production with the Aastrom CPS
is expected to require the collection of a small volume of starting material
compared to current collection procedures, eliminating the requirement for
general surgical anesthesia, multiple drug injections and blood apheresis.
Patient benefits are expected to include fewer needle sticks than with current
cell collection and infusion methods and a reduction in overall patient
procedure time. Additionally, Aastrom's process for cell expansion is expected
to minimize the time requirement for physicians compared with bone marrow
harvest.
 
  Enhanced Multicycle High-Dose Chemotherapy.  The long restoration period for
the hematopoietic system following myeloablative therapy effectively limits
patients to one opportunity for cell collection prior to cancer therapy. The
Aastrom CPS may enhance the practice of multicycle, high-dose chemotherapy by
providing the ability to produce a therapeutic dose of cells from a small
starting volume. The initial cell collection can be divided into multiple
samples and stored frozen until expansion at a later time is required.
 
  Reduced Quantity of Lymphocytes. The Company believes its approach to stem
cell therapy may provide an additional benefit over current methods by
depleting potentially harmful cells such as T-cells and B-cells. These cells
are believed to be primarily responsible for graft-versus-host disease, a
common manifestation of allogeneic transplants in which the grafted donor's
cells attack the host's tissues and organs.
 
                                      28

<PAGE>
 
  Tumor Cell Purging. Cancer patients with tumor metastases, in which the
cancer has spread to the blood and bone marrow, have not traditionally been
candidates for autologous stem cell transplants because transplant may
reintroduce cancer cells into the patient. Additionally, patients may have
undetected tumor cells in their marrow or PBPC transplant, which can
reestablish the cancer in the patient following transplant. The Aastrom CPS
process may offer benefits for these groups of patients. The Company and other
investigators have shown that some primary human tumor cells die or do not
grow during hematopoietic cell culture. Further, the smaller volume of
starting cells used for the Aastrom CPS compared with bone marrow harvest or
PBPC transplants may provide approximately 10 to 70 fold less tumor cells in a
transplant. This combination of passive depletion during culture with the
lower starting volume of tumor cells may result in a tumor-free or tumor-
reduced cell product for transplant. The benefit of such tumor depletion, if
any, will vary depending upon the type of cancer and state of disease.
 
CLINICAL DEVELOPMENT
 
  The Company's clinical development plan is initially to obtain regulatory
approval in the United States to market the Aastrom CPS for autologous stem
cell therapy and in Europe for more general cell therapy applications. The
Company also intends to pursue approval of the Aastrom CPS for additional
clinical indications.
 
  The Company believes that the Aastrom CPS for stem cell therapy will be
regulated as a medical device and that the Company will be required to submit
a PMA application to, and obtain approval from, the FDA to allow it to market
this product in the United States. In order to obtain PMA approval, the
Company will be required to complete clinical trials under an IDE. See "--
Government Regulation--Devices."
 
  In a dose-ranging study conducted by the University of Michigan (the
"University") in 1993, ex vivo produced cells utilizing the Company's
proprietary cell production technology were infused into seven patients with
non-Hodgkin's lymphoma after they received myeloablative chemotherapy. These
patients also received cells obtained from either an autologous bone marrow
harvest or PBPC procedure. No safety issues attributable to the infused cells
were observed in this trial and the patients exhibited recovery profiles
consistent with traditional transplantation techniques.
 
  Aastrom completed the first feasibility trial of its cell production system
technology under an IDE at the MD Anderson Cancer Center in October 1995. In
this trial, ten breast cancer patients, who were subjected to myeloablative
chemotherapy, were treated with cells obtained from a bone marrow harvest and
with cells produced from a sample of such cells with a predecessor of the
Aastrom CPS. The patients exhibited standard clinical recoveries, providing
evidence of the clinical safety of cells obtained from the Company's cell
production process and of the feasibility of cell production with a
predecessor of the Aastrom CPS by clinical personnel at an investigational
site.
   
  Aastrom is currently conducting a pre-pivotal stem cell therapy clinical
trial under an IDE submitted to the FDA. This clinical trial is designed to
demonstrate that cells produced using the Aastrom CPS can provide
hematopoietic recovery in accordance with trial endpoints in breast cancer
patients who have received myeloablative chemotherapy. Bone marrow obtained
from the patients by traditional methods will be available for precautionary
reasons at defined clinical stages. The results from the five patients accrued
at the first trial site have provided evidence of the clinical safety of the
Aastrom CPS-produced cells in patients and that the hematopoietic recovery
endpoints specified for the trial are achievable. The patients at this trial
site were Stage IV breast cancer patients who had received significant prior
cytotoxic therapies for their cancer. Four of these five patients received the
precautionary back-up marrow pursuant to the trial protocol. Preliminary
results from the first trial site were reviewed with the FDA, and the IDE was
amended to expand the trial to a second site. The amended IDE provided for the
enrollment of Stage II, III and IV patients, and a delayed use of the
precautionary back-up bone marrow. As of the date of this Prospectus, patient
accrual is ongoing and patient data from this site provides further evidence
that the hematopoietic recovery endpoints specified for the trial are
achievable.     
 
                                      29

<PAGE>
 
   
  The objective of the current and anticipated future trials is to establish
the protocol for the pivotal trial of the Aastrom CPS in autologous stem cell
therapy in breast cancer. Provided that these pre-pivotal trials provide
further evidence of feasibility and safety of the cells produced in the
Aastrom CPS, the Company anticipates initiating a pivotal clinical trial at
multiple sites no earlier than mid-1997, with the patient enrollment typical
to support a PMA filing, although this schedule is subject to numerous risks
and uncertainties. See "Risk Factors--Uncertainties Related to Preclinical and
Clinical Testing."     
   
  Aastrom, in partnership with Cobe, intends to initiate a clinical trial in
Europe by mid-1997 to evaluate the use of Aastrom CPS cells to promote
hematopoietic recovery in breast cancer patients undergoing aggressive
myelosuppressive chemotherapy. The Company intends to seek approval to market
the Aastrom CPS in Europe through CE Mark Registration. See "--Government
Regulation--Regulatory Process in Europe."     
 
  The preliminary results of the Company's pre-pivotal trial may not be
predictive of results that will be obtained from subsequent patients in the
trial or from more extensive trials. Further, there can be no assurance that
the Company's pre-pivotal or pivotal trial will be successful, or that PMA
approval or required foreign regulatory approvals for the Aastrom CPS will be
obtained in a timely fashion, or at all.
 
BUSINESS STRATEGY
 
  Aastrom's objective is to build a leadership position in cell therapy
process technology. The primary elements of the Company's business strategy
are as follows:
 
  Establish Consumable Based Business Model. Aastrom's strategy is to sell the
Aastrom CPS to institutions, hospitals, and other clinical care or commercial
cell production facilities that are administering cell therapy. The Company
plans to obtain ongoing revenue from the sale of single-use disposable Cell
Cassettes and related cell culture media and reagents, which are utilized in
individual cell therapy applications. After cells are cultured in the Cell
Cassette, the cassette is discarded and a new cassette is utilized for a
subsequent patient. Along with ongoing revenue from the sale of instruments
and disposables for cell therapy applications, the Company believes it will be
able to obtain license revenue from its stem cell therapy applications for its
proprietary stem cell processes.
 
  Focus Initially on Established and Reimbursed Therapies. Aastrom will seek
to establish the use of the Aastrom CPS in the field of stem cell therapy for
the treatment of toxicity resulting from many cancer therapies, including
those for breast cancer, lymphoma, ovarian cancer, germ cell cancers,
leukemias and aplastic anemias. Stem cell therapy is a well-established and
growing treatment modality in cancer therapy, and current cell collection
procedures are widely reimbursed by third party payors.
 
  Leverage Platform Technology Across Multiple Market Opportunities. In
addition to stem cell therapy applications, the Company believes that the
Aastrom CPS may serve as a platform product that can be used to produce a
variety of other cells for multiple therapeutic applications, such as T-cells
for use in lymphocyte therapies, chondrocytes for cartilage replacement, and
mesenchymal cells for use in certain solid tissue therapies. The Company
believes that if the Aastrom CPS is well established as a method for cell
production for use in stem cell therapy, the system will be positioned for
commercialization of new cell and ex vivo gene therapies that are under
development.
 
  Market Through Collaborative Relationships. The Company plans to reach end-
user markets through collaborative relationships with companies that have
established positions in those markets. In 1993, the Company formed a
strategic partnership with Cobe, a leading provider of blood cell processing
equipment and disposables. Cobe is the Company's exclusive, worldwide
distributor of the Aastrom CPS for stem cell therapy applications, not
including stem cell gene therapy. The Company will seek to establish
additional collaborations for other cell therapies as those therapies and the
Company's product lines develop. See "Business--Strategic Relationships."
 
 
                                      30

<PAGE>
 
ADDITIONAL STEM CELL AND OTHER CELL THERAPIES
   
  The Company believes that the Aastrom CPS hardware and disposables may be
developed to serve as platform products for application in a variety of other
emerging cell therapies in addition to stem cell therapy. The Company believes
that the Aastrom CPS has the potential to supplant current manual cell culture
methods to produce therapeutic quantities of cell types such as T-cells,
chondrocytes, mesenchymal cells, keratinocytes, neuronal cells and dendritic
cells. Other than a limited application of chondrocyte therapy, novel cell
therapies are still in early stages of development by third parties and no
assurance can be given that such other cell therapies will be successfully
developed. Potential advantages of the Aastrom CPS in these therapies may
include: (i) reducing labor and capital costs; (ii) enhancing process
reliability; (iii) automating quality assurance; and (iv) reducing the need
for specialized, environmentally controlled facilities.     
   
  Modification of such processes and application of the Company's products to
the expansion of other cell types may require substantial additional
development of specialized culture environments and which may need to be
incorporated within the Company's existing cell cassettes. There can be no
assurance that the Company will be able to successfully modify or develop
existing or future products to enable such additional cell production
processes. The Company's business opportunity is dependent upon successful
development and regulatory approval of these novel cell therapies. No
assurance can be given that such novel therapies will be successfully
developed by other companies or approved by applicable regulatory authorities,
or that the Company's processes or product candidates will find successful
application in such therapies. See "--Business Strategy" and "--Clinical
Development," "Use of Proceeds," and "Risk Factors--Future Capital Needs;
Uncertainty of Additional Funding."     
 
  Immunotherapies
   
  Immunotherapy involves using cells of the immune system to eradicate a
disease target. T-cell lymphocytes and dendritic cells are being actively
investigated by other companies for this purpose, and the Company anticipates
that many of these procedures will require ex vivo cell production.     
 
  T-cells, a class of lymphocyte white blood cells, play a critical role in
the human immune system and are responsible for the human immune response in a
broad spectrum of diseases, including cancers and infectious diseases.
Cytotoxic T-lymphocytes ("CTLs") is a new process that involves collecting T-
cells from a patient and culturing them in an environment resulting in T-cells
with specificity for a particular disease target. Clinical trials by third
parties have been initiated to demonstrate CTL effectiveness. The ex vivo
production of these cells under conditions for use in medical treatment
represents a critical step in the advancement of this therapy.
   
  Dendritic cells (the potent antigen presenting cells) are believed to play
an important role in the function of the immune system. Researchers believe
that cultured dendritic cells could augment the natural ability of a patient
to present antigens from the infectious agents to the immune system and aid in
the generation of a cytotoxic T-cell response to the infectious agent.     
 
  Solid Tissue Cell Therapies
   
  One of the newest areas of cell therapy involves the production of
chondrocytes for the restoration of cartilage. Chondrocyte therapy involves
the surgical removal of a small amount of tissue from the patient's knee and a
therapeutic quantity of chondrocytes is produced from this surgical biopsy.
The cells are then implanted into the patient's knee. Published reports
indicate that such cells then reestablish mature articular cartilage.
Currently, this cell production process is completed in highly specialized
laboratory facilities using trained scientists and manual laboratory
procedures. The Company believes that the Aastrom CPS may have the potential
to reduce costs associated with the cell production procedure and, if
successfully developed by the Company for this application, may eventually
facilitate the transfer of the cell production capability away from
specialized facilities directly to the clinical care sites.     
 
  Other Stem Cell Therapies
   
  Autoimmune Diseases. Stem cell therapy is under clinical investigation by
third parties for the treatment of other diseases. Clinical studies have
suggested a potential role for stem cell therapy in treatment of     
 
                                      31

<PAGE>
 
autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and lupus
erythematosus. The generic cause of these diseases is a malfunctioning immune
system, including T-lymphocytes. Clinical trials in which the patient receives
treatment resulting in immune ablation (usually involving myelotoxic cancer
drugs or radiation), followed by stem cell therapy to restore the bone marrow
and cells of the blood and immune system, have demonstrated remission of the
autoimmune disease in some patients.
 
  Organ Transplantation. Recently, a number of academic and corporate
researchers and companies have identified the potential use of stem cell
therapy to facilitate successful solid organ and tissue transplants between
human donors and recipients, as well as using organs from non-human species
for transplantation into humans. These proposed applications are based on the
observation that donor-specific bone marrow, infused concurrent with or prior
to the organ transplant, can provide for reduction of the normal immune
rejection response by the transplant recipient (e.g. heart, lung, liver or
kidney transplants).
   
  A major limitation to the use of stem cell therapy in solid organ transplant
is the limited availability of sufficient amounts of bone marrow to obtain a
desired therapeutic response of immune tolerization. This limitation is
particularly problematic when cadaveric donor organs are available, which has
traditionally been the source of cells for these procedures. Bone marrow is
also often available from the cadaveric donor, but only in a limited amount.
Normally this amount may be sufficient for one transplant, but a donor might
provide multiple organs for transplant into multiple recipients. Aastrom
believes that the ability to expand the available bone marrow ex vivo will
enhance the use of stem cell therapy for such transplant procedures and may
pursue development of its products for application in such therapy in the
future.     
 
AASTROM PRODUCT CANDIDATES FOR EX VIVO GENE THERAPY
 
  A novel form of cell therapy is ex vivo gene therapy. For this type of cell
therapy, cells procured from the patient or a donor are genetically modified
prior to their infusion into the patient. Analogous to other cell therapies,
the ability to produce a therapeutic dose of these gene-modified cells is a
major limitation to the commercialization of these cell therapies. This
limitation is further exacerbated by the additional requirement that the cells
be genetically modified under conditions that are sterile and comply with GMP.
   
  Gene therapy is a therapeutic modality that holds the potential to
significantly impact the delivery of healthcare and the delivery of
therapeutically useful protein-based drugs within the body. Gene therapies are
generally targeted at the introduction of a missing normal gene into otherwise
defective human tissue, or the introduction of novel biologic capability into
the body via the introduction of a gene not ordinarily present (for example,
genes providing for the enhanced recognition and destruction or inhibition of
the HIV-1 virus). The major developmental focus of the ex vivo gene therapy
industry has been to identify the therapeutic gene of interest, insert it into
a suitable vector that can be used to transport and integrate the gene into
the DNA of the target cell, and then cause the gene to become expressed. The
Company believes that for ex vivo gene therapy to progress to clinical
applications, a process to produce a sufficient quantity of therapeutic cells
is required as is an efficient means to insert the gene vector into target
cells. Gene therapy is still in an early stage of development by third
parties. The Company's business opportunity is dependent upon the successful
development and regulatory approval of individual gene therapy applications.
No assurance can be given that such applications will be developed or approved
or that the Company's processes or product candidates will find successful
applications in such therapies. Successful development of the Company's
processes and product candidates for application in ex vivo gene therapy will
require substantial additional research and development, including clinical
testing, and will be subject to the Company's ability to finance such
activities on acceptable terms, if at all. See "Risk Factors--Future Capital
Needs; Uncertainty of Additional Funding."     
 
  THE AASTROM CPS FOR GENE THERAPY (GT-CPS)
 
  The Aastrom CPS has been designed to produce cells for therapy and the
Company believes that the Aastrom CPS may be useful in many potential ex vivo
gene therapy applications. Further, the Company
 
                                      32

<PAGE>
 
   
anticipates that its proprietary stem cell production process technology
implemented by the Aastrom CPS may provide the conditions for clinical scale
stem cell division, and enable or enhance the introduction of therapeutic
genes into stem cell DNA. The Company believes that its technology may also
enable expansion of more mature progeny of these stem cells to create a gene
therapy cell product with potential short and long term therapeutic effect.
    
  The Company has two principal objectives for the development of Aastrom GT-
CPS: (i) the enablement of stem cell gene therapies for a variety of
hematologic and other disorders, based on the GT-CPS's ability to enable large
scale stem cell division ex vivo; and (ii) the enablement of gene transfer and
therapeutic cell production by local and regional primary patient care
facilities and ancillary service laboratories.
 
  THE AASTROM GENE LOADER
   
  The Aastrom Gene Loader product technology, which is under development, is
being designed to enhance the efficiency and reliability of the transfer of
new therapeutic genes, which are carried by vectors, into the target cell.
This process, which is typically inefficient in many human cells inhibits many
ex vivo gene therapies from moving forward in the clinic. The Aastrom Gene
Loader is being designed to incorporate the Company's proprietary directed
motion gene transfer technology. Complete product development is expected to
require additional funding sources or collaborations with others, or both.
       
  The Company believes that these issues represent a general bottleneck for
other companies pursuing ex vivo gene therapy clinical applications. The
Company's technology under development may favorably influence these gene
therapy applications, the development of which are impeded due to low
transduction efficiencies and the resultant need for use of extreme quantities
of gene vectors and/or target "delivery" tissues.     
 
STRATEGIC RELATIONSHIPS
   
  On October 22, 1993, the Company entered into a Distribution Agreement (the
"Distribution Agreement") with Cobe for Cobe to be the Company's exclusive,
worldwide distributor of the Aastrom CPS for stem cell therapy applications
(the "Stem Cell Therapy Applications"). Under the terms of the Company's
Distribution Agreement with Cobe, other than with respect to sales to
affiliates, the Company is precluded from selling the Aastrom CPS to customers
for stem cell therapy applications. The Company has, however, reserved the
right to sell the Aastrom CPS for: (i) all diagnostic or other non-therapeutic
clinical applications; (ii) all gene therapy or gene transfer applications,
including those for stem cells; (iii) all non-human applications; (iv) certain
permitted clinical research applications; and (v) all applications that are
labeled not for human use. The Company has also reserved the unconditional
right to sell other products under development, including but not limited to
products based upon its gene loading technology. The initial term of the
Distribution Agreement expires on October 22, 2003, and Cobe has the option to
extend the term for an additional ten-year period. The Company is responsible
for the expenses to obtain FDA and other regulatory approval in the United
States, while Cobe is responsible for the expenses to obtain regulatory
approval in foreign countries to allow for worldwide marketing of the Aastrom
CPS for Stem Cell Therapy Applications. See "Risk Factors--Consequences of
Cobe Relationship."     
   
  Under the terms of the Distribution Agreement, the Company will realize
approximately 60% and 58% of the net sales price at which Cobe ultimately
sells the Aastrom CPS in the United States and Europe, respectively, for Stem
Cell Therapy Applications, subject to certain negotiated discounts and volume-
based adjustments and subject to the obligation of the Company to make royalty
payments ranging from 2% to 5% to certain licensors of its technology. The
Company is also entitled to a premium on United States sales in any year in
which worldwide sales exceed specified levels.     
   
  The Distribution Agreement may be terminated by Cobe upon twelve months
prior notice to the Company in the event that any person or entity other than
Cobe beneficially owns more than 50% of the Company's outstanding Common Stock
or voting securities. The Distribution Agreement may also be terminated by
Cobe at any time after December 31, 1997 if Cobe determines that
commercialization of the Aastrom CPS for stem cell therapy on or prior to
December 31, 1998 is unlikely.     
 
                                      33

<PAGE>
 
  In conjunction with the Distribution Agreement, the Company also entered
into a Stock Purchase Agreement with Cobe (the "Cobe Stock Agreement"),
whereby Cobe acquired certain option, registration, preemptive and other
rights pertaining to shares of the Company's stock. Pursuant to such
preemptive rights, Cobe has elected to purchase $5,000,000 of Common Stock in
this offering at the initial public offering price per share. See "Description
of Capital Stock--Rights of Cobe" and "Certain Transactions."
 
MANUFACTURING
 
  The Company has no current intention of internally manufacturing its product
candidates and, accordingly, is developing relationships with third party
manufacturers which are FDA registered as suppliers for the manufacture of
medical products.
 
  On May 10, 1994, the Company entered into a Collaborative Product
Development Agreement with SeaMED Corporation, ("SeaMED"). Pursuant to this
agreement, the Company and SeaMED will collaborate on the further design of
certain instrument components in the Aastrom CPS, and enable SeaMED to
manufacture pre-production units of the instrument components for laboratory
and clinical evaluation. The Company is paying SeaMED for its design and pre-
production work on a "time and materials" basis, utilizing SeaMED's customary
hourly billing rates and actual costs for materials. Subject to certain
conditions, the Company has committed to enter into a manufacturing agreement
with SeaMED for commercial manufacture of the instrument components for three
years after shipment by SeaMED of the first commercial unit pursuant to a
pricing formula set forth in the agreement. The Company retains all
proprietary rights to its intellectual property which is utilized by SeaMED
pursuant to this agreement.
   
  On November 8, 1994, the Company entered into a Collaborative Product
Development Agreement with Ethox Corporation ("Ethox"). Pursuant to this
agreement, the Company and Ethox will collaborate on the further design of
certain bioreactor assembly and custom tubing kit components of the Aastrom
CPS, and enable Ethox to manufacture pre-production units of such components
for laboratory and clinical evaluation. The Company is paying Ethox for its
design and production work on a "time and materials" basis, utilizing Ethox's
customary hourly billing rates and actual costs for materials. The Company
retains all proprietary rights to its intellectual property which are utilized
by Ethox pursuant to this Agreement.     
   
  In April 1996, the Company entered into a five-year License and Supply
Agreement with Immunex to purchase and resell certain cytokines and ancillary
materials for use in conjunction with the Aastrom CPS. The agreement required
the Company to pay Immunex an initial up-front fee of $1,500,000 to be
followed by subsequent annual renewal payments equal to $1,000,000 per year
during the term of the agreement in addition to payment for supplies purchased
by the Company. Unless earlier terminated or renewed by the Company for an
additional 5 year term, the agreement will expire in April 2001. The agreement
may be terminated by either party effective immediately upon written notice of
termination to the other party in the event that such party materially
breaches the agreement and such breach continues unremedied after notice and
expiration of a specified cure period or in the event that a bankruptcy
proceeding is commenced against a party and is not dismissed or stayed within
a 45 day period. In addition, Immunex has the right to cease the supply to the
Company of cytokines and ancillary materials if the Company fails to purchase
a minimum amount of its forecasted annual needs from Immunex after notice to
the Company and expiration of a specified cure period. The Company also has
the right to terminate the agreement at any time subject to the payment to
Immunex of a specified amount for liquidated damages. In the event that
Immunex elects to cease to supply to the Company cytokines and ancillary
materials or is prevented from supplying such materials to the Company by
reason of force majeure, limited manufacturing rights will be transferred to
the Company under certain circumstances. There is, however, no assurance that
the Company could successfully manufacture the compounds itself or identify
others that could manufacture these compounds to acceptable quality standards
and costs, if at all.     
   
  On December 16, 1996, the Company entered into a Collaborative Supply
Agreement with Anchor Advanced Products, Inc., Mid-State Plastics Division
("MSP"). Under this agreement, MSP will conduct both pre-production
manufacturing development and commercial manufacturing and assembly of the
cell cassette component of the Aastrom CPS for the Company. During the initial
phase of the seven-year agreement, the     
 
                                      34

<PAGE>
 
   
Company will pay MSP for its development activities on a time and materials
basis. Upon reaching certain commercial manufacturing volumes, MSP will be
paid by the Company on a per unit basis for cell cassettes delivered to the
Company under a pricing formula specified in the agreement. Throughout the
term of this agreement, the Company has agreed to treat MSP as its preferred
supplier of cell cassettes, using MSP as its supplier of at least 60% of its
requirements for cell cassettes.     
 
  There can be no assurance that the Company will be able to continue its
present arrangements with its suppliers, supplement existing relationships or
establish new relationships or that the Company will be able to identify and
obtain the ancillary materials that are necessary to develop its product
candidates in the future. The Company's dependence upon third parties for the
supply and manufacture of such items could adversely affect the Company's
ability to develop and deliver commercially feasible products on a timely and
competitive basis. See "Risk Factors--Manufacturing and Supply Uncertainties;
Dependence on Third Parties."
 
PATENTS AND PROPRIETARY RIGHTS
 
  The Company's success depends in part on its ability, and the ability of its
licensors, to obtain patent protection for its products and processes. The
Company and its licensors are seeking patent protection for technologies
related to (i) human stem and progenitor cell production processes; (ii)
bioreactors and systems for stem and progenitor cell production and production
of other cells; and (iii) gene transfer devices and processes. The Company has
exclusive license rights to five issued United States patents that present
claims to (i) certain methods for ex vivo stem cell division as well as ex
vivo human hematopoietic stem cell stable genetic transformation and expanding
and harvesting a human hematopoietic stem cell pool; (ii) certain apparatus
for cell culturing, including a bioreactor suitable for culturing human stem
cells or human hematopoietic cells; and (iii) certain methods of infecting or
transfecting target cells with vectors. Patents equivalent to two of these
United States patents have also been issued in other jurisdictions: one in
Australia and another in Canada and under the European Patent Convention.
These eight issued patents are due to expire beginning in 2006, through 2013.
In addition, the Company and its exclusive licensors have filed applications
for patents in the United States and equivalent applications in certain other
countries claiming other aspects of the Company's products and processes,
including five United States patent applications and corresponding
applications in other countries related to various components of the Aastrom
CPS. Of these pending patent applications, the Company has received notices of
allowance for certain claims in a United States application relating to
methods for obtaining ex vivo stem cell division, and claims in a European
Patent Convention application and in a United States application relating to
methods for efficient proliferation of hematopoietic cells in culture.
 
  The validity and breadth of claims in medical technology patents involve
complex legal and factual questions and, therefore, may be highly uncertain.
No assurance can be given that any patents based on pending patent
applications or any future patent applications of the Company or its licensors
will be issued, that the scope of any patent protection will exclude
competitors or provide competitive advantages to the Company, that any of the
patents that have been or may be issued to the Company or its licensors will
be held valid if subsequently challenged or that others will not claim rights
in or ownership of the patents and other proprietary rights held or licensed
by the Company. Furthermore, there can be no assurance that others have not
developed or will not develop similar products, duplicate any of the Company's
products or design around any patents that have been or may be issued to the
Company or its licensors. Since patent applications in the United States are
maintained in secrecy until patents issue, the Company also cannot be certain
that others did not first file applications for inventions covered by the
Company's and its licensors' pending patent applications, nor can the Company
be certain that it will not infringe any patents that may issue to others on
such applications.
 
  The Company relies on certain licenses granted by the University of Michigan
and Dr. Cremonese for the majority of its patent rights. If the Company
breaches such agreements or otherwise fails to comply with such agreements, or
if such agreements expire or are otherwise terminated, the Company may lose
its rights under the patents held by the University of Michigan and Dr.
Cremonese, which would have a material adverse effect on the Company's
business, financial condition and results of operations. See "--University of
Michigan Research Agreement and License Agreement" and "--License Agreement
with J.G. Cremonese."
 
                                      35

<PAGE>
 
  The Company also relies on trade secrets and unpatentable know-how which it
seeks to protect, in part, by confidentiality agreements. It is the Company's
policy to require its employees, consultants, contractors, manufacturers,
outside scientific collaborators and sponsored researchers, and other advisors
to execute confidentiality agreements upon the commencement of employment or
consulting relationships with the Company. These agreements provide that all
confidential information developed or made known to the individual during the
course of the individual's relationship with the Company is to be kept
confidential and not disclosed to third parties except in specific limited
circumstances. The Company also requires signed confidentiality or material
transfer agreements from any company that is to receive its confidential data.
In the case of employees, consultants and contractors, the agreements
generally provide that all inventions conceived by the individual while
rendering services to the Company shall be assigned to the Company as the
exclusive property of the Company. There can be no assurance, however, that
these agreements will not be breached, that the Company would have adequate
remedies for any breach, or that the Company's trade secrets or unpatentable
know-how will not otherwise become known or be independently developed by
competitors.
 
  The Company's success will also depend in part on its ability to develop
commercially viable products without infringing the proprietary rights of
others. The Company has not conducted freedom of use patent searches and no
assurance can be given that patents do not exist or could not be filed which
would have an adverse effect on the Company's ability to market its products
or maintain its competitive position with respect to its products. If the
Company's technology components, devices, designs, products, processes or
other subject matter are claimed under other existing United States or foreign
patents or are otherwise protected by third party proprietary rights, the
Company may be subject to infringement actions. In such event, the Company may
challenge the validity of such patents or other proprietary rights or be
required to obtain licenses from such companies in order to develop,
manufacture or market its products. There can be no assurances that the
Company would be able to obtain such licenses or that such licenses, if
available, could be obtained on commercially reasonable terms. Furthermore,
the failure to either develop a commercially viable alternative or obtain such
licenses could result in delays in marketing the Company's proposed products
or the inability to proceed with the development, manufacture or sale of
products requiring such licenses, which could have a material adverse effect
on the Company's business, financial condition and results of operations. If
the Company is required to defend itself against charges of patent
infringement or to protect its own proprietary rights against third parties,
substantial costs will be incurred regardless of whether the Company is
successful. Such proceedings are typically protracted with no certainty of
success. An adverse outcome could subject the Company to significant
liabilities to third parties and force the Company to curtail or cease its
development and sale of its products and processes.
 
  Certain of the Company's and its licensors' research has been or is being
funded in part by the Department of Commerce and by a Small Business
Innovation Research Grant obtained from the Department of Health and Human
Services. As a result of such funding, the United States Government has
certain rights in the technology developed with the funding. These rights
include a non-exclusive, paid-up, worldwide license under such inventions for
any governmental purpose. In addition, the government has the right to require
the Company to grant an exclusive license under any of such inventions to a
third party if the government determines that (i) adequate steps have not been
taken to commercialize such inventions, (ii) such action is necessary to meet
public health or safety needs or (iii) such action is necessary to meet
requirements for public use under federal regulations. Additionally, under the
federal Bayh Dole Act, a party which acquires an exclusive license for an
invention that was partially funded by a federal research grant is subject to
the following government rights: (i) products using the invention which are
sold in the U.S. are to be manufactured substantially in the U.S., unless a
waiver is obtained; (ii) if the licensee does not pursue reasonable
commercialization of a needed product using the invention, the government may
force the granting of a license to a third party who will make and sell the
needed product; and (iii) the U.S. government may use the invention for its
own needs.
 
  UNIVERSITY OF MICHIGAN RESEARCH AGREEMENT AND LICENSE AGREEMENT
 
  In August 1989, the Company entered into a Research Agreement (the "Research
Agreement") with the University, pursuant to which the Company funded a
research project at the University under the direction of
 
                                      36

<PAGE>
 
Stephen G. Emerson, M.D., Ph.D., as the principal inventor, together with
Michael F. Clarke, M.D., and Bernhard O. Palsson, Ph.D., as co-inventors.
Pursuant to the Research Agreement, the Company was granted the right to
acquire an exclusive, worldwide license to utilize all inventions, know-how
and technology derived from the research project. By Extension Agreements, the
Company and the University extended the scope and term of the Research
Agreement through December 1994.
 
  On March 13, 1992, the Company and the University entered into the License
Agreement, as contemplated by the Research Agreement. There have been
clarifying amendments to the License Agreement, dated March 13, 1992, October
8, 1993 and June 21, 1995. Pursuant to this License Agreement, (i) the Company
acquired exclusive worldwide license rights to the patents and know-how for
the production of blood cells and bone marrow cells as described in the
University's research project or which resulted from certain further research
conducted through December 31, 1994, and (ii) the Company is obligated to pay
to the University a royalty equal to 2% of the net sales of products which are
covered by the University's patents. Unless it is terminated earlier at the
Company's option or due to a material breach by the Company, the License
Agreement will continue in effect until the latest expiration date of the
patents to which the License Agreement applies.
 
  LICENSE AGREEMENT WITH J. G. CREMONESE
   
  In July 1992, the Company entered into a License Agreement with Joseph G.
Cremonese pursuant to which the Company obtained exclusive worldwide license
rights for all fields of use, to utilize U.S. Patent No. 4,839,292, entitled
"Cell Culture Flask Utilizing a Membrane Barrier," which patent was issued to
Dr. Cremonese on June 13, 1989, and to utilize any other related patents that
might be issued to Dr. Cremonese. Pursuant to the License Agreement, the
Company has reimbursed Dr. Cremonese for $25,000 of his patent costs. Under
the terms of the License Agreement, the Company is to pay to Dr. Cremonese a
royalty of 3% of net sales of the products which are covered by said patent,
subject to specified minimum royalty payments ranging from $20,000 to $50,000
per year, commencing in calendar year 1997. Unless earlier terminated, the
License Agreement will continue in effect until the latest expiration date of
the patents to which the License Agreement applies, which latest expiration
date is currently August 2009. The License Agreement may be terminated by
either party upon default by the other party of any of its obligations under
the agreement without cure after expiration of a 30-day notice period. The
Company also has the right to terminate the License Agreement at any time
without cause upon 30 days prior written notice to Dr. Cremonese.     
 
GOVERNMENT REGULATION
 
  The Company's research and development activities and the manufacturing and
marketing of the Company's products are subject to the laws and regulations of
governmental authorities in the United States and other countries in which its
products will be marketed. Specifically, in the United States the FDA, among
other activities, regulates new product approvals to establish safety and
efficacy of these products. Governments in other countries have similar
requirements for testing and marketing. In the U.S., in addition to meeting
FDA regulations, the Company is also subject to other federal laws, such as
the Occupational Safety and Health Act and the Environmental Protection Act,
as well as certain state laws.
 
  REGULATORY PROCESS IN THE UNITED STATES
 
  To the Company's knowledge, it is the first to develop a culture system for
ex vivo human cell production to be sold for therapeutic applications.
Therefore, to a certain degree, the manner in which the FDA will regulate the
Company's products is uncertain.
 
  The Company's products are potentially subject to regulation as medical
devices under the Federal Food, Drug, and Cosmetic Act, and as biological
products under the Public Health Service Act, or both. Different regulatory
requirements may apply to the Company's products depending on how they are
categorized by the FDA under these laws. To date, the FDA has indicated that
it intends to regulate the Aastrom CPS product for
 
                                      37

<PAGE>
 
stem cell therapy as a Class III medical device through the Center for
Biologics Evaluation and Research. However, there can be no assurance that FDA
will ultimately regulate the Aastrom CPS as a medical device.
 
  Further, it is unclear whether the FDA will separately regulate the cell
therapies derived from the Aastrom CPS. The FDA is still in the process of
developing its requirements with respect to somatic cell therapy and gene cell
therapy products and has recently issued a draft document concerning the
regulation of umbilical cord blood stem cell products. If the FDA adopts the
regulatory approach set forth in the draft document, the FDA may require
separate regulatory approval for such cells in some cases. The FDA also
recently proposed a new type of license, called a biologic license application
("BLA"), for autologous cells manipulated ex vivo and intended for structural
repair or reconstruction. This proposal may indicate that the FDA will extend
a similar approval requirement to other types of autologous cellular
therapies, such as autologous cells for stem cell therapy. Any such additional
regulatory or approval requirements could significantly delay the introduction
of the Company's product candidates to the market, and have a material adverse
impact on the Company.
 
  Approval of new medical devices and biological products is a lengthy
procedure leading from development of a new product through preclinical and
clinical testing. This process takes a number of years and the expenditure of
significant resources. There can be no assurance that the Company's product
candidates will ultimately receive regulatory approval.
 
  Regardless of how the Company's product candidates are regulated, the
Federal Food, Drug, and Cosmetic Act and other Federal statutes and
regulations govern or influence the research, testing, manufacture, safety,
labeling, storage, recordkeeping, approval, distribution, use, reporting,
advertising and promotion of such products. Noncompliance with applicable
requirements can result in civil penalties, recall, injunction or seizure of
products, refusal of the government to approve or clear product approval
applications or to allow the Company to enter into government supply
contracts, withdrawal of previously approved applications and criminal
prosecution.
 
  DEVICES
 
  In order to obtain FDA approval of a new medical device sponsors must
generally submit proof of safety and efficacy. In some cases, such proof
entails extensive clinical and preclinical laboratory tests. The testing,
preparation of necessary applications and processing of those applications by
the FDA is expensive and may take several years to complete. There can be no
assurance that the FDA will act favorably or in a timely manner in reviewing
submitted applications, and the Company may encounter significant difficulties
or costs in its efforts to obtain FDA approvals which could delay or preclude
the Company from marketing any products it may develop. The FDA may also
require postmarketing testing and surveillance of approved products, or place
other conditions on the approvals. These requirements could cause it to be
more difficult or expensive to sell the products, and could therefore restrict
the commercial applications of such products. Product approvals may be
withdrawn if compliance with regulatory standards is not maintained or if
problems occur following initial marketing. For patented technologies, delays
imposed by the governmental approval process may materially reduce the period
during which the Company will have the exclusive right to exploit such
technologies.
 
  If human clinical trials of a proposed device are required and the device
presents significant risk, the manufacturer or distributor of the device will
have to file an IDE application with the FDA prior to commencing human
clinical trials. The IDE application must be supported by data, typically
including the results of pre-clinical and laboratory testing. If the IDE
application is approved, human clinical trials may commence at a specified
number of investigational sites with the number of patients approved by the
FDA.
 
  The FDA categorizes devices into three regulatory classifications subject to
varying degrees of regulatory control. In general, Class I devices require
compliance with labeling and recordkeeping regulations, GMPs, 510(k) pre-
market notification, and are subject to other general controls. Class II
devices may be subject to additional regulatory controls, including
performance standards and other special controls, such as postmarket
surveillance. Class III devices, which are either invasive or life-sustaining
products, or new products never before
 
                                      38

<PAGE>
 
marketed (for example, non-"substantially equivalent" devices), require
clinical testing to demonstrate safety and effectiveness and FDA approval
prior to marketing and distribution. The FDA also has the authority to require
clinical testing of Class I and Class II devices.
 
  If a manufacturer or distributor of medical devices cannot establish that a
proposed device is substantially equivalent, the manufacturer or distributor
must submit a PMA application to the FDA. A PMA application must be supported
by extensive data, including preclinical and human clinical trial data, to
prove the safety and efficacy of the device. Upon receipt, the FDA conducts a
preliminary review of the PMA application. If sufficiently complete, the
submission is declared filed by the FDA. By regulation, the FDA has 180 days
to review a PMA application once it is filed, although PMA application reviews
more often occur over a significantly protracted time period, and may take
approximately one year or more from the date of filing to complete.
 
  Some of the Company's products may be classified as Class II or Class III
medical devices. The Company has submitted several IDEs for the Aastrom CPS,
and is currently conducting a pre-pivotal clinical study under one of these
IDEs. The Company believes that the Aastrom CPS product will be regulated by
the FDA as a Class III device, although there can be no assurance that the FDA
will not choose to regulate this product in a different manner.
 
  The Company and any contract manufacturer are required to be registered as a
medical device manufacturer with the FDA. As such, they will be inspected on a
routine basis by the FDA for compliance with the FDA's GMP regulations. These
regulations will require that the Company and any contract manufacturer
manufacture products and maintain documents in a prescribed manner with
respect to manufacturing, testing, distribution, storage, design control and
service activities, and that adequate design and service controls are
implemented. The Medical Device Reporting regulation requires that the Company
provide information to the FDA on deaths or serious injuries alleged to be
associated with the use of its devices, as well as product malfunctions that
are likely to cause or contribute to death or serious injury if the
malfunction were to recur. In addition, the FDA prohibits a company from
promoting an approved device for unapproved applications and reviews company
labeling for accuracy.
 
  BIOLOGICAL PRODUCTS
 
  For certain of the Company's new products which may be regulated as
biologics, the FDA requires (i) preclinical laboratory and animal testing,
(ii) submission to the FDA of an investigational new drug ("IND") application
which must be effective prior to the initiation of human clinical studies,
(iii) adequate and well-controlled clinical trials to establish safety and
efficacy of the product for its intended use, (iv) submission to the FDA of a
product license application ("PLA") and establishment license application
("ELA") and (v) review and approval of the PLA and ELA as well as inspections
of the manufacturing facility by the FDA prior to commercial marketing of the
product.
 
  Preclinical testing covers laboratory evaluation of product chemistry and
formulation as well as animal studies to assess the safety and efficacy of the
product. The results of these tests are submitted to the FDA as part of the
IND. Following the submission of an IND, the FDA has 30 days to review the
application and raise safety and other clinical trial issues. If the Company
is not notified of objections within that period, clinical trials may be
initiated. Clinical trials are typically conducted in three sequential phases.
Phase I represents the initial administration of the drug or biologic to a
small group of humans, either healthy volunteers or patients, to test for
safety and other relevant factors. Phase II involves studies in a small number
of patients to assess the efficacy of the product, to ascertain dose tolerance
and the optimal dose range and to gather additional data relating to safety
and potential adverse effects. Once an investigational drug is found to have
some efficacy and an acceptable safety profile in the targeted patient
population, multi-center Phase III studies are initiated to establish safety
and efficacy in an expanded patient population and multiple clinical study
sites. The FDA reviews both the clinical plans and the results of the trials
and may request the Company to discontinue the trials at any time if there are
significant safety issues.
 
                                      39

<PAGE>
 
  The results of the preclinical tests and clinical trials are submitted to
the FDA in the form of a PLA for marketing approval. The testing and approval
process is likely to require substantial time and effort and there can be no
assurance that any approval will be granted on a timely basis, if at all.
Additional animal studies or clinical trials may be requested during the FDA
review period that may delay marketing approval. After FDA approval for the
initial indications, further clinical trials may be necessary to gain approval
for the use of the product for additional indications. The FDA requires that
adverse effects be reported to the FDA and may also require post-marketing
testing to monitor for adverse effects, which can involve significant expense.
 
  Under current requirements, facilities manufacturing biological products
must be licensed. To accomplish this, an ELA must be filed with the FDA. The
ELA describes the facilities, equipment and personnel involved in the
manufacturing process. An establishment license is granted on the basis of
inspections of the applicant's facilities in which the primary focus is on
compliance with GMP and the ability to consistently manufacture the product in
the facility in accordance with the PLA. If the FDA finds the inspection
unsatisfactory, it may decline to approve the ELA, resulting in a delay in
production of products. Although reviewed separately, approval of both the PLA
and ELA must be received prior to commercial marketing of a cellular biologic.
 
  As part of the approval process for human biological products, each
manufacturing facility must be registered and inspected by FDA prior to
marketing approval. In addition, state agency inspections and approvals may
also be required for a biological product to be shipped out of state.
 
  REGULATORY PROCESS IN EUROPE
 
  The Company believes that the Aastrom CPS will be regulated in Europe as a
Class IIb medical device, under the authority of the new Medical Device
Directives ("MDD") being implemented by European Union ("EU") member
countries. This classification applies to medical laboratory equipment and
supplies including, among other products, many devices that are used for the
collection and processing of blood for patient therapy. Certain ancillary
products (e.g., biological reagents) used with the Aastrom CPS may be
considered Class III medical devices.
 
  The MDD regulations vest the authority to permit affixing of the "CE Mark"
with various "Notified Bodies." These are private and state organizations
which operate under license from the EU to certify that appropriate quality
assurance standards and compliance procedures are followed by developers and
manufacturers of medical device products or, alternatively, that a
manufactured medical product meets a more limited set of requirements.
Notified Bodies are also charged with responsibility for determination of the
appropriate standards to apply to a medical product. Receipt of permission to
affix the CE Mark enables a company to sell a medical device in all EU member
countries. Other registration requirements may also need to be satisfied in
certain countries, although there is a general trend among EU member countries
not to impose additional requirements beyond those specified for CE Mark
certification.
 
COMPETITION
 
  The biotechnology and medical device industries are characterized by rapidly
evolving technology and intense competition. The Company's competitors include
major pharmaceutical, medical device, medical products, chemical and
specialized biotechnology companies, many of which have financial, technical
and marketing resources significantly greater than those of the Company. In
addition, many biotechnology companies have formed collaborations with large,
established companies to support research, development and commercialization
of products that may be competitive with those of the Company. Academic
institutions, governmental agencies and other public and private research
organizations are also conducting research activities and seeking patent
protection and may commercialize products on their own or through joint
ventures. The Company's product development efforts are primarily directed
toward obtaining regulatory approval to market the Aastrom CPS for stem cell
therapy. That market is currently dominated by the bone marrow harvest and
PBPC collection methods. The Company's clinical data, although early, is
inconclusive as to whether or not cells expanded in the Aastrom CPS will
enable hematopoietic recovery within the time frames currently achieved by
 
                                      40

<PAGE>
 
the bone marrow harvest and PBPC collection methods. In addition, the bone
marrow harvest and PBPC collection methods have been widely practiced for a
number of years and, recently, the patient costs associated with these
procedures have begun to decline. There can be no assurance that the Aastrom
CPS method, if approved for marketing, will prove to be competitive with these
established collection methods on the basis of hematopoietic recovery time,
cost or otherwise. The Company is aware of certain other products manufactured
or under development by competitors that are used for the prevention or
treatment of certain diseases and health conditions which the Company has
targeted for product development. In particular, the Company is aware that
competitors such as Amgen, Inc., CellPro, Incorporated, Systemix, Inc., Baxter
Healthcare Corp. and RPR are in advanced stages of development of technologies
and products for use in stem cell therapy and other market applications
currently being pursued by the Company. In addition, Cobe, a significant
shareholder of the Company, is a market leader in the blood cell processing
products industry and, accordingly, a potential competitor of the Company.
There can be no assurance that developments by others will not render the
Company's product candidates or technologies obsolete or noncompetitive, that
the Company will be able to keep pace with new technological developments or
that the Company's product candidates will be able to supplant established
products and methodologies in the therapeutic areas that are targeted by the
Company. The foregoing factors could have a material adverse effect on the
Company's business, financial condition and results of operations.
 
  The Company's products under development are expected to address a broad
range of existing and new markets. The Company believes that its stem cell
therapy products will, in large part, face competition by existing procedures
rather than novel new products. The Company's competition will be determined
in part by the potential indications for which the Company's products are
developed and ultimately approved by regulatory authorities. In addition, the
first product to reach the market in a therapeutic or preventive area is often
at a significant competitive advantage relative to later entrants to the
market. Accordingly, the relative speed with which the Company or its
corporate partners can develop products, complete the clinical trials and
approval processes and supply commercial quantities of the products to the
market are expected to be important competitive factors. The Company's
competitive position will also depend on its ability to attract and retain
qualified scientific and other personnel, develop effective proprietary
products, develop and implement production and marketing plans, obtain and
maintain patent protection and secure adequate capital resources. The Company
expects its products, if approved for sale, to compete primarily on the basis
of product efficacy, safety, patient convenience, reliability, value and
patent position.
 
FACILITIES
 
  The Company leases approximately 20,000 square feet of office and research
and development space in Ann Arbor, Michigan under a lease agreement expiring
in May 1998. The lease is renewable at the option of the Company for up to an
additional five-year term. The Company believes that its facilities will be
adequate for its currently anticipated needs. Contract manufacturing or
additional facilities will be required in the future to support expansion of
research and development and to manufacture products.
 
EMPLOYEES
   
  As of November 30, 1996, the Company employed approximately 65 individuals
full-time. A significant number of the Company's management and professional
employees have had prior experience with pharmaceutical, biotechnology or
medical product companies. None of the Company's employees are covered by
collective bargaining agreements, and management considers relations with its
employees to be good.     
 
LEGAL PROCEEDINGS
 
  The Company is not party to any material legal proceedings, although from
time to time it may become involved in disputes in connection with the
operation of its business.
 
                                      41

<PAGE>
 

                                  MANAGEMENT
 
DIRECTORS AND EXECUTIVE OFFICERS
   
  The following table provides information concerning directors and executive
officers of the Company as of November 30, 1996:     
 

<TABLE>   
<CAPTION>
              NAME                    AGE     POSITION
              ----                    ---     --------
<S>                                <C>        <C>
Robert J. Kunze(2)(3)............      61     Chairman of the Board; Director
R. Douglas Armstrong, Ph.D.(3)...      43     President and Chief Executive Officer; Director
James Maluta.....................      49     Vice President, Product Development
Todd E. Simpson..................      35     Vice President, Finance & Administration; Chief
                                              Financial Officer; Secretary; and Treasurer
Walter C. Ogier..................      40     Vice President, Marketing
Thomas E. Muller, Ph.D...........      61     Vice President, Regulatory Affairs
Alan K. Smith, Ph.D..............      41     Vice President, Research
Stephen G. Emerson, M.D., Ph.D...      43     Director; Scientific Advisor
Albert B. Deisseroth, M.D.,
 Ph.D.(2)........................      55     Director; Scientific Advisor
G. Bradford Jones(1)(3)..........      41     Director
Horst R. Witzel, Dr.-Ing.........      69     Director
Edward C. Wood, Jr.(1)(3)........      52     Director
</TABLE>
    
- --------
(1) Member of Audit Committee.
(2) Member of Compensation Committee.
(3) Member of Executive Committee.
   
  All directors hold office until the next election of the class for which
such directors have been chosen and until their successors have been duly
elected and qualified. The Company's Bylaws provide that the Board of
Directors will consist of between five and nine members, and the number of
directors is currently set at seven members. The Bylaws also provide that the
Board of Directors will serve staggered three-year terms, or until their
successors are elected and qualified. The terms of office of the Company's
current directors expire as follows: Mr. Jones, Dr. Deisseroth and Mr. Wood,
1999; Mr. Kunze and Dr. Emerson, 1998; and Dr. Armstrong and Dr. Witzel, 1997.
Officers are elected by and serve at the discretion of the Board of Directors.
There are no family relationships among the directors or officers of the
Company.     
 
  Robert J. Kunze a director of the Company since its inception in 1989, is a
founder of the Company and served as its President and Chief Executive Officer
through May 1991. Since 1987, he has been a General Partner of H&Q Life
Science Venture Partners, a venture capital fund specializing in medical
products and biotechnology investments. Previous to that, Mr. Kunze was
Managing Partner of Hambrecht & Quist Venture Partners. Prior to that he
served as a senior executive with W.R. Grace & Co. and General Electric. Mr.
Kunze also serves on the Board of Directors of Escalon Medical Corporation.
 
  R. Douglas Armstrong, Ph.D. joined the Company in June 1991 as a director
and as its President and Chief Executive Officer. From 1987 to 1991, Dr.
Armstrong served in different capacities, including as Executive Vice
President and a Trustee of the La Jolla Cancer Research Foundation ("LJCRF"),
a 250-employee scientific research institute located in San Diego, California.
Dr. Armstrong received his doctorate in Pharmacology and Toxicology from the
Medical College of Virginia, and has held faculty and staff positions at Yale
University, University of California, San Francisco, LJCRF and University of
Michigan. Dr. Armstrong also serves on the Board of Directors of Nephros
Therapeutics, Inc.
 
  James Maluta joined the Company in August 1992 as Vice President, Product
Development. Mr. Maluta has a broad background in the development and
manufacturing of medical devices, with 25 years of experience in the industry,
principally with OHMEDA and with Cobe BCT, Inc. While with Cobe BCT, Inc., Mr.
Maluta was Program Manager for the Cobe Spectra Apheresis System, a device for
blood cell processing and apheresis. Mr. Maluta held other engineering
management positions and also was director of Quality Assurance for Cobe BCT.
Mr. Maluta received his degree in electrical engineering from the University
of Wisconsin.
 
                                      42

<PAGE>
 
  Todd E. Simpson joined the Company in January 1996 as Vice President,
Finance and Administration and Chief Financial Officer and is also the
Company's Secretary and Treasurer. Prior to that, Mr. Simpson was Treasurer of
Integra LifeSciences Corporation ("Integra"), a biotechnology company, which
acquired Telios Pharmaceuticals, Inc. ("Telios") in August 1995 in connection
with the reorganization of Telios under Chapter 11 of the U.S. Bankruptcy
Code. Mr. Simpson served as Vice President of Finance and Chief Financial
Officer of Telios up until its acquisition by Integra and held various other
financial positions at Telios after joining that company in February 1992.
Telios was a publicly-held company engaged in the development of
pharmaceutical products for the treatment of dermal and ophthalmic wounds,
fibrotic disease, vascular disease, and osteoporosis. From August 1983 through
February 1992, Mr. Simpson practiced public accounting with the firm of Ernst
& Young, LLP. Mr. Simpson is a Certified Public Accountant and received his
B.S. degree in Accounting and Computer Science from Oregon State University.
 
  Walter C. Ogier joined the Company in March 1994 as Director of Marketing
and was promoted to Vice President, Marketing during 1995. Prior to that, Mr.
Ogier was at Baxter Healthcare Corporation's Immunotherapy Division, where he
served as Director, Business Development from 1992 to 1994 and as Manager,
Marketing and Business Development in charge of the company's cell therapy
product lines from 1990 to 1992. Mr. Ogier previously held positions with
Ibbottson Associates and with the Business Intelligence Center at SRI
International (formerly Stanford Research Institute). Mr. Ogier received his
B.A. degree in Chemistry from Williams College in 1979 and his Masters of
Management degree from the Yale School of Management in 1987.
 
  Thomas E. Muller, Ph.D. joined the Company in May 1994 as Vice President,
Regulatory Affairs. Prior to that, Dr. Muller was Director, Biomedical Systems
with W.R. Grace & Company in Lexington, Massachusetts. Prior to this, Dr.
Muller was Vice President, Engineering and Director of Research and
Development with the Renal Division of Baxter Healthcare in Deerfield,
Illinois. Dr. Muller has also served as Adjunct Professor at Columbia
University and as Visiting Professor at the University of Gent, Belgium. Dr.
Muller graduated from the Technical University in Budapest, Hungary, in 1956
with a B.S. in Chemical Engineering. Dr. Muller received his M.S. degree in
1959 and was awarded a Ph.D. in 1964, both in Polymer Chemistry, from McGill
University.
 
  Alan K. Smith, Ph.D. joined the Company in November 1995 as Vice President,
Research. Previously, Dr. Smith was Vice President of Research and Development
at Geneic Sciences, Inc., a developmental stage bone marrow transplantation
company. Prior to that, Dr. Smith held the position of Director, Cell
Separations Research and Development of the Immunotherapy Division of Baxter
Healthcare Corporation. In this capacity, he was responsible for the research
and development activities for a stem cell concentration system approved for
clinical use in Europe and currently in pivotal clinical trials in the United
States. Dr. Smith has also held positions as Research and Development Manager
at BioSpecific Technologies, as Director of Biochemistry at HyClone
Laboratories and as a member of the Board of Directors of Dallas Biomedical.
Dr. Smith received his B.S. degree in Chemistry from Southern Utah State
College in 1976 and a Ph.D. in Biochemistry from Utah State University in
1983.
 
  Stephen G. Emerson, M.D., Ph.D. a director since the inception of the
Company in 1989, is a scientific founder of the Company and has been an active
advisor of the Company since that time. Dr. Emerson has been a Professor of
Medicine at the University of Pennsylvania since 1994 where he serves as head
of Hematology and Oncology. From 1991 to 1994, Dr. Emerson was an Associate
Professor of Medicine at the University of Michigan. Dr. Emerson received his
doctorate degrees in Medicine and Cell Biology/Immunology from Yale
University. He completed his internship and residency at Massachusetts General
Hospital and his clinical and research fellowship in hematology at the Brigham
and Women's Hospital, the Dana-Farber Cancer Institute and Children's Hospital
Medical Center.
 
  Albert B. Deisseroth, M.D., Ph.D. a director since August 1991, currently
serves as an Ensign Professor of Medicine and the Chief, Section of Medical
Oncology at Yale University and is a professor at both the University of Texas
Graduate School of Biomedical Sciences and the University of Texas Health
Science Center Medical
 
                                      43

<PAGE>
 
School in Houston, Texas. Prior to that, Dr. Deisseroth had been Chairman of
the Department of Hematology and a Professor of Medicine and Cancer Treatment
and Research at the University of Texas, M.D. Anderson Cancer Center in
Houston, Texas. Previous to this, Dr. Deisseroth served as Professor of
Medicine at the University of California, San Francisco, and Chief,
Hematology/Oncology at the San Francisco Veteran's Administration Medical
Center. Dr. Deisseroth received his doctorate degrees in Medicine and
Biochemistry from the University of Rochester. Dr. Deisseroth is currently a
member of the Scientific Advisory Boards of Ingenex, Inc., Genvec, Inc. and
Incell.
 
  G. Bradford Jones a director since April 1992, is a general partner of
Brentwood V Ventures, L.P., the general partner of Brentwood Associates V,
L.P.  Brentwood Associates V, L.P. is a partnership organized by the firm
Brentwood Venture Capital, which Mr. Jones joined in 1981. Mr. Jones was
elected to the Board of Directors of the Company pursuant to the terms of the
Series B Preferred Stock Purchase Agreement dated April 7, 1992 with the
Company, of which Brentwood Associates V, L.P. is a party. Mr. Jones received
a B.A. degree in Chemistry and an M.A. degree in Physics from Harvard
University and M.B.A. and J.D. degrees from Stanford University. Mr. Jones
also serves on the Board of Directors of Interpore International, ISOCOR, Onyx
Acceptance Corporation, Plasma & Materials Technologies, and several
privately-held companies.
 
  Horst R. Witzel, Dr.-Ing. a director since June 1994, served as Chairman of
the Board of Executive Directors of Schering AG in Berlin, Germany from 1986
until his retirement in 1989, whereupon he became a member of the Supervisory
Board of Schering AG until 1994. Prior to that, Dr. Witzel held various
leadership positions in research and development with Schering AG where he was
responsible for worldwide production and technical services. Dr. Witzel
received his doctorate in chemistry from the Technical University of West
Berlin. Dr. Witzel also serves on the Board of Directors of The Liposome
Company, Inc. and Cephalon, Inc. and is a member of the Supervisory Board of
Brau and Brunnen AG.
 
  Edward C. Wood, Jr. a director since August 1994, has served as president of
Cobe BCT, Inc., a division of Cobe Laboratories, Inc., since 1991. Cobe is a
subsidiary of Gambro AB, a Swedish company, and is a leading provider of blood
cell processing products. Prior to that, Mr. Wood held various positions in
manufacturing, research and development, and marketing with Cobe. Mr. Wood
received degrees in chemistry from Harvey Mudd College and in management from
the University of Colorado.
 
LIMITATION OF LIABILITY AND INDEMNIFICATION MATTERS
 
  The Company has adopted provisions in its Restated Articles of Incorporation
that limit the liability of its directors for monetary damages arising from a
breach of their fiduciary duty as directors, except under certain
circumstances which include breach of the director's duty of loyalty to the
Company or its shareholders, acts or omissions not in good faith or that
involve intentional misconduct or a knowing violation of the law.
 
  The Company's Bylaws provide that the Company shall indemnify its directors
to the fullest extent authorized or permitted by the Michigan Business
Corporation Act. Additionally, the Company has entered into an Indemnification
Agreement, originally dated as of December 14, 1993 (the "Indemnification
Agreement"), with certain of its directors, officers and other key personnel,
which may, in certain cases, be broader than the specific indemnification
provisions contained under applicable law. The Indemnification Agreement may
require the Company, among other things, to indemnify such officers, directors
and key personnel against certain liabilities that may arise by reason of
their status or service as directors, officers or employees of the Company, to
advance the expenses incurred by such parties as a result of any threatened
claims or proceedings brought against them as to which they could be
indemnified, and to cover such officers, directors and key employees under the
Company's directors' and officers' liability insurance policies to the maximum
extent that insurance coverage is maintained.
 
  At present, there is no pending litigation or proceeding involving a
director, officer, employee or agent of the Company where indemnification by
the Company will be required or permitted. The Company is not aware of any
threatened litigation or proceeding which may result in a claim for such
indemnification.
 
                                      44

<PAGE>
 

EXECUTIVE COMPENSATION
 
  The following table summarizes the compensation paid to or earned by the
Company's Chief Executive Officer and all other executive officers of the
Company whose salary and bonus for services rendered in all capacities to the
Company during the fiscal year ended June 30, 1996 exceeded $100,000 (the
"named executive officers"):
 
                          SUMMARY COMPENSATION TABLE
 

<TABLE>
<CAPTION>
                                        ANNUAL COMPENSATION
                               -------------------------------------
     NAME AND 1996                                    OTHER ANNUAL      ALL OTHER
   PRINCIPAL POSITION     YEAR SALARY ($) BONUS ($) COMPENSATION ($) COMPENSATION ($)
   ------------------     ---- ---------- --------- ---------------- ----------------
<S>                       <C>  <C>        <C>       <C>              <C>
R. Douglas Armstrong,     
 Ph.D...................  1996  $156,962   $55,000         --             $8,885(1)
 President and Chief 
 Executive Officer

James Maluta............  1996  $118,942   $10,000         --                 --
 Vice President, Product
 Development

Thomas E. Muller, Ph.D..  1996  $118,560        --         --                 --
 Vice President, 
 Regulatory Affairs

Walter C. Ogier.........  1996  $106,250   $ 7,500         --                 --
 Vice President, 
 Marketing
</TABLE>

- --------
(1) Consists of vacation pay to Dr. Armstrong in 1996.
 
  1996 Option Grants
 
  The following table contains information about the stock option grants to
the named executive officers in 1996:
 
                       OPTION GRANTS IN LAST FISCAL YEAR
 

<TABLE>
<CAPTION>
                                                                                       POTENTIAL REALIZED
                                                                                        VALUE AT ASSUMED
                                                                                        ANNUAL RATES OF
                                                                                          STOCK PRICE
                                                                                          APPRECIATION
                                               INDIVIDUAL GRANTS                       FOR OPTION TERM(1)
                          ------------------------------------------------------------ -------------------
                              NUMBER OF          % OF TOTAL
                              SECURITIES     OPTIONS GRANTED TO EXERCISE OR
                          UNDERLYING OPTIONS    EMPLOYEES IN    BASE PRICE  EXPIRATION
   NAME                      GRANTED (#)        FISCAL YEAR       ($/SH)       DATE     5% ($)    10% ($)
   ----                   ------------------ ------------------ ----------- ---------- --------  ---------
<S>                       <C>                <C>                <C>         <C>        <C>       <C>
R. Douglas Armstrong,
 Ph.D. .................          --                 --             --            --        --         --
James Maluta............          --                 --             --            --        --         --
Thomas E. Muller, Ph.D..        6,667               4.3%           1.20      02/14/06     5,000     12,734
Walter C. Ogier.........        6,667               4.3%           1.20      02/14/06     5,000     12,734
</TABLE>

- --------
(1) The 5% and the 10% assumed rates of appreciation are established by the
    rules of the Securities and Exchange Commission and do not represent the
    Company's estimate or projection of the future Common Stock price. If the
    Common Stock price of $1.20 on the date of grant for the options granted
    in 1996 were to appreciate at the rates indicated, it would be $1.95 per
    share (at a 5% compounded appreciation) and $3.11 per share (at a 10%
    compounded appreciation) on the date of expiration of those options.
 
                                      45

<PAGE>
 
  Option Exercises and Year-End Values
 
  The following table provides information about the number of shares issued
upon option exercise by the named executive officers during 1996, and the
value realized by the named executive officers. The table also provides
information about the number and value of options held by the named executive
officers at June 30, 1996:
 
                AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                           AND FY-END OPTION VALUES
 

<TABLE>
<CAPTION>
                                                     NUMBER OF SECURITIES      VALUE OF UNEXERCISED
                                                    UNDERLYING UNEXERCISED         IN-THE-MONEY
                                                     OPTIONS AT FY-END (#)   OPTIONS AT FY-END ($)(1)
                                                   ------------------------- -------------------------
                             SHARES
                          ACQUIRED ON     VALUE
   NAME                   EXERCISE (#) REALIZED($) EXERCISABLE UNEXERCISABLE EXERCISABLE UNEXERCISABLE
   ----                   ------------ ----------- ----------- ------------- ----------- -------------
<S>                       <C>          <C>         <C>         <C>           <C>         <C>
R. Douglas Armstrong,
 Ph.D...................        --          --          --           --            --           --
James Maluta............     29,999      86,847      16,668          --        $48,254          --
Thomas E. Muller, Ph.D..        --          --       15,000       18,334        29,925      $36,576
Walter C. Ogier.........      5,000       9,975      13,750       21,250        27,431       42,394
</TABLE>

- --------
(1) The option value represents fair market value of the underlying securities
    on the exercise date minus the aggregate exercise price of such options,
    multiplied by the number of shares of Common Stock subject to the option.
    For purposes of this calculation, a fair market value of $3.20 per share
    was used, the fair market value of the securities as determined by the
    Board of Directors on June 30, 1996.
 
  No compensation intended to serve as incentive for performance to occur over
a period longer than one fiscal year was paid pursuant to a long-term
incentive plan during the last fiscal year to any of the persons named in the
Summary Compensation Table. The Company does not have any defined benefit or
actuarial plan with any of the persons named in the Summary Compensation Table
under which benefits are determined primarily by final compensation or average
final compensation and years of service.
 
EMPLOYMENT AGREEMENTS
 
  The Company has a policy of entering into employment agreements with all of
its employees, and has entered into such agreements with all of its executive
officers other than Dr. Armstrong. Such employment agreements generally
establish salary levels (which are subject to periodic review) and provide for
customary fringe benefits such as vacation leave, sick leave and health
insurance. The agreements also generally provide for the protection of
confidential information and the assignment to the Company of inventions
conceived by the employee during his or her employment and permit the
termination of the employment relationship by either party upon fourteen days
prior written notice. The following is a summary of the employment agreements
between the Company and its executive officers.
 
  The Company entered into employment agreements with no defined terms with
James Maluta, Walter C. Ogier, Thomas E. Muller, Ph.D., Alan K. Smith, Ph.D.
and Todd E. Simpson in June 1992, February 1994, April 1994, October 1995 and
December 1995, respectively. Pursuant to these agreements, the Company agreed
to pay Messrs. Maluta, Ogier, Muller, Smith and Simpson annual base salaries
of $90,000, $87,500, $110,000, $122,500 and $122,500, respectively, certain of
which base salaries have been increased by the Board of Directors and are
subject to annual review and adjustment. Pursuant to the terms of the
foregoing employment agreements, either party may generally terminate the
employment relationship without cause at any time upon 14 days prior written
notice to the other party or immediately with cause upon notice.
 
 
                                      46

<PAGE>
 
STOCK OPTION AND EMPLOYEE BENEFIT PLANS
 
  1989 STOCK OPTION PLAN
 
  In 1989, the Company established the 1989 Stock Option Plan. As of September
30, 1996, options to purchase an aggregate of 932,266 shares of Common Stock
have been exercised at $0.15 per share. Options to purchase 13,127 shares of
Common Stock at $0.15 per share were cancelled unexercised. No additional
shares remain available for grant under the 1989 Stock Option Plan.
 
  ANCILLARY PLAN
 
  In 1991, the Company established an Ancillary Plan to grant options to
individuals who were not eligible to receive options under the 1989 Stock
Option Plan. Options to purchase an aggregate of 7,498 shares of the Company's
Common Stock were granted under the Ancillary Plan, of which options to
purchase 4,328 shares have been exercised at $0.15 per share and the remaining
options to purchase 3,170 shares have been cancelled. No additional shares
remain available for grant under the Ancillary Plan.
 
  AMENDED AND RESTATED 1992 INCENTIVE AND NON-QUALIFIED STOCK OPTION PLAN
 
  In 1992, the Company adopted the 1992 Incentive and Non-Qualified Stock
Option Plan (the "1992 Plan"), providing for the grant of options to purchase
666,667 shares of Common Stock. The Company allocated an additional 100,000
shares of Common Stock during 1992, an additional 333,333 shares of Common
Stock in 1994 and an additional 800,000 shares of Common Stock in 1996 to the
1992 Plan, resulting in a total share reserve of 1,900,000 shares. The 1992
Plan was amended and restated to its current form in 1996. Options under the
1992 Plan for a total of 462,840 shares have been exercised as of September
30, 1996. As of September 30, 1996, options to purchase 336,254 shares of
Common Stock were outstanding with a weighted average exercise price of $1.27
per share.
 
  The 1992 Plan provides for grants to employees and officers of "incentive
stock options" within the meaning of Section 422 of the Internal Revenue Code
of 1986, as amended, provided that such employee or officer is an employee on
the date of grant. The 1992 Plan also provides for grants to employees,
officers, consultants or service providers of nonqualified stock options. The
1992 Plan previously has been administered by the Board of Directors, but is
currently administered by the Compensation Committee of the Board of Directors
(the "Committee"). Each option granted pursuant to the 1992 Plan is authorized
by the Committee and evidenced by a notice in such form as the Committee may
from time to time determine.
 
  The exercise price of each incentive stock option granted under the 1992
Plan must be at least equal to the fair market value of a share of Common
Stock on the date of grant, except for incentive stock options granted to
individuals who, at the time of grant, own stock possessing more than 10% of
the total combined voting power of the Company, which options must have an
exercise price of at least 110% of the fair market value of a share of Common
Stock on the date of grant and must expire five years from the date of grant.
The exercise price of each nonqualified stock option granted under the 1992
Plan must be at least 85% of the fair market value of the shares on the date
of grant. No option shall be treated as an incentive stock option to the
extent that such option would cause the aggregate fair market value
(determined as of the date of grant of such option) of the shares with respect
to which incentive stock options are exercisable by such optionee for the
first time during any calendar year to exceed $100,000. The terms of all
incentive stock options and nonqualified stock options granted under the 1992
Plan may not exceed ten years. The exercise price may be paid in cash or, at
the Committee's discretion, by delivery of previously owned shares of the
Company's Common Stock, by a combination of cash and shares, or any other form
of legal consideration acceptable to the Committee. Options under the 1992
Plan generally may not be granted after April 2006.
 
                                      47

<PAGE>
 
  The 1992 Plan provides that if the Company is a party to any merger in which
the Company is not the surviving entity, any consolidation or dissolution
(other than the merger or consolidation of the Company with one or more of its
wholly-owned subsidiaries), the Company must cause any successor corporation
to assume the options or substitute similar options for outstanding options or
continue such options in effect. In the event that any successor to the
Company in a merger, consolidation or dissolution will not assume the options
or substitute similar options, then with respect to options held by optionees
performing services for the Company, the time for exercising such options will
be accelerated and such options will be terminated if not exercised prior to
such merger, consolidation or dissolution.
 
  1996 OUTSIDE DIRECTORS STOCK OPTION PLAN
 
  A total of 150,000 shares of Common Stock have been reserved for issuance
under the Company's 1996 Outside Directors Stock Option Plan (the "Directors
Plan"). As of the date of this Prospectus, no options have been granted under
the Directors Plan. The Directors Plan provides for the automatic granting of
non-qualified stock options to directors of the Company who are not employees
of the Company ("Outside Directors"). Under the Directors Plan, each Outside
Director serving on the effective date of this Offering or elected after the
date of this offering will automatically be granted an option to purchase
5,000 shares of Common Stock on the effective date of this offering or on the
date of his or her election or appointment. In addition, each serving Outside
Director will thereafter automatically be granted an option to purchase 5,000
shares of Common Stock following each annual meeting of shareholders after
their election, provided that the Outside Director continues to serve in such
capacity and that the Outside Director has served continuously as a director
for at least six months. The exercise price of the options in all cases will
be equal to the fair market value of the Common Stock on the date of grant.
Options granted under the Directors Plan generally vest over a one-year period
in equal monthly installments and must be exercised within ten years from the
date of grant.
 
  1996 EMPLOYEE STOCK PURCHASE PLAN
 
  A total of 250,000 shares of the Company's Common Stock have been reserved
for issuance under the Company's 1996 Employee Stock Purchase Plan (the
"Purchase Plan"), none of which have been issued. The Purchase Plan permits
eligible employees to purchase Common Stock at a discount through payroll
deductions, during sequential 24-month offering periods. Each offering period
is divided into four consecutive six-month purchase periods. Unless otherwise
provided by the Board of Directors prior to the commencement of an offering
period, the price at which stock is purchased under the Purchase Plan for such
offering period is equal to 85% of the lesser of the fair market value of the
Common Stock on the first day of such offering period or the last day of the
purchase period of such offering period. The initial offering period will
commence on the effective date of this offering.
 
SECTION 401(K) PLAN
 
  Effective January 1, 1994, the Company adopted the Aastrom Biosciences, Inc.
401(k) Plan (the "Plan"). The Plan is intended to be a qualified retirement
plan under the Internal Revenue Code. Employees of the Company are eligible to
participate in the Plan upon the completion of three consecutive months of
employment. Participants may make salary deferral contributions to the Plan of
up to 15% of compensation, subject to the limitations imposed under the
Internal Revenue Code. The Company may, but is not required to, make matching
contributions to the Plan based on the participants' salary-defined
contributions. Employer contributions are subject to a graduated vesting
schedule based upon an employee's years of service with the Company. It is not
anticipated that the Company will make any contributions to the Plan for the
1997 Plan Year. All contributions to the Plan are held in a trust which is
intended to be exempt from income tax under Section 501(a) of the Internal
Revenue Code. The Plan's trustees are R. Douglas Armstrong and Todd E.
Simpson. Participants may direct the investment of their contributions among
specified Merrill Lynch investment funds. The Plan may be amended or
terminated by the Company at any time, subject to certain restrictions imposed
by the Internal Revenue Code and the Employee Retirement Income Security Act
of 1974.
 
                                      48

<PAGE>
 
COMPENSATION OF DIRECTORS
 
  Directors of the Company do not receive cash for services provided as a
director, however, directors who are not employees of the Company will receive
annual grants of options to purchase Common Stock in accordance with the
Directors Plan. No stock options or any other form of non-cash compensation
were granted to directors of the Company during the Company's fiscal year
ending June 30, 1996. See "Stock Option and Employee Benefit Plans--1996
Outside Directors Stock Option Plan."
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION IN COMPENSATION
DECISIONS
 
  During the fiscal year ended June 30, 1996, Robert J. Kunze, formerly an
officer of the Company until 1991, R. Douglas Armstrong, President and Chief
Executive Officer of the Company, and G. Bradford Jones were the members of
the Compensation Committee of the Board of Directors. Dr. Armstrong resigned
from the Compensation Committee and was replaced by Albert B. Deisseroth,
M.D., Ph.D. on April 30, 1996, however, Mr. Kunze continues to be a member of
this committee.
 
                                      49

<PAGE>
 

                             CERTAIN TRANSACTIONS
       
  In April 1995, the Company sold 775,001 shares of Series D Preferred Stock
at a price per share of $4.00 to the following investors: (i) H&Q Life Science
Technology Fund I purchased 167,001 shares for a purchase price of $668,004,
(ii) H&Q London Ventures purchased 100,000 shares for a purchase price of
$400,000, (iii) Brentwood Associates V, L.P. ("Brentwood") purchased 231,250
shares for a purchase price of $925,000, (iv) Windpoint Partners II, L.P.
purchased 89,250 shares for a purchase price of $357,000, and (v) the State
Treasurer of the State of Michigan ("Michigan") purchased 187,500 shares for a
purchase price of $750,000. In May 1995, Cobe purchased 1,250,000 shares of
Series D Preferred Stock for a purchase price of $5,000,000. Upon the closing
of this offering, each outstanding share of Series D Preferred Stock will be
converted into two-thirds of a share of Common Stock.
 
  In April 1995, Dr. Armstrong and Dr. Emerson agreed to grant to Brentwood an
option to purchase up to 28,000 shares and 14,667 shares of Common Stock,
respectively, and, together with two other shareholders of the Company, an
aggregate of up to 66,667 shares of Common Stock at a purchase price of
$100,000. Brentwood exercised this option in April, 1996 purchasing an
aggregate of 66,667 shares of Common Stock at a purchase price of $100,000
from such shareholders.
 
  In September 1995, the Company and RPR entered into a collaborative
relationship for use of the Aastrom CPS as a component of its lymphoid cell
therapy program. On September 6, 1996, RPR notified the Company that it would
not exercise its option to continue the collaboration. As a result, $3,500,000
of option payments previously paid to the Company by RPR were converted into
205,882 shares of the Company's Series E Preferred Stock.
 
  In October 1995, the Company repurchased 62,500 shares of Series D Preferred
Stock from Brentwood at the original purchase price of $250,000 and in
December 1995 resold these shares to Northwest Ohio Venture Fund, a
shareholder of the Company, for a total purchase price of $250,000.
   
  In January 1996, the Company sold 1,411,765 shares of Series E Preferred
Stock at a price per share of $4.25 to the following investors: (i) Michigan
purchased 470,588 shares for a total purchase price of $1,999,999, and (ii)
SBIC Partners, L.P. purchased 941,177 shares for a total purchase price of
$4,000,002. Upon the closing of this offering, each outstanding share of
Series E Preferred Stock will be converted into two-thirds of a share of
Common Stock.     
 
  On November 18, 1993, in connection with the purchase of Common Stock upon
exercise of stock options granted to R. Douglas Armstrong under the 1989 Stock
Option Plan, the Company loaned to Dr. Armstrong $120,000 at an interest rate
of 4% per annum pursuant to a full recourse promissory note. Interest on the
note is payable on an annual basis and principal and accrued but unpaid
interest is due on June 30, 1997. Dr. Armstrong is the President and Chief
Executive Officer and is a director of the Company.
 
  On October 20, 1993, in connection with the purchase of Common Stock upon
exercise of stock options granted to Stephen G. Emerson under the 1989 Stock
Option Plan, the Company loaned to Dr. Emerson $47,303 at an interest rate of
6% per annum pursuant to a full recourse promissory note. Interest on the note
is payable on an annual basis and principal and accrued but unpaid interest is
due June 30, 1997. The loan is secured by 258,687 shares of Common Stock held
by Dr. Emerson. Dr. Emerson is a director of the Company.
   
  In October 1993, the Company issued and sold 10,000 shares of Series C
Preferred Stock to Cobe at a purchase price of $1,000 per share. Upon the
closing of this offering, each outstanding share of Series C Preferred Stock
will be converted into 166 and two-thirds shares of Common Stock.     
 
  In October 1996, the Company executed a financing commitment with Cobe to
provide the Company with up to $5,000,000 (the "Equity Commitment") and up to
$5,000,000 in funding from Michigan under a convertible loan commitment
agreement ("Convertible Loan Commitment"). As of the date of this Prospectus,
the Company has not obtained any financing under these commitments. Both the
Equity Commitment and the Convertible Loan Commitment will terminate upon the
consummation of this offering.
 
                                      50

<PAGE>
 
  Under the terms of the Equity Commitment, the Company has an option to sell
up to $5,000,000 of Series F Preferred Stock at a price of $6.00 per share to
Cobe upon at least ninety days notice, which notice may be given at any time
until September 1, 1997. Cobe's obligation to purchase such shares will
terminate upon the closing of this offering. Although no shares of Series F
Preferred Stock are outstanding as of the date of this Prospectus, any
outstanding shares of Series F Preferred Stock would convert upon the closing
of this offering into Common Stock based upon a conversion price of 80% of the
price of two-thirds of a share of Common Stock sold in this offering. To the
extent shares are sold to Cobe under the Equity Commitment, Cobe's preemptive
right in the Company's next financing and the Company's Put Option to Cobe
would be reduced.
   
  On December 10, 1996, the Company issued to Cobe a notice to sell to Cobe
500,000 shares of Series F Preferred Stock for an aggregate purchase price of
$3,000,000 under the Equity Commitment. Such sale is scheduled to close on
March 19, 1997. In the event that this offering closes prior to March 19,
1997, Cobe's obligation to purchase Series F Preferred Stock under the Equity
Commitment will terminate. In the event that this offering closes after March
19, 1997, Cobe's participation in this offering will be reduced by $3,000,000,
the amount of its purchase of Series F Preferred Stock pursuant to the Equity
Commitment.     
   
  Upon the sale of $5,000,000 of Series F Preferred Stock under the Equity
Commitment, the Company becomes entitled to borrow funds from Michigan under
the Convertible Loan Commitment. The Company may borrow such funds upon at
least 45 days notice, which notice may be given during a period commencing on
October 15, 1996 and ending on September 1, 1997. Upon the completion by the
Company of a Qualifying Financing (as defined in the Convertible Loan
Commitment), the Company has the option to repay outstanding principal and
interest under the Convertible Loan Commitment in cash or to convert such
borrowings into convertible Preferred Stock at a conversion price equivalent
to 90% of the price per share in such financing. Under certain circumstances,
the Convertible Loan Commitment converts or is convertible into Series G
Preferred Stock. Interest accrues at an annual rate of 10% under the
Convertible Loan Commitment, and the Company may repay such principal and
interest at any time without penalty.     
 
  The Company has issued warrants to Michigan to purchase 69,444 shares of
Common Stock as consideration for securing the Convertible Loan Commitment and
has agreed to issue additional warrants to purchase 8,333 shares of Common
Stock for each $1,000,000 borrowed under the Convertible Loan Commitment, as
adjusted to the level of borrowing. The warrants become exercisable 90 days
after the closing of this offering. The warrants expire on October 15, 2000 if
not exercised, and may be exercised, in whole or in part, at a price equal to
the lesser of (a) $9.00 per share, which price increases by $3.00 per share
upon each anniversary of the closing of the offering made hereby; and (b) 85%
of the fair market value of the Company's Common Stock at the time of
exercise.
 
  Pursuant to its letter dated November 11, 1996, Cobe has elected to purchase
$5,000,000 of the Company's Common Stock in this offering at the initial
public offering price per share in satisfaction of its preemptive rights under
the Cobe Stock Agreement. In addition, the Company has elected not to exercise
its put option rights under the Cobe Stock Agreement with respect to this
offering. See "Description of Capital Stock--Rights of Cobe."
 
  The Company has entered into employment agreements with certain of its
executive officers. See "Management--Employment Agreements." The Company has
also entered into an Indemnification Agreement with certain of its directors,
officers and other key personnel. See "Management--Limitation of Liability and
Indemnification Matters."
 
                                      51

<PAGE>
 
                            PRINCIPAL SHAREHOLDERS
 
  The following table sets forth certain information regarding the beneficial
ownership of the shares of the Company's Common Stock as of September 30,
1996, and as adjusted to give effect to the sale of 3,250,000 shares of Common
Stock in this offering assuming (a) conversion of all of the Company's
outstanding shares of Preferred Stock into Common Stock and (b) no exercise of
the Underwriters' over-allotment option, and as adjusted to reflect the sale
of shares offered in this offering, (i) by each person the Company knows to be
the beneficial owner of 5% or more of the outstanding shares of Common Stock,
(ii) each named executive officer listed in the Summary Compensation Table,
(iii) each director of the Company, and (iv) all executive officers and
directors of the Company as a group.
 

<TABLE>
<CAPTION>
                                   SHARES BENEFICIALLY     SHARES BENEFICIALLY
                                      OWNED BEFORE             OWNED AFTER
                                     THE OFFERING(1)         THE OFFERING(1)
                                   ----------------------- -----------------------
BENEFICIAL OWNER                     NUMBER     PERCENT      NUMBER     PERCENT
- ----------------                   ------------ ---------- ------------ ----------
<S>                                <C>          <C>        <C>          <C>
H&Q Life Science(2)..............     1,061,334     10.6%     1,061,334      8.0%
 Technology Fund I
 One Bush Street, 18th Floor
 San Francisco, CA 94104
H&Q London Ventures..............       816,666      8.2%       816,666      6.2%
 One Bush Street, 18th Floor
 San Francisco, CA 94104
State Treasurer of the State of       1,338,724     13.4%     1,338,724     10.1%
 Michigan,(3)....................
 Custodian of certain retirement
 systems
 c/o Venture Capital Division
 430 West Allegan
 Lansing, MI 48992
SBIC Partners, L.P...............       627,451      6.3%       627,451      4.7%
 201 Main Street, Suite 2302
 Fort Worth, TX 76102
Brentwood Associates V, L.P.(4)..       745,831      7.5%       745,831      5.6%
 11150 Santa Monica Blvd., Suite
 1200
 Los Angeles, CA 90025
Wind Point Partners II, L.P......       559,500      5.6%       559,500      4.2%
 676 N. Michigan Ave., Suite 3300
 Chicago, IL 60611
Cobe Laboratories, Inc.(5).......     2,499,999     25.0%     3,055,555     23.1%
 1185 Oak Street
 Lakewood, CO 80215
R. Douglas Armstrong, Ph.D.(6)...       501,555      5.0%       501,555      3.8%
Albert B. Deisseroth, M.D.,              25,000        *         25,000        *
 Ph.D. ..........................
Stephen G. Emerson, M.D., Ph.D. .       256,789      2.6%       256,789      1.9%
G. Bradford Jones(7).............       745,831      7.5%       745,831      5.6%
Robert J. Kunze(8)...............     1,061,334     10.6%     1,061,334      8.0%
James Maluta(9)..................        83,333        *         83,333        *
Thomas E. Muller, Ph.D.(10)......        15,000        *         15,000        *
Walter C. Ogier(11)..............        20,833        *         20,833        *
Horst R. Witzel, Dr.-Ing.(12)....         8,237        *          8,237        *
Edward C. Wood, Jr.(13)..........     2,499,999     25.0%     3,055,555     23.1%
All officers and directors as a       5,237,911     52.1%     5,793,467     43.5%
 group (12 persons)(14)..........
</TABLE>

- --------
*  Represents less than 1% of outstanding Common Stock or voting power.
 
                                      52

<PAGE>
 
   
(1) Shares beneficially owned and percentage of ownership are based on
    9,985,734 shares of Common Stock outstanding before this offering and
    13,235,734 shares of Common Stock outstanding after the closing of this
    offering. Beneficial ownership is determined in accordance with the rules
    of the SEC and generally includes voting or disposition power with respect
    to securities.     
(2) Robert J. Kunze, Chairman of the Board of the Company, is a general
    partner of H&Q Life Science Venture Partners. See footnote 8, below.
(3) Does not include 69,444 shares issuable upon exercise of warrants held by
    Michigan that are exercisable 90 days after the closing of this offering.
(4) G. Bradford Jones, a director of the Company, is a general partner of
    Brentwood Associates V Ventures, L.P., which is the general partner of
    Brentwood Associates V, L.P. See footnote 7, below.
(5) The shares attributed to Cobe in the "Shares Beneficially Owned After the
    Offering" column include 555,556 shares of Common Stock which Cobe has
    agreed to purchase in this offering, assuming the closing of this offering
    at an initial public offering price of $9.00 per share. In addition,
    pursuant to the Cobe Stock Agreement, Cobe has an option to purchase from
    the Company an amount of Common Stock equal to 30% of the Company's fully
    diluted shares after the exercise of such option, at a purchase price
    equal to 120% of the public market trading price of the Company's Common
    Stock for a three-year period following the closing of this offering. Cobe
    also has a "right of first negotiation" in the event the Company receives
    any proposal concerning, or otherwise decides to pursue, a merger,
    consolidation or other transaction in which all or a majority of the
    Company's equity securities or all or substantially all of the Company's
    assets, or any material portion of the assets of the Company used by the
    Company in performing its obligations under the Distribution Agreement
    would be acquired by a third party outside of the ordinary course of
    business. Edward C. Wood, Jr., a director of the Company, is the President
    of Cobe BCT, Inc., an affiliate of Cobe. See footnote 13, below.
(6) Does not include 333,333 shares issuable upon exercise of options held by
    Dr. Armstrong that are exercisable upon the effective date of this
    offering.
(7) Consists of 745,831 shares held by Brentwood Associates V, L.P. See
    footnote 4, above. Mr. Jones, as a general partner of Brentwood Associates
    V Ventures, L.P., which is the general partner of Brentwood Associates V,
    L.P., may be deemed to beneficially own such shares, but Mr. Jones
    disclaims beneficial ownership of all such shares except to the extent of
    his pecuniary interest therein.
(8) Consists of 1,061,334 shares held by H&Q Life Science Technology Fund I.
    See footnote 2, above. Mr. Kunze, as a general partner of H&Q Life Science
    Venture Partners, may be deemed to beneficially own such shares, but Mr.
    Kunze disclaims beneficial ownership of all such shares except to the
    extent of his pecuniary interest therein.
(9) Includes 16,668 shares issuable upon exercise of options held by Mr.
    Maluta that are exercisable within the 60-day period following September
    30, 1996. Also includes 66,665 shares held of record by James Maluta and
    Deborah Vincent, as Trustees, with shared voting and investment power, of
    the James Maluta and Deborah Vincent Living Trust dated October 26, 1993.
(10) Consists of 15,000 shares issuable upon exercise of options held by Dr.
     Muller that are exercisable within the 60-day period following September
     30, 1996.
(11) Includes 15,833 shares issuable upon exercise of options held by Mr.
     Ogier that are exercisable within the 60-day period following September
     30, 1996.
(12) Includes 2,237 shares issuable upon exercise of options held by Dr.
     Witzel that are exercisable within the 60-day period following September
     30, 1996.
(13) The shares attributed to Mr. Wood in the "Shares Beneficially Owned
     Before the Offering" column consist of 2,499,999 shares held by Cobe and
     the shares attributed to Mr. Wood in the "Shares Beneficially Owned After
     the Offering" column consist of such shares and an additional 555,556
     shares which Cobe has agreed to purchase in this offering, assuming the
     closing of this offering at an initial public offering price of $9.00 per
     share. See footnote 5, above. Mr. Wood, as the President of Cobe BCT,
     Inc., an affiliate of Cobe, may be deemed to beneficially own such
     shares, but Mr. Wood disclaims beneficial ownership of all such shares.
(14) Includes 69,738 shares issuable upon exercise of options that are
     exercisable within the 60-day period following September 30, 1996. Does
     not include 333,333 shares issuable upon exercise of options that are
     exercisable as of the date of this Prospectus.
 
                                      53

<PAGE>
 

                         DESCRIPTION OF CAPITAL STOCK
 
  Upon the closing of this offering, the authorized capital stock of the
Company will consist of 40,000,000 shares of Common Stock, no par value per
share, and 5,000,000 shares of Preferred Stock, no par value per share.
 
COMMON STOCK
 
  As of September 30, 1996, without giving effect to the conversion of each
share of Preferred Stock into Common Stock upon the closing of this offering,
there were 1,887,312 shares of Common Stock outstanding held of record by 32
shareholders.
   
  The holders of Common Stock are entitled to one vote per share on all
matters to be voted upon by the shareholders. Subject to preferences that may
be applicable to outstanding shares of Preferred Stock, the holders of Common
Stock are entitled to receive ratably such dividends, if any, as may be
declared from time to time by the Board of Directors out of funds legally
available therefor. See "Dividend Policy." In the event of liquidation,
dissolution or winding up of the Company, the holders of Common Stock are
entitled to share ratably in all assets remaining after payment of
liabilities, subject to prior liquidation rights of holders of Preferred Stock
then outstanding. The Common Stock has no preemptive or conversion rights or
other subscription rights. There are no redemption or sinking fund provisions
applicable to the Common Stock. All outstanding shares of Common Stock are
fully paid and nonassessable. The rights, preferences and privileges of
holders of Common Stock are set forth in the Company's Restated Articles of
Incorporation, which Articles may be amended by the holders of at least two-
thirds of the outstanding shares of Common Stock. The rights of the holders of
Common Stock are also subject to, and may be adversely affected by, the rights
of the holders of any shares of any Preferred Stock which the Company may
designate and issue in the future.     
 
PREFERRED STOCK
 
  As of the closing of this offering, no shares of Preferred Stock will be
outstanding. Thereafter, the Board of Directors will be authorized, without
further shareholder approval, to issue up to 5,000,000 shares of Preferred
Stock in one or more series and to fix the rights, preferences, privileges and
restrictions granted or imposed upon any unissued shares of Preferred Stock
and to fix the number of shares constituting any series and the designations
of such series.
 
  The issuance of Preferred Stock may have the effect of delaying or
preventing a change in control of the Company. The issuance of Preferred Stock
could decrease the amount of earnings and assets available for distribution to
the holders of Common Stock or could adversely affect the rights and powers,
including voting rights, of the holders of the Common Stock. In certain
circumstances, such issuance could have the effect of decreasing the market
price of the Common Stock. The Company currently has no plans to issue any
shares of Preferred Stock.
 
MICHIGAN LAW AND CERTAIN CHARTER PROVISIONS
 
  The Company is a Michigan corporation and is subject to certain anti-
takeover provisions of the Michigan Business Corporation Act (the "MBCA")
which could delay or make more difficult a merger or tender offer involving
the Company. Chapter 7A of the MBCA prevents, in general, an "interested
shareholder" (defined generally as a person owning 10% or more of a
corporation's outstanding voting shares) from engaging in a "business
combination" (as defined therein) with a Michigan corporation unless: (a) the
Board of Directors issues an advisory statement, holders of 90% of the shares
of each class of stock entitled to vote approve the transaction, and holders
of two-thirds of the "disinterested" shares of each class of stock approve the
transaction; or (b) the interested shareholder has been an interested
shareholder for at least five years and has not acquired beneficial ownership
of any additional shares of the corporation subsequent to the transaction
which resulted in such shareholder being classified as an interested
shareholder, and meets certain requirements, including, but not limited to,
provisions relating to the fairness of the price and the form of consideration
paid; or (c) the Board of Directors, by resolution, exempts a particular
interested shareholder from these provisions prior to the interested
 
                                      54

<PAGE>
 
shareholder becoming an interested shareholder. The MBCA also contains certain
other provisions which could have anti-takeover effects, including, but not
limited to, Section 368, which pertains to "greenmail."
 
  The Company's Bylaws provide that the Board of Directors is divided into
three classes of directors, with each class serving a staggered three-year
term. The classification system of electing directors may tend to discourage a
third party from making a tender offer or otherwise attempting to obtain
control of the Company and may maintain the incumbency of the Board of
Directors, as it generally makes it more difficult for shareholders to replace
a majority of the directors. The Company's Restated Articles of Incorporation
eliminate the right of shareholders to act without a meeting and do not
provide for cumulative voting in the election of directors. The amendment of
any of these provisions would require approval by holders of at least two-
thirds of the shares of outstanding Common Stock.
 
  The foregoing and other statutory provisions and provisions of the Company's
Restated Articles of Incorporation could have the effect of deterring certain
takeovers or delaying or preventing certain changes in control or management
of the Company, including transactions in which shareholders might otherwise
receive a premium for their shares over then-current market prices.
 
REGISTRATION RIGHTS
 
  Pursuant to the Amended and Restated Investors Rights Agreement, dated as of
April 7, 1992, as amended (the "Investors Agreement"), certain holders of
outstanding shares of Common Stock, including shares of Common Stock issuable
upon conversion of the Preferred Stock (the "Registrable Securities"), are
entitled to certain demand and incidental registration rights with respect to
such shares, subject to certain customary limitations. Under the Investors
Agreement, subject to certain exceptions, the holders of at least 50% of the
Registrable Securities may require the Company to use its diligent best
efforts to register Registrable Securities for public resale on one occasion
(so long as such registration includes at least 20% of the Registrable
Securities or a lesser percentage if the anticipated aggregate offering price
net of underwriting discounts and commissions would exceed $2 million). In
addition, whenever the Company proposes to register any of its securities
under the Act, holders of Registrable Securities are entitled, subject to
certain restrictions (including customary underwriters "cut back"
limitations), to include their Registrable Securities in such registration.
Subject to certain limitations, the holders of Registrable Securities may also
require the Company to register such shares on Form S-3 no more than once
every twelve months, provided that the anticipated aggregate proceeds would
exceed $500,000. The Company is required to bear all registration and selling
expenses (other than underwriter's discounts and commissions and more than a
single special counsel to the selling shareholders) in connection with the
registration of Registrable Securities in one demand registration and two
piggy-back registrations. The participating investors are required to bear all
expenses in connection with the registration of Registrable Securities on Form
S-3.
 
  Registration rights may be transferred to an assignee or transferee provided
that such assignee or transferee acquires at least 66,667 shares of the
Registrable Securities held by the transferring holder (13,333 shares in the
case of a transfer from the holder of certain stock options). These
registration rights may be amended or waived (either generally or in a
particular instance) only with the written consent of the Company and the
holders of a majority of the Registrable Securities then outstanding.
 
  The registration rights granted under the Investors Agreement shall not be
exercisable by a holder during the period in which the holder may sell all of
the holder's shares under Rule 144 or Rule 144A during a single 90-day period.
   
  Pursuant to the Stock Purchase Agreement dated October 22, 1993 by and
between Cobe and the Company (the "Cobe Stock Agreement"), the Company granted
to Cobe certain stock registration rights for any and all of the Company's
Common Stock which Cobe acquires by conversion or otherwise. Cobe's stock
registration rights commence 30 months following an initial public offering,
or earlier in the event of any termination of the Distribution Agreement.
Pursuant to Cobe's registration rights, Cobe is entitled to two demand
registration rights, and an unlimited number of piggyback registration rights.
Cobe's stock registration rights are subject to     
 
                                      55

<PAGE>
 
customary underwriter's "cut back" requirements. The registration rights
granted to Cobe shall not be exercisable during the period in which Cobe has
the ability to sell all of its shares pursuant to Rule 144 during a single
ninety-day period. Subject to certain conditions, these registration rights
may be transferred with the transfer of stock to certain affiliates of the
transferor or to a transferee who acquires the greater of 66,667 shares or 20%
of the transferor's registrable stock.
 
RIGHTS OF COBE
 
  Pursuant to the Cobe Stock Agreement, Cobe purchased an aggregate of
$10,000,000 of shares of the Company's Series C Preferred Stock. Such shares
of Series C Preferred Stock will automatically convert into 1,666,666 shares
of Common Stock upon the closing of this offering.
 
  Pursuant to the Cobe Stock Agreement, Cobe also has certain preemptive
rights to purchase a portion of any new stock issued by the Company, subject
to certain exceptions, so as to enable Cobe to maintain its relative
percentage ownership and voting power interests in the Company. Pursuant to
such preemptive rights, Cobe has elected to purchase $5,000,000 of Common
Stock in this offering at the initial public offering price per share. Under
the terms of the Cobe Stock Agreement, the Company also has the right to
require Cobe to purchase stock issued by the Company in certain qualifying
offerings, under certain circumstances (the "Put Option"). The Put Option may
generally require Cobe to purchase up to 25% of the stock issued by the
Company in a qualifying offering upon the same terms and conditions as the
underwriters or other purchasers participating in the offering provided that
Cobe shall not be required to purchase stock having an aggregate purchase
price of more than $5,000,000. If the Company exercises the Put Option with
respect to any such qualifying offering, Cobe has the option to purchase the
greater of up to 40% of the number of shares to be offered in the qualifying
offering or the number of shares necessary to maintain its percentage
ownership interest in the Company. The Company has elected not to exercise the
Put Option with respect to this offering.
 
  Additionally, for a three-year period following the Company's completion of
its initial public offering of stock, Cobe will have an option to purchase
from the Company a quantity of new shares of the Company's Common Stock at a
price equal to 120% of the public market trading price for the Company's
Common Stock. The quantity of Common Stock to be purchased if Cobe exercises
this option shall be equal to 30% of the Company's fully diluted shares after
the exercise of this option.
 
  In the Cobe Stock Agreement, the Company also granted to Cobe a "right of
first negotiation" in the event the Company receives any proposal concerning,
or otherwise decides to pursue, a merger, consolidation or other transaction
in which all or a majority of the Company's equity securities or all or
substantially all of the Company's assets, or any material portion of the
assets of the Company used by the Company in performing its obligations under
the Distribution Agreement would be acquired by a third party outside of the
ordinary course of business.
 
  Pursuant to the Stock Purchase Commitment Agreement with Cobe, dated October
29, 1996, the Company agreed to use reasonable and good faith efforts to cause
a nominee of Cobe, who must be deemed by the Board of Directors to be
qualified to be elected to the Board of Directors for as long as Cobe owns at
least 15% of the outstanding Common Stock.
 
                                      56

<PAGE>
 
                        SHARES ELIGIBLE FOR FUTURE SALE
 
  Upon completion of this offering, the Company will have 13,235,734 shares of
Common Stock outstanding, assuming no exercise of any outstanding options
under any of the Company's option plans after September 30, 1996. Of these
shares, the 3,250,000 shares of Common Stock sold in this offering will be
freely transferable without restriction under the Securities Act unless they
are held by the Company's affiliates as that term is used in Rule 144 under
the Securities Act.
 
  The remaining 9,985,734 shares of Common Stock outstanding are "restricted
securities" as the term is defined by Rule 144 promulgated under the
Securities Act (the "Restricted Shares"). Of the 9,985,734 Restricted Shares,
6,996,920 shares may be sold under Rule 144, subject in some cases to certain
volume restrictions and other conditions imposed thereby. An additional
152,056 shares will become eligible for sale 90 days after completion of this
offering pursuant to Rule 144 and 701. The remaining 2,836,758 shares will be
eligible for sale upon the expiration of their respective holding periods as
set forth in Rule 144. The Securities and Exchange Commission has proposed
certain amendments to Rule 144 that would reduce by one year the holding
periods required for shares subject to Rule 144 to become eligible for resale
in the public market. This proposal, if adopted, would permit earlier resale
of shares of Common Stock currently subject to holding periods under Rule 144.
No assurance can be given concerning whether or when the proposal will be
adopted by the Securities and Exchange Commission. Furthermore, 9,947,757 of
the Restricted Shares are subject to lock-up agreements expiring 180 days
following the date of this Prospectus. Such agreements provide that Cowen &
Company may, in its sole discretion and at any time without notice, release
all or a portion of the shares subject to these lock-up agreements. Upon the
expiration of the lock-up agreements, 7,148,976 of the 9,985,734 Restricted
Shares may be sold pursuant to Rule 144 or 701, subject in some cases to
certain volume restrictions imposed thereby. Certain existing shareholders
have rights to include shares of Common Stock owned by them in future
registrations by the Company for the sale of Common Stock or to request that
the Company register their shares under the Securities Act. See "Description
of Capital Stock--Registration Rights." Following the date of this Prospectus,
the Company intends to register on one or more registration statements on Form
S-8 approximately 1,837,160 shares of Common Stock issuable under its stock
option and stock purchase plan. Of the 1,837,160 shares issuable under the
Company's stock option and stock purchase plans, 336,254 shares are subject to
outstanding options as of September 30, 1996, all of which shares are subject
to lock-up agreements. Shares covered by such registration statements will
immediately be eligible for sale in the public market upon the filing of such
registration statements. The Company also has issued warrants to purchase
69,444 shares of Common Stock which become exercisable 90 days after the
closing of this offering and, upon the effective date of this offering, will
grant an immediately exercisable option to purchase 333,333 shares of Common
Stock. The shares issuable upon exercise of such warrants and the shares
issuable upon exercise of such option will be subject to lock-up agreements.
In addition, Cobe has agreed to purchase $5,000,000 of Common Stock in this
offering at the initial public offering price per share, all of which shares
will be subject to a lock-up agreement.
 
  In general, under Rule 144, a person (or persons whose shares are
aggregated), shareholders, including an affiliate, who has beneficially owned
shares for at least two years is entitled to sell in broker transactions,
within any three-month period, commencing 90 days after this offering, a
number of shares that does not exceed the greater of (i) 1% of the then
outstanding Common Stock (approximately 132,357 shares immediately after this
offering assuming no exercise of the Underwriters' over-allotment option) or
(ii) the average weekly trading volume in the Common Stock during the four
calendar weeks preceding the sale, subject to the filing of a Form 144 with
respect to the sale and other limitations. In general, shares issued in
compliance with Rule 701 may be sold by non-affiliates subject to the manner
of sale requirements of Rule 144, but without compliance with the other
requirements of Rule 144. Affiliates may sell shares they acquired under Rule
701 in compliance with the provisions of Rule 144, except that there is no
required holding period. A person who is not an affiliate, has not been an
affiliate within three months prior to sale and has beneficially owned the
Restricted Shares for at least three years, is entitled to sell such shares
under Rule 144 without regard to any of the limitations described above.
 
  The Company has also agreed not to offer, sell, contract to sell or
otherwise dispose of any shares of Common Stock or any securities convertible
into or exercisable or exchangeable for Common Stock or any rights to acquire
Common Stock for a period of 180 days after the date of this Prospectus,
without the prior written consent of the Underwriters, subject to certain
limited exceptions (including exercises of stock options).
 
  Prior to this offering, there has been no public market for the Common Stock
of the Company. No prediction can be made regarding the effect, if any, that
the sale or availability for sale of shares of additional Common Stock will
have on the market price of the Common Stock. Nevertheless, sales of
substantial numbers of shares by existings shareholders or by shareholders
purchasing in their offering could have a negative effect on the market price
of the Common Stock.
 
                                      57

<PAGE>
 

                                 UNDERWRITING
 
  Subject to the terms and conditions of the Underwriting Agreement, the
Underwriters named below (the "Underwriters"), through their Representatives,
Cowen & Company and J.P. Morgan Securities Inc., have severally agreed to
purchase from the Company the following respective number of shares of Common
Stock at the initial public offering price less the underwriting discounts and
commissions set forth on the cover page of this Prospectus:

<TABLE>
<CAPTION>
                                                                    NUMBER OF
                                                                    SHARES OF
     UNDERWRITER                                                   COMMON STOCK
     -----------                                                   ------------
   <S>                                                             <C>
   Cowen & Company................................................
   J.P. Morgan Securities Inc.....................................
                                                                    ---------
     Total........................................................  3,250,000
                                                                    =========
</TABLE>

 
  The Underwriting Agreement provides that the obligations of the Underwriters
are subject to certain conditions precedent and that the Underwriters will
purchase all of the Common Stock offered hereby if any of such shares are
purchased.
 
  The Company has been advised by the Representatives of the Underwriters that
the Underwriters propose to offer the shares of Common Stock to the public at
the initial public offering price set forth on the cover page of this
Prospectus and to certain dealers at such price less a concession not in
excess of $    per share. The Underwriters may allow, and such dealers may
reallot, a concession not in excess of $    per share to certain other
dealers. After the initial public offering, the offering price and other
selling terms may be changed by the Representatives of the Underwriters.
 
  The Company has granted to the Underwriters an option, exercisable not later
than 30 days after the date of this Prospectus, to purchase up to 487,500
additional shares of Common Stock at the initial public offering price less
the underwriting discounts and commissions set forth on the cover page of this
Prospectus. To the extent that the Underwriters exercise such option, each of
the Underwriters will have a firm commitment to purchase approximately the
same percentage thereof that the number of shares of Common Stock to be
purchased by it shown in the above table bears to 3,250,000, and the Company
will be obligated, pursuant to the option, to sell such shares to the
Underwriters. The Underwriters may exercise such option only to cover over-
allotments made in connection with the sale of the Common Stock offered
hereby. If purchased, the Underwriters will offer such additional shares on
the same terms as those on which the 3,250,000 shares are being offered.
 
  As part of this offering, Cobe has agreed with the Company to purchase from
the Underwriters $5,000,000 of Common Stock at the initial public offering
price per share.
 
  The Company has agreed to indemnify the several Underwriters against certain
liabilities, including liabilities under the Securities Act.
 
  The Company and its directors and officers, and certain of its other
shareholders and optionholders, have entered into agreements providing that,
for a period of 180 days after the date of this Prospectus, they will not,
without the prior written consent of Cowen & Company, offer, sell, contract to
sell or otherwise dispose of any shares of Common Stock or any securities
convertible into, or exchangeable for, or warrants to purchase, any shares of
Common Stock, or grant any option to purchase or right to acquire or acquire
any option to dispose of any shares of Common Stock, except in certain limited
circumstances. See "Shares Eligible for Future Sale."
 
  The Representatives of the Underwriters have advised the Company that the
Underwriters do not intend to confirm sales to any account over which they
exercise discretionary authority.
 
 
                                      58

<PAGE>
 
  Prior to this offering, there has been no public market for the Common Stock
of the Company. Consequently, the initial public offering price for the Common
Stock has been determined by negotiations between the Company and the
Representatives of the Underwriters. Among the factors considered in such
negotiations were prevailing market conditions, the results of operations of
the Company in recent periods, the market capitalizations and stages of
development of other companies that the Company and the Representatives of the
Underwriters believe to be comparable to the Company, estimates of the
business potential of the Company, the present state of the Company's
development, and other factors deemed relevant.
 
TRANSFER AGENT AND REGISTRAR
 
  The Transfer Agent and Registrar for the Common Stock is Continental Stock
Transfer & Trust Company. Its telephone number in New York, New York is (212)
509-4000.
 

                                 LEGAL MATTERS
 
  The validity of the Common Stock offered hereby will be passed upon for the
Company by Pepper, Hamilton & Scheetz, Detroit, Michigan. Michael B. Staebler,
a partner at Pepper, Hamilton & Scheetz, is the beneficial owner of 3,333
shares of Common Stock. Gray Cary Ware & Freidenrich, A Professional
Corporation, San Diego, California, has acted as special counsel to the
Company in connection with the offering. Certain legal matters in connection
with this offering will be passed upon for the Underwriters by Brobeck,
Phleger & Harrison LLP, New York, New York.
 

                                    EXPERTS
 
  The balance sheets of the Company as of June 30, 1995 and 1996, and the
statements of operations, shareholders' equity, and cash flows for the years
ended June 30, 1994, 1995 and 1996 and the cumulative period from March 24,
1989 (Inception) to June 30, 1996 included in this Prospectus, have been
included herein in reliance on the report of Coopers & Lybrand L.L.P.,
independent accountants, given upon the authority of that firm as experts in
accounting and auditing.
 
  The statements in this Prospectus concerning the patents and patent
applications either owned or licensed by the Company under the captions "Risk
Factors--Uncertainty Regarding Patents and Proprietary Rights" and "Business--
Patents and Proprietary Rights" and the other references herein concerning the
patents and patent applications either owned or licensed by the Company have
been reviewed and approved by Oblon, Spivak, McClelland, Maier & Neustadt,
P.C., Arlington, Virginia, patent counsel to the Company, as experts on such
matters, and are included herein in reliance upon that review and approval.
 
                            ADDITIONAL INFORMATION
 
  The Company has filed with the Securities and Exchange Commission,
Washington, D.C. 20549, a Registration Statement on Form S-1 under the
Securities Act of 1933, as amended, with respect to the Common Stock offered
hereby. This Prospectus does not contain all of the information set forth in
the Registration Statement and the exhibits and schedules thereto. For further
information with respect to the Company and the Common Stock, reference is
made to the Registration Statement and the exhibits and schedules filed as a
part thereof. Statements contained in this Prospectus as to the contents of
any contract or any other document referred to are not necessarily complete,
and, in each instance, if such contract or document is filed as an exhibit,
reference is made to the copy of such contract or document filed as an exhibit
to the Registration Statement, each such statement being qualified in all
respects by such reference to such exhibit. The Registration Statement,
including exhibits and schedules thereto, may be inspected without charge at
the Commission's principal office in Washington, D.C., and copies of all or
any part thereof may be obtained from such office after payment of fees
prescribed by the Commission.
 
  The Company intends to furnish to its shareholders annual reports containing
financial statements audited by its independent certified public accountants
and make available to its shareholders quarterly reports containing unaudited
financial data for the first three quarters of each fiscal year.
 
                                      59

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 

                         INDEX TO FINANCIAL STATEMENTS
 

<TABLE>
<CAPTION>
                                                                          PAGE
                                                                          ----
<S>                                                                       <C>
Report of Independent Accountants........................................ F-2
Balance Sheets as of June 30, 1995 and 1996 and September 30, 1996
 (Unaudited)............................................................. F-3
Statements of Operations for the years ended June 30, 1994, 1995 and
 1996, for the period from March 24, 1989 (Inception) to June 30, 1996,
 for the three months ended September 30, 1995 and 1996 (Unaudited) and
 for the period from March 24, 1989 (Inception) to September 30, 1996
 (Unaudited)............................................................. F-4
Statements of Shareholders' Equity from March 24, 1989 (Inception) to
 June 30, 1996 and for the three months ended September 30, 1996
 (Unaudited)............................................................. F-5
Statements of Cash Flows for the years ended June 30, 1994, 1995 and
 1996, for the period from March 24, 1989 (Inception) to June 30, 1996,
 for the three months ended September 30, 1995 and 1996 (Unaudited) and
 for the period from March 24, 1989 (Inception) to September 30, 1996
 (Unaudited)............................................................. F-6
Notes to Financial Statements............................................ F-7

</TABLE>

 
                                      F-1

<PAGE>
 

                       REPORT OF INDEPENDENT ACCOUNTANTS
 
To the Board of Directors of
Aastrom Biosciences, Inc.:
 
  We have audited the accompanying balance sheets of Aastrom Biosciences, Inc.
(a Michigan corporation in the development stage) as of June 30, 1995 and
1996, and the related statements of operations, stockholders' equity, and cash
flows for the years ended June 30, 1994, 1995 and 1996, and the cumulative
period from March 24, 1989 (inception) to June 30, 1996. These financial
statements are the responsibility of the Company's management. Our
responsibility is to express an opinion on these financial statements based on
our audits.
 
  We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to
obtain reasonable assurance about whether the financial statements are free of
material misstatement. An audit includes examining, on a test basis, evidence
supporting the amounts and disclosures in the financial statements. An audit
also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial
statement presentation. We believe that our audits provide a reasonable basis
for our opinion.
 
  In our opinion, the financial statements referred to above present fairly,
in all material respects, the financial position of Aastrom Biosciences, Inc.
as of June 30, 1995 and 1996, and the results of its operations and its cash
flows for the years ended June 30, 1994, 1995 and 1996, and the cumulative
period from March 24, 1989 (inception) to June 30, 1996, in conformity with
generally accepted accounting principles.
 
Detroit, Michigan
August 9, 1996

 

To the Board of Directors of
Aastrom Biosciences, Inc.:
 
  The financial statements herein have been adjusted to give effect to the 2
for 3 reverse stock split of the Company's outstanding Common Shares as
described more fully in Note 1 to the financial statements. The above report
is in the form that will be signed by Coopers & Lybrand L.L.P. upon the
effectiveness of such split assuming that, from October 31, 1996 to the
effective date of such split, no other events shall have occurred that would
affect the accompanying financial statements or notes thereto.
 
                                          Coopers & Lybrand L.L.P.
 
Detroit, Michigan
October 31, 1996

 
                                      F-2

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                                 BALANCE SHEETS
 

<TABLE>
<CAPTION>
                                                                     PRO FORMA
                                                                   SHAREHOLDERS'
                                  JUNE 30,                           EQUITY AT
                          -------------------------  SEPTEMBER 30, SEPTEMBER 30,
                              1995         1996          1996          1996
                          -------------------------  ------------- -------------
                                                      (UNAUDITED)   (UNAUDITED)
<S>                       <C>           <C>          <C>           <C>
ASSETS
CURRENT ASSETS:
  Cash and cash
   equivalents........... $  2,680,000  $10,967,000   $ 5,908,000
  Short-term investments.    8,388,000           --     1,200,000
  Receivables............       99,000       81,000       220,000
  Prepaid expenses.......      105,000      437,000       378,000
                          ------------  -----------   -----------
    Total current assets.   11,272,000   11,485,000     7,706,000
PROPERTY, NET............    1,279,000    1,188,000     1,225,000
                          ------------  -----------   -----------
    Total assets......... $ 12,551,000  $12,673,000   $ 8,931,000
                          ============  ===========   ===========
LIABILITIES AND SHAREHOLDER'S EQUITY
CURRENT LIABILITIES:
  Accounts payable and
   accrued expenses...... $    328,000  $ 1,192,000   $   841,000
  Accrued employee
   expenses..............      130,000       97,000        80,000
  Current portion of
   capital lease
   obligations...........      270,000      223,000       192,000
  Deferred revenue.......      225,000      122,000        53,000
                          ------------  -----------   -----------
    Total current
     liabilities.........      953,000    1,634,000     1,166,000
CAPITAL LEASE
 OBLIGATIONS.............      412,000      189,000       147,000
COMMITMENTS (Note 7)
SHAREHOLDERS' EQUITY:
Preferred Stock, no par
 value, shares
 authorized--8,540,000,
 9,951,765 and
 10,157,647,
 respectively, issued and
 outstanding--8,040,001,
 9,451,766 and 9,657,648,
 respectively (none--pro
 forma), (liquidation
 preference of
 $34,560,000 and
 $35,375,000 at June 30,
 1996 and September 30,
 1996, respectively).....   28,253,000   34,218,000    37,718,000   $        --
Common Stock, no par
 value, shares
 authorized--17,000,000,
 18,500,000 and
 18,500,000,
 respectively, issued and
 outstanding--1,731,463,
 1,886,479 and 1,887,312,
 respectively
 (9,985,734--pro forma)..      241,000      324,000       365,000    38,083,000
Deficit accumulated
 during the development
 stage...................  (17,108,000) (27,025,000)  (30,298,000)  (30,298,000)
Shareholder notes
 receivable..............     (198,000)    (167,000)     (167,000)     (167,000)
Stock purchase rights....           --    3,500,000            --            --
Unrealized losses on
 investments.............       (2,000)          --            --            --
                          ------------  -----------   -----------   -----------
  Total shareholders'
   equity................   11,186,000   10,850,000     7,618,000   $ 7,618,000
                          ------------  -----------   -----------   ===========
    Total liabilities and
     shareholders'
     equity.............. $ 12,551,000  $12,673,000   $ 8,931,000
                          ============  ===========   ===========
</TABLE>

 
   The accompanying notes are an integral part of these financial statements.
 
                                      F-3

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                            STATEMENTS OF OPERATIONS
 

<TABLE>
<CAPTION>
                                                                                                            MARCH 24,
                                                                   MARCH 24,                                  1989
                                                                      1989        THREE MONTHS ENDED      (INCEPTION)
                                  YEAR ENDED JUNE 30,             (INCEPTION)        SEPTEMBER 30,             TO
                          --------------------------------------  TO JUNE 30,   ------------------------  SEPTEMBER 30,
                             1994         1995          1996          1996         1995         1996          1996
                          -----------  -----------  ------------  ------------  -----------  -----------  -------------
                                                                                      (UNAUDITED)          (UNAUDITED)
<S>                       <C>          <C>          <C>           <C>           <C>          <C>          <C>
REVENUES:
 Research and
  development
  agreements............  $    49,000  $   396,000  $  1,342,000  $  1,787,000  $   172,000  $   195,000  $  1,982,000
 Grants.................      823,000      121,000       267,000     1,995,000       39,000       29,000     2,024,000
                          -----------  -----------  ------------  ------------  -----------  -----------  ------------
   Total revenues.......      872,000      517,000     1,609,000     3,782,000      211,000      224,000     4,006,000
COSTS AND EXPENSES:
 Research and
  development...........    5,627,000    4,889,000    10,075,000    25,075,000    1,195,000    3,160,000    28,235,000
 General and
  administrative........    1,565,000    1,558,000     2,067,000     7,089,000      446,000      452,000     7,541,000
                          -----------  -----------  ------------  ------------  -----------  -----------  ------------
   Total costs and
    expenses............    7,192,000    6,447,000    12,142,000    32,164,000    1,641,000    3,612,000    35,776,000
                          -----------  -----------  ------------  ------------  -----------  -----------  ------------
LOSS BEFORE OTHER INCOME
 AND EXPENSE............   (6,320,000)  (5,930,000)  (10,533,000)  (28,382,000)  (1,430,000)  (3,388,000)  (31,770,000)
                          -----------  -----------  ------------  ------------  -----------  -----------  ------------
OTHER INCOME (EXPENSE):
 Interest income........      245,000      279,000       678,000     1,576,000      149,000      126,000     1,702,000
 Interest expense.......      (65,000)     (66,000)      (62,000)     (219,000)     (18,000)     (11,000)     (230,000)
                          -----------  -----------  ------------  ------------  -----------  -----------  ------------
   Other income.........      180,000      213,000       616,000     1,357,000      131,000      115,000     1,472,000
                          -----------  -----------  ------------  ------------  -----------  -----------  ------------
NET LOSS................  $(6,140,000) $(5,717,000) $ (9,917,000) $(27,025,000) $(1,299,000) $(3,273,000) $(30,298,000)
                          ===========  ===========  ============  ============  ===========  ===========  ============
PRO FORMA NET LOSS PER
 SHARE..................  $      (.82) $      (.66) $       (.98)               $      (.13) $      (.32)
                          ===========  ===========  ============                ===========  ===========
Pro forma weighted
 average number of
 common and common
 equivalent shares
 outstanding............    7,461,000    8,644,000    10,103,000                 10,094,000   10,107,000
                          ===========  ===========  ============                ===========  ===========
</TABLE>

 
 
   The accompanying notes are an integral part of these financial statements.
 
                                      F-4

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.

                         (A DEVELOPMENT STAGE COMPANY)
 
                       STATEMENTS OF SHAREHOLDERS' EQUITY
 

<TABLE>
<CAPTION>
                                                                   DEFICIT
                                                                 ACCUMULATED
                       PREFERRED STOCK         COMMON STOCK       DURING THE   SHAREHOLDER   STOCK       UNREALIZED
                    ----------------------  -------------------  DEVELOPMENT      NOTES     PURCHASE   GAINS (LOSSES)
                     SHARES      AMOUNT      SHARES     AMOUNT      STAGE      RECEIVABLE    RIGHTS    ON INVESTMENTS
                    ---------  -----------  ---------  --------  ------------  ----------- ----------  --------------
 <S>                <C>        <C>          <C>        <C>       <C>           <C>         <C>         <C>
 Balance, March
  24, 1989
  (Inception)....          --  $        --         --  $     --  $         --   $      --  $       --    $      --
 Non-cash
  issuance of
  Common Stock...                             454,545        --
 Issuance of
  Series A
  Preferred Stock
  at $1.00 per
  share in August
  1989...........   1,500,000    1,500,000
 Net loss........                                                    (500,000)
                    ---------  -----------  ---------  --------  ------------   ---------  ----------    ---------
 Balance, June
  30, 1990.......   1,500,000    1,500,000    454,545        --      (500,000)         --          --           --
 Issuance of
  Series A
  Preferred Stock
  in March 1991
  at $1.00 per
  share, net of
  issuance costs
  of $5,000......   1,000,000      995,000
 Net loss........                                                    (636,000)
                    ---------  -----------  ---------  --------  ------------   ---------  ----------    ---------
 Balance, June
  30, 1991.......   2,500,000    2,495,000    454,545        --    (1,136,000)         --          --           --
 Issuance of
  Series B
  Preferred Stock
  in April 1992
  at $2.00 per
  share, net of
  issuance costs
  of $46,000.....   3,030,000    6,014,000
 Net loss........                                                  (1,268,000)
                    ---------  -----------  ---------  --------  ------------   ---------  ----------    ---------
 Balance, June
  30, 1992.......   5,530,000    8,509,000    454,545        --    (2,404,000)         --          --           --
 Issuance of
  Common Stock
  for services...                              33,333    10,000
 Exercise of
  stock option...                               6,873     1,000
 Net loss........                                                  (2,847,000)
                    ---------  -----------  ---------  --------  ------------   ---------  ----------    ---------
 Balance, June
  30, 1993.......   5,530,000    8,509,000    494,751    11,000    (5,251,000)         --          --           --
 Issuance of
  Series C
  Preferred Stock
  in October 1993
  at $1,000 per
  share, net of
  issuance costs
  of $175,000....      10,000    9,825,000
 Exercise of
  stock options..                           1,222,609   229,000                  (198,000)
 Net loss........                                                  (6,140,000)
                    ---------  -----------  ---------  --------  ------------   ---------  ----------    ---------
 Balance, June
  30, 1994.......   5,540,000   18,334,000  1,717,360   240,000   (11,391,000)   (198,000)         --           --
 Issuance of
  Series D
  Preferred Stock
  in April and
  May 1995 at
  $4.00 per
  share, net of
  issuance costs
  of $81,000.....   2,500,001    9,919,000
 Exercise of
  stock options..                              39,103     8,000
 Retirement of
  Common Stock
  outstanding....                             (25,000)   (7,000)
 Unrealized loss
  on investments.                                                                                           (2,000)
 Net loss........                                                  (5,717,000)
                    ---------  -----------  ---------  --------  ------------   ---------  ----------    ---------
 Balance, June
  30, 1995.......   8,040,001   28,253,000  1,731,463   241,000   (17,108,000)   (198,000)         --       (2,000)
 Issuance of
  Series E
  Preferred Stock
  in January 1996
  at $4.25 per
  share, net of
  issuance costs
  of $35,000.....   1,411,765    5,965,000
 Exercise of
  stock options..                             130,016    53,000
 Issuance of
  Common Stock at
  $1.20 per
  share..........                              25,000    30,000
 Issuance of
  Stock Purchase
  Rights for cash
  in September
  1995 and March
  1996...........                                                                           3,500,000
 Repurchase of
  Series D
  Preferred Stock
  at $4.00 per
  share..........     (62,500)    (250,000)
 Sale of Series D
  Preferred Stock
  at $4.00 per
  share..........      62,500      250,000
 Principal
  payment
  received under
  shareholder
  note
  receivable.....                                                                  31,000
 Unrealized gain
  on investments.                                                                                            2,000
 Net loss........                                                  (9,917,000)
                    ---------  -----------  ---------  --------  ------------   ---------  ----------    ---------
 Balance, June
  30, 1996.......   9,451,766   34,218,000  1,886,479   324,000   (27,025,000)   (167,000)  3,500,000           --
 Unaudited:
 Exercise of
  stock options..                                 833     1,000
 Issuance of
  Series E
  Preferred Stock
  to RPR at
  $17.00 per
  share..........     205,882    3,500,000                                                 (3,500,000)
 Compensation
  expense related
  to stock
  options
  granted........                                        40,000
 Net loss........                                                  (3,273,000)
                    ---------  -----------  ---------  --------  ------------   ---------  ----------    ---------
 Balance,
  September 30,
  1996
  (Unaudited)....   9,657,648  $37,718,000  1,887,312  $365,000  $(30,298,000)  $(167,000) $       --    $      --
                    =========  ===========  =========  ========  ============   =========  ==========    =========
<CAPTION>
                        TOTAL
                    SHAREHOLDERS'
                       EQUITY
                    -------------
 <S>                <C>
 Balance, March
  24, 1989
  (Inception)....    $       --
 Non-cash
  issuance of
  Common Stock...            --
 Issuance of
  Series A
  Preferred Stock
  at $1.00 per
  share in August
  1989...........     1,500,000
 Net loss........      (500,000)
                    -----------
 Balance, June
  30, 1990.......     1,000,000
 Issuance of
  Series A
  Preferred Stock
  in March 1991
  at $1.00 per
  share, net of
  issuance costs
  of $5,000......       995,000
 Net loss........      (636,000)
                    -----------
 Balance, June
  30, 1991.......     1,359,000
 Issuance of
  Series B
  Preferred Stock
  in April 1992
  at $2.00 per
  share, net of
  issuance costs
  of $46,000.....     6,014,000
 Net loss........    (1,268,000)
                    -----------
 Balance, June
  30, 1992.......     6,105,000
 Issuance of
  Common Stock
  for services...        10,000
 Exercise of
  stock option...         1,000
 Net loss........    (2,847,000)
                    -----------
 Balance, June
  30, 1993.......     3,269,000
 Issuance of
  Series C
  Preferred Stock
  in October 1993
  at $1,000 per
  share, net of
  issuance costs
  of $175,000....     9,825,000
 Exercise of
  stock options..        31,000
 Net loss........    (6,140,000)
                    -----------
 Balance, June
  30, 1994.......     6,985,000
 Issuance of
  Series D
  Preferred Stock
  in April and
  May 1995 at
  $4.00 per
  share, net of
  issuance costs
  of $81,000.....     9,919,000
 Exercise of
  stock options..         8,000
 Retirement of
  Common Stock
  outstanding....        (7,000)
 Unrealized loss
  on investments.        (2,000)
 Net loss........    (5,717,000)
                    -----------
 Balance, June
  30, 1995.......    11,186,000
 Issuance of
  Series E
  Preferred Stock
  in January 1996
  at $4.25 per
  share, net of
  issuance costs
  of $35,000.....     5,965,000
 Exercise of
  stock options..        53,000
 Issuance of
  Common Stock at
  $1.20 per
  share..........        30,000
 Issuance of
  Stock Purchase
  Rights for cash
  in September
  1995 and March
  1996...........     3,500,000
 Repurchase of
  Series D
  Preferred Stock
  at $4.00 per
  share..........      (250,000)
 Sale of Series D
  Preferred Stock
  at $4.00 per
  share..........       250,000
 Principal
  payment
  received under
  shareholder
  note
  receivable.....        31,000
 Unrealized gain
  on investments.         2,000
 Net loss........    (9,917,000)
                    -----------
 Balance, June
  30, 1996.......    10,850,000
 Unaudited:
 Exercise of
  stock options..         1,000
 Issuance of
  Series E
  Preferred Stock
  to RPR at
  $17.00 per
  share..........            --
 Compensation
  expense related
  to stock
  options
  granted........        40,000
 Net loss........    (3,273,000)
                    -----------
 Balance,
  September 30,
  1996
  (Unaudited)....    $7,618,000
                    ===========
</TABLE>

 
   The accompanying notes are an integral part of these financial statements.
 
                                      F-5

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.

                         (A DEVELOPMENT STAGE COMPANY)
 
                            STATEMENTS OF CASH FLOWS
 

<TABLE>
<CAPTION>
                                                                                                           MARCH 24,
                                                                  MARCH 24,                                  1989
                                                                     1989        THREE MONTHS ENDED       (INCEPTION)
                                  YEAR ENDED JUNE 30,            (INCEPTION)        SEPTEMBER 30,             TO
                          -------------------------------------  TO JUNE 30,   ------------------------  SEPTEMBER 30,
                             1994         1995         1996          1996         1995         1996          1996
                          -----------  -----------  -----------  ------------  -----------  -----------  -------------
                                                                                     (UNAUDITED)          (UNAUDITED)
<S>                       <C>          <C>          <C>          <C>           <C>          <C>          <C>
OPERATING ACTIVITIES:
 Net loss...............  $(6,140,000) $(5,717,000) $(9,917,000) $(27,025,000) $(1,299,000) $(3,273,000) $(30,298,000)
 Adjustments to
  reconcile net loss to
  net cash used for
  operating activities:
   Depreciation and
    amortization........      248,000      329,000      536,000     1,267,000       91,000      136,000     1,403,000
   Loss on property held
    for resale..........           --           --           --       110,000           --           --       110,000
   Amortization of
    discounts and
    premiums on
    investments.........           --       (9,000)    (110,000)     (119,000)     (48,000)          --      (119,000)
   Expense related to
    stock and stock
    options granted.....           --           --           --        10,000           --       40,000        50,000
   Changes in assets and
    liabilities:
     Receivables........       11,000      132,000       18,000       (81,000)       4,000     (139,000)     (220,000)
     Prepaid expenses...      (17,000)     (59,000)    (332,000)     (437,000)      27,000       59,000      (378,000)
     Accounts payable
      and accrued
      expenses..........      (45,000)     (40,000)     864,000     1,192,000      (35,000)    (351,000)      841,000
     Accrued employee
      expenses..........       53,000       28,000      (33,000)       97,000      (58,000)     (17,000)       80,000
     Deferred revenue...      146,000       79,000     (103,000)      122,000     (172,000)     (69,000)       53,000
                          -----------  -----------  -----------  ------------  -----------  -----------  ------------
 Net cash used for
  operating activities..   (5,744,000)  (5,257,000)  (9,077,000)  (24,864,000)  (1,490,000)  (3,614,000)  (28,478,000)
INVESTING ACTIVITIES:
 Organizational costs...           --           --           --       (73,000)          --           --       (73,000)
 Purchase of short-term
  investments...........     (967,000) (10,981,000)          --   (11,948,000)          --   (1,200,000)  (13,148,000)
 Maturities of short-
  term investments......           --    3,567,000    8,500,000    12,067,000    2,500,000           --    12,067,000
 Capital purchases......     (320,000)    (118,000)    (445,000)   (1,718,000)     (15,000)    (173,000)   (1,891,000)
 Proceeds from sale of
  property held for
  resale................           --           --           --       400,000           --           --       400,000
                          -----------  -----------  -----------  ------------  -----------  -----------  ------------
 Net cash provided by
  (used for) investing
  activities............   (1,287,000)  (7,532,000)   8,055,000    (1,272,000)   2,485,000   (1,373,000)   (2,645,000)
FINANCING ACTIVITIES:
 Issuance of Preferred
  Stock.................    9,825,000    9,919,000    5,965,000    34,218,000           --           --    34,218,000
 Issuance of Common
  Stock.................       31,000        1,000       83,000       116,000        3,000        1,000       117,000
 Payments received for
  stock purchase rights.           --           --    3,500,000     3,500,000    1,500,000           --     3,500,000
 Payments received under
  shareholder notes.....           --           --       31,000        31,000           --           --        31,000
 Principal payments
  under capital lease
  obligations...........     (147,000)    (214,000)    (270,000)     (762,000)     (65,000)     (73,000)     (835,000)
                          -----------  -----------  -----------  ------------  -----------  -----------  ------------
 Net cash provided by
  (used for) financing
  activities............    9,709,000    9,706,000    9,309,000    37,103,000    1,438,000      (72,000)   37,031,000
                          -----------  -----------  -----------  ------------  -----------  -----------  ------------
NET INCREASE (DECREASE)
 IN CASH AND CASH
 EQUIVALENTS............    2,678,000   (3,083,000)   8,287,000    10,967,000    2,433,000   (5,059,000)    5,908,000
CASH AND CASH
 EQUIVALENTS AT
 BEGINNING OF PERIOD....    3,085,000    5,763,000    2,680,000            --    2,680,000   10,967,000            --
                          -----------  -----------  -----------  ------------  -----------  -----------  ------------
CASH AND CASH
 EQUIVALENTS AT END OF
 PERIOD.................  $ 5,763,000  $ 2,680,000  $10,967,000  $ 10,967,000  $ 5,113,000  $ 5,908,000  $  5,908,000
                          ===========  ===========  ===========  ============  ===========  ===========  ============
SUPPLEMENTAL DISCLOSURES
 OF CASH FLOW
 INFORMATION:
 Interest paid..........  $    65,000  $    66,000  $    62,000  $    219,000  $    18,000  $    11,000  $    230,000
                          ===========  ===========  ===========  ============  ===========  ===========  ============
SUPPLEMENTAL DISCLOSURES
 OF NON-CASH INVESTING
 AND FINANCING
 ACTIVITIES:
 Additions to capital
  lease obligations.....  $   348,000  $   270,000  $        --  $  1,174,000  $        --  $        --  $  1,174,000
                          ===========  ===========  ===========  ============  ===========  ===========  ============
</TABLE>

 
   The accompanying notes are an integral part of these financial statements.
 
                                      F-6

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                         NOTES TO FINANCIAL STATEMENTS
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)
 
1. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
 
  Overview--Aastrom Biosciences, Inc. (the "Company") was incorporated in
March 1989 ("Inception") under the name Ann Arbor Stromal, Inc. The Company
changed its name in 1991 concurrent with the commencement of employee-based
operations. The Company is in the development stage with its principal
business activities being research and product development, conducted both on
its own behalf and in connection with various collaborative research and
development agreements with other companies, involving the development of
processes and instrumentation for the ex-vivo production of human stem cells
and their progeny, and hematopoetic and other tissues. Successful future
operations are subject to several technical and business risks, including
satisfactory product development and obtaining regulatory approval and market
acceptance for its products.
   
  Significant Revenue Relationships--Two companies accounted for 49% and 28%
of total revenues for the year ended June 30, 1995 and one company accounted
for 83% of total revenues for the year ended June 30, 1996. One of these
companies accounted for 42% of total revenues for the period from Inception to
June 30, 1996. One company accounted for 82% and 87% of total revenues for the
three months ended September 30, 1995 and 1996, respectively, and accounted
for 45% of total revenues for the period from Inception to September 30, 1996.
Grant revenues consist of grants sponsored by the U.S. government.     
 
  Cash and Cash Equivalents--Cash and cash equivalents include cash and short-
term investments with original maturities of three months or less.
 
  Short-Term Investments--Short-term investments consist of U.S. government
securities and commercial paper with original maturities of over three months
but less than one year. Short-term investments are classified as available-
for-sale, and are carried at market value, in accordance with Financial
Accounting Standards Board Statement No. 115, "Accounting for Certain
Investments in Debt and Equity Securities," which was adopted July 1, 1994.
Application of this pronouncement results in the inclusion of unrealized gains
and losses on investments in shareholders' equity. Application of this
accounting treatment in prior periods would not have materially changed the
amounts as presented.
 
  Diversity of Credit Risk--The Company invests its excess cash in U.S.
government securities and commercial paper, maintained in U.S. financial
institutions, and has established guidelines relative to diversification and
maturities in an effort to maintain safety and liquidity. The Company plans to
continue to invest its excess funds in short-term, investment grade, interest-
bearing instruments. These guidelines are periodically reviewed and modified
to take advantage of trends in yields and interest rates. The Company has not
experienced any significant losses on its cash equivalents or short-term
investments.
 
  Property--Property is recorded at cost and depreciated or amortized using
the straight-line method over the estimated useful life of the asset
(primarily five years) or the remaining lease term, if shorter, with respect
to leasehold improvements and certain capital lease assets.
 
  Revenue Recognition--Revenue from grants and research agreements is
recognized on a cost reimbursement basis consistent with the performance
requirements of the related agreement. Funding received in advance of costs
incurred is presented as deferred revenue in the accompanying financial
statements.
 
  Research and Development Costs--Research and development costs are expensed
as incurred. Such costs and expenses related to programs under collaborative
agreements with other companies totaled $49,000, $146,000 and $1,294,000 for
the years ended June 30, 1994, 1995 and 1996, respectively, and $1,489,000 for
the period from Inception to June 30, 1996 and $158,000, $117,000 and
$1,606,000 for the three months ended September 30, 1995 and 1996 and for the
period from Inception to September 30, 1996, respectively.
 
                                      F-7

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                  NOTES TO FINANCIAL STATEMENTS--(CONTINUED)
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)
 
  Restatement of Common Stock Information--The Company's Board of Directors
authorized a two-for-three reverse stock split of the Company's Common Stock
("Reverse Stock Split") to be effected prior to the closing of the proposed
IPO. Accordingly, all references in the accompanying financial statements to
common share or per common share information have been restated to reflect the
Reverse Stock Split.
 
  Pro Forma Information (Unaudited)--Pro forma net loss per share is computed
using the weighted average number of common and common equivalent shares
outstanding during the period. Common equivalent shares are not included in
the per-share calculation where the effect of their inclusion would be anti-
dilutive, except that common and common equivalent shares issued during the 12
month period preceding the filing of the registration statement for the
proposed initial public offering ("IPO"), contemplated in the Prospectus in
which these financial statements are included, at a price below $8.00 per
share (the lowest expected selling price in the proposed IPO) are considered
to be cheap stock and have been included in the calculation as if they were
outstanding for all periods using the treasury stock method, if applicable,
even though their inclusion is anti-dilutive. Upon the completion of the
Company's proposed IPO, all 9,657,648 shares of the Company's outstanding
Preferred Stock will automatically convert into 8,098,422 shares of Common
Stock. As a result, all outstanding shares of Preferred Stock are assumed to
have been converted to Common Stock at the time of issuance, except for those
shares considered to be cheap stock which are treated as outstanding for all
periods presented. The pro forma effect of these conversions has been
reflected in the accompanying balance sheet assuming the conversion had
occurred on September 30, 1996.
 
  Historical net loss per share information is not considered meaningful due
to the significant changes in the Company's capital structure which will occur
upon the closing of the proposed IPO; accordingly, such per-share data
information is not presented.
 
  Use of Estimates--The preparation of financial statements in accordance with
generally accepted accounting principles requires management to make estimates
that affect the amounts reported in the financial statements and disclosures
made in the accompanying notes to financial statements. Actual results could
differ from those estimates.
 
  Financial Instruments--Management evaluates the fair value of those assets
and liabilities identified as financial instruments under Statement of
Financial Accounting Standards No. 107 and estimates that the fair value of
such financial instruments generally approximates the carrying value in the
accompanying financial statements. Fair values have been determined through
information obtained from market sources and management estimates.
 
  Recent Pronouncements--During October 1995, the Financial Accounting
Standards Board issued Statement No. 123, "Accounting for Stock-Based
Compensation," which establishes a fair value based method of accounting for
stock-based compensation and incentive plans and requires additional
disclosures for those companies that elect not to adopt the new method of
accounting. Adoption of this pronouncement is required for the Company's
fiscal year beginning July 1, 1996 and the Company intends to provide the
additional disclosures required by the pronouncement in its financial
statements for the year ended June 30, 1997.
 
  During March 1995, the Financial Accounting Standards Board issued Statement
No. 121 (SFAS 121), "Accounting for the Impairment of Long-Lived Assets and
for Long-Lived Assets to Be Disposed Of," which requires the Company to review
for impairment of long-lived assets, certain identifiable intangibles, and
goodwill related to those assets whenever events or changes in circumstances
indicate that the carrying amount of an asset
 
                                      F-8

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                  NOTES TO FINANCIAL STATEMENTS--(CONTINUED)
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)

   
might not be recoverable. In certain situations, an impairment loss would be
recognized. SFAS 121 will become effective for the Company's fiscal year
beginning July 1, 1996. Management has studied the effect of implementing SFAS
121 and, based upon its evaluation, has determined that the impact on the
Company's financial condition and results of operations is not significant for
the period ended September 30, 1996.     
 
  Unaudited Financial Information--The financial information as of September
30, 1996, and for the three-month periods ended September 30, 1995 and 1996,
and for the period from Inception to September 30, 1996, is unaudited. In the
opinion of management, such information contains all adjustments, consisting
only of normal recurring accruals, necessary for a fair statement of the
results of operations for the interim periods. The results of operations for
the three months ended September 30, 1996, are not necessarily indicative of
the results to be expected for the full year or for any other period.
 
2. SHORT-TERM INVESTMENTS
 
  All short-term investments are available-for-sale, and have maturities of
one year or less and are summarized as follows:
 

<TABLE>
<CAPTION>
                                                 GROSS      GROSS
                                               UNREALIZED UNREALIZED ESTIMATED
                                       COST      GAINS      LOSSES   FAIR VALUE
                                    ---------- ---------- ---------- ----------
   <S>                              <C>        <C>        <C>        <C>
   June 30, 1995:
     U.S. Government Securities.... $4,890,000  $     --   $ (2,000) $4,888,000
     Commercial Paper..............  3,500,000        --         --   3,500,000
                                    ----------  --------   --------  ----------
                                    $8,390,000  $     --   $ (2,000) $8,388,000
                                    ==========  ========   ========  ==========
<CAPTION>
                                                 GROSS      GROSS
                                               UNREALIZED UNREALIZED ESTIMATED
                                       COST      GAINS      LOSSES   FAIR VALUE
                                    ---------- ---------- ---------- ----------
   <S>                              <C>        <C>        <C>        <C>
   September 30, 1996 (Unaudited):
     U.S. Government Securities.... $1,200,000  $     --   $     --  $1,200,000
                                    ==========  ========   ========  ==========
</TABLE>

 
3. PROPERTY
 
  Property consists of the following:
 

<TABLE>
<CAPTION>
                                                JUNE 30,
                                          ----------------------  SEPTEMBER 30,
                                             1995        1996         1996
                                          ----------  ----------  -------------
                                                                   (UNAUDITED)
   <S>                                    <C>         <C>         <C>
   Machinery and equipment............... $1,140,000  $1,337,000   $1,341,000
   Office equipment......................    405,000     482,000      604,000
   Leasehold improvements................    380,000     520,000      567,000
                                          ----------  ----------   ----------
                                           1,925,000   2,339,000    2,512,000
   Less accumulated depreciation and
    amortization.........................   (646,000) (1,151,000)  (1,287,000)
                                          ----------  ----------   ----------
                                          $1,279,000  $1,188,000   $1,225,000
                                          ==========  ==========   ==========
</TABLE>

 
  Equipment under capital leases totaled $1,162,000, $1,131,000 and $1,131,000
at June 30, 1995 and 1996 and September 30, 1996, respectively, with related
accumulated amortization of $407,000, $622,000 and $679,000, respectively
(Note 7).
 
                                      F-9

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                  NOTES TO FINANCIAL STATEMENTS--(CONTINUED)
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)
 
4. SHAREHOLDERS' EQUITY:
 
  Preferred Stock--The Company has the following outstanding Preferred Stock:
 

<TABLE>
<CAPTION>
                            SHARES       SHARES ISSUED AND OUTSTANDING   LIQUIDATION PREFERENCE AT
                          AUTHORIZED   --------------------------------- -------------------------
                         SEPTEMBER 30, JUNE 30,  JUNE 30,  SEPTEMBER 30,  JUNE 30,   SEPTEMBER 30,
                             1996        1995      1996        1996         1996         1996
                         ------------- --------- --------- ------------- ----------- -------------
                          (Unaudited)                       (Unaudited)               (Unaudited)
<S>                      <C>           <C>       <C>       <C>           <C>         <C>
Series A................   2,500,000   2,500,000 2,500,000   2,500,000   $ 2,500,000  $ 2,500,000
Series B................   3,030,000   3,030,000 3,030,000   3,030,000     6,060,000    6,000,000
Series C................      10,000      10,000    10,000      10,000    10,000,000   10,000,000
Series D................   3,000,000   2,500,001 2,500,001   2,500,001    10,000,000   10,000,000
Series E................   1,617,647          -- 1,411,765   1,617,647     6,000,000    6,875,000
                          ----------   --------- ---------   ---------   -----------  -----------
                          10,157,647   8,040,001 9,451,766   9,657,648   $34,560,000  $35,375,000
                          ==========   ========= =========   =========   ===========  ===========
</TABLE>

 
  All preferred shares have voting rights equal to the equivalent number of
common shares into which they are convertible. Conversion rights on all
outstanding classes of preferred stock are on a two-for-three basis to give
effect for the Reverse Stock Split, except for the Series C Preferred Stock,
each share of which is convertible into approximately 250 shares of Common
Stock. Conversion rights on certain classes of preferred stock are subject to
anti-dilution adjustments. Dividends accrue annually at 8% on all series of
Preferred Stock, but do not accumulate. No cash dividends have been declared
or paid through September 30, 1996. Dividends and liquidation preferences on
the Series B, Series C and Series D Preferred Stock are senior to those of the
Series A Preferred Stock. Dividends and liquidation preferences on the Series
E Preferred Stock are senior to those of all other outstanding series of
preferred stock. Conversion of preferred stock is automatic in the event of
the closing of an underwritten public stock offering meeting certain minimum
requirements such as the offering contemplated by the Prospectus in which
these financial statements are included.
 
  Cobe Laboratories, Inc. Stock Purchase Rights--In connection with the
purchase of the Series C Preferred Stock by Cobe Laboratories, Inc. ("Cobe")
in October 1993, Cobe received a preemptive right to purchase a pro-rata
portion of any newly issued shares of stock by the Company in order to
maintain its then current percentage ownership interest. Any such purchase of
newly issued shares shall be at the net price to the Company after deducting
underwriters' discounts and commissions, if any. Cobe has waived its right to
such discount on its intended purchase of shares in the proposed IPO. The
Company has an option ("Put Option") to require Cobe to purchase the lesser of
20%, or $5,000,000, in an offering of equity securities meeting certain
minimum requirements. In the event that the Company exercises the Put Option,
Cobe then has the option to purchase up to 40% of that offering.
 
  During the three-year period following the completion of an initial public
offering of Common Stock by the Company, Cobe has an option to purchase
additional shares from the Company equal to 30% of the total number of shares
outstanding assuming exercise of the option. Such option, if exercised, must
be exercised in full with the purchase price of the shares being established
at 120% of the public market trading price as determined by the 30-day average
market price preceding the date of exercise of the option.
 
  The Company has granted Cobe a right of first negotiation in the event the
Company receives any proposal concerning, or otherwise decides to pursue, a
merger, consolidation or other transaction in which all or a majority
 
                                     F-10

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                  NOTES TO FINANCIAL STATEMENTS--(CONTINUED)
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)

of the Company's equity securities or all or substantially all of the
Company's assets, or any material portion of the assets of the Company used by
the Company in performing its obligations under the Distribution Agreement
(Note 6) would be acquired by a third party outside of the ordinary course of
business.
 
  Stock Option Plans--The Company has various stock option plans which provide
for the issuance of nonqualified and incentive stock options to acquire up to
2,836,594 shares of Common Stock. Such options may be granted by the Company's
Board of Directors to certain of the Company's founders, employees, directors
and consultants. The exercise price of incentive stock options shall not be
less than the fair market value of the shares on the date of grant. In the
case of individuals who are also holders of 10% or more of the outstanding
shares of Common Stock, the exercise price of incentive stock options shall
not be less than 110% of the fair market value of the shares on the date of
grant. The exercise price of non-qualified stock options shall not be less
than 85% of the fair market value on the date of grant. Options granted under
these plans expire no later than ten years from the date of grant and
generally become exercisable ratably over a four-year period following the
date of grant.
 
  For certain options granted, the Company recognizes compensation expense for
the difference between the deemed value for accounting purposes and the option
exercise price on the date of grant. During the three-month period ended
September 30, 1996, compensation expense totaling approximately $40,000 has
been charged with respect to these options. Additional future compensation
expense with respect to the issuance of such options totals approximately
$130,000 and will be recognized through October 2000.
 
 
                                     F-11

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                   NOTES TO FINANCIAL STATEMENTS--(CONTINUED)
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)

  The following table summarizes option activity under the Company's stock
option plans:
 

<TABLE>
<CAPTION>
                                                       OPTIONS
                                           OPTIONS    AVAILABLE   EXERCISE PRICE
                                         OUTSTANDING  FOR GRANT     PER SHARE
                                         -----------  ----------  --------------
   <S>                                   <C>          <C>         <C>
   March 24, 1989(Inception)
     Options authorized.................         --    1,703,261
     Options granted....................  1,528,778   (1,528,778) $  .15 - $ .30
     Options exercised..................     (6,873)          --  $  .15 - $ .15
     Options canceled...................    (13,793)      13,793  $  .15 - $ .15
                                         ----------   ----------
   Balance, June 30, 1993...............  1,508,112      188,276  $  .15 - $ .30
     Options granted....................    198,333     (198,333) $  .30 - $1.20
     Options exercised.................. (1,222,609)          --  $  .15 - $ .30
     Options canceled...................    (90,171)      90,171  $  .15 - $1.20
                                         ----------   ----------
   Balance, June 30, 1994...............    393,665       80,114  $  .15 - $1.20
     Options authorized.................         --      333,333
     Options granted....................     55,333      (55,333) $ 1.20 - $1.20
     Options exercised..................    (39,103)          --  $  .30 - $ .30
     Options canceled...................    (60,230)      60,230  $  .30 - $1.20
                                         ----------   ----------
   Balance, June 30, 1995...............    349,665      418,344  $  .15 - $1.20
     Options authorized.................         --      800,000
     Options granted....................    155,337     (155,337) $ 1.20 - $3.20
     Options exercised..................   (130,016)          --  $  .15 - $1.20
     Options canceled...................    (44,690)      44,690  $  .30 - $1.20
                                         ----------   ----------
   Balance, June 30, 1996...............    330,296    1,107,697  $  .30 - $3.20
    Unaudited:
     Options granted....................     13,334      (13,334) $ 3.20 - $3.20
     Options exercised..................       (833)          --  $ 1.20 - $1.20
     Options canceled...................     (6,543)       6,543  $ 1.20 - $1.20
                                         ----------   ----------
   Balance, September 30, 1996
    (Unaudited).........................    336,254    1,100,906  $  .30 - $3.20
                                         ==========   ==========
   Options Exercisable,                     101,021
    June 30, 1996....................... ==========               $  .30 - $1.20
    September 30, 1996 (Unaudited)......    122,612               $  .30 - $1.20
                                         ==========
</TABLE>

 
  Common Shares Reserved--The Company has reserved shares of Common Stock for
future issuance as follows:
 

<TABLE>
<CAPTION>
                                                         JUNE 30,  SEPTEMBER 30,
                                                           1996        1996
                                                         --------- -------------
                                                                    (Unaudited)
   <S>                                                   <C>       <C>
   Issuance under 1992 Stock Option Plan................ 1,437,993   1,437,160
   Conversion of preferred stock........................ 7,961,168   8,098,422
                                                         ---------   ---------
                                                         9,399,161   9,535,582
                                                         =========   =========
</TABLE>

 
                                      F-12

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                  NOTES TO FINANCIAL STATEMENTS--(CONTINUED)
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)
 
5. FEDERAL INCOME TAXES
 
  Deferred tax assets consist of the following:
 

<TABLE>
<CAPTION>
                                                              JUNE 30,
                                                       ------------------------
                                                          1995         1996
                                                       -----------  -----------
   <S>                                                 <C>          <C>
   Net operating loss carryforwards................... $ 5,280,000  $ 9,210,000
   Tax credits and other..............................     360,000      440,000
                                                       -----------  -----------
   Gross deferred tax assets..........................   5,640,000    9,650,000
   Deferred tax assets valuation allowance............  (5,640,000)  (9,650,000)
                                                       -----------  -----------
                                                       $        --  $        --
                                                       ===========  ===========
</TABLE>

 
  Due to the historical losses incurred by the Company, a full valuation
allowance for deferred tax assets has been provided. If the Company achieves
profitability, these deferred tax assets may be available to offset income
taxes. The Company's net operating loss and tax credit carryforwards will
expire from 2004 through 2011, if not utilized.
 
  The Company's ability to utilize its net operating loss and tax credit
carryforwards would be limited in the event of a future change in ownership
for tax purposes. Such a change in ownership may likely occur upon the
completion of an initial public offering of the Company's Common Stock.
 
6. LICENSES, ROYALTIES AND COLLABORATIVE AGREEMENTS
   
  University of Michigan--In March 1989, the Company entered into a research
agreement with the University of Michigan (the "University") for the
development of an adaptable, high-efficiency blood cell factory and to conduct
related research. Under the terms of this research agreement, as amended, the
Company agreed to reimburse the University for research costs in this regard
through the date of its expiration in December 1994. Payments made to the
University under the aforementioned agreements totaled $316,000, $121,000 and
$2,521,000 for the years ended June 30, 1994, 1995 and for the period from
Inception to June 30, 1996, respectively, which amounts are included in
research and development expense in the accompanying Statements of Operations.
As part of this relationship, the Company issued to the University 454,545
shares of Common Stock in August 1989. No value has been assigned to these
shares in the accompanying financial statements. In March 1992, the Company
entered into a license agreement for the technology developed under the
research agreement. The license agreement, as amended, provides for a royalty
to be paid to the University equal to 2% of net sales of products containing
the licensed technology sold by the Company.     
 
  Cobe BCT, Inc.--In connection with the issuance of the Series C Preferred
Stock to Cobe in October 1993, the Company and Cobe BCT, Inc. ("Cobe BCT"), an
affiliate of Cobe, entered into an agreement which grants to Cobe BCT
exclusive worldwide distribution and marketing rights to the Company's Cell
Production System ("CPS") for stem cell therapy applications ("Distribution
Agreement"). The term of the Distribution Agreement is ten years, with an
option, exercisable by Cobe BCT, to extend the term for an additional ten
years. Pursuant to the Distribution Agreement, Cobe BCT will perform worldwide
marketing and distribution activities of the CPS for use in stem cell therapy
and will receive a share of the resulting net sales, as defined, ranging from
38% to 42%, subject to certain negotiated discounts and volume-based
adjustments.
 
                                     F-13

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                  NOTES TO FINANCIAL STATEMENTS--(CONTINUED)
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)
 
  The agreements establishing this collaboration provided for payments
totaling $5,000,000 to be made by Cobe BCT upon the Company meeting certain
development milestones. In May 1995, the Company accepted, as part of the sale
of the Series D Preferred Stock, an equity investment of $5,000,000 from Cobe
in lieu of those future milestone payments.
 
  M.D. Anderson Cancer Center--In December 1992, the Company entered into a
research agreement with the University of Texas, M.D. Anderson Cancer Center
("M.D. Anderson"). Under this agreement, the Company funded certain research
being conducted at M.D. Anderson and issued to M.D. Anderson 33,333 shares of
its Common Stock subject to vesting rights over the succeeding four year
period. In November 1994, the Company and M.D. Anderson terminated the
collaboration and 25,000 shares of Common Stock held by M.D. Anderson were
returned to the Company.
 
  License and Royalty Agreements--In July 1992, the Company licensed certain
cell culture technology under which it obtained an exclusive worldwide license
to the technology in exchange for a royalty of up to 3% of net sales on
products utilizing the licensed technology.
 
  In March 1996, the Company executed a license agreement which provides for
the use of licensed products in the CPS. Pursuant to this license agreement,
the Company recorded a charge to research and development expense of
$1,500,000 representing the license fee payable upon execution of the
agreement. The license agreement provides for annual renewal fees of
$1,000,000 over the five year license term and can be extended at the
Company's option for an additional five years.
 
  Rhone-Poulenc Rorer Inc.--In September 1995, the Company entered into a
research and development collaboration with Rhone-Poulenc Rorer Inc. ("RPR"),
granting RPR a right to license the Company's CPS for Lymphoid cell
applications. Prior to the establishment of this collaboration, the Company
received a option fee of $250,000 and a development deposit of $225,000 to
initiate the preliminary research and development plan. Pursuant to the
agreements establishing this collaboration, RPR was obligated to fund certain
costs associated with the development of the CPS for Lymphoid cell
applications and was entitled to make equity purchases of up to $12,500,000
subject to the Company's satisfaction of certain milestones and RPR's decision
to exercise certain options. As of June 30, 1996, the Company has received
$3,500,000 in equity payments and recognized $1,342,000 in research revenue
through June 30, 1996 and $1,537,000 through September 30, 1996. The remaining
$9,000,000 equity payment was to be paid by RPR by October 1996 pending RPR's
evaluation of the research efforts for Lymphoid cell applications and its
decision to proceed with the collaboration (Note 9).
 
 
7. COMMITMENTS
 
  The Company leases certain machinery and equipment and office equipment
under capital leases. Obligations under these leasing arrangements bear
interest at rates ranging from 9.7% to 12.1% and mature at dates ranging from
November 1996 to May 1999. Additionally, the Company leases its facilities
under an operating lease which expires in May 1998, at which time the Company
has the option to renew the lease for an additional period of up to five
years.
 
                                     F-14

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                  NOTES TO FINANCIAL STATEMENTS--(CONTINUED)
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)
 
  Future minimum payments under capital leases and non-cancelable operating
leases are as follows:
 

<TABLE>
<CAPTION>
                                                             CAPITAL   OPERATING
                                                              LEASES    LEASES
                                                             --------  ---------
      <S>                                                    <C>       <C>
      Year Ended June 30,
        1997................................................ $255,000  $453,000
        1998................................................  138,000   435,000
        1999................................................   69,000        --
                                                             --------  --------
      Total minimum lease payments..........................  462,000  $888,000
                                                                       ========
      Less amount representing interest.....................  (50,000)
                                                             --------
      Obligations under capital lease....................... $412,000
                                                             ========
</TABLE>

 
  Certain of the Company's capital lease agreements contain restrictive
provisions which require that the Company's total assets exceed its total
liabilities by at least $1,000,000. Should the Company fall out of compliance
with this provision, and a waiver cannot be obtained from the lessor,
remaining amounts due under the leases become immediately due and payable.
 
  Rent expense for the years ended June 30, 1994, 1995 and 1996, was $176,000,
$241,000 and $338,000, respectively, and for the period from Inception to June
30, 1996 was $822,000. Rent expense for the three months ended September 30,
1995 and 1996, was $83,000 and $107,000, respectively, and for the period from
Inception to September 30, 1996 was $929,000.
 
8. EMPLOYEE SAVINGS PLAN
 
  The Company has a 401(k) plan that became effective in January 1994. The
plan allows participating employees to contribute up to 15% of their salary,
subject to annual limits and minimum qualifications. The Board may, at its
sole discretion, approve Company contributions. Through June 30, 1996, the
Company has made no contributions to the plan.
 
9. SUBSEQUENT EVENTS (UNAUDITED)
 
  In September 1996, RPR notified the Company of its intent to terminate its
collaboration with the Company. This notification was made after RPR had
determined that for strategic reasons its support for the development of the
technologies being pursued under the collaboration would be discontinued. As a
result of this termination, no further equity payments or research funding is
due from RPR and RPR's license rights to the Company's CPS for Lymphoid cell
applications are terminated. Upon termination of the collaboration, RPR became
entitled to receive shares of the Company's Series E Preferred Stock at $17.00
per share for the $3,500,000 in equity payments made by RPR under the
collaboration. Accordingly, the accompanying financial statements as of
September 30, 1996 reflect the issuance of 205,882 shares of Series E
Preferred Stock issuable to RPR in this regard.
 
  In October 1996, the Company executed a financing commitment for up to
$5,000,000 in additional equity funding from Cobe ("Equity Commitment") and
$5,000,000 in funding under a convertible loan agreement ("Convertible Loan
Commitment") with another current investor. Under the terms of the Equity
Commitment,
 
                                     F-15

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.
                         (A DEVELOPMENT STAGE COMPANY)
 
                  NOTES TO FINANCIAL STATEMENTS--(CONTINUED)
 
         (INFORMATION AS OF SEPTEMBER 30, 1996 AND FOR THE THREE-MONTH
            PERIODS ENDED SEPTEMBER 30, 1995 AND 1996 IS UNAUDITED)

the Company may sell up to $5,000,000 of preferred stock at $6.00 per share
during a funding period that extends from January 1997 to December 1997. The
conversion rights of such preferred stock will be adjusted to provide for a
conversion at 80% of the per share price in the Company's next financing, as
adjusted for the Reverse Stock Split, and provided that such financing meets
certain minimum requirements ("Qualifying Financing"), such as the proposed
IPO in which these financial statements appear. If such a financing is not
completed by December 1997, then the conversion rights of this class of
preferred stock into Common Stock will be set at $6.98 per share of Common
Stock. To the extent shares are sold to Cobe under the Equity Commitment, its
preemptive right in the Company's next Qualifying Financing and the Company's
Put Option to Cobe is reduced to the extent of its purchase.
 
  Upon the sale of $5,000,000 in preferred stock under the Equity Commitment,
the Company becomes entitled to borrow funds under the Convertible Loan
Commitment. Such funds may be borrowed by the Company during a funding period
that extends from January 1997 to September 1997. Upon the completion of a
Qualifying Financing by the Company, the Company has the option to repay
outstanding borrowings under the Convertible Loan Commitment, in cash, or to
convert such borrowings into preferred stock. The conversion rights of such
class of preferred stock will be adjusted to provide for a conversion at 90%
of the per share price in the Company's next Qualifying Financing, as adjusted
for the Reverse Stock Split. If such financing is not completed by December
1997, then the conversion rights of this class of preferred stock will be set
at $6.98 per share of Common Stock. Interest accrues at 10% on amounts
borrowed under the Convertible Loan Commitment, which is due at maturity, and
may be retired in a manner consistent with principal. The Company may repay
borrowed amounts at anytime prior to the maturity date which is established
for all amounts borrowed as one year from the date of the first borrowing.
 
  In connection with the Convertible Loan Commitment, the Company has issued
warrants to purchase 69,444 shares of Common Stock for securing the
commitment. The Company will issue additional warrants to purchase 8,333
shares of Common Stock for each $1,000,000 borrowed under the Convertible Loan
Commitment, with such additional warrants to be prorated to the level of
borrowing. The warrants expire on October 15, 2000 if not exercised, and may
be exercised, in whole or in part, at a price equal to the lesser of (a) $9.00
per share, which price increases by $3.00 per share on each anniversary of the
closing of the offering being made in the Prospectus to which these financial
statements are included; or (b) 85% of the fair market value of the Company's
Common Stock at the time of exercise.
   
  On December 10, 1996, the Company issued to Cobe a notice to sell to Cobe
500,000 shares of Series F Preferred Stock for an aggregate purchase price of
$3,000,000 under the Equity Commitment. Such sale is scheduled to close on
March 19, 1997. In the event that the IPO closes prior to March 19, 1997,
Cobe's obligation to purchase Series F Preferred Stock under the Equity
Commitment will terminate. In the event that the IPO closes after March 19,
1997, Cobe's participation in this offering will be reduced by $3,000,000, the
amount of its purchase of Series F Preferred Stock pursuant to the Equity
Commitment. The Equity Commitment and the Convertible Loan Commitment expire
upon the closing of the IPO.     
 
                                     F-16

<PAGE>
 

 
                     Inside back cover page of Prospectus
                     ------------------------------------












       








       [COLOR DIAGRAM OF CELL LINEAGES OF HUMAN BONE MARROW STEM CELLS]

<PAGE>
 
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
  No dealer, salesperson or other person has been authorized to give any
information or to make any representations other than those contained in this
Prospectus, and, if given or made, such information or representation must not
be relied upon as having been authorized by the Company or any of the
Underwriters or any other person. This Prospectus does not constitute an offer
to sell or a solicitation of an offer to buy any security other than the shares
of Common Stock offered, nor does it constitute an offer to sell or a
solicitation of an offer to buy any of the securities offered to any person in
any jurisdiction or in which it is unlawful to make such offer or solicitation
to such person. Neither the delivery of this Prospectus nor any sale made
hereunder shall under any circumstances create an implication that the
information contained herein is correct as of any date subsequent to the date
hereof.
 
                              -------------------
 
 
                              TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                            PAGE
                                                                            ----
<S>                                                                         <C>
Prospectus Summary........................................................    3
Risk Factors..............................................................    5
The Company...............................................................   15
Use of Proceeds...........................................................   15
Dividend Policy...........................................................   15
Capitalization............................................................   16
Dilution..................................................................   17
Selected Financial Data...................................................   18

Management's Discussion and Analysis of Financial Condition and Results of
 Operations...............................................................   19
Business..................................................................   23
Management................................................................   42
Certain Transactions......................................................   50
Principal Shareholders....................................................   52
Description of Capital Stock..............................................   54
Shares Eligible for Future Sale...........................................   57
Underwriting..............................................................   58
Legal Matters.............................................................   59
Experts...................................................................   59
Additional Information....................................................   59
Index to Financial Statements.............................................  F-1
</TABLE>

 
                              -------------------
 
  Until             , 1997 (25 days after the date of this Prospectus), all
dealers effecting transactions in the Common Stock offered, whether or not
participating in this distribution, may be required to deliver a Prospectus.
This is in addition to the obligation of dealers to deliver a Prospectus when
acting as Underwriters and with respect to their unsold allotments or
subscriptions.
 
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
                                3,250,000 Shares
 
                       [LOGO OF AASTROM BIOSCIENCES INC]
 
 
                                  Common Stock
 
                              -------------------
                                   PROSPECTUS
                              -------------------
 
                                COWEN & COMPANY
 
                               J.P. MORGAN & CO.
                                   
                                    , 1997     
 
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

<PAGE>
 

                                    PART II
 
                    INFORMATION NOT REQUIRED IN PROSPECTUS
 

ITEM 13. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION
 
  Other expenses in connection with the registration of the securities
hereunder, which will be paid by the Company, will be substantially as
follows:
 

<TABLE>
<CAPTION>
   ITEM                                                                 AMOUNT
   ----                                                                --------
   <S>                                                                 <C>
   Securities and Exchange Commission registration fee................ $ 11,326
   NASD filing fee....................................................    4,238
   Nasdaq National Market fee.........................................   50,000
   Blue sky qualification fees and expenses...........................   20,000
   Accounting fees and expenses.......................................   85,000
   Legal fees and expenses............................................  350,000
   Printing and engraving expenses....................................  115,000
   Transfer agent and registrar fees..................................    7,500
   Officers' and Directors' Insurance.................................  200,000
   Miscellaneous expenses.............................................   56,936
                                                                       --------
     Total............................................................ $900,000
                                                                       ========
</TABLE>

 

ITEM 14. INDEMNIFICATION OF DIRECTORS AND OFFICERS
 
  Sections 1561 through 1565 of the Michigan Business Corporation Act (the
"MBCA") authorize a corporation to grant or a court to award, indemnity to
directors, officers, employees and agents in terms sufficiently broad to
permit such indemnification under certain circumstances for liabilities
(including reimbursement for expenses incurred) arising under the Securities
Act of 1933.
 
  The Bylaws of the Company (see Exhibit 3.3), provide that the Company shall,
to the fullest extent authorized or permitted by the MBCA, or other applicable
law, indemnify a director or officer who was or is a party or is threatened to
be made a party to any proceeding by or in the right of the Company to procure
a judgment in its favor by reason of the fact that such person is or was a
director, officer, employee or agent of the Company, against expenses,
including actual and reasonable attorneys' fees, and amounts paid in
settlement incurred in connection with the action or suit, if the indemnitee
acted in good faith and in a manner the person reasonably believed to be in,
or not opposed to, the best interests of the Company or its shareholders. This
section also authorizes the Company to advance expenses incurred by any agent
of the Company in defending any proceeding prior to the final disposition of
such proceeding upon receipt of an undertaking by or on behalf of the agent to
repay such amount unless it shall be determined ultimately that the agent is
entitled to be indemnified.
 
  The Bylaws also authorize the Company to purchase and maintain insurance on
behalf of any person who is or was a director, officer, employee or agent of
the Company against any liability asserted against or incurred by such person
in such capacity or arising out of such person's status as such, regardless of
whether the Company would have the power to indemnify such person against such
liability under the provisions of the MBCA.
 
  The Company has entered into an indemnification agreement with certain of
its directors, officers and other key personnel, which contains provisions
that may in some respects be broader than the specific indemnification
provisions contained under applicable law. The indemnification agreement may
require the Company, among other things, to indemnify such directors, officers
and key personnel against certain liabilities that may arise by reason of
their status or service as directors, officers or employees of the Company, to
advance the expenses incurred by such parties as a result of any threatened
claims or proceedings brought against them as to which
 
                                     II-1

<PAGE>
 
they could be indemnified, and, to the maximum extent that insurance coverage
of such directors, officers and key employees under the Company's directors'
and officers' liability insurance policies is maintained.
 
  Section 1209 of the MBCA permits a Michigan corporation to include in its
Articles of Incorporation a provision eliminating or limiting a director's
liability to a corporation or its shareholders for monetary damages for
breaches of fiduciary duty. The enabling statute provides, however, that
liability for breaches of the duty of loyalty, acts or omissions not in good
faith or involving intentional misconduct or knowing violation of the law, or
the receipt of improper personal benefits cannot be eliminated or limited in
this manner. The Company's Restated Articles of Incorporation include a
provision which eliminates, to the fullest extent permitted by the MBCA
director liability for monetary damages for breaches of fiduciary duty.
 
  Section 6 of the Underwriting Agreement filed as Exhibit 1.1 hereto sets
forth certain provisions with respect to the indemnification of certain
controlling persons, directors and officers against certain losses and
liabilities, including certain liabilities under the Securities Act.
 

ITEM 15. RECENT SALES OF UNREGISTERED SECURITIES
 
  (a)   ISSUANCES OF COMMON STOCK
 
  Since October 1, 1993, the Company has sold the following shares of Common
Stock:
 
  In October 1995, the registrant issued 37,500 shares of Common Stock to
Albert B. Deisseroth at a price of $.80 per share.
 
  (b)   ISSUANCES OF SHARES OF PREFERRED STOCK
 
  Since October 1, 1993, the Company has sold the following shares of
Preferred Stock:
 
  In October 1993, the registrant issued 10,000 shares of Series C Preferred
Stock to Cobe at a price of $1,000 per share.
 
  In April and May 1995, the registrant issued an aggregate of 2,500,001
shares of Series D Preferred Stock to 11 accredited investors at a price of
$4.00 per share.
 
  In December 1995, the registrant issued 62,500 shares of Series D Preferred
Stock to Northwest Ohio Venture Fund, L.P. at a purchase price of $4.00 per
share.
 
  In January 1996, the registrant issued an aggregate of 1,411,765 shares of
Series E Preferred Stock to SBIC Partners, L.P. and the State Treasurer of the
State of Michigan at a purchase price of $4.25 per share.
 
  Pursuant to a Governance Agreement between the Company and Rhone-Poulenc
Rorer Inc. ("RPR"), dated September 15,1995, RPR terminated its contractual
relationship with the Company on September 6, 1996. As a result of such
termination, the Company became obligated to issue 205,882 shares of Series E
Preferred Stock to RPR at a purchase price of $17.00 per share.
   
  In October 1996, the Company issued warrants to Michigan to purchase 69,444
shares of Common Stock as consideration for the Convertible Loan Commitment
and has agreed to issue additional warrants to purchase 8,333 shares of Common
Stock for each $1,000,000 borrowed under the Convertible Loan Commitment, as
adjusted to the level of borrowing.     
 
  (c) OPTION ISSUANCES TO, AND EXERCISES BY, EMPLOYEES AND DIRECTORS
 
  From January 18, 1990 to the present, the registrant has granted options to
purchase a total of 2,945,174 shares of Common Stock at exercise prices
ranging from $.10 to $2.13 per share to 95 employees and one non-employee
director. No consideration was paid to the Registrant by any recipient of any
of the foregoing options for the grant of any such options. From October 30,
1992 to the present, the Registrant issued a total of 2,829,735 shares of
Common Stock to 26 employees and one non-employee director upon exercise of
stock options at exercise prices ranging from $.10 to $2.13 per share.
 
  There were no underwriters employed in connection with any of the
transactions set forth in Item 15.
 
 
                                     II-2

<PAGE>
 
  The issuances described in Items 15(a) and 15(b) were exempt from
registration under the Securities Act in reliance on Section 4(2) of the
Securities Act as transactions by an issuer not involving a public offering.
The issuances described in Item 15(c) were exempt from registration under the
Securities Act in reliance on Rule 701 promulgated thereunder as transactions
pursuant to compensatory benefit plans and contracts relating to compensation.
The recipients of securities in each such transaction represented their
intention to acquire the securities for investment only and not with a view to
or for sale in connection with any distribution thereof and appropriate
legends were affixed to the share certificates and other instruments issued in
such transactions.
 

ITEM 16. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES
 
  (a)   Exhibits
       
  1.1*      Form of Underwriting Agreement.
 
  3.1**     Restated Articles of Incorporation.
     
  3.2       Form of Restated Articles of Incorporation (to be filed with the
            Secretary of State of the State of Michigan prior to the closing
            of this offering).     
 
  3.3**     Bylaws, as amended.
     
  4.1       Specimen Common Stock Certificate.     
 
  4.2**     Amended and Restated Investors' Rights Agreement dated April 7, 
            1992.
     
  5.1       Opinion of Pepper, Hamilton & Scheetz, counsel to the Company,
            with respect to the legality of the securities being registered,
            including their consent to being named in the Registration
            Statement.     
 
  10.1**    Form of Indemnification Agreement.
 
  10.2**    1989 Stock Option Plan and form of agreement thereunder.
 
  10.3**    Ancillary Stock Option Plan and form of agreement thereunder.
 
  10.4**    401(k) Plan.
 
  10.5**    Amended and Restated 1992 Incentive and Non-Qualified Stock
            Option Plan and forms of agreements thereunder.
 
  10.6**    1996 Outside Directors Stock Option Plan and forms of agreements
            thereunder.
 
  10.7**    1996 Employee Stock Purchase Plan and form of agreement thereunder.
 
  10.8**    Form of Employment Agreement.
 
  10.9**    Stock Purchase Agreement dated October 22, 1993 between Cobe
            Laboratories, Inc. and the Company and amendment thereto dated
            October 29, 1996.
 
  10.10**+  Distribution Agreement dated October 22, 1993 between Cobe BCT,
            Inc. and the Company and amendments thereto dated March 29, 1995,
            September 11, 1995 and October 29, 1996.
 
  10.11**   License Agreement dated July 17, 1992 between J.G. Cremonese and
            the Company and related addenda thereto dated July 14, 1992 and
            July 7, 1993.
 
  10.12**+  Collaborative Product Development Agreement dated May 10, 1994
            between SeaMED Corporation and the Company.
 
  10.13**+  Collaborative Product Development Agreement dated November 8,
            1994 between Ethox Corporation and the Company.
 
  10.14**+  License and Supply Agreement dated April 1, 1996 between Immunex
            Corporation and the Company.
 
                                     II-3

<PAGE>
 
  10.15**   Lease Agreement dated May 18, 1992 between Domino's Farms
            Holding, L.P. and the Company and amendments thereto dated
            February 26, 1993, October 3, 1994, November 16, 1994 and July
            29, 1996.
 
  10.16**   Clinical Trial Agreement dated April 19, 1996 between the Company
            and the University of Texas M.D. Anderson Cancer Center.
 
 
  10.17**   License Agreement dated March 13, 1992 between the Company and
            the University of Michigan and amendments thereto dated March 13,
            1992, October 8, 1993 and June 21, 1995.
 
  10.18**   Employee Proprietary Information and Invention Agreement
            effective June 1, 1991 between the Company and R. Douglas
            Armstrong.
 
  10.19**   Employment Agreement dated June 19, 1992 between the Company and
            James Maluta.
 
  10.20**   Employment Agreement dated December 8, 1995 between the Company
            and Todd E. Simpson, C.P.A.
 
  10.21**   Employment Agreement dated February 10, 1994 between the Company
            and Walter C. Ogier.
 
  10.22**   Employment Agreement dated April 19, 1994 between the Company and
            Thomas E. Muller, Ph.D.
 
  10.23**   Employment Agreement dated October 26, 1995 between the Company
            and Alan K. Smith, Ph.D.
     
  10.24**   Promissory Note dated November 18, 1993 for $120,000 loan by the
            Company to R. Douglas Armstrong and amendment thereto dated
            October 30, 1996.     
 
  10.25**   Promissory Note dated October 20, 1993 for $47,303 loan by the
            Company to Stephen G. Emerson, M.D., Ph.D and amendment thereto
            dated October 30, 1996.
 
  10.26**   Consulting Agreement dated June 1, 1995 between the Company and
            Stephen G. Emerson, M.D., Ph.D.
 
  10.27**   Clinical Trial Agreement dated August 28, 1996 between the
            Company and Loyola University Medical Center Cancer Center.
 
  10.28**   Stock Purchase Commitment Agreement dated October 29, 1996
            between Cobe Laboratories, Inc. and the Company.
 
  10.29**   Convertible Loan Commitment Agreement dated October 15, 1996
            between the State Treasurer of the State of Michigan and the
            Company.
     
  10.30**   Form of Subscription Agreement for the purchase of Series D
            Preferred Stock (Enterprise Development Fund L.P., Enterprise
            Development Fund II, L.P. and Northwest Ohio Venture Fund Limited
            Partnership).     
     
  10.31**   Stock Purchase Agreement dated January 8, 1996 among the Company,
            SBIC Partners, L.P. and the State Treasurer of the State of
            Michigan.     
     
  10.32**+  Governance Agreement dated September 15, 1995 between the Company
            and Rhone-Poulenc Rorer Inc.     
     
  10.32**+  Governance Agreement dated September 15, 1995 between the Company
            and Rhone-Poulenc Rorer Inc.     
     
  10.33**+  License Agreement dated September 15, 1995 between the Company
            and Rhone-Poulenc Rorer Inc.     
     
  10.34**   Stock Purchase Agreement dated September 15, 1995 between the
            Company and Rhone-Poulenc Rorer Inc.     
       
       
                                     II-4

<PAGE>
 
       
         
            
  10.35**   Letter Agreement dated November 11, 1996 between the Company and
            Cobe Laboratories, Inc.     
     
  10.36**   Form of Subscription Agreement for the purchase of Series D
            Preferred Stock (Brentwood Associates V, L.P., Candice E.
            Appleton Family Trust, Candis J. Stern, Helmut F. Stern, H&Q Life
            Science Technology Fund, H&Q London Ventures, State Treasurer of
            the State of Michigan and Windpoint Partners II, Limited
            Partnership).     
     
  10.37**   Subscription Agreement dated December 11, 1995 between the
            Company and Northwest Ohio Venture Fund Limited Partnership.     
     
  10.38**   Subscription Agreement dated May 30, 1995 between the Company and
            Cobe Laboratories, Inc.     
     
  10.39**   Termination Agreement dated November 14, 1996 between the Company
            and Rhone-Poulenc Rorer Inc.     
     
  10.40**   Stock Purchase Agreement dated November 14, 1996 between the
            Company and Rhone-Poulenc Rorer Inc.     
     
  10.41+    Collaborative Supply Agreement dated December 16, 1996 between
            the Company and Anchor Advanced Products, Inc., Mid-State
            Plastics Division.     
 
  11.1**    Statement re computation of pro forma net loss per share.
 
  23.1      The consent of Coopers & Lybrand, L.L.P.
     
  23.2      The consent of Pepper, Hamilton & Scheetz is contained in their
            opinion filed as Exhibit 5.1 of the Registration Statement.     
     
  23.3**    The consent of Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
                
  24.1**    Power of Attorney.
 
  27.1**    Financial Data Schedule.
 
  27.2**    Financial Data Schedule.
 
  27.3**    Financial Data Schedule.
 
  27.4**    Financial Data Schedule.
 
  27.5**    Financial Data Schedule.
 
  27.6**    Financial Data Schedule.
- --------
*  To be filed by Amendment.
** Previously filed.
+  The Company has applied for confidential treatment with respect to certain
   portions of these documents.
 
  (b) Financial Statement Schedules
 
  Schedules other than those referred to above have been omitted because they
are not applicable or not required under the instructions contained in
Regulation S-X or because the information is included elsewhere in the
Financial Statements or the notes thereto.
 

ITEM 17. UNDERTAKINGS
 
  Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
Registrant, pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Act and is,
therefore, unenforceable. In the event that
 
                                     II-5

<PAGE>
 
a claim for indemnification against such liabilities (other than the payment
by the Registrant of expenses incurred or paid by a director, officer or
controlling person of the Registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the Registrant
will, unless in the opinion of its counsel the matter has been settled by
controlling precedent, submit to a court of appropriate jurisdiction the
question whether such indemnification by it is against public policy as
expressed in the Act and will be governed by the final adjudication of such
issue.
 
  The undersigned Registrant hereby undertakes that:
 
  (1) For purposes of determining any liability under the Securities Act of
1933, the information omitted from the form of prospectus filed as part of
this registration statement in reliance upon Rule 430A and contained in a form
of prospectus filed by the Registrant pursuant to Rule 424(b)(1) or (4) or
497(h) under the Securities Act of 1933 shall be deemed to be part of this
registration statement as of the time it was declared effective.
   
  (2) For the purpose of determining any liability under the Securities Act of
1933, each post-effective amendment that contains a form of prospectus shall
be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.     
   
  The undersigned Registrant hereby undertakes to provide to the underwriter
at the closing specified in the underwriting agreements certificates in such
denominations and registered in such names as required by the underwriters to
permit prompt delivery to each purchaser.     
 
                                     II-6

<PAGE>
 

                                  SIGNATURES
     
  Pursuant to the requirements of the Securities Act of 1933, the Registrant
has duly caused this amendment to the registration statement to be signed on
its behalf by the undersigned, thereunto duly authorized, in the City of Ann
Arbor, State of Michigan, on the 19th day of December, 1996.     
 
                                       AASTROM BIOSCIENCES, INC.
 
                                           
                                       By: /s/ R. Douglas Armstrong
                                           ___________________________________
                                           R. Douglas Armstrong, Ph.D.
                                           President and Chief Executive
                                           Officer
                                           (Principal Executive Officer)
 
  Pursuant to the requirements of the Securities Act of 1933, this amendment
to the registration statement has been signed by the following persons in the
capacities and on the dates indicated.
 

<TABLE>
<CAPTION>
             SIGNATURE                                 TITLE                          DATE
             ---------                                 -----                          ----
<S>                                  <C>                                        <C>
      /s/ R. Douglas Armstrong       President, Chief Executive Officer,        December 19, 1996  
____________________________________ and Director (Principal Executive Officer)                    
    R. Douglas Armstrong, Ph.D.                                                                    
                                                                                                   
          Todd E. Simpson*           Vice President, Finance & Administration   December 19, 1996  
____________________________________ and Chief Financial Officer (Principal                        
          Todd E. Simpson            Financial and Accounting Officer)                             
                                                                                                   
                                                                                                   
          Robert J. Kunze*           Chairman of the Board and Director         December 19, 1996  
____________________________________                                                               
          Robert J. Kunze                                                                          
                                                                                                   
       Albert B. Deisseroth*         Director                                   December 19, 1996  
____________________________________                                                               
 Albert B. Deisseroth, M.D., Ph.D.                                                                 
                                                                                                   
        Stephen G. Emerson*          Director                                   December 19, 1996  
____________________________________                                                               
  Stephen G. Emerson, M.D., Ph.D.                                                                  
                                                                                                   
         G. Bradford Jones*          Director                                   December 19, 1996  
____________________________________                                                               
         G. Bradford Jones                                                                         
                                                                                                   
          Horst R. Witzel*           Director                                   December 19, 1996  
____________________________________                                                               
     Horst R. Witzel, Dr.-Ing.                                                                     
                                                                                                   
          Edward C. Wood*            Director                                   December 19, 1996  
____________________________________                                                                
        Edward C. Wood, Jr.         
</TABLE>

 
   
*By: /s/ R. Douglas Armstrong
  ---------------------------
     R. Douglas Armstrong
       Attorney-in-Fact
 
                                     II-7

<PAGE>
 

                                 EXHIBIT INDEX
 
  1.1*     Form of Underwriting Agreement.
 
  3.1**    Restated Articles of Incorporation.
     
  3.2      Form of Restated Articles of Incorporation (to be filed with the
           Secretary of State of the State of Michigan prior to the closing
           of this offering).     
 
  3.3**    Bylaws, as amended.
     
  4.1      Specimen Common Stock Certificate.     
 
  4.2**    Amended and Restated Investors' Rights Agreement dated April 7, 1992.
     
  5.1      Opinion of Pepper, Hamilton & Scheetz, counsel to the Company,
           with respect to the legality of the securities being registered,
           including their consent to being named in the Registration
           Statement.     
 
  10.1**   Form of Indemnification Agreement.
 
  10.2**   1989 Stock Option Plan and form of agreement thereunder.
 
  10.3**   Ancillary Stock Option Plan and form of agreement thereunder.
 
  10.4**   401(k) Plan.
 
  10.5**   Amended and Restated 1992 Incentive and Non-Qualified Stock Option
           Plan and forms of agreements thereunder.
 
  10.6**   1996 Outside Directors Stock Option Plan and forms of agreements
           thereunder.
 
  10.7**   1996 Employee Stock Purchase Plan and form of agreement thereunder.
 
  10.8**   Form of Employment Agreement.
 
  10.9**   Stock Purchase Agreement dated October 22, 1993 between Cobe
           Laboratories, Inc. and the Company and amendment thereto dated
           October 29, 1996.
 
  10.10**+ Distribution Agreement dated October 22, 1993 between Cobe BCT,
           Inc. and the Company and amendments thereto dated March 29, 1995,
           September 11, 1995 and October 29, 1996.
 
  10.11**  License Agreement dated July 17, 1992 between J.G. Cremonese and
           the Company and related addenda thereto dated July 14, 1992 and
           July 7, 1993.
 
  10.12**+ Collaborative Product Development Agreement dated May 10, 1994
           between SeaMED Corporation and the Company.
 
  10.13**+ Collaborative Product Development Agreement dated November 8, 1994
           between Ethox Corporation and the Company.
 
  10.14**+ License and Supply Agreement dated April 1, 1996 between Immunex
           Corporation and the Company.
 
  10.15**  Lease Agreement dated May 18, 1992 between Domino's Farms Holding,
           L.P. and the Company and amendments thereto dated February 26,
           1993, October 3, 1994, November 16, 1994 and July 29, 1996.
 
  10.16**  Clinical Trial Agreement dated April 19, 1996 between the Company
           and the University of Texas M.D. Anderson Cancer Center.
 
 
  10.17**  License Agreement dated March 13, 1992 between the Company and the
           University of Michigan and amendments thereto dated March 13,
           1992, October 8, 1993 and June 21, 1995.

<PAGE>
 
  10.18**   Employee Proprietary Information and Invention Agreement
            effective June 1, 1991 between the Company and R. Douglas
            Armstrong.
 
  10.19**   Employment Agreement dated June 19, 1992 between the Company and
            James Maluta.
 
  10.20**   Employment Agreement dated December 8, 1995 between the Company
            and Todd E. Simpson, C.P.A.
 
  10.21**   Employment Agreement dated February 10, 1994 between the Company
            and Walter C. Ogier.
 
  10.22**   Employment Agreement dated April 19, 1994 between the Company and
            Thomas E. Muller, Ph.D.
 
  10.23**   Employment Agreement dated October 26, 1995 between the Company
            and Alan K. Smith, Ph.D.
     
  10.24**   Promissory Note dated November 18, 1993 for $120,000 loan by the
            Company to R. Douglas Armstrong and amendment thereto dated
            October 30, 1996.     
 
  10.25**   Promissory Note dated October 20, 1993 for $47,303 loan by the
            Company to Stephen G. Emerson, M.D., Ph.D and amendment thereto
            dated October 30, 1996.
 
  10.26**   Consulting Agreement dated June 1, 1995 between the Company and
            Stephen G. Emerson, M.D., Ph.D.
 
  10.27**   Clinical Trial Agreement dated August 28, 1996 between the
            Company and Loyola University Medical Center Cancer Center.
 
  10.28**   Stock Purchase Commitment Agreement dated October 29, 1996
            between Cobe Laboratories, Inc. and the Company.
 
  10.29**   Convertible Loan Commitment Agreement dated October 15, 1996
            between the State Treasurer of the State of Michigan and the
            Company.
     
  10.30**   Form of Subscription Agreement for the purchase of Series D
            Preferred Stock (Enterprise Development Fund L.P., Enterprise
            Development Fund II, L.P. and Northwest Ohio Venture Fund Limited
            Partnership).     
     
  10.31**   Stock Purchase Agreement dated January 8, 1996 among the Company,
            SBIC Partners, L.P. and the State Treasurer of the State of
            Michigan.     
     
  10.32**+  Governance Agreement dated September 15, 1995 between the Company
            and Rhone-Poulenc Rorer Inc.     
     
  10.33**+  License Agreement dated September 15, 1995 between the Company
            and Rhone-Poulenc Rorer Inc.     
     
  10.34**   Stock Purchase Agreement dated September 15, 1995 between the
            Company and Rhone-Poulenc Rorer Inc.     
     
  10.35**   Letter Agreement dated November 11, 1996 between the Company and
            Cobe Laboratories, Inc.     
     
  10.36**   Form of Subscription Agreement for the purchase of Series D
            Preferred Stock (Brentwood Associates V, L.P., Candice E.
            Appleton Family Trust, Candis J. Stern, Helmut F. Stern, H&Q Life
            Science Technology Fund, H&Q London Ventures, State Treasurer of
            the State of Michigan and Windpoint Partners II, Limited
            Partnership).     
     
  10.37**   Subscription Agreement dated December 11, 1995 between the
            Company and Northwest Ohio Venture Fund Limited Partnership.     

<PAGE>
 
     
  10.38**   Subscription Agreement dated May 30, 1995 between the Company and
            Cobe Laboratories, Inc.     
     
  10.39**   Termination Agreement dated November 14, 1996 between the Company
            and Rhone-Poulenc Rorer Inc.     
     
  10.40**   Stock Purchase Agreement dated November 14, 1996 between the
            Company and Rhone-Poulenc Rorer Inc.     
     
  10.41+    Collaborative Supply Agreement dated December 16, 1996 between
            the Company and Anchor Advanced Products, Inc., Mid-State
            Plastics Division.     
 
  11.1**    Statement re computation of pro forma net loss per share.
 
  23.1      The consent of Coopers & Lybrand, L.L.P.
     
  23.2      The consent of Pepper, Hamilton & Scheetz is contained in their
            opinion filed as Exhibit 5.1 of the Registration Statement.     
     
  23.3**    The consent of Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
                
  24.1**    Power of Attorney.
 
  27.1**    Financial Data Schedule.
 
  27.2**    Financial Data Schedule.
 
  27.3**    Financial Data Schedule.
 
  27.4**    Financial Data Schedule.
 
  27.5**    Financial Data Schedule.
 
  27.6**    Financial Data Schedule.
- --------
*  To be filed by Amendment.
** Previously filed.
+  The Company has applied for confidential treatment with respect to certain 
   portions of these documents.





<PAGE>

                                                                     EXHIBIT 3.2
- --------------------------------------------------------------------------------
|      MICHIGAN DEPARTMENT OF COMMERCE - CORPORATION AND SECURITIES BUREAU 
|-------------------------------------------------------------------------------
| Date Received   |            |                       (FOR BUREAU USE ONLY)
|                 |            |
|------------------------------|
|                 |            |
|                 |            |
|------------------------------------|
|Name                                |
|      T. Knox Bell, Esq.            |
|------------------------------------|
|Address                             |
|Gray Cary Ware & Freidenrich        |
|4365 Executive Drive, Suite 1600    |
|------------------------------------|
|City            State       Zip Code|
|  San Diego      CA           92121 |
- -------------------------------------| EFFECTIVE DATE:
                                     -------------------------------------------
DOCUMENT WILL BE RETURNED TO THE NAME AND ADDRESS YOU ENTER ABOVE


                      RESTATED ARTICLES OF INCORPORATION

                    FOR USE BY DOMESTIC PROFIT CORPORATIONS
          (Please read information and instructions on the last page)

Pursuant to the provisions of Act 284, Public Acts of 1972, the undersigned 
corporation executes the following Articles:
- -------------------------------------------------------------------------------
|1.  The present name of the corporation is:
|                Aastrom Biosciences, Inc.
|                                                  
|2.  The identification number assigned by the Bureau is: 529 - 456
|
|3.  All former names of the corporation are:
|                Ann Arbor Stromal, Inc.
|
|4.  The date of filing the original Articles of Incorporation was:
|    March 24, 1989
|    --------------
|-------------------------------------------------------------------------------
         
         The following Restated Articles of Incorporation supersede the
         Articles of Incorporation as amended and shall be the Articles
         of Incorporation for the corporation:

ARTICLE I

- --------------------------------------------------------------------------------
|   The name of the corporation is:
|
|                           Aastrom Biosciences, Inc.
|     
- --------------------------------------------------------------------------------

ARTICLE II

- -------------------------------------------------------------------------------
|   The purpose or purposes for which the corporation is formed are:
|
|               To engage in any activity within the purpose for
 which
|       corporations may be organized under the Michigan Business Corporation
|       Act.
- -------------------------------------------------------------------------------


<PAGE>
 
ARTICLE III
- -------------------------------------------------------------------------------
|The total authorized shares:   
|
|   Common shares  40,000,000                  Preferred shares  10,990,980
|                  ----------                                    ----------
|
|   A statement of all or any of the relative rights, preferences and
|   limitations of the shares of each class is as follow:
|
|               See Rider attached hereto and made a part hereof.
|
- --------------------------------------------------------------------------------

ARTICLE IV

- --------------------------------------------------------------------------------
| 1.  The address of the current registered office is:
|  
|     36th Floor, 100 Renaissance Center, Detroit, Michigan         48243
|     -------------------------------------------           --------------------
|     (Street Address)                    (City)                    (Zip Code)
|
| 2.  The mailing address of the current registered office, if different than
|     above:
|                                                  Michigan
|     -------------------------------------------,          --------------------
|     (Street Address or P.O. Box)        (City)                    (Zip Code)
| 
| 3.  The name of the current resident agent is:  Michael B. Staebler
|                                               --------------------------------
- --------------------------------------------------------------------------------

ARTICLE V (OPTIONAL.  DELETE IF NOT APPLICABLE)
- --------------------------------------------------------------------------------
|  When a compromise or arrangement or a plan of reorganization of this
|  corporation is proposed between this corporation and its creditors or any
|  class of them or between this corporation and its shareholders or any class 
|  of them, a court of equity jurisdiction within the state, on application of 
|  this corporation or of a creditor or shareholder thereof, or on application
|  of a receiver appointed for the corporation, may order a meeting of the
|  creditors or class of creditors or of the shareholders or class of
|  shareholders to be affected by the proposed compromise or arrangement or
|  reorganization, to be summoned in such manner as the court directs. If a
|  majority in number representing 3/4 in value of the creditors or class of
|  creditors, or of the shareholders or class of shareholders to be affected
|  by the proposed compromise or arrangement or a reorganization, agree to a
|  compromise or arrangement or a reorganization of this corporation as a
|  consequence of the compromise or arrangement, the compromise or arrangement
|  and the reorganization, if sanctioned by the court to which the application
|  has been made, shall be binding on all the creditors or class of creditors,
|  or on all the shareholders or class of shareholders and also on this
|  corporation.
- --------------------------------------------------------------------------------

ARTICLE VI (OPTIONAL.  DELETE IF NOT APPLICABLE)
- --------------------------------------------------------------------------------
|  Any action required or permitted by the Act to be taken at an annual or
|  special meeting of shareholders may be taken without a meeting, without
|  prior notice, and without a vote, if consents in writing, setting forth the
|  action so taken, are signed by the holders of outstanding shares having not
|  less than the minimum number of votes that would be necessary to authorize
|  or take the action at a meeting at which all shares entitled to vote on the
|  action were present and voted.  The written consents shall bear the date of
|  signature of each shareholder who signs the consent. No written consents
|  shall be effective to take the corporate action referred to unless, within
|  60 days after the record date for determining shareholders entitled to
|  express consent to or to dissent from a proposal without a meeting, written
|  consents dated not more than 10 days before the record date and signed by
|  a sufficient number of shareholders to take the action are delivered to the
|  corporation.  Delivery shall be to the corporation's registered office, its
|  principal place of business, or an officer or agent of the corporation
|  having custody of the minutes of the proceedings of its shareholders.  
|  Delivery made to a corporation's registered office shall be by hand or by
|  certified or registered mail, return receipt requested.
|  
|  Prompt notice of the taking of the corporate action without a meeting by
|  less than unanimous written consent shall be given to shareholders who would
|  have been entitled to notice of the shareholder meeting if the action had 
|  been taken at a meeting and who have not consented in writing.
- --------------------------------------------------------------------------------

<PAGE>
 
ARTICLE VII. (Additional provisions, if any, may be inserted here; attach 
additional pages if needed.)

________________________________________________________________________________
|
|             See Rider attached hereto and made a part hereof.
|_______________________________________________________________________________
5.  COMPLETE SECTION (a) IF THE RESTATED ARTICLES WERE ADOPTED BY THE UNANIMOUS 
    CONSENT OF THE INCORPORATOR(S) BEFORE THE FIRST MEETING OF THE BOARD OF 
    DIRECTORS; OTHERWISE, COMPLETE SECTION (b).  DO NOT COMPLETE BOTH.
                                                 --------------------

    a. [_] These Restated Articles of Incorporation were duly adopted on the
       ______________ day of ____________________, 19__________, in accordance 
       with the provisions of Section 642 of the Act by the unanimous consent of
       the incorporator(s) before the first meeting of the Board of Directors.

             Signed this __________ day of ______________________, 19__________.

       ____________________________________  ___________________________________

       ____________________________________  ___________________________________
        (Signatures of Incorporators; Type or Print Name Under Each Signature)

    b. [X] These Restated Articles of Incorporation were duly adopted on the
           30th day of October, 1996 in accordance with the provisions of
           ----        -------    -- 
           Section 642 of the Act and: (check one of the following)

           [_] were duly adopted by the Board of Directors without a vote of the
               shareholders. These Restated Articles of Incorporation only
               restate and integrate and do not further amend the provisions of
               the Articles of Incorporation as heretofore amended and there is
               no material discrepancy between those provisions and the
               provisions of these Restated Articles.

           [_] were duly adopted by the shareholders. The necessary number of 
               shares as required by statute were voted in favor of these 
               Restated Articles.

           [X] were duly adopted by the written consent of the shareholders
               having not less than the minimum number of votes required by
               statute in accordance with Section 407(1) of the Act. Written
               notice to shareholders who have not consented in writing has been
               given. (Note: Written consent by less than all of the
               shareholders is permitted only if such provision appears in the
               Articles of Incorporation.)

           [_] were duly adopted by the written consent of all the shareholders 
               entitled to vote in accordance with section 407(2) of the Act.

                  Signed this ______________ day of __________________, 19______

                  By____________________________________________________________
                    (Only Signature of President, Vice-President, Chairperson, 
                                        or Vice-Chairperson)

                       R. DOUGLAS ARMSTRONG, PH.D.            PRESIDENT
                  ______________________________________________________________
                          (Type or Print Name)          (Type or Print Title)

<PAGE>
 
Name of person or organization                    Preparer's name and business
remitting fees:                                   telephone number:

- -----------------------------------               ----------------------------
                                                  (      )
- -----------------------------------               ----------------------------
- --------------------------------------------------------------------------------
|                         INFORMATION AND INSTRUCTIONS
|
|  1.  The articles of incorporation cannot be restated until this form, or
|      a comparable document, is submitted.
|
|  2.  Submit one original of this document.  Upon filing, the document will
|      be added to the records of the Corporation and Securities Bureau.  The
|      original will be returned to the address appearing in the box on the
|      front as evidence of filing.
|
|      Since this document will be maintained on optical disk media, it is
|      important that the filing be legible.  Documents with poor black and
|      white contrast, or otherwise illegible, will be rejected.
|
|  3.  This document is to be used pursuant to sections 641 through 643 of the
|      Act for the purpose of restating the articles of incorporation of a
|      domestic profit corporation.  Restated articles of incorporation are
|      an integration into a single instrument of the current provisions of
|      the corporation's articles of incorporation, along with any desired
|      amendments to those articles.
|
|  4.  Restated articles of incorporation which do not amend the articles of
|      incorporation may be adopted by the board of directors without a vote
|      of the shareholders.  Restated articles of incorporation which amend
|      the articles of incorporation require adoption by the shareholders.
|      Restated articles of incorporation submitted before the first meeting
|      of the board of directors require adoption by all of the incorporators.
|
|  5.  Item 2 - Enter the identification number previously assigned by the
|      Bureau.  If this number is unknown, leave it blank.
|
|  6.  The duration of the corporation should be stated in the restated
|      articles of incorporation only if it is not perpetual.
|
|  7.  This document is effective on the date endorsed "filed" by the Bureau.
|      A later effective date, no more than 90 days after the date of
|      delivery, may be stated as an additional article.
|
|  8.  If the restated articles are adopted before the first meeting of
|      the board of directors, item 5(a) must be completed and signed in
|      ink by a majority of the incorporators.  Other restated articles
|      must be signed by the president, vice-president, chairperson or
|      vice-chairperson.
|
|  9.  FEES:  Make remittance payable to the State of Michigan.  Include
|      corporation name and identification number on check or money order.
|
| 
<TABLE>
|      <S>                                                                                                                  <C>
|      NONREFUNDABLE FEE................................................................................................    $10.00
|      TOTAL MINIMUM FEE................................................................................................    $10.00
|      ADDITIONAL FEES DUE FOR INCREASED AUTHORIZED SHARES ARE:
|          each additional 20,000 authorized shares or portion thereof.......................................$     30.00
|          maximum fee for first 10,000,000 authorized shares................................................$  5,000.00
|          each additional 20,000 authorized shares or portion thereof in excess of 10,000,000 shares........$     30.00
|          maximum fee per filing for authorized shares in excess of 10,000,000 shares.......................$200,000.00
| </TABLE>
 
|
| 10.  Mail form and fee to:                   The office is located at:
|
|           Michigan Department of Commerce           6546 Mercantile Way
|           Corporation and Securities Bureau         Lansing, MI 48910
|           Corporation Division                      Telephone: (517) 334-6302
|           P.O. Box 30054
|           Lansing, MI 48909-7554
- --------------------------------------------------------------------------------

<PAGE>
 
                              RIDER TO ARTICLE III
                              --------------------


PART A:  COMMON STOCK

     Section 1.  Voting Rights.
     ---------   ------------- 

          1.1  One Vote Per Share.  The holders of shares of Common Stock shall
               ------------------                                              
be entitled to one vote for each share so held with respect to all matters voted
on by the shareholders of the Corporation, subject in all cases to Section 4 of
Part B of this Article III.

          1.2  Two-Thirds Consent.  Effective immediately upon and at all times
               ------------------                                              
following the closing of the Corporation's first firm commitment underwritten
public offering of Common Stock (the "IPO") registered under the Securities Act
of 1933, as amended (the "Securities Act"), consent of the holders of at least
two-thirds (2/3) of the outstanding shares of Common Stock shall be required for
(i) any action which results in a consolidation or merger which would be treated
as a liquidation, dissolution or winding up of the Corporation under Section 3.4
of Part B of this Article III, or which results in the liquidation, sale or
assignment of all or substantially all of the assets of the Corporation; (ii)
any amendment to these Articles of Incorporation; or (iii) any amendment by the
shareholders of the Corporation of the Bylaws of the Corporation (the Board of
Directors of the Corporation, as provided in Section 3 of Article VII, shall
have the authority to amend the Bylaws of the Corporation without the consent of
the shareholders of the Corporation).

          Section 2.  Liquidation Rights.  The rights of the holders of Common
          ---------   ------------------                                      
Stock upon any voluntary or involuntary liquidation, dissolution or winding up
of the affairs of the Corporation shall be as set forth in Section 3 of Part B
of this Article III.  However, all distributions made or funds paid to the
holders of Common Stock upon the occurrence of such an event shall be made on
the basis of the number of shares of Common Stock held by each of them.

          Section 3.  Dividends.  Dividends may be paid on the Common Stock as
          ---------   ---------                                               
and when declared by the Board of Directors, subject in all cases to Section 2
of Part B of this Article III.

          Section 4.  Reverse Stock Split.  Immediately upon the effectiveness
          ---------   -------------------                                     
of these Articles of Incorporation (the "Effective Date"), each issued and
outstanding share of Common Stock shall automatically convert into two-thirds
(2/3) of a share of Common Stock.  No fractional shares shall be issued upon
such reverse stock split, and in lieu thereof the Corporation shall pay to each
holder of a fractional interest of a share of Common Stock an amount equal to
the fair market value of such fractional interest on the date of such reverse
stock split as such fair market value is determined in good faith by the Board
of Directors of the Corporation.  Following the Effective Date, each stock
certificate representing shares of Common Stock outstanding prior to the
Effective Date shall represent the appropriate number of shares of Common Stock
which the Common

<PAGE>
 
Stock represented by such stock certificate shall become as a result of the
reverse stock split referenced in this Section 4 of Part A of Article III.

PART B:  PREFERRED STOCK

          Section 1.  Designation.  The Preferred Stock shall consist of six
          ---------   -----------                                           
series to be designated and known as "Series A Preferred Stock" (or "Series A"),
"Series B Preferred Stock" (or "Series B"), "Series C Preferred Stock" (or
"Series C"), "Series D Preferred Stock" (or "Series D"), "Series E Preferred
Stock" (or "Series E") and "Series F Preferred Stock" (or "Series F").  All
series of Preferred Stock shall be identical with each other in all respects
except as otherwise provided herein.  As used herein, the term "Preferred Stock"
without designation shall refer to shares of Series A, Series B, Series C,
Series D, Series E and Series F Preferred Stock, or to shares of any series.
The number of shares constituting each such series of Preferred Stock shall be
as set forth below:
 
         .   Series A Preferred Stock:   2,500,000 shares.
             -------------------------
         .   Series B Preferred Stock:   3,030,000 shares.
             -------------------------
         .   Series C Preferred Stock:   10,000 shares.
             -------------------------
         .   Series D Preferred Stock:   3,000,000 shares.
             -------------------------
         .   Series E Preferred Stock:   1,617,647 shares.
             -------------------------
         .   Series F Preferred Stock:    833,333 shares.
             -------------------------
 
         Section 2.  Dividends.  Dividends are payable when and as declared by 
         ---------   ---------
the Board of Directors subject to the restrictions imposed by the Michigan
Business Corporation Act. Dividends on the Preferred Stock shall not be
cumulative and no right to such dividends shall accrue to holders of Preferred
Stock unless declared by the Board of Directors. Holders of outstanding shares
of certain series of Preferred Stock shall be entitled to receive dividends in
preference to any dividend (whether in cash, securities of the Corporation or
other property) on certain other shares of capital stock of the Corporation, as
set forth below in terms of four "Levels," to be designated and known as "Level
1," "Level 2," "Level 3" and "Level 4." No dividends or other distributions
shall be made with respect to a particular Level until all dividends on the
preceding Levels have been paid on or set apart for payment. For example,
dividends on Level 3 shall not be paid or set apart for payment until full
dividends on Level 1 and Level 2 have been paid or set apart for payment.
Dividends, if paid, must be paid on, or, if declared and set apart for payment
on, must be declared and set apart for payment on, all outstanding shares of
capital stock on a particular Level contemporaneously, and if less than full
dividends are paid on or if declared and set apart for payment on a particular
Level, then the same percentage of the respective dividend rate on all shares on
such Level shall be paid or declared and set apart for payment.

          .   Level 1:  $0.48 per share of Series F Preferred Stock; and
              -------
                        $0.34 per share of Series E Preferred Stock.
 
          .   Level 2:  $0.32 per share of Series D Preferred Stock;
              -------
                        $80.00 per share of Series C Preferred Stock; and
                        $0.16 per share of Series B Preferred Stock.

<PAGE>
 
          .   Level 3:  $0.08 per share of Series A Preferred Stock.
              -------

          .   Level 4:  If a dividend is declared with respect to the Common
                        Stock, then a contemporaneous dividend must be declared
                        with respect to the Series E and Series F Preferred
                        Stock in an amount equal to that which would be received
                        if the Series E and Series F Preferred Stock had been
                        converted to Common Stock on the declaration date of
                        such dividend.

     Section 3.  Liquidation Preference.
     ---------   ---------------------- 

     3.1  Preferential Amounts.  In the event of any voluntary or involuntary
          --------------------                                               
liquidation, dissolution or winding up of the Corporation, any distribution of
the assets or surplus funds of the Corporation to holders of shares of capital
stock of the Corporation by reason of their ownership thereof must take place as
set herein.  Holders of shares of certain series of Preferred Stock shall be
entitled to receive such distributions prior and in preference to any such
distributions on certain other shares of capital stock of the Corporation, as
set forth below in terms of four "Tiers," to be designated and known as "Tier
1," "Tier 2," "Tier 3" and "Tier 4."  No such distributions shall be made with
respect to a particular Tier until all such preferential distributions on the
preceding Tiers have been made.  For example, such distributions on Tier 3 shall
not be made until the full preferential distributions on Tier 1 and Tier 2 have
been made.  If the assets or surplus funds of the Corporation available for
distribution to stockholders are insufficient to permit payment in full of
amounts to which the holders of the outstanding shares on a particular Tier are
entitled pursuant to this Section 3, then such available assets and funds shall
be distributed ratably among the holders of the outstanding shares on such Tier
in proportion to the full preferential distribution each such holder is
otherwise entitled to receive.  The preferential amounts set forth below shall
be adjusted for any stock dividends, combinations or splits with respect to such
shares.

          .    Tier One: $6.00 per share of Series F Preferred Stock, plus all
               --------                                                       
                         accrued or declared but unpaid dividends thereon (the
                         "Series F Preferential Amount"); and
                         $4.25 per share of Series E Preferred Stock, plus all
                         accrued or declared but unpaid dividends thereon (the
                         "Series E Preferential Amount").

          .    Tier Two: $4.00 per share of Series D Preferred Stock, plus all
               --------                                                       
                         accrued or declared but unpaid dividends thereon (the
                         "Series D Preferential Amount");
                         $1,000.00 per share of Series C Preferred Stock, plus
                         all accrued or declared but unpaid dividends thereon
                         (the "Series C Preferential Amount"); and
                         $2.00 per share of Series B Preferred Stock, plus all
                         accrued or declared but unpaid dividends thereon (the
                         "Series B Preferential Amount").

<PAGE>
 
          .  Tier Three: $1.00 per share of Series A Preferred Stock, plus all
             ----------                                                        
                         accrued or declared but unpaid dividends thereon (the
                         "Series A Preferential Amount").
 
     3.2  Participation of Preferred Stock.  After the payment or setting apart
          --------------------------------                                     
for payment of the Series A Preferential Amount, the Series B Preferential
Amount, the Series C Preferential Amount, the Series D Preferential Amount, the
Series E Preferential Amount and the Series F Preferential Amount, the remaining
assets or surplus funds of the Corporation available for distribution upon such
liquidation, dissolution or winding up shall be divided pro rata among the
holders of Common Stock and Preferred Stock, treating the Preferred Stock as if
converted to Common Stock on the date of such liquidation, dissolution or
winding up.

     3.3  Limits on Participation.  In the event of such distribution upon a
          -----------------------                                           
liquidation, dissolution or winding up of the Corporation, the amount otherwise
payable to a holder of Preferred Stock shall not exceed the amount per share set
forth opposite the name of the particular series of Preferred Stock, as set
forth below and as adjusted for any stock dividends, combinations or splits with
respect to such shares.
 
          .  Series A Preferred Stock:  $5.00 per share.
          .  Series B Preferred Stock:  $6.00 per share.
          .  Series C Preferred Stock:  $2,500.00 per share.
          .  Series D Preferred Stock:  $6.00 per share.
          .  Series E Preferred Stock:  $6.00 per share.
          .  Series F Preferred Stock:  $9.00 per share.

     3.4  Consolidation or Merger.  A consolidation or merger of the Corporation
          -----------------------                                               
with or into another corporation or entity shall be regarded as a liquidation,
dissolution or winding up of the Corporation with respect to the Preferred Stock
within the meaning of this Section 3 unless such consolidation or merger is not
intended to effect a change in the ownership or control of the Corporation or of
its assets and is not intended to alter materially the business or assets of the
Corporation, including, by way of example and without limiting the generality of
the foregoing:  (i) a consolidation or merger which merely changes the identity,
form or place of organization of the Corporation, or which is between or among
the Corporation and any of its direct or indirect subsidiaries, or (ii)
following such merger or consolidation, shareholders of the Corporation
immediately prior to such event own not less than 51% of the voting power of
such corporation immediately after such merger or consolidation on a pro rata
basis.

     Section 4.  Voting Rights.
     ---------   ------------- 

     4.1  General.  Except as otherwise required by law, the holder of each
          -------                                                          
share of Preferred Stock issued and outstanding shall have the number of votes
equal to the number of shares of Common Stock into which such shares of
Preferred Stock could be converted at the record date for determination of the
shareholders entitled to vote on such matters, or, if no such record date is
established, at the date such vote is taken or any written consent of
shareholders is solicited, such votes to be counted together with

<PAGE>
 
all other shares of stock of the Corporation having general voting power and not
separately as a class.

     4.2  Merger or Sale of Assets.  Consent of the holders of at least the
          ------------------------                                         
percentage or ratio of the outstanding shares of the class or series set forth
opposite the name of such particular class or series of capital stock of the
Corporation, as set forth below, shall be required for any action which results
in a consolidation or merger which would be treated as a liquidation,
dissolution or winding up of the Corporation under Section 3.4, or the
liquidation, sale or assignment of all or substantially all of the assets of the
Corporation.
 
          .  Common Stock and Preferred Stock, with the exception of
             Series C Preferred Stock:  2/3.
          .  Series A Preferred Stock:  2/3.
          .  Series B Preferred Stock:  2/3.
          .  Series D Preferred Stock:  2/3.
          .  Series E Preferred Stock:  51%.
          .  Series F Preferred Stock:  51%.
 
     4.3  Changes Affecting a Particular Series. Consent of the holders of at
          -------------------------------------
least the percentage or ratio of the outstanding shares of a particular series
of Preferred Stock set forth opposite the name of such series, as set forth
below, with only the affected series voting and with each such affected series
voting as a separate class, shall be required for any action which: (a) alters
the rights, preferences, privileges or restrictions of such series; (b)
increases or decreases the authorized number of shares of such series; or (c)
creates any new class or series of capital stock of the Corporation having
rights, preferences or privileges senior to or on a parity with such series.
 
          .  Series A Preferred Stock:  2/3.
          .  Series B Preferred Stock:  2/3.
          .  Series C Preferred Stock:  Majority.
          .  Series D Preferred Stock:  2/3.
          .  Series E Preferred Stock:  51%.
          .  Series F Preferred Stock:  51%.
 
     4.4  Other Actions.  Consent of the holders of at least the percentage or
          ------------- 
ratio of the outstanding shares of a particular series of Preferred Stock set
forth opposite the name of such series, as set forth below, with each such
series voting as a separate class, shall be required for: (a) any purchase or
redemption by the Corporation of any shares of Preferred Stock; (b) any
repurchase by the Corporation of any shares of Common Stock, other than
repurchases from directors, employees and consultants of the Corporation which
do not in any consecutive twelve-month period exceed One Hundred Thousand
Dollars ($100,000); (c) any declaration or payment by the Corporation of a
dividend or distribution on account of the Common Stock prior to the conversion
of all shares of Preferred Stock, other than a dividend or distribution payable
in shares of Common Stock or otherwise taken into account by the anti-dilution
provisions set forth in these Articles of Incorporation for the benefit of the
Preferred Stock; (d) the sale by 

<PAGE>
 
any wholly-owned subsidiary of the Corporation of any shares of its stock to a
third person; and (e) any amendment to these Articles of Incorporation.
 
          .  Series A Preferred Stock:  2/3.
          .  Series B Preferred Stock:  2/3.
          .  Series D Preferred Stock:  2/3.
          .  Series E Preferred Stock:  51%.
          .  Series F Preferred Stock:  51%.

     4.5  Series C Quorum Requirement.  At any meeting of the holders of all
          ---------------------------                                       
outstanding shares of Preferred Stock to vote as a class, the presence in person
or by proxy of the holders of a majority of the outstanding shares of Series C
Preferred Stock shall be required to constitute a quorum; in the absence of a
quorum a majority of the holders present in person or by proxy shall have the
power to adjourn the meeting from time to time without notice, other than
announcement at the meeting, until a quorum shall be present.

     Section 5.  Redemption.  The Preferred Stock is not redeemable.
     ---------   ----------                                         

     Section 6.  Conversion of Preferred Stock.  The holders of Preferred Stock
     ---------   -----------------------------                                 
shall have conversion rights as follows (the "Conversion Rights"):

     6.1  Conversion Prices.
          ----------------- 

          6.1.1 Series A, Series B, Series C, Series D and Series E Preferred 
                -------------------------------------------------------------
Stock.
- -----

     Upon any conversion of Series A, Series B, Series C, Series D and Series E
Preferred Stock into Common Stock pursuant to this Section 6, each such share of
such series of Preferred Stock shall be converted into such number of fully paid
and nonassessable shares of Common Stock as is determined by taking the
respective preferential amount for such series of Preferred Stock, as set forth
below:

          .  Series A Preferred Stock:   $1.00;
          .  Series B Preferred Stock:   $2.00;
          .  Series C Preferred Stock:   $1,000.00;
          .  Series D Preferred Stock:   $4.00;
          .  Series E Preferred Stock:   $4.25;

          and dividing such preferential amount set forth above by the
respective conversion price for such series of Preferred Stock, as set forth
below:
 
          .  "Series A Conversion Price":   $1.00;
          .  "Series B Conversion Price":   $2.00;
          .  "Series C Conversion Price":   $4.00;
          .  "Series D Conversion Price":   $4.00;
          .  "Series E Conversion Price":   $4.25.

<PAGE>
 
          The Applicable Conversion Price (as defined below in Section 6.1.3)
for each such series shall be subject to adjustment as provided below in Section
6.5.

          6.1.2  Series F Preferred Stock.  Upon any conversion of Series F
                 ------------------------                                  
Preferred Stock into Common Stock pursuant to this Section 6, each such share of
Series F Preferred Stock shall be converted into such number of fully paid and
nonassessable shares of Common Stock as is determined by dividing $6.00 by the
Series F Conversion Price, as such Series F Conversion Price is determined
pursuant to Section 6.3.4.

          6.1.3  Applicable Conversion Price.  The term "Applicable Conversion
                 ---------------------------                                  
Price" shall refer to the Series A Conversion Price with respect to the Series A
Preferred Stock, the Series B Conversion Price with respect to the Series B
Preferred Stock, the Series C Conversion Price with respect to the Series C
Preferred Stock, the Series D Conversion Price with respect to the Series D
Preferred Stock, the Series E Conversion Price with respect to the Series E
Preferred Stock and the Series F Conversion price with respect to the Series F
Preferred Stock, subject to adjustment as provided below in Section 6.5.

     6.2  Voluntary Conversion.
          -------------------- 

          6.2.1  Series A, Series B, Series D and Series E Preferred Stock.
                 ---------------------------------------------------------  
Each share of Series A, Series B, Series D, and Series E Preferred Stock shall
be convertible into Common Stock, at the option of the holder thereof, at any
time after the date of issuance of such share at the office of the Corporation
or any transfer agent for such stock.

          6.2.2  Series C Preferred Stock.  Each share of Series C Preferred
                 ------------------------                                   
Stock shall be convertible into Common Stock, at the option of the holder
thereof, at any time after April 1, 1998, at the office of the Corporation or
any transfer agent for such stock.

     6.3  Automatic Conversion.
          -------------------- 

          6.3.1  Series A, Series B and Series D Preferred Stock.  Each share of
                 -----------------------------------------------                
Series A, Series B and Series D Preferred Stock shall automatically be converted
into shares of Common Stock at the then effective Applicable Conversion Price
immediately upon the closing of the sale of the Corporation's Common Stock in a
firm commitment, underwritten public offering registered under the Securities
Act (other than a registration relating solely to a transaction under Rule 145
under the Securities Act or any successor thereto or to an employee benefit plan
of the Corporation) at a public offering price (prior to underwriter commissions
and expenses) equal to or exceeding $4.26 per share of Common Stock, as adjusted
for any stock dividends, combinations or splits with respect to such shares, and
the gross proceeds of which exceed $10,000,000.  In addition, each share of
Series A, Series B and Series D Preferred Stock shall automatically be converted
into shares of Common Stock at the then effective Applicable Conversion Price
for such particular series upon the conversion of a majority of the shares of
such particular series then outstanding.

<PAGE>
 
          6.3.2  Series C Preferred Stock.  Each share of Series C Preferred
                 ------------------------                                   
Stock shall automatically be converted into shares of Common Stock at the then
effective Series C Conversion Price immediately upon the closing of the sale of
the Corporation's Common Stock in a firm commitment, underwritten public
offering registered under the Securities Act (other than a registration relating
solely to a transaction under Rule 145 under the Securities Act or any successor
thereto or to an employee benefit plan of the Corporation).

          6.3.3  Series E Preferred Stock.  Each share of Series E Preferred
                 ------------------------                                   
Stock shall automatically be converted into shares of Common Stock at the then
effective Series E Conversion Price immediately upon the closing of the sale of
the Corporation's Common Stock in a firm commitment, underwritten public
offering registered under the Securities Act (other than a registration relating
solely to a transaction under Rule 145 under the Securities Act or any successor
thereto or to an employee benefit plan of the Corporation) at a public offering
price (prior to underwriter commissions and expenses) equal to or exceeding
$4.26 per share of Common Stock, as adjusted for any stock dividends,
combinations or splits with respect to such shares, and the gross proceeds of
which exceed $12,500,000.  In addition, each share of Series E Preferred Stock
shall automatically be converted into shares of Common Stock at the then
effective Series E Conversion Price upon the conversion of a majority of the
shares of Series E Preferred Stock then outstanding.

          6.3.4  Series F Preferred Stock.  Each share of Series F Preferred
                 ------------------------                                   
Stock shall automatically be converted into shares of Common Stock at the then
effective Series F Conversion Price as follows:

                 (a) Initial Public Offering. Each share of Series F Preferred
                     -----------------------
Stock shall automatically be converted into shares of Common Stock at the then
effective Series F Conversion Price immediately upon the closing of the sale of
the Corporation's Common Stock in a firm commitment, underwritten public
offering registered under the Securities Act (other than a registration relating
solely to a transaction under Rule 145 under the Securities Act of any successor
thereto or to an employee benefit plan of the Corporation). In the event that
the conversion of Series F Preferred Stock shall occur pursuant to this Section
6.3.4(a), the Series F Conversion Price shall equal eighty percent (80%) of the
price per share of the Common Stock sold in such initial public offering (prior
to any underwriter commissions, fees or discounts), and such conversion shall
occur following any adjustment to the Series F Conversion Price pursuant to
Section 6.5.

                 (b) Qualifying Financing. Each share of Series F Preferred
                     --------------------
Stock shall automatically be converted into shares of Common Stock at the then
effective Series F Conversion Price immediately upon the closing of a non-public
equity financing (including a transaction with multiple closings for the sale of
shares of the same class at the same price per share within any twelve-month
period) wherein the aggregate consideration for such issuance received by the
Corporation is at least $10,000,000, of which at least $1,000,000 is from new
investors, and the Corporation is not subjected to any restrictions imposed by
the investors in such equity financing upon the use of such funds. In the event
that the conversion of the Series F Preferred Stock into shares of

<PAGE>
 
Common Stock shall occur pursuant to this Section 6.3.4(b), the Series F
Conversion Price shall equal eighty percent (80%) of the price per share (on an
"as converted" into Common Stock basis) paid in said non-public equity
financing, and such conversion shall occur following any adjustment to the
Series F Conversion Price pursuant to Section 6.5.

                 (c) Merger, etc.  Each share of Series F Preferred Stock shall
                     -----------                                               
automatically be converted into shares of Common Stock at the then effective
Series F Conversion Price immediately prior to the closing of a consolidation or
merger of the Corporation with or into another corporation which would be
treated as a liquidation, dissolution or winding up pursuant to Section 3.4 or
the sale or conveyance to another corporation of all or substantially all of the
assets of the Corporation, which results in aggregate consideration to the
Corporation or its shareholders with a fair market value of at least
$85,000,000, as determined in good faith by the Board of Directors of the
Corporation.    In the event that the conversion of the Series F Preferred Stock
into shares of Common Stock shall occur pursuant to this Section 6.3.4(c), the
Series F Conversion Price shall equal eighty percent (80%) of the value per
share (on an "as converted" into Common Stock basis) realized by the Company's
shareholders from the consideration received in said consolidation or merger,
which value shall be determined by the mutual agreement between the Company and
the Purchaser.  If the Company and the Purchaser do not reach mutual agreement
as to said value, then said value shall be determined by a nationally recognized
investment banking firm which is mutually selected by the Company and the
Purchaser, with the fees for obtaining said valuation determination to be borne
equally by the Company and the Purchaser.  Such conversion shall occur following
any adjustment to the Series F Conversion Price pursuant to Section 6.5.

                 (d) Operational Plan. Each share of Series F Preferred Stock
                     ----------------
shall automatically be converted into shares of Common Stock at the then
effective Series F Conversion Price immediately upon the adoption by resolution
of the Corporation's Board of Directors of an operational plan for the
Corporation which provides for the Corporation to continue its operations in the
ordinary course of business through revenues, working capital or other resources
through at least December 31, 1998 without any further infusion of capital from
investors through debt or equity investment in the Corporation; provided,
however, that any such operational plan, as determined in good faith by the
Corporation's Board of Directors, must be consistent with the intent of the then
current annual Product Development Plan pursuant to the Distribution Agreement
by and between the Corporation and Cobe BCT, Inc., dated October 22, 1993. In
the event that the conversion of the Series F Preferred Stock into shares of
Common Stock shall occur pursuant to this Section 6.3.4(d), the Series F
Conversion Price shall equal eighty percent (80%) of the fair market value of a
share of Series F Preferred Stock, as determined by the mutual agreement of the
Company and the Purchaser. If the Company and the Purchaser do not reach mutual
agreement as to said value, then said value shall be determined by a nationally
recognized investment banking firm which is mutually selected by the Company and
the Purchaser, with the fees for obtaining said valuation determination to be
borne equally by the Company and the Purchaser. Such

<PAGE>
 
conversion shall occur following any adjustment to the Series F Conversion Price
pursuant to Section 6.5.

                 (e) December 1, 1997. If not earlier converted pursuant to this
                     ----------------
Section 6.3.4, each share of Series F Preferred Stock shall automatically be
converted into shares of Common Stock at the then effective Series F Conversion
Price on December 1, 1997; provided, however, that in the event that prior to
December 1, 1997, the Corporation has entered into a letter of intent (whether
or not such letter of intent is intended to be binding or non-binding on the
Corporation) which contemplates a transaction which would trigger automatic
conversion of the Series F Preferred Stock into Common Stock pursuant to
paragraph (a), (b) or (c) of this Section 6.3.4 and contemplates the
consummation of the closing of such transaction on or before February 1, 1998,
then each share of Series F Preferred Stock shall automatically be converted
into shares of Common Stock at then effective Series F Conversion Price on
February 2, 1998. In the event that the conversion of the Series F Preferred
Stock into shares of Common Stock shall occur pursuant to this Section 6.3.4(e),
the Series F Conversion Price shall be $4.65, as adjusted pursuant to Section
6.5.

     6.4  Mechanics of Conversion.  No fractional shares of Common Stock shall
          -----------------------                                             
be issued upon conversion of shares of Preferred Stock.  In lieu of any
fractional shares to which the holder would otherwise be entitled, the
Corporation shall pay cash equal to such fraction multiplied by the then
effective Applicable Conversion Price for the series.  Before any holder of
Preferred Stock shall be entitled to convert the same into shares of Common
Stock pursuant to Section 6.2, such holder shall surrender the certificate or
certificates therefor at the principal office of the Corporation or of any
transfer agent for such stock and shall give written notice to the Corporation
at such office that such holder elects to convert the same and shall state
therein the name or names of the nominees in which such holder wishes the
certificate or certificates for shares of Common Stock to be issued.  The
Corporation shall, as soon as practicable thereafter, issue and deliver at such
office to such holder of Preferred Stock, or to their respective nominee or
nominees, a certificate or certificates for the number of shares of Common Stock
to which such holder or nominee shall be entitled as aforesaid, together with
cash in lieu of any fraction of a share.  Such conversion shall be deemed to
have been made immediately prior to the close of business on the date of such
surrender of the shares of Preferred Stock to be converted, and the person or
persons entitled to receive the shares of Common Stock issuable upon such
conversion shall be treated for all purposes as the record holder or holders of
such shares of Common Stock on such date.

     6.5  Adjustments to Conversion Prices.
          -------------------------------- 

          6.5.1  Special Definitions.  For purposes of this Section 6.5, the
                 -------------------                                        
following definitions shall apply:

                 (a) "Options" shall mean rights, options or warrants to
                      -------
subscribe for, purchase or otherwise acquire either Common Stock or Convertible
Securities (defined below).

<PAGE>
 
                 (b) "Original Issue Date" shall mean the date on which a share
                      -------------------
of a particular series of Preferred Stock was first issued.

                 (c) "Convertible Securities" shall mean any evidence of
                      ----------------------
indebtedness, shares or other securities directly or indirectly convertible into
or exchangeable for Common Stock.

                 (d) "Additional Shares of Common Stock" shall mean all shares
                      ---------------------------------  
of Common Stock issued (or, pursuant to Section 6(D)(3) deemed to be issued) by
the Corporation after the Original Issue Date, other than shares of Common Stock
issued or issuable:

                     (i) upon conversion of shares of Preferred Stock;
 
                     (ii) to the University of Michigan, Stephen G. Emerson,
Bernhard O. Palsson, Michael F. Clarke, or to the officers, employees,
consultants or directors of the Corporation pursuant to any stock purchase plan
or arrangement, stock option plan, or other stock incentive plan or agreement
approved by the Corporation's Board of Directors; or

                     (iii) by way of dividend or other distribution on shares
excluded from the definition of Additional Shares of Common Stock by the
foregoing clauses (i) or (ii), or this clause (iii).

          6.5.2  No Adjustment of Applicable Conversion Price.  No adjustment in
                 --------------------------------------------                   
the Applicable Conversion Prices for the series of Preferred Stock shall be made
with respect to the issuance of Additional Shares of Common Stock or otherwise,
unless the consideration per share (determined pursuant to Section 6.5.5 hereof)
for an Additional Share of Common Stock issued or deemed to be issued by the
Corporation is less than the Applicable Conversion Price for such series in
effect on the date of, and immediately prior to, the issue of such Additional
Share of Common Stock.

          6.5.3  Deemed Issuances of Additional Shares of Common Stock.
                 ----------------------------------------------------- 

                 (a) Options and Convertible Securities. In the event the
                     ----------------------------------
Corporation at any time or from time to time after the Original Issue Date of a
particular series shall issue any Options or Convertible Securities or shall fix
a record date for the determination of holders of any class of securities
entitled to receive any such Options or Convertible Securities, then the maximum
number of shares (as set forth in the instrument relating thereto without regard
to any provisions contained therein for a subsequent adjustment of such number)
of Common Stock issuable upon the exercise of such Options or, in the case of
Convertible Securities and Options therefor, the conversion or exchange of such
Convertible Securities, shall be deemed to be Additional Shares of Common Stock
issued as of the time of such issue or, in case such a record date shall have
been fixed, as of the close of business on such record date, provided that
Additional Shares of Common Stock shall not be deemed to have been issued with
respect to the Preferred Stock unless the consideration per share (determined
pursuant

<PAGE>
 
to Section 6.5.5 hereof) of such Additional Shares of Common Stock would be less
than the Applicable Conversion Price of such series in effect on the date of and
immediately prior to such issue, or such record date, as the case may be, and
provided further that in any case in which Additional shares of Common Stock are
deemed to be issued the following provisions shall apply:

                     (i) Exercise or Conversion. No further adjustment in the
                         ----------------------
Applicable Conversion Price shall be made upon the subsequent issue of
Convertible Securities or shares of Common Stock upon the exercise of such
Options or conversion or exchange of such Convertible Securities.

                     (ii) Increase or Decrease. If such Options or Convertible
                          -------------------- 
Securities by their terms provide, with the passage of time or otherwise, for
any increase in the consideration payable to the Corporation, or decrease in the
number of shares of Common Stock issuable, upon the exercise, conversion or
exchange thereof, the Applicable Conversion Price computed upon the original
issue thereof (or upon the occurrence of a record date with respect thereto),
and any subsequent adjustments based thereon, shall, upon any such increase or
decrease becoming effective, be recomputed to reflect such increase or decrease
insofar as it affects such Options or the rights of conversion or exchange under
such Convertible Securities.

                     (iii) Expiration. Upon the expiration of any such Options
                           ----------
or any rights of conversion or exchange under such Convertible Securities which
shall not have been exercised, the Applicable Conversion Prices computed upon
the original issue thereof (or upon the occurrence of a record date with respect
thereto), and any subsequent adjustments based thereon, shall, upon such
expiration, be recomputed as follows:

                           (A) Underlying Common Stock. In the case of
                               -----------------------
Convertible Securities or Options for Common Stock, any such subsequent
adjustments shall be recomputed as if the only Additional Shares of Common Stock
issued were the shares of Common Stock, if any, actually issued upon the
exercise of such Options or the conversion or exchange of such Convertible
Securities and the consideration received therefor was the consideration
actually received by the Corporation for the issue of all such Options, whether
or not exercised, plus the consideration actually received by the Corporation
upon such exercise, or for the issue of all such Convertible Securities which
were actually converted or exchanged, plus the additional consideration, if any,
actually received by the Corporation upon such conversion or exchange.

                           (B) Underlying Convertible Securities. In the case of
                               ---------------------------------
Options for Convertible Securities, any such subsequent adjustments shall be
recomputed as if only the Convertible Securities, if any, actually issued upon
the exercise thereof were issued at the time of issue of such Options, and the
consideration received by the Corporation for the Additional Shares of Common
Stock deemed to have been then issued was the consideration actually received by
the Corporation for the issue of all such Options, whether or not exercised,
plus the consideration deemed to have been

<PAGE>
 
received by the Corporation (determined pursuant to Section 6.5.5 upon the issue
of the Convertible Securities with respect to which such Options were actually
exercised.

                     (iv) Limitation. No readjustment pursuant to clause (ii) or
                          ----------  
(iii) above shall have the effect of increasing the Applicable Conversion Price
to an amount which exceeds the lower of (A) such Applicable Conversion Price on
the original adjustment date, or (B) such Applicable Conversion Price that would
have resulted from any issuance of Additional Shares of Common Stock between the
original adjustment date and such readjustment date (nor shall any shares issued
upon conversion prior to such readjustment be affected by such readjustment).

                     (v) Short-Term Options. In the case of any Options that
                         ------------------
expire by their terms not more than thirty (30) days after the date of issue
thereof, no adjustment of the Applicable Conversion Price shall be made until
the expiration or exercise of all such Options, whereupon such adjustment shall
be made in the same manner as provided in clause (iii) above.

               
                     (vi) Date of Issuance. If such record date shall have been
                          ----------------
fixed and such Options or Convertible Securities are not issued on the date
fixed therefor, the adjustment previously made in the Applicable Conversion
Price which became effective on such record date shall be cancelled as of the
close of business on such record date, and thereafter the Applicable Conversion
Price shall be adjusted pursuant to this Section 6.5.3 as of the actual date of
their issuance.

                 (b) Stock Dividends, Stock Distributions and Subdivisions. In
                     ------------------------------------------------------ 
the event the Corporation at any time or from time to time after the Original
Issue Date shall declare or pay any dividend or make any other distribution on
the Common Stock payable in Common Stock, or effect a subdivision of the
outstanding shares of Common Stock (by reclassification or otherwise than by
payment of a dividend in Common Stock), then and in any such event, Additional
Shares of Common Stock shall be deemed to have been issued as follows:

                     (i) Dividend or Distribution. In the case of any such
                         ------------------------
dividend or distribution, immediately after the close of business on the record
date for the determination of holders of any class of securities entitled to
receive such dividend or distribution.

                     (ii) Subdivision. In the case of any such subdivision, at
                          -----------
the close of business on the date immediately prior to the date upon which such
corporate action becomes effective.

          If such record date shall have been fixed and such dividend shall not
have been fully paid on the date fixed therefor, the adjustment previously made
in the Applicable Conversion Price which became effective on such record date
shall be cancelled as of the close of business on such record date, and
thereafter the Applicable Conversion Price shall be adjusted pursuant to this
Section 6.5.3 as of the time of actual payment of such dividend.

<PAGE>
 
          6.5.4  Anti-Dilution Adjustment of Applicable Conversion Price Upon
                 ------------------------------------------------------------
Issuance of Additional Shares of Common Stock.
- --------------------------------------------- 

                 (a) Series A, Series B and Series E Preferred Stock. In the
                     -----------------------------------------------
event the Corporation, at any time after the Original Issue Date, shall issue
Additional Shares of Common Stock (including Additional Shares of Common Stock
deemed to be issued pursuant to Section 6.5.3 but excluding Additional Shares of
Common Stock issued pursuant to Section 6.5.3(b) which event is dealt with in
Section 6.5.6 hereof) without consideration or for a consideration per share
less than the Series A Conversion Price, Series B Conversion Price or Series E
Conversion Price in effect on the date of and immediately prior to such
issuance, then and in such event, the Applicable Conversion Price for the
affected Series A, Series B and Series E Preferred Stock, respectively, shall be
reduced, concurrently with such issuance, in order to increase the number of
shares of Common Stock into which shares of such series of Preferred Stock is
convertible, to a price (calculated to the nearest cent) determined by the
following formula:

                            C
                          -----
     CP(1) = CP(O) x CS + CP(O)
                     ----------
                       CS + AS

     where:

     CP(O) = the Applicable Conversion Price for Series A, Series B or Series E
     Preferred Stock in effect on the date of and immediately prior to such
     issuance;

     CP(1) = the Applicable Conversion Price for Series A, Series B or Series E
     Preferred Stock as so adjusted;

     CS = the number of shares of Common Stock outstanding immediately prior to
     such issuance (including shares of Common Stock issuable upon conversion or
     exercise of any Convertible Securities or Options);

     C = the aggregate consideration received by the Corporation for the total
     number of Additional Shares of Common Stock so issued; and

     AS = the number of such Additional Shares of Common Stock so issued.

Notwithstanding the foregoing, the Applicable Conversion Price for Series A,
Series B or Series E Preferred Stock shall not be so reduced if the amount of
such reduction would be an amount less than $0.01, but any such amount shall be
carried forward and applied toward any subsequent reduction which, together with
such amount and any other amount or amounts so carried forward, shall aggregate
$0.01 or more.

<PAGE>
 
               (b)  Series D Preferred Stock.
                    ------------------------ 

                    (i) Ratchet Adjustment. In the event the Corporation shall
                        ------------------  
issue Additional Shares of Common Stock (including Additional Shares of Common
Stock deemed to be issued pursuant to Section 6.5.3, but excluding Series D
Preferred Stock and Additional Shares of Common Stock issued pursuant to Section
6.5.3(b) (which event is dealt with in Section 6.5.6 hereof)), either without
consideration or for a consideration per share less than the Series D Conversion
Price in effect on the date of and immediately prior to such issuance, wherein
the aggregate consideration for such issuance received by the Corporation is at
least $2,000,000, the following will be applicable:

                        (A) Single Transaction. In a private financing
                            ------------------
transaction (including a transaction with multiple closings for the sale of
shares of the same class at the same price per share within any twelve-month
period), the Series D Conversion Price shall be reduced concurrently with such
issuance to a price equal to the consideration per share (as determined pursuant
to Section 6.5.5 hereof) received by the Corporation for such Additional Shares
of Common Stock; provided, however, that in no event shall the Series D
Conversion Price be reduced to less than $3.00.

                        (B) Multiple Transactions. In multiple transactions at
                            ---------------------
different per share prices during any twelve-month period, the Series D
Conversion Price shall be reduced to an amount equal to the weighted average
consideration received by the Corporation for such Additional Shares of Common
Stock during such twelve-month period (but in no event shall the Series D
Conversion Price be reduced to less than $3.00. Such weighted average
consideration shall be determined by dividing the aggregate consideration
received by the Corporation for the Additional Shares of Common Stock over such
twelve-month period by the aggregate number of Additional Shares of Common Stock
issued over the same period.

                    (ii) Formula Adjustment. In the event the Corporation shall
                         ------------------
issue Additional Shares of Common Stock (including Additional Shares of Common
Stock deemed to be issued pursuant to Section 6.5.3 but excluding Series D
Preferred Stock and Additional Shares of Common Stock issued pursuant to Section
6.5.3(b), which event is dealt with in Section 6.5.6 for a per share
consideration less than the Series D Conversion Price in effect on the date of
and immediately prior to such issuance, in a single transaction or in a series
of transactions, and for aggregate consideration less than $2,000,000 during any
twelve-month period, then the Series D Conversion Price shall be adjusted for
such Additional Shares of Common Stock pursuant to the formula provided in
Section 6.5.4(a) as if the Series D Preferred Stock were Series B Preferred
Stock (except for the Applicable Conversion Price which shall be the Series D
Conversion Price).

                    (iii) Single Adjustment.  For purposes of this Section
                          -----------------                               
6.5.4(b) any issuance of Additional Shares of Common Stock shall be included in
only one twelve-month period (and in only one adjustment of the Series D
Conversion Price), which period shall be the earliest twelve-month period which
may be applicable (and

<PAGE>
 
which adjustment shall be the adjustment to be made with respect to the earliest
applicable twelve-month period).  After the first twelve-month period with
respect to which an adjustment is made to the Series D Conversion Price, any new
twelve-month period shall be deemed to commence on the date of issuance of
Additional Shares of Common Stock first occurring more than twelve months
following the date of issuance of Additional Shares of Common Stock which caused
the most recent prior twelve-month period to begin.

          (c) Series F Preferred Stock.  In the event the Corporation shall
              ------------------------                                     
issue Additional Shares of Common Stock (including Additional Shares of Common
Stock deemed to be issued pursuant to Section 6.5.3, but excluding Series F
Preferred Stock and Additional Shares of Common Stock issued pursuant to Section
6.5.3(b), which event is dealt with in Section 6.5.6, either without
consideration or for a consideration per share less than the Series F Conversion
Price in effect on the date of and immediately prior to such issuance, in a
private financing transaction (including a transaction with multiple closings
for the sale of shares of the same class at the same price per share within any
twelve-month period), wherein the aggregate consideration for such issuance
received by the Corporation is at least $1,000,000, then the Series F Conversion
Price shall be adjusted for such Additional Shares of Common Stock pursuant to
the formula provided in Section 6.5.4(a) as if the Series F Preferred Stock were
Series B Preferred Stock (except the Applicable Conversion Price shall be the
Series F Conversion Price); provided, however, that the adjustment to the Series
F Conversion Price provided for in this Section 6.5.4(c) shall apply only to the
Corporation's first such private financing following the Original Issue Date of
the Series F Preferred Stock.

          6.5.5  Determination of Consideration.  For purposes of this Section
                 ------------------------------                               
6.5 the consideration received by the Corporation for the issue of any
Additional Shares of Common Stock shall be computed as follows:

                 (a) Cash and Property.  Such consideration shall be computed as
                     -----------------                                          
follows:

                     (i) Cash. Insofar as it consists of cash, such
                         ----  
consideration shall be computed at the aggregate amount of cash received by the
Corporation;

                     (ii) Property. Insofar as it consists of property other
                          --------
than cash, such consideration shall be computed at the fair value thereof at the
time of such issue, as determined in good faith by the Board of Directors; and

                     (iii) Combination. In the event Additional Shares of Common
                           ----------- 
Stock are issued together with other shares or securities or other assets of the
Corporation for consideration which covers both, such consideration shall be the
proportion of such consideration so received, computed as provided in clauses
(i) and (ii) above, as determined in good faith by the Board of Directors.

<PAGE>
 
                 (b) Options and Convertible Securities. The consideration per
                     ----------------------------------
share received by the Corporation for Additional Shares of Common Stock deemed
to have been issued pursuant to Section 6.5.3(a), relating to Options and
Convertible Securities, shall be determined by dividing:

                     (i) the total amount, if any, received or receivable by the
Corporation as consideration for the issue of such Options or Convertible
Securities, plus the minimum aggregate amount of additional consideration (as
set forth in the instruments relating thereto, without regard to any provision
contained therein for a subsequent adjustment of such consideration) payable to
the Corporation upon the exercise of such Options or the conversion or exchange
of such Convertible Securities, or in the case of Options for Convertible
Securities, the exercise of such Options for Convertible Securities and the
conversion or exchange of such Convertible Securities; by

                    (ii) the maximum number of shares of Common Stock (as set
forth in the instruments relating thereto, without regard to any provision
contained therein for a subsequent adjustment of such number) issuable upon the
exercise of such Options or the conversion or exchange of such Convertible
Securities.

          6.5.6  Adjustment for Dividends or Combinations.
                 ---------------------------------------- 

                 (a) Stock Dividends, Distributions or Subdivisions. In the
                     ----------------------------------------------
event the Corporation shall issue Common Stock pursuant to Section 6.5.3(b) in a
stock dividend, stock distribution or subdivision, the Applicable Conversion
Price in effect immediately prior to such stock dividend, stock distribution or
subdivision shall, concurrently with the effectiveness of such stock dividend,
stock distribution or subdivision, be proportionately decreased.

                 (b) Combinations or Consolidations. In the event the
                     ------------------------------
outstanding shares of Common Stock shall be combined or consolidated, by
reclassification or otherwise, into a lesser number of shares of Common Stock,
the Applicable Conversion Price in effect immediately prior to such combination
or consolidation shall, concurrently with the effectiveness of such combination
or consolidation, be proportionately increased.

          6.5.7  Adjustment for Merger or Reorganization.  In the event of any
                 ---------------------------------------                      
consolidation or merger of the Corporation with or into another corporation or
the sale or conveyance of all or substantially all of the assets of the
Corporation to another corporation, each share of Series A, Series B, Series C,
Series D and Series E Preferred Stock shall thereafter be convertible into the
number of shares of stock or other securities or property to which a holder of
the number of shares of Common Stock of the Corporation deliverable upon
conversion of such series would have been entitled upon such consolidation,
merger or conveyance, and, in any such case, appropriate adjustment (as
determined by the Board of Directors) shall be made in the application of the
provisions herein set forth with respect to the rights and interest thereafter
of the holders of the series, in order that the provisions set forth herein
(including provisions with respect to changes in and other adjustments of the
Applicable Conversion Price) shall

<PAGE>
 
thereafter be applicable, as nearly as reasonably may be, in relation to any
shares of stock or other property thereafter deliverable upon the conversion of
that series of Preferred Stock.  However, in the case of any merger or
consolidation which is treated as a liquidation, dissolution or winding up of
the affairs of the Corporation pursuant to Section 3.4, each share of Series A,
Series B, Series C, Series D and Series E Preferred Stock shall not be converted
into shares of stock or other securities or property of the resulting
corporation, but shall be cancelled and surrendered to the Corporation upon
distribution to the holders of Series A, Series B, Series C, Series D and Series
E Preferred Stock of all cash or other property to which they are entitled
pursuant to Section 3 as a result of such transaction being treated as a
liquidation, dissolution, or winding up under Section 3.4.

          6.5.8  Adjustment to Series C Conversion Price for Distributions to
                 ------------------------------------------------------------
Holders of Common Stock.  In the event that the Corporation shall distribute to
- -----------------------                                                        
the holders of its Common Stock (whether pursuant to a reclassification, merger
or consolidation or otherwise) evidences of its indebtedness or assets
(including cash, securities, intangible assets or other property), then the
Series C Conversion Price shall be adjusted so that the number of shares of
Common Stock into which a share of Series C Preferred Stock is convertible
equals the number of shares of Common Stock determined as follows:  multiply the
number of shares of Common Stock into which each share of Series C Preferred
Stock is convertible at the then effective Series C Conversion Price by a
fraction, the numerator of which shall be the Series C Conversion Price
effective on the record date for determination of shareholders entitled to
receive such distribution, and the denominator of which shall be such Series C
Conversion Price less the fair market value of such property, as determined in
good faith by the Board of Directors of the Corporation, distributed with
respect to each share of Common Stock.  Such adjustment to the Series C
Conversion Price shall be made whenever any such distribution is made.

     6.6  No Impairment.  The Corporation will not, by amendment of these
          -------------                                                  
Restated Articles of Incorporation or through any reorganization, transfer of
assets, consolidation, merger, dissolution, issue or sale of securities or any
other voluntary action, avoid or seek to avoid the observance or performance of
any of the terms to be observed or performed hereunder by the Corporation but
will at all times in good faith assist in the carrying out of all the provisions
of this Section 6 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of the
Preferred Stock against impairment.

     6.7  Certificate as to Adjustments.  Upon the occurrence of each adjustment
          -----------------------------                                         
or readjustment of the Applicable Conversion Prices pursuant to this Section 6,
the Corporation at its expense shall promptly compute such adjustments or
readjustments in accordance with the terms hereof and furnish to each holder of
Preferred Stock a certificate setting forth such adjustment or readjustment and
showing in detail the facts upon which such adjustment or readjustment is based.
The Corporation shall, upon the written request at any time from any holder of
Preferred Stock, furnish or cause to be furnished to such holder a like
certificate setting forth (i) such adjustments and readjustments, (ii) the
Applicable Conversion Price at the time in effect, and (iii) the number of
shares of Common Stock and the amount, if any, of other property which at

<PAGE>
 
the time would be received upon the conversion of such holder's shares of
Preferred Stock.

     6.8  Notices of Record Date.  In the event of any taking by the Corporation
          ----------------------                                                
of a record of the holders of any class of securities (other than Preferred
Stock) for the purposes of determining the holders thereof who are entitled to
receive any dividend (other than a cash dividend which is the same as cash
dividends paid in previous quarters) or other distribution, the Corporation
shall mail to each holder of Preferred Stock at least ten (10) days prior to the
date specified therein, a notice specifying the date on which any such record is
to be taken for the purpose of such dividend or distribution.

     6.9  Common Stock Reserved.  The Corporation shall reserve and keep
          ---------------------                                         
available out of its authorized but unissued Common Stock such number of shares
of Common Stock as shall from time to time be sufficient to effect conversion of
the Preferred Stock.  The Corporation shall not take any corporate action which
would require an adjustment in the number of shares of Common Stock into which
any share of Preferred Stock is convertible unless either (i) immediately after
such corporate action is taken and the transactions contemplated thereby are
consummated, the number of authorized and unissued shares of Common Stock would
be sufficient to effect the conversion of all outstanding shares of Preferred
Stock at the Applicable Conversion Prices then in effect, or (ii) concurrently
with the taking of such corporate action, the Corporation shall take such
corporate action as, in the opinion of its counsel, may be necessary to increase
its authorized and unissued shares of Common Stock to such number as shall be
sufficient to provide for such conversion.


          6.10  Taxes Upon Conversion of Series C Preferred Stock.  The
                -------------------------------------------------      
Corporation shall pay any and all taxes that may be payable in respect of the
issue or delivery of shares of Common Stock on conversion of shares of Series C
Preferred Stock pursuant hereto.  The Corporation shall not, however, be
required to pay any tax which may be payable in respect of any transfer involved
in the issue and delivery of shares of Common Stock in a name other than that in
which the shares of Series C Preferred Stock so converted were registered, and
no such issue or delivery shall be made unless and until the person requesting
such issue has paid to the Corporation the amount of any such tax or has
established, to the satisfaction of the Corporation, that such tax has been
paid.

<PAGE>
 
                              RIDER TO ARTICLE VII
                              --------------------

                                  ARTICLE VII

          1.   Director Liability.  A director of the Corporation shall not be
               ------------------                                             
personally liable to the Corporation or its shareholders for monetary damages
for breach of fiduciary duty as a director.  However, this provision does not
eliminate or limit the liability of a director for any of the following:

               (a) any breach of the director's duty of loyalty to the
Corporation or its shareholders;

               (b) any acts or omissions not in good faith or that involve
intentional misconduct or a knowing violation of law;

               (c) a violation of Section 551(1) of the Michigan Business
Corporation Act, as amended (the "MBCA");

               (d) a transaction from which the director derived an improper
personal benefit; or

               (e) an act or omission occurring before the date these Articles
of Incorporation became effective in accordance with the pertinent provisions of
the MBCA.

Any repeal, amendment or other modification of this Article VII shall not
adversely affect any right or protection of a director of the Corporation
existing at the time of such repeal, amendment or other modification.

          If the MBCA is amended, after this Article becomes effective, to
authorize corporate action further eliminating or limiting personal liability of
directors, then the liability of directors shall be eliminated or limited to the
fullest extent permitted by the MBCA as so amended.

          2.   Control Share Acquisitions.  Chapter 7B of the MBCA, known as the
               --------------------------                                       
"Stacey, Bennett, and Randall shareholder equity act," does not apply to control
share acquisitions of shares of the Corporation.

          3.   Amendment of Bylaws.  In furtherance and not in limitation of the
               -------------------                                              
powers conferred by statute, the Board of Directors of the Corporation is
expressly authorized to make, alter or repeal the Bylaws of the Corporation.

          4.   Deletion of Article V.  Effective immediately upon the IPO,
               ---------------------                                      
Article V of these Articles of Incorporation shall be deleted in its entirety.

          5.   Deletion of Article VI.  Effective immediately upon the IPO,
               ----------------------                                      
Article VI of these Articles of Incorporation shall be deleted in its entirety.



<PAGE>

                                                                     EXHIBIT 4.1

NUMBER           
AST                               [LOGO OF AASTROM]                       SHARES
COMMON STOCK                                                        COMMON STOCK

                                             SEE REVERSE FOR CERTAIN DEFINITIONS
INCORPORATED UNDER THE LAWS                                      CUSIP 00253U107
OF THE STATE OF MICHIGAN                            

This Certifies that




is the Owner of:

    FULLY PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK, NO PAR VALUE, OF

                           AASTROM BIOSCIENCES, INC.
 
transferable on the books of the Corporation by the holder hereof in person or 
by duly authorized attorney under surrender of this Certificate properly
endorsed or accompanied by a proper assignment.

   This certificate and the shares represented hereby are issued and shall be 
held subject to all of the provisions of the Articles of Incorporation and the 
Bylaws of the Corporation, and all amendments thereto, copies of which are on 
file at the principal offices the Corporation and the Transfer Agent, to all of 
which the holder of this Certificate by acceptance hereof consents.

   This Certificate is not valid unless countersigned by the Transfer Agent and
registered by the Registrar.

   WITNESS the signatures of the Corporation's duly authorized officers.

Dated:
      -------------

/s/ TODD E. SIMPSON                     /s/ R. DOUGLAS ARMSTRONG
- -------------------                     -------------------------------------
SECRETARY                               PRESIDENT AND CHIEF EXECUTIVE OFFICER

COUNTERSIGNED AND REGISTERED:
    CONTINENTAL
 STOCK TRANSFER & TRUST COMPANY
    (JERSEY CITY, N.J.)
    TRANSFER AGENT AND REGISTRAR
    AUTHORIZED OFFICER

<PAGE>
 
                           AASTROM BIOSCIENCES, INC.

THE CORPORATION WILL FURNISH WITHOUT CHARGE TO EACH SHAREHOLDER WHO SO REQUESTS 
THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE, PARTICIPATING, OPTIONAL OR 
OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OR SERIES THEREOF AND THE 
QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH PREFERENCES AND/OR RIGHTS.

The following abbreviations, when used in the inscription on the face of this 
certificate, shall be construed as though they were written out in full
according to applicable laws and regulations.

<TABLE> 
<CAPTION> 
<S>                                            <C> 
TEN COM - as tenants in common                 UNIF GIFT MIN ACT - ..........CUSTODIAN..........
TEN ENT - as tenants by the entireties                              (cust)             (minor)  
JT TEN  - as joint tenants with right of       under or Uniform Gifts to Minors 
          survivorship and not as tenants       Act..............................................
          in common                                                  (state)
</TABLE>
 
    Additional abbreviations may also be used throughout in the above list.

For value received, ____________________________________ hereby sell, assign 
and transfer unto

Please insert social security or other
IDENTIFYING NUMBER OF ASSIGNEE
[_]


- --------------------------------------------------------------------------------
 (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE OF ASSIGNEE)


- --------------------------------------------------------------------------------


- --------------------------------------------------------------------------------


- -------------------------------------------------------------------------shares
of the Capital Stock represented by the within Certificate, and do hereby 
irrevocably constitute and appoint.


- ----------------------------------------------------------------------- Attorney
to transfer the said stock on the books of the within named Corporation with 
full power of substitution in the premises.

Dated
     ------------------------------------------



                                NOTICE:_________________________________________
                                       THE SIGNATURE TO THIS ASSIGNMENT MUST
                                       CORRESPOND WITH THE NAME AS WRITTEN UPON
                                       THE FACE OF THE CERTIFICATE IN EVERY
                                       PARTICULAR, WITHOUT ALTERATION OR
                                       ENLARGEMENT OR ANY CHANGES WHATEVER.


                  SIGNATURE(S) GUARANTEED:______________________________________
                                       THE SIGNATURE(S) SHOULD OR GUARANTEED BY
                                       AN ELIGIBLE GUARANTOR INSTITUTION (BANKS,
                                       STOCKBROKERS, SAVING & LOAN ASSOCIATIONS
                                       AND CREDIT UNIONS WITH MEMBERSHIP IN AN
                                       APPROVED SIGNATURE GUARANTEE MEDALLON
                                       PROGRAM), PURSUANT TO SEC RULE 17AD-15.

          

- --------------------------------------------------------------------------------

 



<PAGE>
 
                                                                     EXHIBIT 5.1

                  [LETTERHEAD OF PEPPER, HAMILTON & SCHEETZ]

                                                    December 19, 1996


Securities and Exchange Commission
Judiciary Plaza
450 Fifth Street, N.W.
Washington, D.C. 20549

        Re:  Aastrom Biosciences, Inc. Registration
             Statement on Form S-1
             File No. 333-15415

Gentlemen:

       We have acted as special counsel to Aastrom Biosciences, Inc., a Michigan
corporation (the "Company"), in connection with the preparation and filing with 
the Securities and Exchange Commission (the "Commission") of a registration 
statement (the "Registration Statement") of the Company on Form S-1 under the 
Securities Act of 1933, as amended (the "Act"). The Registration Statement 
relates to the proposed offer and sale by the Company of up to 3,737,500 shares 
(the "Shares") of the Company's Common Stock (the "Common Stock").

       In this connection, we have examined the Registration Statement,
including the exhibits thereto, the originals or copies, certified or otherwise
identified to our satisfaction, of the Articles of Incorporation and the By-Laws
of the Company amended to date, resolutions of the Company's Board of Directors
and such other documents and corporate records relating to the Company, and the
issuance and sale of the Shares as we have deemed appropriate. The
 opinion
expressed herein is based exclusively on the applicable provisions of the
Michigan Business Corporation Act as in effect on the date hereof.

       On the basis of the foregoing, we are of the opinion that the Shares 
identified in the above-referenced Registration Statement to be issued and sold 
by the Company will be, upon effectiveness of the Registration Statement and 
receipt by the 
  

<PAGE>
 
Company of payment therefor, duly authorized, validly issued, fully paid, and 
non-assessable.

      We hereby consent to the reference to our firm under the caption "Legal 
Matters" in the Registration Statement and to the filing of this opinion as an 
exhibit to the Registration Statement. Such consent does not constitute a 
consent under Section 7 of the Act, since we have not certified any part of such
Registration Statement and do not otherwise come within the categories of 
persons whose consent is required under Section 7 of the Act or the rules and 
regulations of the Commission promulgated thereunder.

                                           Very truly yours,
                                        
                                           PEPPER, HAMILTON & SCHEETZ

                                           By: /s/ MICHAEL B. STAEBLER
                                               ------------------------
                                                   MICHAEL B. STAEBLER
 



<PAGE>
 
                                                                   EXHIBIT 10.41

                         COLLABORATIVE SUPPLY AGREEMENT


                                    between

                           AASTROM BIOSCIENCES, INC.

                                      and

                               MID-STATE PLASTICS

<PAGE>
 
                               TABLE OF CONTENTS
                               -----------------


<TABLE>
<CAPTION>
                                                                            Page
                                                                            ----
<S>         <C>                                                             <C>
Section 1.  Definitions...................................................    2
 
Section 2.  Purchase and Sale.............................................    4
 
Section 3.  Forecasts; Delivery; Shipment.................................    4
            (a)  Rolling Forecasts........................................    5
            (b)  No Limit on Sales........................................    5
            (c)  No Liens.................................................    5
            (d)  Delivery.................................................    5
            (e)  Shipment.................................................    5
            (f)  Acceptance Procedures....................................    6
            (g)  Lot Testing..............................................    6
 
Section 4.  Prices........................................................    7
            (a)  Cell Cassette Prices.....................................    7
            (b)  Phase I Collaboration Charge.............................    7
            (c)  Component Order and Prices...............................    7
            (d)  Best Diligent Efforts....................................    7
  
Section 5.  Payment and Collection........................................    8
            (a)  Payment..................................................    8
            (b)  Deductions from Invoice..................................    8
            (c)  Relief for Non-Payment...................................    8
 
Section 6.  Specifications, DMR and Changes...............................    8
            (a)  Specifications...........................................    8
            (b)  Establish DMR............................................    9
            (c)  Specification and DMR Changes............................    9
            (d)  MSP Refusal to Change Specification......................    9
            (e)  Other Changes............................................    9
            (f)  Returns..................................................    9
 
Section 7.  MSP's Facilities and Manufacturing Environment................    9
 
Section 8.  MSP Manufacturing Procedures..................................   10
 
Section 9.  Collaborative and Other Responsibilities of the Parties.......   11
            (a)  Overview.................................................   11
            (b)  Responsibilities of AASTROM..............................   11
            (c)  MSP's Collaboration......................................   12
            (d)  Other Responsibilities of MSP............................   12
</TABLE>

                                      -i-

<PAGE>
 

<TABLE>
<C>         <S>                                                             <C> 
Section 10. Equipment....................................................   13
            (a)  Ownership...............................................   14
            (b)  Identification Tags.....................................   14
            (c)  Liens and Insurance.....................................   14
            (d)  Inspection..............................................   14
            (e)  No Modification.........................................   14
            (f)  Maintenance.............................................
   14
            (g)  Use.....................................................   14
 
Section 11. Right of Inspection..........................................   15
            (a)  Rights of Inspection....................................   15
            (b)  Waiver..................................................   15
            (c)  Self-Certification......................................   15
            (d)  Records; Inspection.....................................   15
 
Section 12. Warranty; Recalls............................................   16
            (a)  Warranty................................................   16
            (b)  DISCLAIMER..............................................   16
            (c)  No Third-Person Warranty................................   16
            (d)  Recalls.................................................   16
 
Section 13. Limitation of Damages Liability..............................   17
            (a)  Third Party Claims Not Related to Manufacturing Defect..   17
            (b)  Third Party Claims Related to MSP's Delays..............   17
            (c)  Third Party Claims for Product Liability................   17
            (d)  AASTROM's Claims - Phase I..............................   17
            (e)  AASTROM's Claims - Phase II.............................   17
            (f)  Willful Wrongdoing......................................   18
            (g)  Nature of Damages.......................................   18
            (h)  Mitigation..............................................   18
            (i)  AASTROM's Liabilities...................................   18
 
Section 14. Indemnity....................................................   18
            (a)  AASTROM's General Indemnity.............................   18
            (b)  MSP's General Indemnity.................................   19
            (c)  Intellectual Property Warranty..........................   19
            (d)  Intellectual Property Indemnity by AASTROM..............   20
            (e)  Intellectual Property Indemnity by MSP..................   20
 
Section 15. Ownership of Intellectual Property...........................   21
            (a)  Ownership of Intellectual Property......................   21
            (b)  Return of Intellectual Property.........................   21
  
Section 16. Confidential Information.....................................   21
            (a)  Title to Confidential Information and Related Documents.   21
            (b)  Non-Disclosure and Non-Use of Confidential Information..   21
</TABLE>


                                     -ii-

<PAGE>
 

<TABLE>
<C>         <S>                                                             <C> 
            (c)  Protection of Confidential Information..................   22
 
Section 17. Term and Termination.........................................   22
            (a)  Term of Agreement.......................................   22
            (b)  Termination Upon Default................................   22
            (c)  Termination Upon Insolvency.............................   22
            (d)  Termination Upon Inability of MSP to Perform............   22
            (e)  Effect of Termination...................................   23
            (f)  Liabilities When No Termination.........................   23
            (g)  Alternative Purchase of Product.........................   23
  
Section 18. Preferred Supplier; Alternative Supplier.....................   24
            (a)  Preferred Supplier......................................   24
            (b)  Alternate Suppliers.....................................   24
 
Section 19. Representations and Warranties...............................   24
 
Section 20. Force Majeure................................................   24
            (a)  Suspension of Performance...............................   24
            (b)  Cooperation.............................................   25
            (c)  Allocation of Resources.................................   25
 
Section 21. MSP Competitiveness; Shared Investment Return................   25
            (a)  MSP's Competitiveness...................................   25
            (b)  Shared Investment Return................................   25
                 (1)  MSP Capital Investments............................   25
                 (2)  Recoupment of MSP Capital Investment; Cost Sharing.   25
                 (3)  AASTROM Capital Investments........................   26
 
Section 22. Insurance....................................................   26
 
Section 23. Similar Products.............................................   26
            (a)  Continuing Prohibition..................................   26
            (b)  Similar Products........................................   26
 
Section 24. Governing Law; Dispute Resolution............................   27
            (a)  Governing Law...........................................   27
            (b)  Dispute Resolution......................................   27
 
Section 25. Notices......................................................   28
 
Section 26. Successors and Assigns; Survival.............................   29
 
Section 27. Headings.....................................................   29
 
Section 28. Severability.................................................   29
</TABLE>


                                     -iii-

<PAGE>
 

<TABLE>
<C>          <S>                                                            <C> 
Section 29.  Amendment and Waiver.........................................  29
 
Section 30.  Counterparts.................................................  30
 
Section 31.  Independent Contractors......................................  30
 
Section 32.  Entire Agreement.............................................  30
</TABLE>


APPENDICES:

 I        Equipment
 II       Specifications
 III      Pricing Schedule for Phase I and II
 IV       Pro Forma Invoice
 V        Bill of Materials

                                     -iv-

<PAGE>
 
                                 COLLABORATIVE

                                SUPPLY AGREEMENT


          THIS COLLABORATIVE SUPPLY AGREEMENT (this "Agreement") is made
effective as of December 16, 1996 (the "Effective Date") by and between Aastrom
Biosciences, Inc., a Michigan corporation with principal offices at Domino's
Farms, Lobby L, Ann Arbor, Michigan 48106 ("AASTROM") and Anchor Advanced
Products, Inc., Mid-State Plastics Division, a Delaware corporation with offices
at U.S. Highway 220 North, Seagrove, North Carolina 27341 ("MSP").

                              W I T N E S S E T H:

          WHEREAS, AASTROM is developing medical devices to implement
proprietary cell production processes for cellular therapy procedures;

          WHEREAS, such development work has led to the development by AASTROM
of the AASTROM(TM) Cell Production System, a proprietary medical device for the
production of human stem cells (the "AASTROM CPS"), consisting in part of
single-use, sterile culture chambers;

          WHEREAS, MSP has expertise and experience in plastic injection
molding, in general, and in the production and assembly of plastic parts for
products that are classified as medical devices under the regulations of the
U.S. Food and Drug Administration (the "FDA"), in particular;

          WHEREAS, AASTROM and MSP anticipate that the AASTROM CPS will be a
Class III medical device requiring Pre-Marketing Approval under FDA regulations
and a Class IIb device under regulations of the Medical Device Directives of the
European Community (the "EC"); and

          WHEREAS, in consideration of MSP's expertise and stated intention to
be a cost effective and a capable manufacturer and supplier of Cell Cassettes
and Components (as defined herein), AASTROM desires for MSP to be a preferred
manufacturer of such Cell Cassettes and Components throughout the Term of this
Agreement, and MSP desires to be such supplier for such period; and

          WHEREAS, AASTROM and MSP desire for MSP to work with AASTROM to
develop and produce Cell Cassettes for the AASTROM CPS.

          NOW, THEREFORE, in consideration of these premises and the mutual
undertakings hereinafter set forth, and for other good and valuable
consideration given by AASTROM and MSP to each other, the receipt and
sufficiency of which is hereby acknowledged, AASTROM and MSP, intending to be
legally bound, agree as follows:

                                      -1-

<PAGE>
 
SECTION 1.  DEFINITIONS.
            ----------- 

The terms set forth below when used with capital letters shall have the meanings
set forth below.  Other terms are defined in the Sections of this Agreement
pertinent to their definitions.


<TABLE> 
<CAPTION> 
<C>  <C>                 <S>    
(a)  "the Act"           The Act shall mean the Federal Food, Drug and Cosmetics
                         Act, 21 U.S.C. 301, et seq. (1938), as amended, and the
                                             -- --- 
                         rules and regulations promulgated thereunder.

(b)  "Cell Cassette(s)"  Cell Cassette shall mean a single-use, sterile cell
                         culture chamber consisting of plastic injection molded
                         and other parts made, assembled and encased in a
                         plastic injection molded cassette manufactured in
                         accordance with the DMR (as defined below) and used in
                         the AASTROM CPS or similar products made by or for
                         AASTROM, and all improvements and modifications to
                         Components thereof that are intended to replace the
                         then current Components.

(c)  "Component(s)"      Component shall mean any component part of a Cell
                         Cassette (e.g., the individual injection molded pieces,
                         bioreactor assembly or fluid pathway tubing assembly).

(d)  "Confidential
     Information"        Confidential Information shall mean any and all
                         technical and non-technical information, (whether or
                         not disclosed by AASTROM prior to the Effective Date
                         under the terms of the Confidentiality Agreement
                         between the Parties dated December 22, 1993), data,
                         techniques, manufacturing procedures, know-how,
                         discoveries, inventions, trade secrets, improvements or
                         innovations that are maintained as proprietary and
                         confidential by the Party owning or controlling the
                         same; but Confidential Information shall not include
                         information that (i) the Recipient can clearly
                         demonstrate to have been in its possession at the time
                         Confidential Information is disclosed to it, provided
                         that, such information is not known by the Recipient to
                         be subject to another confidentiality agreement with,
                         or under other obligation of secrecy to, the Disclosing
                         Party or another party, or (ii) becomes generally
                         available to the public other than as a result of a
                         disclosure by the Recipient, its agents or employees,
                         or (iii) becomes available to the Recipient on a non-
                         confidential basis from a source other than the
                         Disclosing Party, provided that, the Recipient does not
                                           -------- ----
                         know, or have reason to know, that such source is bound
                         by a confidentiality agreement with, or other
                         obligation of secrecy to the Disclosing Party or
                         another party, or (iv) the Recipient can clearly
                         demonstrate to have developed itself independent of the
                         Confidential Information, or (v) the Disclosing Party
                         consents in writing may be disclosed by the Recipient.
</TABLE>
 

                                      -2-

<PAGE>
 

<TABLE> 
<C>  <C>                  <S>  
(e)  "Disclosing Party"   Disclosing Party shall mean the Party disclosing
                          Confidential Information.

(f)  "DMR"                DMR shall mean the Device Master Record for the Cell
                          Cassette consisting of a compilation of records
                          containing the design, formulation, Specifications (as
                          defined below), complete manufacturing procedures,
                          quality assurance requirements and labeling and
                          packaging requirements.

(g)  "Equipment"          Equipment shall mean the molds and other equipment
                          listed on Appendix I, annexed hereto, and categorized
                          as being provided either by AASTROM or by MSP. AASTROM
                          Equipment shall also include any equipment procured by
                          MSP for manufacture of the Cell Cassettes in accordance
                          with Section 21(b)(1).

(h)  "GMPs"               GMPs shall mean the then-current Good Manufacturing
                          Practices published at 21 CFR Part 820, et seq.
                                                                  -- ---
                          applicable to a Class III medical device, but only
                          such GMPs that are applicable to the Cell Cassette or
                          Components.
 
(i)  "ISO"                ISO shall mean the International Standards
                          Organization.
 
(j)  "Party or "Parties"  Party shall mean either AASTROM or MSP, and Parties
                          shall mean both AASTROM and MSP.
 
(k)  "Phase I"            Phase I shall mean the period of time from the
                          Effective Date until AASTROM has approved the DMR in
                          writing and has accepted delivery of two consecutive
                          Shipment Lots. 
 
(l)  "Phase II"           Phase II shall mean the period of time from the first
                          day of the month following the month in which Phase I
                          ends until the end of the Term.
 
 
(m)  "Recipient"          Recipient shall mean the Party receiving Confidential
                          Information.

(n)  "Requirements"       Requirements shall mean the rolling three-month firm
                          order forecast to be provided by AASTROM under Section
                          3(a), below, constituting at least sixty percent (60%)
                          of AASTROM's then-current requirements for Cell
                          Cassettes during the Term.

(o)  "Shipment Lot"       Shipment Lot shall initially mean 250 Cell Cassettes.
                          On a quarterly basis, concurrently with the provision
                          by AASTROM of its rolling twelve-month forecast, the
                          Parties shall mutually review and by mutual written
                          consent may revise the number of Cell Cassettes that
                          constitute a Shipment Lot, for the purchase order to
                          be submitted by AASTROM during such quarter,
                          considering volume
</TABLE>
 

                                      -3-

<PAGE>
 

<TABLE> 
<C>  <C>                  <S>  
                          requirements and anticipated delivery schedules. The
                          mutually agreed upon quantity constituting the
                          Shipment Lot shall be reflected in each purchase order
                          submitted by AASTROM.

(p)  "Specifications"     Specifications shall mean the objective criteria,
                          including, without limitation, design criteria and
                          formulations, required by AASTROM for the production
                          of Cell Cassettes and those contained in the DMR.
                          Specifications shall include without limitation, the
                          criteria for labeling and packaging, including
                          graphics, and quality assurance requirements.
                          Specifications for Cell Cassettes (including, without
                          limitation, those to be contained in the DMR) are
                          annexed hereto as Appendix II, as such Specifications
                          may be changed pursuant to Section 6, below.
                          Specifications shall not include any subjective
                          criteria or any criteria with respect to the efficacy
                          of either the Cell Chamber or the AASTROM CPS with
                          respect to human cell production.

(q)  "Term"               Term shall mean the period of time from the Effective
                          Date until the date upon which this Agreement expires
                          or is earlier terminated pursuant to Section 17,
                          below.

(r)  "UCC"                UCC means the Uniform Commercial Code as enacted in
                          the State of New York and in effect during the Term.
</TABLE>
 

SECTION 2.  PURCHASE AND SALE.
            ----------------- 

AASTROM shall purchase from MSP at least AASTROM's Requirements of Cell
Cassettes, and MSP shall manufacture, assemble and sell to AASTROM all of
AASTROM's purchase orders for Cell Cassettes and Components, subject to the
terms and conditions of this Agreement including, without limitation, AASTROM's
rights to terminate this Agreement in whole or in part pursuant to Sections 6 or
17, below.

SECTION 3.  FORECASTS; DELIVERY; SHIPMENT.
            ----------------------------- 

(a)  Rolling Forecasts.  Each calendar quarter during the Term, AASTROM shall
     -----------------                                                       
provide MSP with a rolling forecast of the anticipated quantity of each model of
Cell Cassettes AASTROM intends to purchase from MSP during each quarter of the
following twelve-month period. The quantities given for the first three months
of each twelve-month rolling forecast shall be firm orders for the immediately
succeeding quarter (i.e., a three-month forecast given on January 1st would be
deemed firm for the period April 1 - June 30) and AASTROM shall issue its
purchase order therefor and note on such purchase order the number of units it
will require for lot testing in accordance with Section 3(g), the method of
shipment and AASTROM destination for delivery, the scheduled delivery date and
the required documentation to be included with the Shipment Lot. MSP shall have
no obligation to purchase materials or supplies without a purchase order from
AASTROM except as is necessary to meet AASTROM's forecasted requirements.
AASTROM shall pay MSP for labor,

                                      -4-

<PAGE>
 
materials, supplies and direct costs (as set forth in Appendix III) expended by
MSP to fill purchase orders by AASTROM for Cell Cassettes in the event that they
are not used to fulfill such purchase orders. Quantities forecasted beyond the
three-month firm-order period are for planning purposes only.

(b)  No Limit on Sales.  MSP has no right to limit its sales of Cell Cassettes
     -----------------                                                        
or Components to AASTROM to a maximum number of units for any period
notwithstanding that AASTROM's Requirements may constitute less than 100% of
AASTROM's total requirements; provided that, the volume of Cell Cassettes and
                              -------- ----
Components ordered is reasonable in the light of forecasted amounts and previous
delivery schedules. MSP shall have adequate capacity to meet AASTROM's then-
current total firm-order requirements as forecasted pursuant to Section 3(a),
above. MSP will take all steps to put in place additional adequate capacity, if
needed, to meet AASTROM's future requirements as forecasted by AASTROM in
accordance with Section 3(a), above; provided that, the Parties shall cooperate
                                     -------- ---- 
to afford a reasonable transition to the availability of such additional
capacity.

(c)  No Liens.  Except with respect to MSP's purchase money security interest in
     --------                                                                   
Cell Cassettes granted pursuant to Section 5(d), below, MSP will deliver Cell
Cassettes to AASTROM free and clear of all liens, claims and encumbrances.

(d)  Delivery.  MSP shall deliver Cell Cassettes, and upon AASTROM's request,
     --------                                                                
any certifications, manufacturing records and test reports as are required for
AASTROM to accept or reject Cell Cassettes under this Section 3, pursuant to
delivery schedules in AASTROM's purchase orders; provided, that, such schedules
are reasonable in light of forecasted amounts and previous delivery schedules.
Delivery schedules in AASTROM's purchase orders shall not be less than fifteen
(15) days after the date of submission by AASTROM of the purchase order without
MSP's consent. In the event that AASTROM submits a purchase order in excess of
its forecasted requirements for said quarter, MSP agrees to employ good faith
efforts to supply such larger quantity of Cell Cassettes within such a
reasonable period of time as the Parties shall mutually agree. MSP shall not
deliver Cell Cassettes more than ten (10) days prior to scheduled delivery dates
without AASTROM's prior consent. MSP shall not be responsible for failure to
meet agreed-upon delivery dates if due to reasons of force majeure as set forth
in Section 20, below. In the event of partial failure to deliver, MSP will have
the right to receive payment pro rata for Cell Cassettes in fact delivered and
                             --- ----
not rejected by AASTROM under Section 3(f), below.

(e)  Shipment.  Shipment shall be made by MSP to AASTROM's designated U.S.
     --------                                                             
locations, in accordance with AASTROM's purchase orders, F.O.B. destination.
Risk of loss or damage in transit shall remain with MSP until delivered to the
destination specified by AASTROM. AASTROM shall notify MSP within five (5)
business days after receipt if there are any shortages or evidence of damage in
transit and will cooperate with MSP in any claim for loss or damage in transit
that MSP makes against a carrier. The method and route of shipment are at
AASTROM's discretion as set forth in its purchase order. MSP will prepay all
costs, insurance premiums, freight and other expenses incurred in shipment until
delivered to the destination specified by AASTROM and such shipping costs shall
be reimbursed by AASTROM at MSP's cost without mark-up. If AASTROM defaults in
payment for Cell

                                      -5-

<PAGE>
 
Cassettes, MSP may suspend further shipments; however, continuation of shipments
does not constitute a waiver of such default.

(f)  Acceptance Procedures.  Delivery of each Cell Cassette unit shall be deemed
     ---------------------                                                      
accepted by AASTROM unless MSP is notified in writing of AASTROM's rejection of
such delivery within forty-five (45) days after the delivery date (the
"Acceptance Period") due to non-conformance with the Specifications. In such
case, AASTROM shall provide MSP with a written notice of rejection setting forth
in detail the reason for rejection and return the rejected Shipment Lot, or
portion thereof, to MSP at MSP's expense for repair or replacement. Upon receipt
of AASTROM's notice of rejection and return of such Shipment Lot of part
thereof, MSP shall (i) within ten (10) business days thereafter, provide AASTROM
with a root-cause analysis and suggested corrective/preventative actions; and
(ii) diligently replace the nonconforming Shipment Lot or part thereof by
delivery of nondefective conforming units within a reasonable time (not to
exceed thirty (30) calendar days after notification) and endeavor to resolve the
issues related to the rejection. MSP shall credit against the purchase price of
Cell Cassettes, AASTROM's out of pocket costs of testing, including, without
limitation, destructive testing of failed Shipment Lots. AASTROM shall invoice
MSP for such costs, which shall be subject to reasonable audit by MSP or its
representative. MSP reserves the right, at MSP's expense, to have one or more
representatives present at any inspection conducted by AASTROM and to verify the
results of any such inspection and rejection of Shipment Lots. MSP shall have
the right to use conforming units or parts therefrom as replacement units
provided that such units or parts therefrom are in conformance with
Specifications. In the event MSP cannot resolve all nonconformities and deliver
conforming replacement Cell Cassettes as required herein MSP shall issue to
AASTROM a credit for the price of each unit rejected and AASTROM may pursue its
remedies pursuant to this Agreement, including but not limited to Section 17,
below. AASTROM shall pay for repair or replacement for defective Cell Cassettes
(or shall not receive a credit therefor) only to the extent that rejection is
due to a defective component supplied directly by AASTROM. In the event that
MSP's delivery of Cell Cassettes fails to conform to the quantity specified in
AASTROM's purchase order, AASTROM may, but shall not be obligated to, accept
such partial shipment and MSP shall deliver any shortfall in delivery quantity
within five (5) calendar days. Notwithstanding the foregoing, AASTROM agrees to
accept partial shipments from MSP provided that the quantity delivered is at
least ninety percent (90%) of the quantity specified in AASTROM's purchase
order, but only if AASTROM may readily use such partial shipment for its
intended purposes, and AASTROM also agrees to use commercially reasonable
efforts to accept partial shipments of quantities of less than ninety percent
(90%) of the quantity specified in AASTROM's purchase order, but only if AASTROM
may readily use such partial shipment for its intended purpose(s). Any
acceptance of partial shipments by AASTROM shall not be deemed to waive
AASTROM's remedies under Section 17(d) and AASTROM shall be entitled to a
payment credit reflecting the extent of such unit shortfall under a partial
shipment. In the event MSP fails to deliver any shortfall in quantity within
such five (5) day period, AASTROM may pursue its remedies pursuant to this
Agreement.

(g)  Lot Testing.  During the Acceptance Period, AASTROM shall have the right,
     -----------                                                              
but not the obligation, to conduct lot testing on a statistically significant
number of units from each

                                      -6-

<PAGE>
 
Shipment Lot. At the time of submission of AASTROM's purchase orders in
accordance with Section 3(a), AASTROM shall note on such purchase order the
number of units it requires for lot testing. Notwithstanding Section 4(a), MSP
agrees to provide such testing units to AASTROM at MSP's cost to manufacture
such units (without mark-up) provided that the number of units requested is
reasonable given the number of units ordered, and provided further that any
units provided by MSP for lot testing shall not be resold by AASTROM. Any lot
testing conducted by AASTROM pursuant to this section shall not be deemed to
relieve MSP of any of its warranties or obligations hereunder.

SECTION 4.  PRICES.
            ------ 

(a)  Cell Cassette Prices.  Prices for Cell Cassettes purchased during Phase I
     --------------------                                                     
and Phase II shall be determined as shown in Appendix III, hereto. Prices are
exclusive of all taxes of any nature imposed by any governmental authority,
except taxes imposed on the income or profits of MSP. All such taxes shall be
for AASTROM's account, whether or not collected, advanced or paid by MSP, and
shall be paid by AASTROM, without mark-up, upon MSP's invoice, unless AASTROM
timely provides proper tax exemption documents.

(b)  Phase I Collaboration Charge.  In addition to being paid for Cell Cassettes
     ----------------------------                                               
ordered by AASTROM during Phase I, AASTROM shall compensate MSP for MSP's
assistance and collaboration, as described in Section 9, below, on the basis set
forth in Appendix III. MSP shall prepare and submit to AASTROM a budget of Phase
I assistance and collaboration costs and expenses for AASTROM's approval. Once
approved, AASTROM may issue purchase orders authorizing the commencement of
collaborative work by MSP. MSP shall submit to AASTROM a monthly invoice
referencing AASTROM's purchase order for assistance and collaboration, together
with such supporting details as AASTROM may reasonably request. Assistance and
collaboration costs shall not exceed the budget approved by AASTROM without
AASTROM's prior written consent. The Parties acknowledge that budgets may need
to be revised to reflect updated cost estimates; however, any changes to
approved budgets will require the Parties' prior written consent.

(c)  Component Order and Prices.  From time to time throughout the Term, AASTROM
     --------------------------                                                 
may submit to MSP purchase orders for Components and MSP shall manufacture and
sell to AASTROM such Components in accordance with the terms of this Agreement
for the manufacture of Cell Cassettes, as they may be applicable, excepting only
the provisions of Sections 3(a) with regard to references to AASTROM's
obligation to forecast and purchase its specific Requirements from MSP. Prices
for any Components purchased by AASTROM during the Term shall be quoted
separately by MSP at the time of order with such quoted price not to exceed
MSP's actual manufacturing costs to produce such Components, multiplied by the
applicable Phase II Mark-Up Rates (as set forth in Section B.3 of Appendix III)
then in effect for the forecasted annual volume of Cell Cassettes to be
purchased by AASTROM.

(d)  Best Diligent Efforts.  At all times during the Term of this Agreement, MSP
     ---------------------                                                      
shall use its best diligent efforts to manufacture Cell Cassettes, procure
components and perform other services as provided in this Agreement at the
lowest cost reasonably practicable.

                                      -7-


<PAGE>
 
Furthermore, subject to Section 21 below, it is the explicit understanding of
the parties that MSP will, on a proactive basis and at no additional cost to
AASTROM, seek out additional methods and means that will lead to reduced costs,
quality improvements and increased efficiency with regard to the manufacture of
Cell Cassettes.

SECTION 5.  PAYMENT AND COLLECTION.
            ---------------------- 

(a)  Payment.  AASTROM shall pay MSP the full amount of the purchase price of
     -------                                                                 
Cell Cassettes upon the due date set forth on MSP's invoice; provided, however
invoices for Cell Cassettes rightfully rejected by AASTROM shall not be due
unless and until repair or replacement units are provided by MSP. With respect
to Cell Cassettes and Components, terms of payment shall be net 45 days from the
date of delivery by MSP pursuant to Section 3, above, and the submission by MSP
of an itemized invoice in the form attached hereto in Appendix IV including the
purchase price for such Cell Cassettes calculated in accordance with Appendix
III, together with such supporting documents as AASTROM may reasonably request.
Accounts unpaid beyond their due date will bear interest at a rate, to be
determined by MSP in its sole, absolute discretion, not to exceed the higher of
1 1/2% per month on the unpaid balance or the highest rate legally permissible
in the state of Michigan. If payment by AASTROM is improperly withheld and MSP
retains an agency and/or attorneys to collect amounts overdue, all collection
costs, including without limitation, reasonable attorneys' fees, shall be
payable by AASTROM.

(b)  Deductions from Invoice.  AASTROM will promptly notify MSP of any disputed
     -----------------------                                                   
invoice. It is the intention of the Parties that disputed invoices will be
settled by the Parties in good faith negotiations prior to the invoice due date.
However, unless MSP issues a credit memo, or unless AASTROM rightfully rejects
Cell Cassettes or notifies MSP of its acceptance of a partial shipment pursuant
to Section 3(f), AASTROM shall make full payment of MSP invoices for accepted
Cell Cassettes without deduction and regardless of any claim, counterclaim or
setoff AASTROM may have against MSP, except as such setoff may otherwise be
permitted under Appendix III, Section 3(f) or Section 12(d). Any such claim,
counterclaim or setoff shall be resolved exclusively as a separate matter
pursuant to Section 24, below.

(c)  Relief for Non-Payment.  In the event payment for Cell Cassettes becomes
     ----------------------                                                  
past due, MSP will have the option, in addition to any other rights it may have
under the UCC or otherwise, in its sole, absolute discretion, to cancel or delay
shipment or orders of AASTROM previously accepted, to declare all sums owing
from AASTROM to be immediately due and payable, and to cancel credit previously
extended.

SECTION 6.  SPECIFICATIONS, DMR AND CHANGES.
            ------------------------------- 

(a)  Specifications.  MSP shall manufacture and assemble Cell Cassettes to then-
     --------------                                                            
current Specifications and no part of MSP's responsibility may be subcontracted
without the prior written consent of AASTROM.

(b)  Establish DMR.  As further described in Section 9, MSP shall prepare a DMR
     -------------                                                             
covering the manufacture of the Cell Cassettes from the Specifications, other
requirements and

                                      -8-

<PAGE>
 
technical information to be provided by AASTROM, and manufacturing and
quality processes and procedures established by MSP.  AASTROM review and
approve the DMR to assure that it accurately reflects the Specifications.

(c)  Specification and DMR Changes.  Notwithstanding any provision of this
     -----------------------------                                        
Agreement to the contrary, MSP shall not have the right to change the
Specifications without the prior written consent of AASTROM. If a Party desires
a change to Specifications or any part of the DMR, it shall submit a proposed
change, setting forth a detailed description and drawings thereof. Subject to
Section 6(d), the Parties shall work in good faith as expeditiously as is
reasonable to reach a determination whether a change to Specifications will be
made and, if so, when such change will be implemented and the effect that such
change will have, if any, on quantities, quality criteria, price and delivery
dates.

(d)  MSP Refusal to Change Specification.  If AASTROM proposes a change to
     -----------------------------------                                  
Specifications that it states is material to the efficacy, safety or reliability
of the Cell Cassette or which AASTROM reasonably demonstrates is necessary for
AASTROM to remain cost competitive, and if such change is currently
manufacturable, then upon the refusal of MSP to implement such change, AASTROM
shall have the right, without liability, in accordance with Section 17(b),
below, to terminate this Agreement on a prospective basis for all Requirements
incorporating the changed Specifications that have not yet been submitted on
purchase orders. The Parties will cooperate to implement changes to
Specifications in an orderly manner and to afford MSP a reasonable transition
time to the extent necessary to effect such Specification changes.

(e)  Other Changes.  AASTROM may cancel or change quantities or delivery dates
     -------------                                                            
     under any purchase order upon terms that make MSP whole for its costs in
     respect of materials and work-in-process as set forth in Section 3(a).

(f)  Returns.  Except as expressly provided in this Agreement including, without
     -------                                                                    
limitation, as provided in Sections 3(f) and 12(a), below, in no case may Cell
Cassettes be returned to MSP without first obtaining MSP's written consent
which will not be unreasonably withheld.

SECTION 7.  MSP's FACILITIES AND MANUFACTURING ENVIRONMENT.  With respect to its
            ----------------------------------------------                      
manufacturing facilities and assembly obligations applicable to the production
of Cell Cassettes, MSP shall:

(a)  be registered with the FDA as a Medical Device Establishment to the extent
required by the Act.  As such, MSP will maintain facility registrations and
inspection records required by the FDA;

(b)  have and maintain a Class 100,000 certified assembly area operating at less
than 20,000 particulate-count and arrange for annual certification to be
conducted by an independent testing service. A routine monitoring plan, to
include at least monthly testing, will also be established and performed by MSP
(the foregoing routine monitoring plan shall be subject to AASTROM's approval,
which approval shall not be unreasonably withheld);

                                      -9-


<PAGE>
 
(c)  maintain adequate personnel and facilities, including but not limited to
sufficient engineering support and assembly resources to support the manufacture
of Cell Cassettes ordered by AASTROM. MSP will provide AASTROM annually with a
project plan to meet AASTROM's forecast annual Requirements and AASTROM will
provide timely comments thereon;

(d)  manufacture and assemble all of the Cell Cassettes in compliance with GMPs
as required by the Act; provided that, AASTROM, as the owner of the DMR, shall
                        -------- ----                                   
have the responsibility for approving the DMR and any changes thereto as
established by MSP in accordance with Section 9, below;

(e)  achieve EN29002 and EN46002 or EN46001 certification by a notified body by
September 17, 1996, establish, maintain and document a quality system as may be
required as a condition of such  certifications;

(f)  together with the Equipment to be provided by AASTROM, provide and maintain
adequate manufacturing Equipment to perform its obligations under Section 6 of
this Agreement;

(g)  have and maintain adequate procedures for procurement, acceptance, supplier
quality audits and material control of all component parts to be used or
incorporated in Cell Cassettes;

(h)  report to AASTROM in writing any known adverse events, circumstances or
potential problems relating to MSP's FDA registration or its EC certifications
referred to in Section 7(e), above;

(i)  allow AASTROM and its agents, at their own cost and risk, to review and
inspect MSP's facilities, FDA compliance files and correspondence to and from
the FDA and notified bodies applicable to this Agreement; and

(j)  maintain files of all Cell Cassette-related complaints received by MSP from
AASTROM and conduct failure investigations, including establishing written
records with conclusions and corrective measures, for all such Cell Cassettes
complaints involving a failure to meet Specifications.

SECTION 8.  MSP MANUFACTURING PROCEDURES.  MSP's obligation to manufacture Cell
            ----------------------------                                       
Cassettes shall be to deliver Cell Cassettes as described in Section 6(a), above
and in accordance with the DMR.  Without expanding or diminishing that
obligation, and for purposes of illustration only, it is contemplated by the
Parties that such obligation shall encompass:

(a)  injection molding and processing the main Components of the bioreactor
device for the Cell Cassette including any sonic welding and vacuum plasma
surface treatment operations;

(b)  assembling the aforesaid bioreactor devices utilizing fixturing provided by
AASTROM, or alternative fixturing as developed;

                                     -10-


<PAGE>
 
(c)  injection molding components of the Cell Cassette fluid pathway tubing
assembly and supplying them to the tubing kit subcontractor;

(d)  injection molding non-fluid contact enclosure components for the Cell
Cassette using molds supplied by AASTROM;

(e)  procuring the waste reservoir and media supply enclosure from an AASTROM-
approved source;

(f)  assembling the enclosure, the waste reservoir and media supply enclosure,
the bioreactor and the fluid pathway tubing assembly described in Sections
8(d), (e), (b) and (c), above, respectively;

(g)  providing AASTROM with a proposal for the procurement of components and for
assembly of the fluid pathway tubing assembly and, once approved by AASTROM,
assuming assembly of the fluid pathway tubing assembly;

(h)  performing testing in accordance with the DMR;

(i)  validating Cell Cassettes to the applicable sterilization assurance level;
and

(j)  performing on-going vendor audits and validation procedures, as required by
GMPs, and conducting a reasonable incoming inspection of purchased components
for compliance with Specifications.

SECTION 9.  COLLABORATIVE AND OTHER RESPONSIBILITIES OF THE PARTIES.
            ------------------------------------------------------- 

(a)  Overview.  AASTROM shall be responsible for the establishment and updating
     --------                                                                  
of the design, development, Specifications and regulatory approval, and for the
marketing and sale (collectively, the "Development") of the Cell Cassette and
Components. MSP shall collaborate in that effort as set forth in Section 9(c),
below. MSP shall be responsible for manufacturing the Cell Cassettes and
Components to Specifications and sterilization as provided in Section 6(a)
above, and in accordance with the DMR, including responsibility for
manufacturing, assembly and sterilization procedures.

(b)  Responsibilities of AASTROM.  AASTROM shall be responsible for establishing
     ---------------------------                                                
the Specifications and any modifications thereto, obtaining all FDA and foreign
regulatory approvals with respect to the Development and commercialization of
the Cell Cassette and Components, including, without limitation, PMAs and CE
Mark and, except, as expressly assumed by MSP under this Agreement, shall be
responsible for all laws, rules and regulations governing the Development of the
Cell Cassette and Components. AASTROM shall develop final Specifications and
functional requirements for the Cell Cassette including all of its Components
and shall select materials and determine the design, quality assurance
requirements and test criteria in consultation with MSP, design contractors and
other manufacturing subcontractors as AASTROM in its sole, absolute discretion
deems appropriate. AASTROM shall establish all process procedures to perform the
required tissue

                                     -11-


<PAGE>
 
culture treatment of portions of the Cell Cassette and Components and will
provide MSP with the AASTROM Equipment and with training in areas of AASTROM's
expertise reasonably necessary or proper for MSP to perform its manufacturing
obligations under this Agreement. AASTROM shall perform simulated use tests and
reliability demonstration tests to assist MSP in the proper manufacture of the
Cell Cassette and Components. AASTROM shall have final approval for choosing all
suppliers to MSP of Components used for Cell Cassettes and shall have complete
responsibility (other than for proper assembly into the Cell Cassette) for
Components supplied directly by AASTROM. Suppliers shall generally be chosen
after AASTROM obtains advice from MSP, but AASTROM shall not choose a supplier
that MSP states will materially impede MSP's obligations under this Agreement.
Prices of supplied Components shall be subject to prior written approval by
AASTROM. Notwithstanding the foregoing, nothing in this Section 9 shall be
deemed to relieve MSP of its responsibility under this Agreement to manufacture
the Cell Cassettes and Components to Specifications, and in accordance with the
DMR.

(c)  MSP's Collaboration.  MSP will collaborate with AASTROM in its Development
     -------------------                                                       
efforts as set forth in this Section 9(c), but in no event shall MSP be
responsible as a result of such collaboration under this Agreement or otherwise
for the Development, including, without limitation, the efficacy, of the Cell
Cassette. MSP shall, as requested by AASTROM, collaborate with AASTROM and the
other design contractors to assist AASTROM in selecting materials and
determining manufacturing process development for the Cell Cassette.
Notwithstanding the foregoing, MSP shall be responsible only for the
manufacture, assembly and sterilization of the Cell Cassette as provided in
Section 6(a), above, and otherwise upon the terms and conditions of this
Agreement, and not for its Development.

(d)  Other Responsibilities of MSP.  In connection with MSP's manufacturing and
     -----------------------------                                             
assembly obligations under this Agreement, MSP shall:

     (1) prepare the DMR in accordance with the then-current manufacturing
Specifications and the criteria for testing the Cell Cassette, all to be
provided by AASTROM.  Manufacturing documentation shall be owned by AASTROM and
shall consist of:  (i) the DMR documentation; (ii) documentation of
Specifications and drawings for Cell Cassette parts to be provided by MSP or
acquired by MSP from approved vendors; (iii) test and acceptance procedures and
criteria documentation; (iv) subassembly specifications, drawings and
requirements documentation; (v) manufacturing instructions and procedures
documentation; and (vi) quality instructions and procedures documentation;

     (2) prepare the DMR as set forth in Section 6(b), above, and maintain the
DMR in accordance with a documented change management system reasonably
acceptable to AASTROM which system shall include the approval of all Cell
Cassette manufacturing changes by AASTROM prior to implementation by MSP.  The
foregoing change management system documentation shall also include the history
of all changes including validation and/or rationale and shall be owned by
AASTROM;

     (3) prepare a gamma sterilization validation plan, utilizing mutually
agreeable subcontractors, and conduct or subcontract the required laboratory
tests, including product

                                     -12-


<PAGE>
 
tests and environmental monitoring, to achieve a 10/-6/ sterility assurance
level per ANSI/AAMI SY32-1991 for the Cell Cassette;

     (4) to the extent required for submittal by AASTROM to the FDA or other
regulatory authorities in connection with the Cell Cassette, prepare a detailed
description of MSP's manufacturing methods, processes, procedures and facility
applicable to the manufacture and testing of the Cell Cassette as requested by
AASTROM;

     (5) establish a finished device packaging plan, utilizing mutually
agreeable subcontractors, conduct packaging validation, and establish final
packaging and shipping specifications based upon functional requirements
provided by AASTROM;

     (6) provide engineering and other support for validation of the Cell
Cassette manufacturing process and for sterility validation for each Shipment
Lot;

     (7) use reasonable efforts to train AASTROM's technical representatives at
MSP's facilities, at AASTROM's request and expense from time to time during the
Term in all applicable procedures for manufacture of the Cell Cassettes.  Such
representatives shall sign reasonable non-disclosure agreements in accordance
with Section 16(b) consistent with the terms of this Agreement to protect MSP's
Confidential Information. AASTROM and such representatives shall also comply
with all of MSP's reasonable regulations with regard to access by visitors
during such training sessions and MSP reserves the right to deny access to its
facilities by non-AASTROM employees provided that such access shall not be
unreasonably withheld; and

     (8) develop a quality measurement system acceptable to AASTROM and report
in a manner reasonably satisfactory to AASTROM on a monthly basis with regard to
MSP's progress.  This system shall include, at a minimum, (i) metrics on the
percent of non-conforming Cell Cassettes, including trending data; (ii) the
percentage of the top five defects; and (iii) a FRACAS (Failure Report Analysis
and Corrective Action System) detailing the root-cause analysis, corrective
actions taken, and proof of implementation.

SECTION 10.  EQUIPMENT.
             --------- 

(a)  Ownership.  The Parties acknowledge that the Equipment is the sole and
     ---------                                                             
exclusive property of the Party indicated on Appendix I as such Appendix may be
augmented by mutual agreement of the Parties from time to time. Equipment shall
be located at the premises of MSP in Seagrove, North Carolina or other
facilities of MSP as the Parties may agree. Except for the sole purpose of
performing maintenance, none of the Equipment owned by AASTROM shall be
relocated by MSP without the prior written consent of AASTROM. It is understood
that AASTROM shall have the right to remove the Equipment it owns from MSP's
facilities at any time upon reasonable notice to MSP, except that if such
removal shall impede MSP's performance under this Agreement, MSP shall so notify
AASTROM and such Equipment shall not be removed until the condition of such
impedance shall no longer pertain. Notwithstanding the foregoing, in the event
that MSP's performance is suspended by reason of force majeure, AASTROM shall be
entitled to remove its Equipment to enable AASTROM

                                     -13-


<PAGE>
 
to continue to manufacture Cell Cassettes. Upon removal of its Equipment,
AASTROM shall pay MSP its reasonable costs of disassembly and freight to a
location of AASTROM's choice. AASTROM shall return such Equipment to MSP's
facilities upon MSP's demonstration (to the extent it can reasonably do so
without the use of such Equipment) to AASTROM's reasonable satisfaction of its
capability to resume manufacture of the Cell Cassettes. Equipment added to
Appendix I shall be owned by the Party that paid for it or in accordance with
Section 21(b), as applicable. Upon expiration or earlier termination of this
Agreement, and the payment by AASTROM of all outstanding invoices, MSP shall,
within thirty (30) days thereafter, return all of AASTROM's Equipment to
AASTROM's facilities (or other location designated by AASTROM in writing) with
all reasonable packing, transportation and insurance costs to be paid by
AASTROM.

(b)  Identification Tags.  Identification tags supplied by AASTROM containing
     -------------------                                                     
information relating to its ownership of Equipment shall be affixed by MSP and
such tags shall not be removed by MSP without the written approval of AASTROM.

(c)  Liens and Insurance.  MSP shall not impair the right, title and interest of
     -------------------                                                        
AASTROM in and to the Equipment it owns, nor shall MSP allow any lien or
encumbrance to be levied upon such Equipment. During the Term, and until
Equipment owned by AASTROM is removed by AASTROM or abandoned, MSP shall carry
and maintain, at its expense, all-risk property insurance covering the Equipment
at full replacement cost.

(d)  Inspection.  AASTROM shall have the right, at reasonable times during
     ----------                                                           
normal business hours and upon reasonable notice, to inspect its Equipment from
time to time to ensure that it is being maintained in accordance with Section
10(f), below, and utilized in a manner consistent with the provisions of this
Agreement.

(e)  No Modification.  MSP will not alter or modify AASTROM's Equipment in any
     ---------------                                                          
material way without the prior consent of AASTROM. If AASTROM gives such
consent, any alteration or modification shall become the property of AASTROM.

(f)  Maintenance.  MSP will conduct day-to-day preventative and operational
     -----------                                                           
maintenance on all of the Equipment. Such day-to-day maintenance will be
adequate: (i) to maintain the Equipment in good working order and condition,
ordinary wear and tear and casualty excepted; (ii) to meet all expressed
conditions required by manufacturers' written warranties, if any, given with the
Equipment so that such warranties remain in effect for their stated terms;
provided that MSP has received from AASTROM a copy of such warranty; and (iii)
- -------- ----
to promote adherence to agreed-upon quality standards as well as the
Specifications and to help minimize unscheduled downtime.

(g)  Use.  Equipment owned by AASTROM shall be used solely for the benefit of
     ---                                                                     
AASTROM to produce Cell Cassettes.

                                     -14-


<PAGE>
 
SECTION 11.  RIGHT OF INSPECTION.
             ------------------- 

(a)  Rights of Inspection.  In addition to AASTROM's right to inspect Cell
     --------------------                                                 
Cassettes upon delivery pursuant to Section 3, AASTROM shall have the following
rights of inspection, each such right to be exercised, if at all, at its own
cost and expense:

     (1) to inspect, sample and test Cell Cassette work-in-progress and review
process control reports and manufacturing records at MSP's facilities upon at
least three (3) work days' prior notice to MSP and shall consult with MSP if it
believes that its inspection shows MSP is failing to meet its obligations under
this Agreement (in such event the parties will work together toward resolution
of any such failure); and

     (2) to inspect, sample and test Cell Cassettes at MSP's facilities after
notice by MSP that a Shipment Lot is ready for shipment to a sterilizer
location.  Such inspection must be conducted, if at all, within ten (10) days
after receipt of such notice.

(b)  Waiver.  AASTROM's right to inspect under this Section 11 and any
     ------                                                           
inspection by AASTROM hereunder, or AASTROM's acceptance of or payment for Cell
Cassettes, shall not be deemed to relieve MSP of any of its obligations under
the terms of this Agreement nor a waiver by AASTROM of its rights to inspect
upon delivery pursuant to Section 3 or with respect to breach of warranty as set
forth in Section 12, below.

(c)  Self-Certification.  The Parties shall work together toward self-
     ------------------                                              
certification pursuant to which MSP will conduct in-process controls and
finished device testing in order to augment, and reduce the need for, exercise
by AASTROM of its inspection rights.

(d)  Records; Inspection.  For at least two years after the expiration or any
     -------------------                                                     
earlier termination of this Agreement (under Section 17 below), MSP shall retain
accurate and complete records with respect to its work and manufacture of the
Cell Cassettes to the extent necessary to reasonably satisfy all applicable FDA
and EC requirements and to verify the time worked and material and other costs
invoiced to AASTROM. MSP shall make available to AASTROM, cost information that
AASTROM may reasonably request in connection with the establishment of Phase II
pricing in accordance with Appendix III. Upon reasonable notice to MSP, AASTROM
and/or its designated independent auditor may inspect and conduct a reasonable
audit on such records. If MSP does not agree with the results of the audit, then
the dispute shall be resolved pursuant to Section 24, below. Furthermore, if the
results of such audit indicate an overcharge by MSP of ten percent (10%) or more
of AASTROM's applicable purchase price from MSP, MSP shall reimburse AASTROM for
the cost of performing such audit, otherwise the cost of such audit shall be
borne by AASTROM. If such audit shows an overcharge by MSP of AASTROM's
applicable purchase price from MSP, MSP shall, upon its review of said audit,
promptly reimburse AASTROM for such overcharge plus interest at a rate of
11/2%/month since the date of payment by AASTROM of the applicable invoice(s).

                                     -15-


<PAGE>
 
SECTION 12.  WARRANTY; RECALLS.
             ----------------- 

(a)  Warranty.  MSP warrants to AASTROM that each Cell Cassette and Component
     --------                                                                
shall comply with the then-current Specifications and shall be free from defects
in material and workmanship and shall be manufactured and assembled in
compliance with the DMR and all United States federal, state and local laws,
rules and regulations and with all applicable EN29002 and EN46002 requirements
(and any amendments thereto and replacements thereof), applicable at the time of
manufacture. For a period of one (1) year after delivery to AASTROM, AASTROM
shall have the right to notify MSP that a Cell Cassette or Component does not
conform to this warranty. Such notice shall set forth in detail the reason for
such non-conformance. AASTROM shall prepare for shipment and return to MSP
allegedly defective Cell Cassette or Component in accordance with MSP's written
directions and at MSP's cost. Upon reasonable verification of noncompliance with
this warranty, MSP shall repair a defective and non-conforming Cell Cassette or
Component or, at its option, replace a defective Cell Cassette or Component with
non-defective, conforming units within thirty (30) days after receipt of notice
from AASTROM of the nonconformance. However, if in MSP's reasonable judgment
such repair or replacement cannot be accomplished within said time, MSP shall
issue to AASTROM a credit for the price of each unit of Cell Cassette or
Component verified as defective. All shipping and other costs incurred in
connection with the repair or replacement of all such nonconforming Cell
Cassette or Component units shall be paid by MSP. The foregoing warranty shall
not apply to the extent that the non-conformance is due to a defective component
supplied by AASTROM or compliance with the Specifications as supplied by
AASTROM. Notwithstanding any statutory or other law to the contrary, it is
understood that the foregoing one (1) year warranty period begins on delivery of
the Cell Cassette or Component to AASTROM regardless as to when a defect in a
Cell Cassette or Component may be discovered.

(b)  DISCLAIMER.  THE WARRANTY SET FORTH IN SECTION 12(a), ABOVE, IS GIVEN TO
     ----------                                                              
AASTROM ONLY AND IS IN LIEU OF ALL OTHER WARRANTIES, WHETHER EXPRESSED BY
AFFIRMATION, PROMISE, DESCRIPTION, MODEL, SAMPLE OR OTHERWISE. ANY AND ALL OTHER
WARRANTIES, INCLUDING, WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF
MERCHANTABILITY AND FITNESS FOR A PARTICULAR USE OR PURPOSE, ARE HEREBY
DISCLAIMED. THE REMEDIES SET FORTH IN THIS AGREEMENT SHALL BE AASTROM'S
EXCLUSIVE REMEDIES FOR DEFECTIVE AND NONCONFORMING PRODUCTS.

(c)  No Third-Person Warranty.  AASTROM will not make any warranty,
     ------------------------                                      
representation or guaranty to any person, either orally or in writing, in the
name of or on behalf of MSP.

(d)  Recalls.  From time to time throughout the Term, AASTROM may in its
     -------                                                            
discretion determine that it is necessary or advisable to recall Cell Cassettes
manufactured by MSP. In such event, if AASTROM reasonably determines that the
number of reported incidence of defective Cell Cassettes is high in relation to
AASTROM's historical incidence rate for defective Cell Cassettes and/or general
medical product industry standards and AASTROM recalls one or more Shipment Lots
due to a failure of such units to meet Specifications during the Warranty
Period, AASTROM shall so notify MSP of the recall and the Parties shall jointly
exchange relevant information and consult on causation of the defective units
prior to

                                     -16-


<PAGE>
 
implementing the recall. In the event it is determined by the Parties that the
Cell Cassettes were defective due to a failure of such units to meet
Specifications during the Warranty Period, MSP agrees to reimburse AASTROM for
the reasonable direct costs incurred by AASTROM in conjunction with the recall
including the cost of replacing, shipping and testing the units of the Shipment
Lot(s) recalled, whether or not all such units are ultimately determined to have
been defective, by way of a reduction in MSP's applicable mark-up rates (as set
forth on Appendix III) to 15% until the cost of the recall has been recovered by
AASTROM. Any disputes regarding causation of defective units involved in a
recall that cannot be resolved by the Parties will be resolved through
arbitration in accordance with Section 24(b). Furthermore, in the event this
Agreement is terminated for any reason prior to AASTROM recovering the full
amount of its recall costs from MSP, MSP shall promptly pay to AASTROM the
amount of any unreimbursed costs. For the purpose of clarification, it is agreed
that AASTROM shall be solely responsible for determining whether any product
recall, correction or withdrawal is required and for complying with all of the
medical device reporting requirements pursuant to 21 CFR Part 803.

SECTION 13.  LIMITATION OF DAMAGES LIABILITY.
             ------------------------------- 

(a)  Third Party Claims Not Related to Manufacturing Defect.  MSP shall have no
     ------------------------------------------------------                    
liability for any damages claimed by a third party if the claim does not arise
from or relate to a manufacturing defect by MSP.

(b)  Third Party Claims Related to MSP's Delays.  MSP shall have no liability
     ------------------------------------------                              
for any damages claimed by a third party arising from or related to MSP's delays
in manufacturing and delivering Cell Cassettes; provided, however, this
limitation of liability shall not apply with respect to any third party which
has a contractual relationship with MSP with respect to claims arising out of
such contract.

(c)  Third Party Claims for Product Liability.  With respect to a third party's
     ----------------------------------------                                  
claim for products liability in connection with the manufacture of the Cell
Cassettes or Components, MSP's liability shall not exceed*, in the aggregate
for the Term of this Agreement.

(d)  AASTROM's Claims - Phase I.  During Phase I, MSP's liability for damages to
     --------------------------                                                 
AASTROM for any breach of MSP's obligations, warranties or representations under
this Agreement shall not exceed* in the aggregate. Notwithstanding the
foregoing this limitation of liability shall not apply with respect to any
breach of MSP's obligations to maintain and protect AASTROM's Equipment,
Intellectual Property and Confidential Information, or MSP's obligations under
Section 23 hereof regarding similar products.

(e)  AASTROM's Claims - Phase II.    During Phase II, MSP's liability for
     ---------------------------                                         
damages to AASTROM for any breaches of MSP's obligations, warranties or
representations under this Agreement shall not exceed: (i) in the event of a
breach which does not result in the termination of this Agreement, an amount
equal to*; or (ii) in the event

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                                     -17-


<PAGE>
 
of a breach which does result in the termination of this Agreement, an amount
equal to*. 

     Notwithstanding the foregoing, the foregoing limitation of liability shall
not apply with respect to any breach of MSP's obligations to maintain and
protect AASTROM's Equipment, Intellectual Property and Confidential Information,
or MSP's obligations under Section 23 hereof regarding similar products.

(f)  Willful Wrongdoing.   Notwithstanding anything to the contrary contained in
     ------------------                                                         
this Agreement, there shall be no limitation on MSP's liabilities arising from
or related to any criminal activity by MSP or any willful wrongdoing by MSP,
excepting however, the* limitation on liability for third party claims for
product liability as specified in Section 13(c) shall remain applicable, even in
the event of criminal activity or willful wrongdoing by MSP.

(g)  Nature of Damages.  The damages referenced in this Section 13 include
     -----------------                                                    
damages of any nature whatsoever including without limitation, direct, indirect,
special, incidental and consequential damages. No Party shall have any liability
for any punitive damages.

(h)  Mitigation.  The non-breaching Party, as well as the breaching Party, shall
     ----------                                                                 
use its best diligent efforts to mitigate the damages caused by the breach.

(i)  AASTROM's Liabilities.  Except with regard to AASTROM's obligations under
     ---------------------                                                    
Sections 14(a) and (d) and 16, it is agreed that AASTROM's liability to MSP with
regard to any claim for damages that may arise from a breach of any of AASTROM's
obligations, warranties and representations under this Agreement shall not
exceed the purchase price for the Cell Cassettes or Components with respect to
which AASTROM is in breach.

     Notwithstanding the foregoing, the foregoing limitation of liability shall
not apply with respect to any breach of AASTROM's obligations with regard to the
Intellectual Property or Confidential Information of MSP, nor shall such
limitations apply in the event of criminal activity or willful wrongdoing by
AASTROM.

SECTION 14.  INDEMNITY.
             --------- 

(a)  AASTROM's General Indemnity.  The Parties acknowledge that AASTROM has
     ---------------------------                                           
designed, developed and established the Specifications for the Cell Cassette and
Components, and is responsible for the Development (as defined in Section 9,
above). To the extent not covered by MSP's indemnification obligations under
Section 14(b) below, and to the extent MSP's liabilities to third parties exceed
the limitation of damage liabilities specified in Section 13(a), (b) and (c)
hereof, AASTROM will indemnify, hold harmless and defend MSP and its parents and
affiliates and its and their officers, directors, agents, employees and
contractors and their successors and assigns (individually and collectively, the
"MSP

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                                     -18-


<PAGE>
 
Indemnitees") from and against any and all loss, liability, cost, damage and
expense, including, without limitation, reasonable attorneys' fees, in
connection with bodily injury, death or otherwise, for claims made by third
parties, including, without limitation, a governmental agency or other entity,
against any of the MSP Indemnitees arising out of or in connection with (1) the
design, manufacture, sale, use, function or operation of the Cell Cassette and
Components or (2) the breach by AASTROM of its covenants, representations or
warranties under this Agreement, or (3) the non-compliance by MSP with GMPs, but
only to the extent that such non-compliance is caused by the failure of AASTROM
to comply with a covenant under this Agreement, or a Specification or written
requirement of AASTROM that is in express direct violation of GMPs. Upon receipt
of a claim indemnified hereunder, MSP shall give AASTROM prompt notice thereof
and shall, at no out-of-pocket expense to MSP, cooperate with AASTROM with
respect to the defense of such matter. MSP shall have the right, without
affecting its indemnity hereunder, to participate in the administration, defense
or settlement of any such matter at its own expense and with counsel of its own
choosing, but AASTROM will control the defense and selection of lead defense
counsel. AASTROM's counsel shall give due consideration to suggestions of MSP's
counsel and AASTROM shall not settle any claim indemnified hereunder unless MSP
is given a full and unconditional release in respect of such matter and any
related matter.

(b)  MSP's General Indemnity.  MSP will indemnify, hold harmless and defend
     -----------------------                                               
AASTROM and its parents and affiliates and its and their officers, directors,
agents, employees and contractors and their successors and assigns (individually
and collectively, the "AASTROM Indemnitees") from and against any and all loss,
liability, cost, damage and expense (collectively, "Losses"), including without
limitation, reasonable attorneys' fees, in connection with any claims made by
third parties, including without limitation, a governmental agency or other
entity, against any of the AASTROM Indemnitees for any product liability claim
arising out of or in connection with the breach of any of MSP's warranties or
obligations hereunder; provided, that notwithstanding anything in this Agreement
to the contrary, MSP's total liability under this Section 14(b) shall not
exceed* dollars, and AASTROM's indemnity set forth in Section 14(a), above,
shall not be affected or limited by Losses that are in excess of MSP's
indemnification obligations under this Section 14(b). Upon the receipt of a
claim of indemnification hereunder, AASTROM shall give MSP prompt notice thereof
and shall, at no out-of-pocket expense to AASTROM, cooperate with MSP with
respect to the defense of such matter. AASTROM shall have the right, without
affecting its indemnity rights hereunder, to participate in the administration,
defense or settlement of any such matter at its own expense and with counsel of
its own choosing, but MSP will control the defense and selection of lead defense
counsel. MSP's counsel shall give due consideration to suggestions of AASTROM's
counsel and MSP shall not settle any claim indemnified hereunder unless AASTROM
is given a full and unconditional release in respect of such matter.

(c)  Intellectual Property Warranty.
     ------------------------------ 

     (1) AASTROM represents and warrants that neither the design nor
Specifications furnished by AASTROM to MSP in connection with this Agreement nor
the manufacture or sale of Cell Cassettes to such design or Specifications or in
conformance with the DMR (but

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                                     -19-


<PAGE>
 
excluding any of MSP's manufacturing process or methods that may be incorporated
into any of the foregoing by MSP), will infringe any United States or foreign
patent, trademark, copyright or other intellectual property right of others.

     (2) MSP represents and warrants to AASTROM that no manufacturing process or
method employed by MSP to manufacture the Cell Cassettes will infringe any
United States or foreign patent, trademark, copyright or other intellectual
property right of others; provided that, such process or method was developed
by, or originated from, MSP but without regard to whether such process or method
is incorporated in the Specifications or DMR.

     (3) Without prejudice to the rights of MSP or AASTROM as set forth in
Sections 14(d) and 14(e) below, respectively, if the manufacture or sale of Cell
Cassettes to such design Specifications or DMR or the manufacturing process or
method, respectively, is held to constitute an infringement of any intellectual
property right of any third party or to result in such wrong, and such
manufacture and sale is enjoined (by temporary, preliminary or permanent
injunction), AASTROM or MSP, as the case may be, at its own expense, shall use
its best diligent efforts to procure for the other party the right to continue
to manufacture and sell Cell Cassettes, as applicable.

(d)  Intellectual Property Indemnity by AASTROM.  AASTROM will indemnify, hold
     ------------------------------------------                               
harmless and defend the MSP Indemnitees from and against any and all
liabilities, costs and expenses, including, without limitation, reasonable
attorneys' fees, with respect to which a claim is made by a third party against
any of the MSP Indemnitees arising out of or in connection with the breach of
AASTROM's warranty and representation set forth in Section 14(c), above. Upon
receipt of a claim indemnified hereunder, MSP shall give AASTROM prompt notice
thereof and shall, at no out-of-pocket expense to MSP, cooperate with AASTROM
with respect to the defense of such matter. MSP shall have the right, without
affecting its indemnity hereunder, to participate in the administration, defense
or settlement of any such matter at its own expense and with counsel of its own
choosing, but AASTROM will control the defense and selection of lead defense
counsel. AASTROM's counsel shall give due consideration to suggestions of MSP's
counsel. AASTROM shall not settle any claim indemnified hereunder unless MSP is
given a full and unconditional release in respect of such matter and any related
matter.

(e)  Intellectual Property Indemnity by MSP.  MSP will indemnify, hold harmless
     --------------------------------------                                    
and defend the AASTROM Indemnitees from and against any and all liabilities,
costs and expenses, including, without limitation, reasonable attorneys fees,
with respect to which claim is made by a third party against any of the AASTROM
Indemnities arising out of or in connection with the breach of MSP's warranty
and representation set forth in Section 14(c), above. Upon receipt of a claim
indemnified hereunder, AASTROM shall give MSP prompt notice thereof and shall,
at no out-of-pocket expense to AASTROM, cooperate with MSP with respect to the
defense of such matter. AASTROM shall have the right, without affecting its
indemnity hereunder, to participate in the administration, defense or settlement
of any such matter at its own expense and with counsel of its own choosing, but
MSP will control the defense and selection of lead defense counsel. MSP's
counsel shall give due consideration to suggestions of AASTROM's counsel. MSP
shall not settle any claim indemnified hereunder unless

                                     -20-

<PAGE>
 
AASTROM is given a full and unconditional release in respect of such matter
and any related matter.

SECTION 15.  OWNERSHIP OF INTELLECTUAL PROPERTY.
             ---------------------------------- 

(a)  Ownership of Intellectual Property.  Each Party shall retain and own (vis a
     ----------------------------------                                         
vis the other Party) all right, title and interest to all copyrightable
material, inventions, trademarks, trade secrets, trade dress or other
intellectual property (collectively, "Intellectual Property") which it now owns.
Notwithstanding the foregoing, AASTROM shall own all Intellectual Property and
documentation generated by MSP in connection with the collaborative development
and manufacture of Cell Cassettes, whether or not such Intellectual Property was
generated prior to or after the Effective Date, except for Intellectual Property
that relates to the molding and fabrication processes performed by MSP and the
know-how in connection therewith. Said documentation to be owned by AASTROM
shall include but not be limited to the Specifications, DMR documentation,
material lists, supplier lists and descriptions of manufacturing methods and
processes for manufacture of the Cell Cassettes (hereinafter, the "AASTROM
Documentation"). Furthermore, notwithstanding anything contained herein, MSP
acknowledges and agrees that the AASTROM Documentation will not embody or
constitute the Intellectual Property of MSP. Nothing in this Agreement shall be
deemed to grant a license to either Party under or with respect to the
Intellectual Property of the other Party.

(b)  Return of Intellectual Property.  Upon expiration of the Term or upon any
     -------------------------------                                          
earlier termination of this Agreement, MSP shall promptly transfer to AASTROM
all AASTROM Documentation and Intellectual Property within MSP's possession or
control, and AASTROM shall promptly transfer to MSP all MSP Intellectual
Property within AASTROM's possession or control. Furthermore, in the event of
any expiration or termination of this Agreement by AASTROM "for cause" pursuant
to Section 17, or by MSP, other than in accordance with Section 17, MSP will
provide AASTROM with full cooperation with regard to the transfer of any know-
how embodied in AASTROM Documentation that is sufficient to allow AASTROM to
manufacture the Cell Cassettes pursuant to this Agreement; provided that, except
                                                           -------- ----
for copying, MSP shall bear no expense of any nature in connection
therewith.

SECTION 16.  CONFIDENTIAL INFORMATION.
             ------------------------ 

(a)  Title to Confidential Information and Related Documents.  Title to
     -------------------------------------------------------           
Confidential Information provided by the Disclosing Party to the Recipient shall
be and remain the sole and exclusive property of the Disclosing Party. Recipient
shall return all such Confidential Information, together with all copies
thereof, except for one archive copy, promptly upon the termination of this
Agreement.

(b)  Non-Disclosure and Non-Use of Confidential Information.  The Recipient
     ------------------------------------------------------                
shall hold all Confidential Information disclosed to it pursuant to this
Agreement in confidence and will use Confidential Information only for the
purpose of performing its obligations under this Agreement and for no other
purpose whatsoever. The Recipient will not disclose Confidential Information to
any third person and will disclose Confidential Information only to such of its
employees as is necessary or reasonably appropriate to the performance of the
Recipient's

                                     -21-

<PAGE>
 
obligations under this Agreement. Recipient shall ensure that its employees and
any permitted subcontractors having access to the Confidential Information of
the Disclosing Party have previously agreed, either as condition of employment
or to obtain the Confidential Information, to be bound by terms and conditions
substantially similar to those found in this Section 16(b) as a condition to
such access. In the event that the Recipient is requested or required by court
or governmental order to disclose any of the Confidential Information, the
Recipient shall provide the Disclosing Party with prompt written notice of such
request or requirement so that the Disclosing Party may seek a protective order
or other appropriate protection. The Recipient will cooperate with Disclosing
Party at the Disclosing Party's expense, to obtain an appropriate protective
order or other reliable assurance that confidential treatment will be accorded
confidential treatment by such court or governmental entity.

(c)  Protection of Confidential Information.  The Recipient will observe
     --------------------------------------                             
reasonable precautions and procedures to protect and preserve Confidential
Information to the same extent that the Recipient uses with respect to its own
like confidential information.

SECTION 17.  TERM AND TERMINATION.
             -------------------- 

(a)  Term of Agreement.  The Term shall commence upon the Effective Date and
     -----------------                                                      
continue until its expiration on the seventh anniversary of the Effective Date,
unless earlier terminated as provided in this Agreement.

(b)  Termination Upon Default.  Except for a failure and the corresponding
     ------------------------                                             
remedy as expressly specified in Sections 3, 12 and 17(d), if either Party shall
commit a material default in any of the material terms or obligations under this
Agreement, the non-defaulting Party shall have the right to give the defaulting
Party notice specifying with particularity the default and the circumstances
surrounding the default. If the defaulting Party shall fail to cure, the noticed
default within thirty (30) days after receipt of such notice (fifteen business
days with respect to non-payment of amounts owed by AASTROM to MSP under this
Agreement), the non-defaulting Party shall have the right to terminate this
Agreement prospectively by giving the defaulting Party further notice of at
least twenty (20) days prior to the effective date of termination set forth in
such further notice.

(c)  Termination Upon Insolvency.  Either Party shall have the right to
     ---------------------------                                       
terminate this Agreement prospectively by notice of at least ten (10) days to
the other Party if the Party receiving such notice has filed a petition in
bankruptcy or insolvency (or if such petition is filed against it and is not
vacated, stayed or bonded within one hundred and twenty (120) days after such
filing), or files a petition or answer seeking reorganization, readjustment or
rearrangement of a substantial part of its business under any law relating to
bankruptcy or leading to bankruptcy or is adjudicated by a competent regulatory
agency to be bankrupt or insolvent, or a receiver is appointed for all or
substantially all of the property of such other Party, or an assignment is made
for the benefit of the creditors of such other Party, or any proceeding are
instituted for the liquidation or winding up of the business of such other
Party.

(d)  Termination Upon Inability of MSP to Perform.  If, on any three occasions
     --------------------------------------------                             
within a twelve-month period during the Term of this Agreement, one or more
of the following events

                                     -22-

<PAGE>
 
occur, then AASTROM shall have the right to notify MSP that AASTROM intends to
terminate this Agreement prospectively, specifying an effective date of
termination not less than thirty (30) days after the date of such notice: (i)
more than ten (10%) percent of the Shipment Lots or units of Cell Cassettes
delivered to AASTROM are properly rejected by AASTROM under Section 3(f), above;
(ii) more than 1 of 1,000 Cell Cassettes accepted by AASTROM fail to meet the
warranty set forth in Section 12(a); or (iii) MSP fails to timely deliver a
complete order of Cell Cassettes meeting Specifications. For purposes of this
Section 17(d), the term "timely deliver" shall mean delivery not more than ten
(10) days prior to, nor more than five (5) days after, scheduled delivery dates.
The foregoing right of termination shall be in addition to AASTROM's right to
seek damages available under law subject to the limitations set forth in Section
13.

(e)  Effect of Termination.  Termination of this Agreement by either Party shall
     ---------------------                                                      
not affect any purchase order submitted by AASTROM to MSP pursuant to the terms
of this Agreement prior to the effective date of termination and the Parties
shall fulfill their obligations under such purchase order or to be undertaken
under this Agreement prior to such termination even if the completion of such
obligations shall be after the effective date of termination. Notwithstanding
the foregoing, upon any termination of this Agreement by AASTROM pursuant to
this Section 17, AASTROM may, in its discretion elect to terminate all in-
process manufacturing of Cell Cassettes by MSP and MSP shall terminate such
manufacturing effective immediately upon notice from AASTROM. Furthermore, upon
the expiration of the Term as specified in Section 17(a), or upon the
termination of this Agreement other than a termination by AASTROM as permitted
by Sections 17(b), (c) or (d), then AASTROM shall purchase, at the price set
forth in this Agreement, all Cell Cassette finished goods, work in process and
unique materials that have been purchased by MSP prior to the effective date of
this Agreement for the manufacture of Cell Cassettes provided that the
quantities of such goods and materials are reasonable in light of AASTROM's
forecasted Requirements and provided that such goods and materials are not
defective (per the Specifications). Without limiting the generality of the
foregoing, to the extent necessary to give effect to the intention of the
Parties expressed therein, the obligations of the Parties under Sections 10
("Equipment"), 11(d) ("Records; Inspection"), 12 ("Warranty; Recalls"), 13
("Limitation of Damages Liability"), 14 ("Indemnity"), 15 ("Ownership of
Intellectual Property"), 16 ("Confidential Information"), 17 ("Term and
Termination"), 18 ("Preferred Supplier; Alternative Supplier"), 19
("Representations and Warranties"), 23 ("Similar Products"), 24 ("Governing Law;
Dispute Resolution"), 25 ("Notices"), 28 ("Severability"), 29 ("Amendment and
Waiver") and 32 ("Entire Agreement") shall survive termination of this Agreement
in accordance with their terms.

(f)  Liabilities When No Termination.  Notwithstanding the foregoing, in the
     -------------------------------                                        
event that MSP is in material breach of any of its warranties or obligations,
and such breach does not allow AASTROM to terminate this Agreement pursuant to
Section 17, then MSP shall be subject to the liabilities and remedies available
at law and by this Agreement for such breach, subject to the limitations set
forth in Section 13.

(g)  Alternative Purchase of Product.  If MSP is in breach of MSP's obligations
     -------------------------------                                           
to make and sell Cell Cassettes or Components as specified in this Agreement,
and such breach does not

                                     -23-

<PAGE>
 
result in a termination of this Agreement, and if AASTROM has available an
alternative manufacturing source for said Cell Cassettes or Components, then
AASTROM may cancel all or any part of any pending purchase orders (which
purchase orders are within the quantities specified in the 12-month rolling
forecast as specified in Section 3(a) hereof) for which MSP is unable or
unwilling to accept and perform; and AASTROM may have said purchase orders
performed by the alternative manufacturing source; and any damages suffered by
AASTROM as a result of MSP's breach shall still be recoverable against MSP
(subject to the limitations specified in Section 13 hereof).

SECTION 18.  PREFERRED SUPPLIER; ALTERNATIVE SUPPLIER.
             ---------------------------------------- 

(a)  Preferred Supplier.  During the Term, AASTROM shall regard MSP as its
     ------------------                                                   
"preferred supplier" for Cell Cassettes and purchase its Requirements from
MSP; provided, however, nothing in this Agreement shall be deemed to
     --------  -------                                              
preclude AASTROM from manufacturing the remaining forty (40%) percent of
AASTROM's total requirements for Cell Cassettes by itself or from utilizing
alternate suppliers for such manufacture.

(b)  Alternate Suppliers.  In the event that AASTROM elects to utilize an
     -------------------                                                 
alternative supplier for the Cell Cassettes during the Term, MSP shall provide
reasonable cooperation by promptly supplying AASTROM with copies of all AASTROM
Documentation at the reasonable expense of AASTROM; provided, however nothing
                                                    --------  ------- 
in this Section 18(b) shall be deemed to require MSP to provide training or
consultation services to the alternate supplier with regard to the manufacture
of the Cell Cassettes.

SECTION 19.  REPRESENTATIONS AND WARRANTIES.  MSP and AASTROM each represents
             ------------------------------                                  
and warrants (1) that each has, respectively, the full right and authority to
enter into this Agreement, and nothing provided in this Agreement will conflict
in any way with any outstanding obligation, contractual or otherwise, of such
Party, and (2) that each shall comply with all United States governmental laws,
rules, regulations and orders applicable to its obligations under this
Agreement.

SECTION 20.  FORCE MAJEURE.
             ------------- 

(a)  Suspension of Performance.  In the event that MSP or AASTROM (other than
     -------------------------                                               
with respect to its obligations to pay money to MSP) is rendered unable, wholly
or in part, to carry out its obligations under this Agreement by reasons of acts
of God, industrial disturbances, outbreak of a state of emergency, war,
hostilities, civil commotion, riots, epidemics, fires, earthquakes, floods or
any other cause or causes similar or dissimilar to the foregoing beyond the
reasonable control of the Party claiming benefit of force majeure, upon such
Party's giving notice and reasonably full particulars of such reason to the
other Party within a reasonable time after the occurrence of the cause relied
upon, then the obligations of the Party giving such notice, so far as they are
affected by such reason, shall be suspended during the continuation of any
inability so caused, but no longer, and such cause shall so far as reasonably
possible be remedied with all reasonable dispatch without the necessity of
expending sums (including, without limitation, for overtime labor) not otherwise
required under this Agreement. When the event operating to suspend performance
by either Party

                                     -24-

<PAGE>
 
shall cease, this Agreement shall continue in full force and effect until
the expiration or earlier termination as provided in this Agreement.

(b)  Cooperation.  In the event of a force majeure, AASTROM and MSP shall
     -----------                                                         
communicate and cooperate in seeking to avoid or minimize potential interruption
of supply and to develop mutually acceptable contingency plans in the spirit of
this Agreement.  In any event, the time for a Party's performance under this
Agreement shall be extended to the extent reasonably necessary to perform the
suspended obligation.

(c)  Allocation of Resources.  In the event of a force majeure resulting in a
     -----------------------                                                 
partial inability of MSP to supply product to its customers, MSP may allocate
resources that have not specifically been earmarked to this Agreement, to all of
its customers in an equitable manner as determined solely by MSP.

Section 21.  MSP Competitiveness; Shared Investment Return.
             --------------------------------------------- 

(a)  MSP's Competitiveness.  The Parties acknowledge that a primary
     ---------------------                                         
consideration for AASTROM with regard to the selection of MSP as its preferred
supplier was MSP's expertise and stated intention to be a cost-effective and a
capable manufacturer and supplier of Cell Cassettes and Components and that
AASTROM's commercialization strategy is dependent in part upon MSP's stated
intention to use best diligent efforts to remain cost effective and capable.
Thus, MSP will use best diligent efforts to search for methods and means that
will lead to in-plant cost reductions, savings and maintenance and quality
improvement. AASTROM will cooperate with MSP in these efforts.

(b)  Shared Investment Return.
     ------------------------ 

     (1) MSP Capital Investments.  If, during the Term, MSP shall invest in an
         -----------------------                                              
AASTROM-approved capital project that results in a cost savings in the
production of Cell Cassettes, MSP shall be entitled to retain such cost savings
until MSP has recouped the entire cost of the capital project from Cell
Cassettes purchased by AASTROM.  Once MSP recoups such capital expenditure, the
cost savings resulting from implementation of the capital expenditure shall be
shared by the Parties on a 50%:50% basis and MSP shall be deemed to have
assigned to AASTROM sole ownership of the capital property purchased by MSP such
that the capital property shall be AASTROM's Equipment.  Throughout the Term,
any such capital property purchased by MSP shall be used by MSP solely for the
manufacture of Cell Cassettes for AASTROM.  The method for recoupment of MSP's
capital investments and implementation of cost sharing shall be as set forth in
Section 21(b)(2) below.

     (2) Recoupment of MSP Capital Investment; Cost Sharing.  Effective on the
         --------------------------------------------------                   
first day of the quarter immediately following the quarter in which a capital
project paid for by MSP is implemented and cost savings first occur, the Base
Cost Assumption (calculated in accordance with Appendix III) shall be
recalculated (RBCA) to reflect the cost savings resulting from implementation of
the capital project.  The difference between the original Base Cost Assumption
(OBCA) and RBCA shall be tracked by MSP on future orders of Cell Cassettes and
the entire cost savings shall be allocated to MSP until MSP has recouped the

                                     -25-

<PAGE>
 
amount MSP expended on the capital project.  Thereafter, the cost savings
resulting from implementation of the capital expenditure shall be allocated to
AASTROM and MSP on a 50%:50% basis with regard to all Cell Cassette orders
submitted by AASTROM.

     (3) AASTROM Capital Investments.  AASTROM shall enjoy all savings that
         ---------------------------                                       
result from capital projects that are paid for by AASTROM or result from any
changes in Specifications made by AASTROM.  In the event that any such cost
savings are implemented, the Base Cost Assumption utilized to calculate
AASTROM's purchase price for Cell Cassettes shall be immediately reduced to
reflect the amount of the cost savings.  AASTROM shall also retain all ownership
rights with regard to any capital property purchased by AASTROM which may be
used by MSP in the manufacture of Cell Cassettes for AASTROM.

SECTION 22.  INSURANCE.
             --------- 

During the Term, each Party shall procure and maintain at its own cost and
expense, including the cost of premiums and deductibles, a general liability
insurance policy, including product liability (completed operations) insurance,
in an amount not less than* dollars per occurrence,* dollars aggregate bodily
injury, death and property damage liability and commercial umbrella coverage of
at least* dollars each occurrence and annual aggregate. Such insurance shall be
written by a reputable insurance company licensed to do business in the United
States, shall name the other Party as an additional insured, shall contain a
broad form vendor's endorsement. During Term, MSP shall also carry and maintain
in full force and effect all-risk property insurance covering the full
replacement value of AASTROM's Equipment and MSP's building, machinery,
equipment and work-in-process, as well as worker's compensation insurance in the
statutory limits required by the State of North Carolina (or other applicable
jurisdiction). Within ten (10) days after the Effective Date, each Party shall
furnish the other Party with a certificate of insurance confirming the existence
of such insurance and stipulating that the insurer will give the other Party at
least ten (10) days' written notice prior to any cancellation of or material
change in such insurance. The availability of the foregoing insurance coverage
shall in no event be construed to limit or expand the Parties' agreement to
limit liability to one another in accordance with Section 13.

SECTION 23.  SIMILAR PRODUCTS.
             ---------------- 

(a)  Continuing Prohibition.  At all times both during and after the Term, MSP
     ----------------------                                                   
shall not make or sell, or enable others to make or sell, the Cell Cassettes
or Components, excepting only for making and selling the Cell Cassettes or
Components for AASTROM.

(b)  Similar Products.  During the Term, MSP shall not (i) manufacture,
     ----------------                                                  
assemble, produce, ship or in any other way make available for use or
distribution, by any party other than AASTROM, any product or system that is
functionally the same as the Cell Cassette or Components, or (ii) in any way
accept engagement with, or render service to, any individual, firm or
corporation, other than AASTROM, as a consultant, instructor, expert, designer,
manufacturer or producer, or act in any other capacity, which engagement or
rendition of

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                                     -26-

<PAGE>
 
services involves the development or production of any product or system that
performs the same function as the Cell Cassette. Furthermore, in the event that
this Agreement is terminated by AASTROM "for cause" under Section 17, the
foregoing prohibitions shall continue until twelve (12) months after the
effective date of such termination. As used herein, a hematopoietic stem cell
expansion product or system does not have the same function as a Cell Cassette
                                 ---
if it utilizes distinctly different methods and distinctly different disposable
components than are used for the Cell Cassette.

SECTION 24.  GOVERNING LAW; DISPUTE RESOLUTION.
             --------------------------------- 

(a)  Governing Law.  The construction, interpretation and enforcement of the
     -------------                                                          
terms, conditions, rights and liabilities set forth in this Agreement shall
be in accordance with the internal laws of the State of New York, excluding
its conflict-of-laws principles.

(b)  Dispute Resolution.
     ------------------ 

     (1)  Any controversy or claim arising out of or relating to this Agreement
or the breach thereof, whether common law or statutory, including, without
limitation, claims asserting violations or the antitrust laws, will be settled
exclusively by arbitration in New York, New York if initiated by AASTROM and in
Ann Arbor, Michigan, if initiated by MSP (unless another location is mutually
agreed in writing), using the American Arbitration Association.  The arbitration
will be heard before three arbitrators, one to be chosen by AASTROM, one to be
chosen by MSP, and the third to be chosen by those two arbitrators.

     (2)  The arbitrators will apply the internal law of the State of New York
as set forth in Section 24(a), except that the arbitrators will not have the
power to alter, modify, amend, add to or subtract from any term or provision of
this Agreement.  To the extent consistent with the terms of this Agreement, the
arbitrators shall have the power to grant injunctive relief.  In all other
respects, the Commercial Rules of the American Arbitration Association will
govern the arbitration.  Judgment on the award of the arbitrators may be entered
by any court having jurisdiction to do so, and the parties to this Agreement
hereby irrevocably consent and submit to the personal jurisdiction and venue of
the applicable federal courts having jurisdiction in the district and state in
which the arbitration is to occur, if at all, in accordance with this Section
24(b) (or in the state court in the county and state in which the arbitration is
to occur, if at all, failing jurisdiction of the federal court) in any action or
proceeding for that purpose as well as for any and all other permitted purposes,
including, without limitation, in respect of a Party seeking injunctive relief,
in connection with this Agreement.  The Parties hereby irrevocably waive any and
all claims and defenses either might otherwise have in any such action or
proceeding in any of such courts based upon any alleged lack of personal
jurisdiction, improper venue, forum non conveniens or any similar claim or
                              ----- --- ----------                        
defense.

     (3)  The failure or refusal of either Party to submit to arbitration as
required by Section 24(b) will constitute a material breach of this Agreement.
If judicial action is commenced in order to compel arbitration, and if
arbitration is in fact compelled, the Party that resisted arbitration will be
required to pay to the other parties all costs and expenses, including,

                                     -27-

<PAGE>
 
without limitation, reasonable attorneys' fees, that they incur in compelling
arbitration.  The prevailing Party in arbitration shall be entitled to its
reasonable attorneys' fees and costs of the arbitration proceeding without
regard to the limitations set forth in Section 13.  All other fees and charges
of the American Arbitration Association will be borne as the arbitrators will
determine in their award.

(c)  Notwithstanding the Parties' agreement to submit to arbitration pursuant to
this Section 24, either Party may petition any court of competent
jurisdiction for injunctive relief in the event of an alleged breach of
Section 15(b) or 16.

SECTION 25.  NOTICES.
             ------- 

All notices required to be made hereunder shall be sent to the respective
Parties set forth below by certified mail, return receipt requested or by
facsimile (with confirmation copy by such certified mail):

          If to MSP:       Mid-State Plastics Division
                           Anchor Advanced Products, Inc.
                           Highway 220
                           P.O. Box 88
                           Seagrove, North Carolina  27341
                           Attn.:  Executive Vice President and General Manager
                           Facsimile: 910-873-8272

          with a copy to:  Piliero Goldstein Jenkins & Hall, LLP
                           292 Madison Avenue
                           New York, NY  10017
                           Attn.: Edward J. Goldstein, Esq.
                           Facsimile: 212-685-2028

          and

          If to AASTROM:   AASTROM Biosciences, Inc.
                           P.O. Box 376
                           Ann Arbor, Michigan  48106
                           Attn:  President and CEO
                           Facsimile: 313-665-0485

          with a copy to:  Gray Cary Ware & Freidenrich, P.C.
                           4365 Executive Drive, Suite 1600
                           San Diego, CA  92121-2189
                           Attn.:  T. Knox Bell, Esq.
                           Facsimile: 619-677-1477

          AASTROM and MSP may change their respective addresses and facsimile
numbers for notices by a notice given by mail in accordance with this Section
25.  Unless

                                     -28-

<PAGE>
 
otherwise shown by documentary evidence, all notices shall be deemed received
upon the earlier of actual receipt or three days after deposit in the U.S. mail,
postage prepaid, or if by facsimile, on the business day next following the day
sent.

SECTION 26.  SUCCESSORS AND ASSIGNS; SURVIVAL.
             -------------------------------- 

This Agreement is not intended to benefit any person not a Party hereto or to
give any rights to any such non-party.  This Agreement shall inure solely to the
benefit of and be binding upon the Parties hereto and their successors and
permitted assigns.  This Agreement shall bind and inure to the benefit of any
successor to a Party by merger or purchase of substantially all of the assets of
the Party.  Except to such a successor, neither AASTROM nor MSP may assign this
Agreement in whole or in part without the prior written consent of the other,
which consent shall not be unreasonably withheld.  Any assignment or purported
assignment by either party without any such required consent shall be null and
void.  The representations, warranties and covenants set forth in this Agreement
shall survive its expiration or earlier termination as expressly provided or as
is necessary to give full effect to the undertakings of the Parties prior to
such expiration or termination.

SECTION 27.  HEADINGS.
             -------- 

Headings inserted in this Agreement are for the convenience of the parties and
shall not govern any conclusion or interpretation of this Agreement or any of
its provisions.  Nouns and verbs in the singular person or tense shall include
the plural person and tense and vice versa.
                                ---- ----- 

SECTION 28.  SEVERABILITY.
             ------------ 

In case any provision or part thereof in this Agreement shall, for any reason,
be held invalid, illegal or unenforceable, such invalidity, illegality or
unenforceability shall not affect any other provision or part thereof, and this
Agreement shall be construed as if such invalid or illegal or unenforceable
provision or part thereof had been reformed so that it would be valid, legal and
enforceable to the maximum extent permitted.  Except as otherwise expressly set
forth in this Agreement, neither Party shall have the right to set off all or
any part of the damages it incurs as a result of the other Party's breach of its
obligations in this Agreement against amounts that are owed to such other Party
hereunder.

SECTION 29.  AMENDMENT AND WAIVER.
             -------------------- 

This Agreement may be amended or modified only by a written instrument executed
by each Party hereto expressly stating that it is an amendment to the terms of
this Agreement.  Without limiting the generality of the foregoing, all sales and
purchases of Cell Cassettes contemplated by this Agreement shall be made solely
pursuant to the terms of this Agreement without consideration of any different
or additional terms of any purchase order or sales acknowledgement or other form
of either Party and any such additional or different terms are hereby objected
to.  The failure of a Party at any time or times to require performance of any
provision hereof shall in no manner affect the Party's right at a later time to
enforce the same.  No waiver by any Party of the breach of any term contained in
this

                                     -29-

<PAGE>
 
Agreement, in any one or more instances, shall be deemed to be construed as a
further or continuing waiver of any such breach or of the breach of any other
term of this Agreement, nor shall any such waiver be deemed to be a custom or
practice of the waiving Party.  No waiver shall be effective unless in writing,
signed by the Party waiving compliance.

SECTION 30.  COUNTERPARTS.
             ------------ 

This Agreement may be executed in two or more counterparts, each of which shall
be deemed an original, but all of which together shall constitute one and the
same instrument.

SECTION 31.  INDEPENDENT CONTRACTORS.
             ----------------------- 

The relationship between the Parties is that of independent contractors and
neither Party shall have the power to bind or obligate the other in any manner,
other than as expressly set forth in this Agreement.

SECTION 32.  ENTIRE AGREEMENT.
             ---------------- 

This Agreement, including, without limitation, its recitals and Appendices, sets
forth the entire agreement and understanding of the parties in respect of the
subject matter hereof, including, without limitation, the purchase and sale of
Cell Cassettes, and supersedes all prior agreements, arrangements, presentations
and understandings relative to the subject matter hereof, whether written or
oral, express or implied.  No oral or written statement, representation,
warranty or promise made prior to or contemporaneously with the execution of
this Agreement shall be binding upon either party with respect to the subject
matter hereof or shall otherwise affect the enforceability of this Agreement in
accordance with its terms.

          IN WITNESS WHEREOF, the undersigned have executed and delivered this
Agreement effective on the Effective Date.

                              ANCHOR ADVANCED PRODUCTS, INC.
 

                              By:  /s/ FRANCIS OLMSTEAD
                                   --------------------------
                                   Francis Olmstead
                                   President and C.E.O.


                              AASTROM BIOSCIENCES, INC.


                              By:  /s/ R. DOUGLAS ARMSTRONG, Ph.D.
                                   -------------------------------
                                   R. Douglas Armstrong, Ph.D.
                                   President and C.E.O.

                                     -30-

<PAGE>
 
                                   APPENDIX I

                                   Equipment


I.   Cell Cassette-related Manufacturing Equipment To be Provided and owned by
AASTROM

     1.   Bioreactor Assembly Fixtures

     2.   Tissue Culture Treatment Process and Equipment Requiring:
          208 Volt 3 Flux 60HZ @ 60 AMPS Clean Earth Ground 2" Exhaust Vent

          Nitrogen       Carbon Dioxide
          Nitrous Oxide       Helium

     3.   Ultrasonic Welder - Dukane 700 Watt Ultracom Assembly System or
          Equivalent

     4.   Portable Clean Air Tent (if required)

     5.   Leak Tester - Industrial Data Systems Sprint LC-P Pressure
          Decay Leak Tester Equivalent

     6.   Sealing equipment for Harvest Bag, Waste Reservoir, and finished
          device packaging (if required)

     7.   UV curable adhesive application and curing equipment

     8.   Injection Molds

     9.   Robotic End Arm Tools

     10.  EMMA Welder and heat sealing station

II.  Manufacturing Equipment To Be Provided and owned by MSP:

     1.   Hand Assembly, Pneumatic Tools, and Dimensional Measurement Equipment
          as required by project

     2.   AutoCad and Pro Engineer workstation(s), either on site or
          readily accessible, to meet program objectives

                                      -1-

<PAGE>
 
     3.   Molding Equipment as Required by Program

          (600 ton, 300 ton, and 75 ton molding machines in class 100,000
          medical molding facility;

          700 ton molding machines in an environment suitable for producing
          parts to be moved into a clean room)

     4.   Robotic pickers for molding machine.

     5.   Class 100,000 Assembly space as required by the Program

                                      -2-

<PAGE>
 
                                  APPENDIX II

                                 Specifications




<PAGE>
 
                                  APPENDIX III

                                Pricing Schedule

                               For Phase I and II



A.  PHASE I PRICING FOR PRODUCTION AND COLLABORATION
    ------------------------------------------------

Pricing of Cell Cassettes and Collaboration during Phase I will be based on
total cost of manufacturing as such costs are defined in (S)A.2 of this Appendix
III (hereinafter "Costs") plus manufacturing "Mark-up".  Accounting will
summarize Costs at the end of each month and add the applicable Mark-up to
generate an invoice in the form attached hereto as Appendix IV to AASTROM.
AASTROM may at any time review MSP's books, records and supporting documentation
with regard to such costs in accordance with Section 11(d) of the Agreement.

1.  MARK-UP
    -------

The manufacturing mark-up on Costs, will be*; provided, however, that in no
                                              --------  -------            
event will MSP add a Mark-up on items supplied by AASTROM at no charge to, MSP;
and provided further that the Mark-up on costs described in item 2(f), below,
    -------- -------                                                         
shall be* and there shall be no additional mark-up for costs described in
items 2(h) and 2(j) below.  Nor shall there be any mark-up on freight, taxes,
insurance and other similar add-on charges with regard to the items listed below
or for costs billed directly to AASTROM.  Finally, in no event will there be
more than one mark-up on any item.

2.   COSTS.  Costs may include the following and will be determined as follows:
     -----                                                                     

     (a) Material.  Accounting will summarize invoiced amounts for all materials
         --------                                                               
used for Cell Cassettes.  This will include, without limitation, generic
materials, resins, packaging, process gases, custom fabricated components,
assemblies, and devices.  Freight-in will be included at invoiced amount.

     (b) General Expenses Purchases.  Accounting will summarize invoiced amounts
         --------------------------                                             
for all products and services (including invoiced expenses in connection
therewith) purchased solely for the Cell Cassette program, including express
freight charges, if applicable.  Purchase orders placed for Cell Cassette
products and services will have a special "X" prefix to indicate to Accounting
to accumulate copies of the invoices.

     (c) Travel expenses.  MSP employees will complete expense reports for
         ---------------                                                  
normal and customary travel, lodging, meals, and items incidental to the
foregoing in connection with the Cell Cassette program.  Expense reports will be
submitted to Accounting accompanied by receipts for all purchases.
- ----------
* CONFIDENTIAL PORTION REDACTED AND FILED SEPARATELY WITH THE COMMISSION

                                      -1-

<PAGE>
 
     (d) Direct Labor.  Direct labor cost will be at an average labor rate for
         ------------                                                         
the employee, calculated each month using a rolling 3-month average.  Operators,
lead operators, certified operators, and floor operators will log into the
AASTROM area in a log book while they are working on the Cell Cassette program.
Warehouse, maintenance, tooling and supervision will complete time sheets
indicating hours and activities for the Cell Cassette program.  Fringes will be
calculated at* of the total cost of direct labor employed in the manufacture
of Cell Cassettes during the month.  At month end, the log will be summarized by
Accounting.

          Current direct labor rates, including fringes, are:

<TABLE>
<CAPTION>
 
                                                   $ Cost/Hr.
                                                   ----------
          <S>                                      <C>
 
          Operator, Assembler, Floor Operator           *
          Inventory Clerk                               *
          Inspector/Auditor/Trainer                     *                     
          Shipping/Receiving/Truck Driver/              
          Material Handler.                             *
          Maintenance                                   *
          Supervisor                                    *
          Tool Maintenance                              *
 
</TABLE>


     (e)  Salary Labor.  Salaried labor will indicate on their weekly time sheet
          ------------                                                          
all hours and activities worked on the Cell Cassette program in minimum one-
tenth hour increments.  Payroll will forward time sheets with AASTROM hours to
Accounting.  At the end of each month, Accounting will total the hours by
employee and charge the base salary plus* for fringes.  Current typical
salaries, including fringes, are:


<TABLE>
<CAPTION>
 
                                   $ Cost/Hr.
                                   ----------
          <S>                      <C>
          Process Engineer              * 
          Customer Service              *
          Cost Accountant               *
          Quality Engineer              *
          Tooling Engineer              *
          Plant Manager                 *
          Operations Director           *
          VP Operations                 *
          VP Engineering                *
          Division President            *
</TABLE>


     (f) Consulting Fees.  Consulting cost will be the invoiced amount including
         ---------------                                                        
expenses.  Current cost rates are:
 
         Tom Brady (manufacturing)           * plus expenses
         Dan Whalan (quality assurance)      * plus expenses
- ----------
* CONFIDENTIAL PORTION REDACTED AND FILED SEPARATELY WITH THE COMMISSION

                                      -2-

<PAGE>
 
         Ms. Trabeau, Bryans
           Practical Consulting/Axios
           (microbiology/sterility assurance)    * plus expenses
         CAD design services                     *

Consulting fees will not be duplicated in item 2(b), above.

     (g) Molding Cost.  Molding cost will be calculated on an annual budgeted
         ------------                                                        
rate per machine hour.  The rate will be modified depending on the press size
and will not include direct labor.  The machine hours used and component
identification for the Cell Cassette program will be recorded in a log book and
summarized at month end by Accounting.  Labor will be logged and billed
separately.  The current average machine-hour rate is *.


<TABLE>
<CAPTION>
 
         Press Tons                     $ Cost/Hr.
         ----------                     ----------
         <S>                            <C>
             75                             *
            150                             *
            230                             *
            300                             *
            350                             *
            650                             *
</TABLE>


     (h) Rent.  Rent will be charged at the cost of monthly building
         ----                                                       
depreciation, insurance, taxes, maintenance and utilities (not including molding
machine utilities) per sq. ft. for the area designated for the Cell Cassette
program only.  The rate will be adjusted by MSP annually.  The current rental
rate including profit mark-up to MSP and estimated square footage for each area
are:


<TABLE>
<CAPTION>
 
           Area          $/sq. ft. per month   Current Estimated Sq. Ft.
           ----          -------------------   -------------------------
           <S>           <C>                   <C>
 
           Cleanroom               *                       1,000
           Warehouse               *                         925
</TABLE>


     (i) Tooling & Fixtures.  Upon prior written approval of AASTROM, unique
         ------------------                                                 
tooling and fixtures will be charged at MSP's cost of manufacture or the invoice
amount, as the case may be, including inbound freight if applicable.

     (j) Equipment.  Items listed in Appendix I as MSP Equipment will not be
         ---------                                                          
charged either individually or through depreciation to AASTROM.  Auto Cad and
Pro Engineer Workstations, also listed in Appendix I, are not charged to
AASTROM.  Freight, installation and training for such equipment will not be
charged.

B.  PHASE II PRICING
    ----------------

Prior to the commencement of Phase II, the Parties shall negotiate in good faith
using best diligent efforts to reach a mutual agreement with regard to the
establishment of a fair and
- ----------
* CONFIDENTIAL PORTION REDACTED AND FILED SEPARATELY WITH THE COMMISSION

                                      -3-

<PAGE>
 
reasonable purchase price for Cell Cassettes during Phase II in accordance with
the provisions of this Section B.

1.   Base Cost Assumption
     --------------------

As part of Phase I development, and prior to the commencement of Phase II, the
Parties will develop a bill of materials which sets forth the cost to produce a
Cell Cassette on a per unit basis assuming an annual production volume of 1,000
Cell Cassettes, hereafter referred to as the "Base Cost Assumption."  Such bill
of materials will be substantially in the form of Appendix V to be attached
hereto (hereinafter, the "Bill of Materials") and the Parties will use best
diligent efforts to mutually agree upon the cost assumptions underlying the Base
Cost Assumption.  Such assumptions shall be based upon manufacturing costs
determined in accordance with Generally Accepted Accounting Principles.

2.   Adjustment to the Base Cost Assumption
     --------------------------------------

A primary consideration in AASTROM's decision to select MSP as its preferred
supplier is MSP's stated intention and capability to use its best diligent
efforts to manufacture Cell Cassettes at the lowest reasonable cost.  As
manufacturing experience and unit and lot volumes increase, certain
manufacturing cost components are expected to decrease.  As part of its
undertaking to use best diligent efforts to capture such decreases, prior to
commencement of Phase II, MSP will meet with AASTROM (and its representatives)
to review, and carry out other activities as necessary to:

     (i)   establish the Bill of Materials for the Cell Cassette which will
include quantities and costs of purchased materials and labor hours and rates
for molding and assembly operations (see Appendix V);
     (ii)  identify the cost components that will be impacted by increased
production volumes;
     (iii) identify methods of improving manufacturing efficiencies in molding
and assembly operations expected to result in manufacturing yield improvements
from experience and volume increases; and
     (iv)  identify methods of improving the economies of procuring raw
materials and other third party components, including without limitation, volume
purchasing, and materials handling and procurement methods.

Once the Base Cost Assumption has initially been established, the Parties will
periodically review the assumptions underlying the Base Cost Assumption and
effect appropriate adjustments to the Base Cost Assumption to reflect changes to
the Bill of Materials including the then-current cost of purchased materials and
labor rates.  Based upon this review process (hereafter referred to as the "Cost
Review Process"), AASTROM and MSP will also establish the appropriate expected
cost reductions that are achievable by MSP at increased manufacturing volumes
and which MSP shall become responsible for achieving upon reaching an annual
Phase II production volume of* Cell Cassettes. Such cost reductions, as agreed
to by the Parties, will be referred to as MSP's Cost Reduction Commitment and
will include those cost reductions resulting from manufacturing efficiencies
achievable from
- ----------
* CONFIDENTIAL PORTION REDACTED AND FILED SEPARATELY WITH THE COMMISSION

                                      -4-

<PAGE>
 
increased manufacturing volume as well as improvements in manufacturing yield as
MSP becomes more proficient in producing Cell Cassettes (hereafter referred to
as "Manufacturing Yield). Upon AASTROM reaching an annual order volume of*
Cell Cassettes, the Parties will agree on MSP's cost Reduction Commitment to be
implemented at an annual order volume of* units. Concurrently with MSP's
efforts to implement cost reductions, AASTROM will endeavor to make design and
manufacturing process changes that will result in additional manufacturing cost
reductions (hereinafter referred to as "AASTROM Cost Reductions"). Such AASTROM
Cost Reductions will be reflected in the Base Cost Assumption. For example,
assuming a* per unit Base Cost Assumption, once AASTROM's annual order
volume reaches* Cell Cassettes, the Base Cost Assumption would be reduced
by MSP's Cost Reduction Commitment of (assuming* as MSP's Cost Reduction
Commitment) reducing the Base Cost Assumption to*. If AASTROM modified the
Specifications to allow for a $20 component to be used in place of a $50
component, the resulting $30 cost savings would further be deducted from the
Base Cost Assumption reducing it to*.

Upon the achievement of an annual production volume of* Cell Cassettes,
the Parties will again diligently undertake a Cost Review Process to determine
subsequent MSP Cost Reduction Commitments at annual production volume increments
of* Cell Cassettes.  The Cost Review Process shall not, however, be deemed
to relieve MSP from undertaking to use best diligent efforts to reduce costs
during any intervening periods wherein the parties are reviewing MSP's Cost
Reduction Commitment.

3.   Mark-Up, Cell Cassette Purchase Price
     -------------------------------------

Prior to the commencement of Phase II and not less than 30 days prior to
expiration of each subsequent calendar year during Phase II thereafter, AASTROM
shall advise MSP of its annual forecast of Cell Cassettes needed from MSP for
the following year and MSP will receive a manufacturing Mark-Up to be determined
each year based upon AASTROM's annual forecast and the manufacturing operations
to be undertaken by MSP as follows;

                     AASTROM Annual Volume Forecast (Units)
                     --------------------------------------

                         *   *   *   *   *   *   


MSP Manufacturing Operation     Mark-Up Rate
- ---------------------------     ------------

<TABLE> 

<S>                           <C>   <C>   <C>   <C>   <C>   <C>
Materials, labor &
    overhead - molding         *     *     *     *     *     *
 
Labor - assembly               *     *     *     *     *     *
 
MSP Purchased Components       *     *     *     *     *     *
 
</TABLE>


                                      -5-

- ----------
* CONFIDENTIAL PORTION REDACTED AND FILED SEPARATELY WITH THE COMMISSION


<PAGE>
 
Cell Cassette Purchase Price - Once the annual percent Mark-Up has been
- ----------------------------                                           
determined for the year, the Purchase Price for the Cell Cassettes to be
delivered to AASTROM for that year will be as follows;

     * (*)  = Purchase Price.

(*) the applicable Mark-Up rates will be based upon AASTROM's annual volume
forecast using the above table.  Once AASTROM's annual volume forecast reaches
a* Cell Cassettes increment, the Base Cost Assumption will be reduced by
MSP's Cost Reduction Commitment on all subsequent purchase orders submitted by
AASTROM, as provided in Section B.2 above, and any AASTROM Cost Reductions would
then be additionally deducted.

Such Purchase Price will be used by MSP to invoice AASTROM for Cell Cassettes
delivered under this Agreement during the following year.

Annual Adjustment - Costs - Within 30 days after the expiration of each year
- -------------------------                                                   
during Phase II, the actual average MSP manufacturing cost to produce a Cell
Cassette will be compared to the Base Cost Assumption, as adjusted, applicable
during the preceding year.  For purposes of this Section B3, the Base Cost
Assumption shall be adjusted to reflect the changes to price of purchased raw
materials and component parts and labor rates.  The Base Cost Assumption shall
not be adjusted for increases in cost resulting from activities within MSP's
control, including but not limited to, manufacturing efficiencies and
manufacturing yield.  If the actual average unit cost is less than such Base
Cost Assumption, then AASTROM shall be entitled to a credit for the difference
between the Base Cost Assumption, as adjusted, and the actual average unit cost
multiplied by the total number of units purchased by AASTROM during the
preceding year.  Such credit will be paid to AASTROM by MSP within 45 days after
AASTROM and MSP have completed the cost review.  Alternatively, if the actual
unit cost exceeds the Base Cost Assumption, as adjusted, AASTROM shall only be
obligated to pay MSP for Cell Cassettes it accepted at the Cell Cassette
Purchase Price in effect at the time the Order was submitted by AASTROM.  For
purposes of determining the actual manufacturing costs as set forth in this
Section B.3, the provisions of Section A 2(a), 2(d), 2(e), 2(g) and (h) of this
Appendix III shall apply, provided however that increases in those cost rates
will not exceed the amount of any increase in the Producer Price Index over the
applicable period and there shall be no mark-up on costs described in items 2(h)
nor shall there be any mark-up on freight, taxes, insurance, sterility
validation or other similar add-on charges with regard to costs directly billed
to AASTROM or for materials supplied directly by AASTROM.

Annual Adjustment - Mark-Up Rates - At such time as the foregoing annual cost
- ---------------------------------                                            
adjustment is made, the actual volume of Cell Cassettes ordered by AASTROM
during such year will be compared to the annual forecast for that year.  If the
actual volume of Cell Cassettes ordered and not canceled by AASTROM during such
year is less than the forecasted volume on which the Mark-Up rates were
established, MSP may invoice AASTROM for the difference resulting from the use
of lower than actual Mark-Up rates based upon the volume of Cell Cassettes
actually ordered by AASTROM.  Similarly, if the forecasted volume of Cell
Cassettes

- ----------
* CONFIDENTIAL PORTION REDACTED AND FILED SEPARATELY WITH THE COMMISSION

                                      -6-

<PAGE>
 
purchased by AASTROM is exceeded in any year, MSP will refund AASTROM for the
difference resulting from the use of higher than actual Mark-Up rates based upon
the volume of Cell Cassettes actually ordered by AASTROM.

Additional Manufacturing Development Activities.
- ----------------------------------------------- 

During Phase II, AASTROM may request that MSP provide assistance to AASTROM that
is beyond the scope of this Agreement.  In this event, any such costs
preapproved by AASTROM in writing and incurred by MSP will be borne by AASTROM
and paid at rates consistent with Phase I pricing.

                                      -7-

<PAGE>
 
                                  APPENDIX IV

                               Pro Forma Invoice

                                                                 
MSP Mid-state plastics                       INVOICE              INVOICE   PAGE
A Division of ANCHOR ADVANCED            ORIGINAL INVOICE         _______   ____
PRODUCTS, INC.                                                              
P.O. BOX 88 . SEAGROVE, NC 27341 .                                
TELEPHONE 910-873-7221                                                  DATE
                                                                        ____
       SOLD TO:                          SHIP TO:
   

                                                                  CURRENCY
                                                                  ________




<TABLE> 
<CAPTION> 

CUSTOMER          
   NO.                   SHIP VIA                  ORDER NO.       SLS. NO.        REFERENCE NO.                   TERMS
- --------      ------------------------------    --------------  -------------   -------------------   ------------------------------
<S>           <C>                               <C>             <C>             <C>                   <C>

</TABLE>
 


<TABLE> 
<CAPTION> 

ITEM NO.                  DESCRIPTION                   U/M             QUANTITY                 UNIT PRICE             AMOUNT
- --------      ----------------------------------    ----------    ----------------------    ---------------------  -----------------
<S>           <C>                                   <C>           <C>                       <C>                    <C>


               Description of item delivered to
               include Production Lot Number
               and Invoice to indicate the 
               number of items delivered at
               cost (in accordance with Section
               3 (g)) for Aastrom testing

</TABLE>
 


WEIGHT                                MISC. CHARGES                  AMOUNT DUE

<PAGE>
 
                                   APPENDIX V

                               Bill of Materials







<PAGE>
 
                                                                    EXHIBIT 23.1
                                                                    


 
                      CONSENT OF INDEPENDENT ACCOUNTANTS

We consent to the inclusion in this registration statement on Form S-1 Amendment
No. 2 (File No. 333-15415) of our report dated October 31, 1996, on our audits
of the financial statements of Aastrom Biosciences, Inc. We also consent to the
reference to our firm under the caption "Experts."


/s/ COOPERS & LYBRAND L.L.P.

Detroit, Michigan
December 19, 1996